Basic Information

Gene Symbol
topi_1
Assembly
GCA_036326145.1
Location
JARFJA010000067.1:326275-331169[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 19 0.024 2.3 9.7 0.1 1 23 263 286 263 286 0.94
2 19 1.7e-05 0.0016 19.6 1.7 1 23 331 353 331 353 0.98
3 19 2.4e-05 0.0022 19.1 0.2 1 23 359 382 359 382 0.97
4 19 5.7e-05 0.0053 17.9 0.2 3 23 390 410 388 410 0.98
5 19 1.7e-06 0.00016 22.7 0.8 1 23 416 438 416 438 0.98
6 19 0.0013 0.12 13.7 0.6 1 23 444 466 444 466 0.97
7 19 9.8e-06 0.00092 20.3 1.9 1 23 472 494 472 494 0.97
8 19 6.4e-05 0.0059 17.8 0.9 1 20 500 519 500 521 0.93
9 19 0.00075 0.07 14.4 1.5 2 23 576 598 576 598 0.96
10 19 0.077 7.2 8.1 0.5 3 23 623 644 621 644 0.92
11 19 9.3e-06 0.00087 20.4 1.9 1 23 653 676 653 676 0.94
12 19 9.3e-05 0.0087 17.3 4.6 1 23 694 717 694 717 0.95
13 19 1.3e-05 0.0012 20.0 1.6 1 23 752 774 752 774 0.98
14 19 9.5e-05 0.0089 17.2 3.0 1 23 780 802 780 803 0.94
15 19 0.0048 0.45 11.9 0.1 1 23 809 831 809 831 0.92
16 19 4.6e-05 0.0043 18.2 1.5 1 23 837 859 837 859 0.94
17 19 4.1e-05 0.0039 18.4 0.4 1 19 865 883 865 884 0.97
18 19 9.6e-05 0.009 17.2 2.0 1 23 893 915 893 915 0.98
19 19 4.1e-05 0.0038 18.4 3.4 2 23 922 943 921 943 0.97

Sequence Information

Coding Sequence
ATGGATCAAGAAATCGAATCCCAAGAAGATGAAATATTAGTGCAAATACCAGAAACTAATTTAATGGGAGTTAATATTATATGTCGATTATGTGCTAATCCCAATGAACGAATTATCGGCATATACAGCGATGAAGGTATTTCCAATGATTTGGCAACTAAAATGAATACATACTTACCAGTGAAAGTGGCCGAAACCGATTCTTTACCTCTACAATGCTGTTGGAATTGCGCCTCGACAGTTTTGGCATGGCACGAGCTTGTTGTAGCAAGTATAGAAGCCGATCGTAGATTACGAGATATTCAATTAAGTGATAAACAAGTTGCCAGCGAAGATGAATATAGTTGCATTGAGGAACCTACAACGCCCATTGACGACAGGTTAGAGCTGAAGTCGCCTGCCGCAAGTCTGAGTGTTTTCTGCCAAGAAACCCCAGACAGTTCGGTACAACAAAAGTGTTTACGATCgtctaagaaaaaaaaacatctgcTGTCTGTCGGTTTCCAAGAACAGATGACTGAAGTTAAAAAAGAAGAATGGATTGAATGCGACATTATCACTGGCGAATCTATTCAAAAATACATTGATAACATGCAAAATCCTTACATTGAATCTAAGCTAACGGAGAGTGTTacagaaaaagaaaaagtcaaacagaatgaaaatattttagaatcgAAGCAAGAGAGCATCGATCAAGAAAATAGTAATACTAAAAATATCGAATCAGACATATATGAAGATGATATAAACGTTGCGAAAAACGAGATGgcagaaaattataatttttcttgtcAATATTGTCctttaatgtttataaatgaaGAAGATATTGTAGATCACGTGAAACAAGAACATCCTGATAAAGAACACGACTTCACTGATGGTACGTCCTCCAacaaatcgaataaaaaagaaCGCAGGAAAAACACAAAACTGGATCACGATGCTGTAAATGCCGTTAAGGTTGTCGTCGAAGGCCGTATCTACTACAACTGTAAAATATGTGGAAAAAGTTTGCATTCTCCATATACATACACTTGGCATATGCGTATTCATACCGGCGAAAGGCCCTACGTTTGTGACTTATGTGGTAAACAATTTAGGGTATCGCAAGGTTTAGTAAGGCACTTGAGGGAAACGCACgaaggtattaaaaatttcggttGTGATATTTGTGGACGAATGTTTGCTACACGGCGTAACGTCGAAGAACATAGACGAATACATACAAACGAAAGACCGTATATATGTGATTTATGTgggaaaagttttaaacagAAAGCGTCGCTCTTTGTTCACAATCGATCACACACTAATTCGTTTCCATTTCGATGTAGTTACTGTAATCAAGGTTTTCGAACTAGACCACCTTTGTTAATACACGTAACGAGACATACAGGAGAAAAACCATACCCTTGTGATGTTTGTGGTAGATGTTTTAGAATTAAGTACGAATTAAAGAGGCATAAACTTATTCATTCCGAAGAAAAACCCTTTTCGTGTAGTGAATGTGGACTTAGTTTTAGACAGAAACGGTATTTGCGAAATCACAATAAGATTCAATCACGATCGAATCACTCAATAATTCATTATTCATTATTGAACAAAGAAAAAGAAGTAGTGGAAACAACCGGATTTGTTAAAGAAGCAGATCAGAAACCAGACCACCACAGCCAAGTTGAACATGCCATCGGTGAACTGCAGGTGGATAAAGATGGACGtgtttgcaaaatttgcaaaagtACTTTTGGACGGAGATCTGACATGTTAAGGCACATAAAACGGCAACACACAGAGAAATCTATCAAGACAATTAAACCTACCAGAAGAAGATGTCGTTTAGATATCGAGTATGGGATATTTTGCGACATTTGCAACATGGGTTTTACTAGAGTTTTGGACATGAAGAAACACAAAGTTAAACAGCATCCCGATGTTGtcgataaaatgttacatATATGcgatatttgtaataaaagatTTGATAGAAAAGTTCAGTTAAACAAACATTTGAAGGAAGATCATAATCAGAAAACCCCACGTTTTAGACGTCAAAAGAGCGATATTATCGCAGAACATTTTTGCGATATATGCAACAAAGGTTTTACGAGGAAATATGATATGCAAAAACACAGAAATAGTAAACATCCAAACGAACCTAAGCCTACGAAGGAACCAATAACACAACAGCAGAAAAATCTGCAACTTTTGGAGAAATGCAAAGTGCCCGGCGATGACAATAAAACGTATTATAAATGTGAAGTATGCGATCGTTTATTTCGACAGTCATATAATTTTGTGCGACACCAAACCGTCCATACCGGTGTTCGTGCATTTTTTTGTCACATATGCGGTAAGAACTTTCGCGTATCCGGAGGTCTTTACAGACATATTACCGAACATCACTACGGTGTTAAAAAGTACGAATGTGATGTGTGCGGCAAAAGTTTTGCAGCAAAGGCAACTAGAGATGatcataaaaacattcatACAAATAATAGACCTTTTATTTGCGATATGTGCGGTAAAGCGTTTAGGCAAAAAGCTTCCCTTCATATTCATAAACTCTTTCACGGCGATAATTACAGATTTTCGTGTAATATTTGTGACAAAAAATACAGGAGAGCGtccgaattaaaaatacattcgTGGTTGCATACCGGACACAAACCCCACCAGTGTACTATATGCGAAGCAAGATTTAGACTACGACAAGACTTAAAAAGACATATAAAAATTCacgataaattaaatgaatgtGTGTGCAAGGAGTGTGGTTCTACATTTCGTCAggaaagatatttaaaaaatcatataaaaactcatcgtgttaaaatttttattcaatctTCAACGTAA
Protein Sequence
MDQEIESQEDEILVQIPETNLMGVNIICRLCANPNERIIGIYSDEGISNDLATKMNTYLPVKVAETDSLPLQCCWNCASTVLAWHELVVASIEADRRLRDIQLSDKQVASEDEYSCIEEPTTPIDDRLELKSPAASLSVFCQETPDSSVQQKCLRSSKKKKHLLSVGFQEQMTEVKKEEWIECDIITGESIQKYIDNMQNPYIESKLTESVTEKEKVKQNENILESKQESIDQENSNTKNIESDIYEDDINVAKNEMAENYNFSCQYCPLMFINEEDIVDHVKQEHPDKEHDFTDGTSSNKSNKKERRKNTKLDHDAVNAVKVVVEGRIYYNCKICGKSLHSPYTYTWHMRIHTGERPYVCDLCGKQFRVSQGLVRHLRETHEGIKNFGCDICGRMFATRRNVEEHRRIHTNERPYICDLCGKSFKQKASLFVHNRSHTNSFPFRCSYCNQGFRTRPPLLIHVTRHTGEKPYPCDVCGRCFRIKYELKRHKLIHSEEKPFSCSECGLSFRQKRYLRNHNKIQSRSNHSIIHYSLLNKEKEVVETTGFVKEADQKPDHHSQVEHAIGELQVDKDGRVCKICKSTFGRRSDMLRHIKRQHTEKSIKTIKPTRRRCRLDIEYGIFCDICNMGFTRVLDMKKHKVKQHPDVVDKMLHICDICNKRFDRKVQLNKHLKEDHNQKTPRFRRQKSDIIAEHFCDICNKGFTRKYDMQKHRNSKHPNEPKPTKEPITQQQKNLQLLEKCKVPGDDNKTYYKCEVCDRLFRQSYNFVRHQTVHTGVRAFFCHICGKNFRVSGGLYRHITEHHYGVKKYECDVCGKSFAAKATRDDHKNIHTNNRPFICDMCGKAFRQKASLHIHKLFHGDNYRFSCNICDKKYRRASELKIHSWLHTGHKPHQCTICEARFRLRQDLKRHIKIHDKLNECVCKECGSTFRQERYLKNHIKTHRVKIFIQSST

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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