Basic Information

Gene Symbol
topi
Assembly
GCA_905340355.1
Location
HG996560.1:11135331-11138074[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 14 0.05 1.5 10.3 4.9 1 21 125 145 125 146 0.95
2 14 9.4e-05 0.0027 18.9 1.7 1 23 169 191 169 191 0.97
3 14 0.017 0.48 11.8 2.9 1 20 195 214 195 216 0.93
4 14 4.7 1.4e+02 4.1 0.0 2 13 236 247 235 249 0.88
5 14 0.91 26 6.4 2.0 2 23 328 349 327 349 0.96
6 14 9.4 2.7e+02 3.2 0.1 1 19 355 373 355 375 0.84
7 14 0.00073 0.021 16.1 2.0 2 22 392 412 392 415 0.89
8 14 0.13 3.8 9.0 3.2 1 23 479 502 479 502 0.98
9 14 0.029 0.85 11.0 0.2 1 23 506 528 506 528 0.92
10 14 1.5e-05 0.00042 21.5 5.7 2 23 535 556 535 556 0.97
11 14 0.013 0.37 12.2 0.3 1 23 562 587 562 587 0.96
12 14 0.04 1.2 10.6 3.3 1 23 593 615 593 615 0.96
13 14 3.3e-05 0.00094 20.3 2.5 1 23 621 643 621 643 0.98
14 14 0.00076 0.022 16.0 1.5 1 23 649 672 649 672 0.97

Sequence Information

Coding Sequence
ATGGATTATTCTAATATTTTCATAAAGGTGCACCGCGTATCCAGCGATGGTACAGTTACCTCGTTTCAAATCGAGGAAGATTTCTTTACCCAAAAATTAGTGTCCGTAACTCCAATTTCCGATGAAAGTTTTACTTGCGATTCGGATTTTGAGCAAGATGGCAATGTTCACTTAATTTTCCCTTATACAAATCTCGACGACAAATCTGTCACCCTCGTTAATATTGGAAACGTAGAAGATTTGAATTCCTTAACCTATTCGGAAGAAGTCAACACCCTGATGAGCAATCCTAGATCTTCTTCCAGCCAAAATATTGGTATTCCTAATTATCCACCTAGACGCAGGGGTAAAATACCCATAATACCAACAAAGCATAGATGTTTGAACTGCAACCAAAGTTTTTCTATAAAATATCATTATGAACGACATATCTGCGAATATACTGGAGAAAAGGTGATGCAGGCAGTACTTCCAGCTTTCGAAAAAGTTGAAGAAGGTATAAAGTACGATTGTCCTATTTGTGGTAAGCAGTTTCTGAGACAGCATAACCTGGATAGGCATCAATCTAGCCACGACGAAACGCATACTTGCGAACACTGTAGCAAAAAATTTACAACTGAAAATCGCCTTCGCATCCATAAGGAAAATTATTGCAAAAAGGTGGCTGACGGCAATATCAAATCTTGGAAAAATGCCACTGTTTGGAAATGCGTTCAGTGTAATCAAGTATTTGCTACTTCTGCCTTGGGCATCGAACACTCTGGATTATGTGCCAAAACTTTCAGGAAAGATATGGTTCCTAATATACCATTTGAATTCATAAACGTACCAGAAGAAAATAGCGGACTTGAATTGGAGAAGGAAGACAAACAAAATGTATTTTCTACCTTACCAAAAAATTTTAAGCAAGAAAATGATGACTGGAACCAAATTGAGAACGCTAATCGAAATGTGGAGAAATTACTGACCGAATTGTTACTACATTGCGAATATTGTAACTCAACATATTTGGAGAAAAGTTCTCTTCTAAACCATCAAATTAAGCATACCACGCAGATCAATTATCAGTGTGTTGTATGTAAAGGAACTTTTGATTCTTATACAACCGCAGTAAATCATTGGATAGAAGTGTGTCCTTATCAAGATGGAATATTTCACCTCCCCAAAATCAGATACTGTGAAATTTGCAATAAGACGTTCAAGACTCACGAAGCTCTGTATAAGCATAAGACAACTTTAGGACACTACACCCAAAAATTGCATGACGTAAACACCATTGATGTTAATTATTTAAGTGCAGAGGATCTTCAGAAAATAACGTCCATAGAAGTTGAATTAGTTTCAGAAAAGAAGGGCAAACGTGGTCGTAAACGAAAACTTCCATTAGAACCACTGCCATCTTCAAGTTCAGCGAATGTTCATGGACAATATAAGTATCAGTGTCATCTATGCATATTGACATTTGATAATACTGATGAAATGGAAAAGCATCGCAAGAAAAAGCATGCTTTATGTTTCCCTTGTGAGATATGTGGACAGGAGTATTCCAGTTCCAAAGCATTGATTTTTCATAACAAGATCCATAAAGGTTTGAAGCCAAATGTTTGTGAAAAGTGTGGCAAACATTTTAGCCAAACTTCACACTTACAGCAGCACATGAGGTTTCATCTAGGGATTAAACCATTTGCATGCCCCCATGAAGGATGCAAAGCTCGCTTCACCATAAGACCAGATTTGAAAGACCATATTCGCAAAGTCCATACTCGTGAACGGCCGTATAAGTGTACAGTGTGTGGTAAATGTTTCCTTACTGGATCTGTTTACTACCAACATCGTCGCATACATGTCCAAGATCGGAGATATCCTTGTGACATTTGCGAAAAAAAATTTTACCGGCGCGACTGTTTAAATATTCACCGGAGAATTCATACAAATGAAAAACCGTACGCTTGTCAATTTTGCGAAAAAGCATTTCGTCAAAATGTAGATCGAAATAAGCATTTACGGTCACGACATGCGAATTTGTTATAA
Protein Sequence
MDYSNIFIKVHRVSSDGTVTSFQIEEDFFTQKLVSVTPISDESFTCDSDFEQDGNVHLIFPYTNLDDKSVTLVNIGNVEDLNSLTYSEEVNTLMSNPRSSSSQNIGIPNYPPRRRGKIPIIPTKHRCLNCNQSFSIKYHYERHICEYTGEKVMQAVLPAFEKVEEGIKYDCPICGKQFLRQHNLDRHQSSHDETHTCEHCSKKFTTENRLRIHKENYCKKVADGNIKSWKNATVWKCVQCNQVFATSALGIEHSGLCAKTFRKDMVPNIPFEFINVPEENSGLELEKEDKQNVFSTLPKNFKQENDDWNQIENANRNVEKLLTELLLHCEYCNSTYLEKSSLLNHQIKHTTQINYQCVVCKGTFDSYTTAVNHWIEVCPYQDGIFHLPKIRYCEICNKTFKTHEALYKHKTTLGHYTQKLHDVNTIDVNYLSAEDLQKITSIEVELVSEKKGKRGRKRKLPLEPLPSSSSANVHGQYKYQCHLCILTFDNTDEMEKHRKKKHALCFPCEICGQEYSSSKALIFHNKIHKGLKPNVCEKCGKHFSQTSHLQQHMRFHLGIKPFACPHEGCKARFTIRPDLKDHIRKVHTRERPYKCTVCGKCFLTGSVYYQHRRIHVQDRRYPCDICEKKFYRRDCLNIHRRIHTNEKPYACQFCEKAFRQNVDRNKHLRSRHANLL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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