Basic Information

Gene Symbol
-
Assembly
GCA_905340355.1
Location
HG996554.1:22264929-22266116[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.00029 0.0082 17.4 4.1 1 23 63 85 63 85 0.95
2 12 0.00011 0.0033 18.7 0.5 1 23 91 113 91 113 0.98
3 12 2.5e-05 0.00072 20.7 2.9 1 23 119 141 119 141 0.98
4 12 6e-08 1.7e-06 29.0 0.6 1 23 147 169 147 169 0.98
5 12 7.2e-05 0.0021 19.3 3.5 1 23 175 197 175 197 0.97
6 12 0.00011 0.0033 18.7 0.5 1 23 203 225 203 225 0.98
7 12 2.5e-05 0.00072 20.7 2.9 1 23 231 253 231 253 0.98
8 12 6e-08 1.7e-06 29.0 0.6 1 23 259 281 259 281 0.98
9 12 7.2e-05 0.0021 19.3 3.5 1 23 287 309 287 309 0.97
10 12 8.1e-06 0.00023 22.2 1.1 1 23 315 337 315 337 0.98
11 12 0.00029 0.0083 17.4 3.8 1 23 343 365 343 365 0.98
12 12 1.6e-06 4.6e-05 24.5 2.7 1 23 371 393 371 393 0.98

Sequence Information

Coding Sequence
ATGAAACGGATCGACCAAGTATCGCAACCTCCATATAATTCTGGTAGCTGTAAAATTAAAGTAGAAGAGCTAGAAGATGTGAAGTTTAATTTGGAAGATTTACATCATTCGATAGACATCAAAGACGAGAGCGATGCAGAACAATTTCCGTTGGAGAAACCCGTAAGAGTAACTAAAAACATAAATTTTTTATGTCAGTTTTGTGACTATAGAAGTGCACATAAATCAAATTTAAACCGACATTTAAAAACTCATACAGGGGAGAAACCTTTTGTTTGTGAGATTTGTGACTATAAATGTGCTCTAAAATCAGGCTTAGAAATTCATATAAAAACTCATACAGGAGAAAAACCTTTTGTTTGTGAGATTTGTGACTATAAATGTTCTCAAAAATCACGTTTAAAAATTCATATAAAAACTCATACAGGAGCAAAACCTTTTGTTTGTGAGATTTGTGACATTAAATTTACTCAAAAATCATCCTTAAAAGTTCACATAAGAACTCACACAGGAGAAAAACTTTTCTTTTGTGAGATTTGTGACTTTAAATGTGCTCGAAAATCATACTTAAAAGTTCACATTAAAACTCACACAGGAGAAAAACCTTTTGTTTGTGAGATTTGTGACTATAAATGTGCTCTAAAATCAGGCTTAGAAATTCATATAAAAACTCATACAGGAGAAAAACCTTTTGTTTGTGAGATTTGTGACTATAAATGTTCTCAAAAATCACGTTTAAAAATTCATATAAAAACTCATACAGGAGAAAAACCTTTTGTTTGTGAGATTTGTGACATTAAATTTACTCAAAAATCATCCTTAAAAGTTCACATAAGAACTCACACAGGAGAAAAACTTTTCTTTTGTGAGATTTGTGACTTTAAATGTGCTCGAAAATCATACTTAAAAGTTCACATTAAAACTCACACAGGAGAAAAACCGTTTGTTTGTAAGATTTGTGACTATAAATTTGCTGAAAAATCACGTTTAAAAGCTCATTTAAAAACTCACACAGGAGAAAAACCTTTTGTTTGTGAGATTTGTGACTTTAAATGTGTTCGAAAATCATACTTAAAAGTTCACTTTAAAACTCACACAGGAGAAAAACCGTTTGTTTGTAAGATTTGTGACTATAAATGTGCTCAAAAATCAAACTTAAAAGTTCACATAAAAACTCACACAGGTTAA
Protein Sequence
MKRIDQVSQPPYNSGSCKIKVEELEDVKFNLEDLHHSIDIKDESDAEQFPLEKPVRVTKNINFLCQFCDYRSAHKSNLNRHLKTHTGEKPFVCEICDYKCALKSGLEIHIKTHTGEKPFVCEICDYKCSQKSRLKIHIKTHTGAKPFVCEICDIKFTQKSSLKVHIRTHTGEKLFFCEICDFKCARKSYLKVHIKTHTGEKPFVCEICDYKCALKSGLEIHIKTHTGEKPFVCEICDYKCSQKSRLKIHIKTHTGEKPFVCEICDIKFTQKSSLKVHIRTHTGEKLFFCEICDFKCARKSYLKVHIKTHTGEKPFVCKICDYKFAEKSRLKAHLKTHTGEKPFVCEICDFKCVRKSYLKVHFKTHTGEKPFVCKICDYKCAQKSNLKVHIKTHTG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-