Basic Information

Gene Symbol
-
Assembly
GCA_905340355.1
Location
HG996554.1:122620992-122633633[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 19 0.002 0.058 14.7 1.7 3 23 139 159 137 159 0.96
2 19 0.0052 0.15 13.4 4.6 1 23 165 187 165 187 0.99
3 19 1.9e-05 0.00055 21.1 4.3 1 23 193 215 193 215 0.99
4 19 0.00014 0.0041 18.3 2.1 1 23 221 243 221 243 0.97
5 19 0.023 0.67 11.4 4.6 1 23 249 271 249 271 0.97
6 19 6.2e-06 0.00018 22.6 4.1 1 23 277 299 277 299 0.98
7 19 0.0001 0.003 18.8 1.8 1 23 305 327 305 327 0.99
8 19 0.00038 0.011 17.0 1.0 1 23 333 355 333 355 0.97
9 19 5.6e-05 0.0016 19.6 0.9 1 23 361 383 361 383 0.97
10 19 0.0016 0.046 15.0 1.9 3 23 391 411 389 411 0.98
11 19 0.00073 0.021 16.1 0.1 1 23 417 440 417 440 0.98
12 19 0.00092 0.027 15.8 4.4 1 23 446 468 446 468 0.98
13 19 7.6e-05 0.0022 19.2 4.5 1 23 474 496 474 496 0.99
14 19 0.00024 0.0068 17.6 0.2 1 23 502 524 502 524 0.97
15 19 0.0018 0.051 14.9 1.4 1 23 530 552 530 552 0.98
16 19 0.00033 0.0094 17.2 2.2 1 23 558 580 558 580 0.98
17 19 0.0036 0.1 13.9 2.6 1 23 586 608 586 608 0.97
18 19 0.61 18 6.9 3.7 1 23 614 637 614 637 0.97
19 19 7.5 2.2e+02 3.5 0.5 1 15 643 657 643 660 0.85

Sequence Information

Coding Sequence
ATGGAGAAGTTTATACTTTTGAACAAATATGAGAAATTTGAAGAAGCTGTCGATGGTTTGCGAGCTCCCACTAACGATTACGAAATTTCAACAGACGAAAAGGAGGTAATGGAAGTCGAACTGGAAAAATTGCACCACTCTATTGATATTAAGGAAGAAGACGATTTGAATTTACAATATCAACAGGATAGTAATGAGGGTACTCGATGGCATTCAAATAGCCACTCCCAAATTAAAACAGAAGAAATAGAACTGAACTTGGAAGATTTGCATCATCATTCCATTTCCGAAGAGACTTTGGTTCACCTTCCGGAAATAAAAACAAGTGGTAAACCTCTCACACATGAAATTCCAGATTATAAATGTGCACTCAAATTACCTTTAGAAACTCATCTAGGGGACAAACTATTGGCGTGTAAATTATGTGATTATAAATGTGAGCGAAAAATAAATTTAATCAATCACATAAAAAATCATCTAACCGAAAAATTGTTTAAGTGTGAAATTTGTAGTTACCAATGTAAAATCTCGTCACGTTTAACGAAACATTTAAGAACCCATACAGGGGAAAAACCGTATTCGTGTGGAATATGTGGCTGCAAATTTGGACACAAAGAAAATTTAAATAGGCATTTAAAAACTCATACAGATGACAAGCCGTTTGCGTGTGATGTTTGTGACTTTAAATGTCGGCAAAAGGGAAGTTTAACAATTCATTTAAGAACCCATACAGGGGAAAAACCGTTTGCATGTGAAATGTGCGATTATAAATGTATACGAAAAATCCATTTAAAATATCATTCGAGAATTCATTTGGGAATAAAATTGTTTACGTGTGAAGTTTGCGAATACAAATTTTCTCGTAAGGAACATTTAAAAAATCATTTAAGAAGTCATACGGGGGAACTACCTTTTAAGTGTGAACTTTGCGATTATAAATGTGCACAGAAAGGGAGTTTAATAATACATCAAAGGAGTCATACCGGGGAGCAACCGTTTGCCTGCGAGTTGTGTGATTATAAAAGTGCTCGCAAGGAACATTTAGCACTTCATTTAAGAACACATACGGGAGACAAGCCGTTTGTGTGTGAAATTTGTAACAACAAATTTGTGCAGAAAACAAGTTTGAACCGGCATTTAAAAGGTCATGCGGGTGACAAACCTTTTGGGTGCGACTTTTGTGACTACAGAACTACGAATAAGAGAAGTTTACAGGAACATACCAGAACCCATACGGGGGAGAGACCGTTTGTATGCGAAATTTGTGACTACAGCGCCGCATCGAAAGGACTTTTAGCACGTCATTCAAGAACAACTCACACAATTGGCAAACAGTTTATGTGCGAAATTTGTGGCTACAAATGTGCTTTGCGAAACCACTTAAAAAGTCATTTGCGAACCCACTCGGGGGACAAGCCGTTCAAGTGTGATATTTGCGACTACAAATGTGCGCAAAAGGGGCATTTAAAAGATCACTTAAGATCCCATACAGGGGAGAAGCCGTTTGCGTGTGATATTTGTGACTTGCAGTACGCGTATAAGGGAAGTCTAAAAATTCATTTAAAAACCCACACGGGGGAGAAGCCCTTTACATGTGAAATTTGCGGTCACAAATTCGCTCAGAATAAAATTTTACAAGGTCATTTAAAAACTCACACGGGAGAAAAACCGTACGCGTGTGAAACTTGCGATTATAAATGTGCTCGTAAGAGAAGCTTAATACTTCACTTGAGAACGCATACGGGGGAGAAACGGTTTGCTTGTGAAACTTGTGATTTTAAATGTGTACGGAAGCGAACGTTAAAAGTTCATTTAATTACTCACACAGACCTAAAACCGTTTTCGTGTGAACTGTGTGATTTTAAATGTGCACGGAAGGTAGAACAAAAAATTCATTTTAGAAAAACGCATGCACCTGCGAAACCGTTTATGTGCACAATTTGTGATTTTAAATGTGCGCATGACAGCAATGTTATTGTGGTGCTTGAAGAAGGTCGATGTAGATCATCAGGTTTGGTTTTGGGGCCTTCAGAATTACGTCGATGA
Protein Sequence
MEKFILLNKYEKFEEAVDGLRAPTNDYEISTDEKEVMEVELEKLHHSIDIKEEDDLNLQYQQDSNEGTRWHSNSHSQIKTEEIELNLEDLHHHSISEETLVHLPEIKTSGKPLTHEIPDYKCALKLPLETHLGDKLLACKLCDYKCERKINLINHIKNHLTEKLFKCEICSYQCKISSRLTKHLRTHTGEKPYSCGICGCKFGHKENLNRHLKTHTDDKPFACDVCDFKCRQKGSLTIHLRTHTGEKPFACEMCDYKCIRKIHLKYHSRIHLGIKLFTCEVCEYKFSRKEHLKNHLRSHTGELPFKCELCDYKCAQKGSLIIHQRSHTGEQPFACELCDYKSARKEHLALHLRTHTGDKPFVCEICNNKFVQKTSLNRHLKGHAGDKPFGCDFCDYRTTNKRSLQEHTRTHTGERPFVCEICDYSAASKGLLARHSRTTHTIGKQFMCEICGYKCALRNHLKSHLRTHSGDKPFKCDICDYKCAQKGHLKDHLRSHTGEKPFACDICDLQYAYKGSLKIHLKTHTGEKPFTCEICGHKFAQNKILQGHLKTHTGEKPYACETCDYKCARKRSLILHLRTHTGEKRFACETCDFKCVRKRTLKVHLITHTDLKPFSCELCDFKCARKVEQKIHFRKTHAPAKPFMCTICDFKCAHDSNVIVVLEEGRCRSSGLVLGPSELRR

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-