Basic Information

Gene Symbol
-
Assembly
GCA_905340355.1
Location
HG996554.1:16656983-16674008[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 1.4e-06 4.2e-05 24.6 2.9 1 23 125 147 125 147 0.99
2 15 0.00011 0.003 18.7 6.9 1 23 153 175 153 175 0.99
3 15 5.7e-05 0.0016 19.6 6.1 1 23 181 203 181 203 0.99
4 15 2.1e-05 0.0006 21.0 5.3 1 23 209 231 209 231 0.99
5 15 4.1e-05 0.0012 20.0 4.5 1 23 237 259 237 259 0.99
6 15 2.4e-05 0.00068 20.8 4.5 1 23 265 287 265 287 0.99
7 15 0.00011 0.003 18.7 6.9 1 23 293 315 293 315 0.99
8 15 5.7e-05 0.0016 19.6 6.1 1 23 321 343 321 343 0.99
9 15 9.2e-08 2.7e-06 28.4 1.2 1 23 349 371 349 371 0.99
10 15 4.1e-05 0.0012 20.0 4.5 1 23 377 399 377 399 0.99
11 15 4.1e-05 0.0012 20.0 4.5 1 23 405 427 405 427 0.99
12 15 2.4e-05 0.00068 20.8 4.5 1 23 433 455 433 455 0.99
13 15 0.00011 0.003 18.7 6.9 1 23 461 483 461 483 0.99
14 15 1.2e-05 0.00036 21.7 2.4 1 23 489 511 489 511 0.99
15 15 0.00047 0.013 16.7 5.5 1 23 517 539 517 539 0.99

Sequence Information

Coding Sequence
ATGGATAAATTGATACCATTGATCAAGTTGGAGAAATTAGAAGAAGCTATCGATGGTTTTCGAGTCCCCAGTGATGATCAAGAAATTACAACAGACGAAATGGAGGCCATGGACGCCAAATTAGAAGATTTGCACCACTCCATCGATATTAAAGAAGAAGACGATGCTAATTTAGAATATCAAGAGGATATCGATGAGGGTACTCTATCAAATTCAAATCGTCACTCCAAAATTAAGAGTGAAGAAATAGAATTGAATTTGGATAAGTTACATCATCATCTCAGTCATAGTCGAGAAGAGATTTCAGTTCATTTTCAGAAGACAAAAACTGATTGTAATCCGCTTACTACGCCTCAAATTTCCAACTATAAGTTTAAGTGTGAAATTTGTGACCACCAATTCACACAGAAGGGAAATTTAAAAGTTCATTTAAAAACGCATTCAGGAGATAAACCGTTTCAGTGTGAAATTTGTGACTATAAATGTGCACGGAAGCATCATTTAATAAGTCATTTAAGAACGCATTCAGGAGATAAACCGTTTCAATGTAAAATTTGTGACTACAAATGTGCACATAAAGAAAGTTTAAAAAATCATTTAAGAACGCATTCAGGAGATAAACCGTTCCAGTGTGAAATTTGTGACCATAAATTTGCACATAGGAATAGTTTAAAAAACCATTTAAGAACGCATTCAGGAGATAAACCGTTTCAGTGTGAAATTTGTGACTATAAATGTGCACAAAAGCAACATTTAATAAATCATTTAAGAACACATTCAGGAGATAAACCGTTTCAGTGTGAAATTTGTGACTATAAATGTGCACATAAGAGTAATTTAAGAGGCCATTTAAGAACGCATTCAGGAAATAAACCGTTTCAGTGTGAAATTTGTGACTATAAATGTGCACGGAAGCATCATTTAATAAGTCATTTAAGAACGCATTCAGGAGATAAACCGTTTCAATGTAAAATTTGTGACTACAAATGTGCACATAAAGAAAGTTTAAAAAATCATTTAAGAACGCATTCAGGAGATAAACCGTTTCAGTGTAACATTTGTGACTACAAATTTGCACAGAAGGGAAATTTAACAAATCATTTAAGAACGCATTCAGGAGATAAACCGTTTCAGTGTGAAATTTGTGACTATAAGTGTGCACAAAAGCAACATTTAATAAATCATTTAAGAACACATTCAGGAGATAAACCGTTTCAGTGTGAAATTTGTGACTATAAATGTGCACAAAAGCAACATTTAATAAATCATTTAAGAACACATTCAGGAGATAAACCGTTTCAGTGTGAAATTTGTGACTATAAATGTGCACATAAGAGTAATTTAAGAGGCCATTTAAGAACGCATTCAGGAAATAAACCGTTTCAGTGTGAAATTTGTGACTATAAATGTGCACGGAAGCATCATTTAATAAGTCATTTAAGAACGCATTCAGGAGATAAACCGTTTCAGTGTGAAATTTGTGACTATAAATGTGCACAGAAGGGAACTTTAACAAATCATTTAAGAACGCATTCAGGAGATAAACCGTTTCAGTGTGAAATTTGTGATTATAAATGTGCACATAGAAATAGTTTAAAAAGCCATTTAAAAACGCATTCAGGTGCTGGCTAA
Protein Sequence
MDKLIPLIKLEKLEEAIDGFRVPSDDQEITTDEMEAMDAKLEDLHHSIDIKEEDDANLEYQEDIDEGTLSNSNRHSKIKSEEIELNLDKLHHHLSHSREEISVHFQKTKTDCNPLTTPQISNYKFKCEICDHQFTQKGNLKVHLKTHSGDKPFQCEICDYKCARKHHLISHLRTHSGDKPFQCKICDYKCAHKESLKNHLRTHSGDKPFQCEICDHKFAHRNSLKNHLRTHSGDKPFQCEICDYKCAQKQHLINHLRTHSGDKPFQCEICDYKCAHKSNLRGHLRTHSGNKPFQCEICDYKCARKHHLISHLRTHSGDKPFQCKICDYKCAHKESLKNHLRTHSGDKPFQCNICDYKFAQKGNLTNHLRTHSGDKPFQCEICDYKCAQKQHLINHLRTHSGDKPFQCEICDYKCAQKQHLINHLRTHSGDKPFQCEICDYKCAHKSNLRGHLRTHSGNKPFQCEICDYKCARKHHLISHLRTHSGDKPFQCEICDYKCAQKGTLTNHLRTHSGDKPFQCEICDYKCAHRNSLKSHLKTHSGAG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01292177;
90% Identity
-
80% Identity
-