Basic Information

Gene Symbol
-
Assembly
GCA_905340355.1
Location
HG996554.1:13801870-13807337[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 20 0.0052 0.15 13.4 3.7 1 23 122 144 122 144 0.99
2 20 0.00013 0.0038 18.4 2.2 1 23 150 172 150 172 0.99
3 20 2.4e-05 0.0007 20.7 2.0 1 23 178 200 178 200 0.99
4 20 0.00049 0.014 16.6 6.7 1 23 206 228 206 228 0.99
5 20 9.2e-07 2.7e-05 25.2 2.0 1 23 234 256 234 256 0.99
6 20 2.1e-05 0.00062 20.9 2.3 1 23 262 284 262 284 0.99
7 20 3.3e-06 9.4e-05 23.5 2.3 1 23 290 312 290 312 0.99
8 20 0.00014 0.0041 18.3 2.0 1 23 318 340 318 340 0.99
9 20 2.4e-05 0.0007 20.7 1.6 1 23 346 368 346 368 0.99
10 20 2.1e-05 0.00062 20.9 2.3 1 23 374 396 374 396 0.99
11 20 3.8e-06 0.00011 23.3 1.9 1 23 402 424 402 424 0.99
12 20 0.0004 0.012 16.9 2.1 1 23 430 452 430 452 0.99
13 20 2.4e-05 0.0007 20.7 1.6 1 23 458 480 458 480 0.99
14 20 2.1e-05 0.00062 20.9 2.3 1 23 486 508 486 508 0.99
15 20 4.3e-06 0.00012 23.1 2.2 1 23 514 536 514 536 0.99
16 20 0.00014 0.0041 18.3 2.0 1 23 542 564 542 564 0.99
17 20 2.4e-05 0.0007 20.7 1.6 1 23 570 592 570 592 0.99
18 20 0.22 6.3 8.3 1.1 1 17 598 614 598 620 0.92
19 20 0.16 4.5 8.8 0.3 1 17 626 642 626 648 0.92
20 20 8.1e-05 0.0023 19.1 3.6 1 23 654 676 654 676 0.99

Sequence Information

Coding Sequence
ATGGATAAATTGATCAAGTTGGAGAAATTAGAAGAAGCTATCGATGGTTTGCGAGCCGCCAGTGATGATGAAGAAATTAGAACAGACAAAATGGAGGCCATGGACGCCAAATTAGAAGATTTGCACCACTCCATCGATATTAAAGAAGATGACGATGCTAATTTAGAATATCAGGAGGATATCGATGAGGGTACTCCATCACATACAAGTCGTCACTCCAAAATTAAGAGTGACGAAATAGAATTGAATTTGGATGAGCTACATCATCATCCCGTTCATAGTCGAAAAGAGATTTCAGATCATTTTCAGAAGACAAAAACTGATTGTAATCCGCTTACTACGCCTCAAATTTCCAACTATAAGTTTAAGTGCGGAATTTGTGACTACAAATCTGGACGGAAGCAACATTTCAAAATGCATTTAATGACGCATTCAGGAGAGAAACCTTTTCAGTGTGAAATTTGTGACTATAAAAGTGCACATAGGAATAGTTTAAAAATTCATTTAAGAACGCATTCAGGAGATAAACCGTATGAGTGTGAAATTTGTGACTACAAATGTGCACAGAAGCAAAATTTACTAAGTCATTTAAGAACGCATACAGGAGATAAACCGTTTCAGTGTGAAATTTGTGACTATAAATGTGCACTGAAGCATCATTTAGAAAGGCATTTAAGAACTCATTCAGGAGATAACCCGTTTCAGTGTGAAATTTGTGACTATAAATTTACAGATAGGAATAGTTTAAAAAGTCATTTAAGAACGCATTCAGGAGATAAACCGTTTCAGTGTGAAATTTGTGACTACAAATGTGCACAGAAGAATAATTTAGTAAGTCATTTAAGAACGCATTCAGGAGATAAACCGTTTCAGTGTGAAGTTTGTGACTATAAATGTACGGATAAGGGAAATTTAGTAAGGCATTTAAGAACGCATTCAGGCGATAAACCGTTTCAGTGTGAAATTTGTGACTATAAATGTGCACTGAAGCAAAATTTAATTAGTCATTTAAGAACGCATACAGGAGATAAACCGTATGAGTGTGAAATTTGTGACTATAAAAGTGCACATAGGAGTAGTTTAAAAATTCATTTAAGAACGCATTCAGGAGATAAACCGTTTCAGTGTGAAATTTGTGACTACAAATGTGCACAGAAGAATAATTTAGTAAGTCATTTAAGAACGCATTCAGGAGATAAACCGTTTCAATGTGAAGTTTGTGACTATAAATGTACGGATAACGGAAATTTAGTAAGGCATTTAAGAACGCATTCAGGCGATAAACCGTTTCAGTGTGAAATTTGTGACTTTAAATGTGCACTGAAGCAAAATTTAATTAGTCATTTAAGAACGCATACAGGAGATAAACCGTATGAGTGTGAAATTTGTGACTATAAAAGTGCACATAGGAGTAGTTTAAAAATTCATTTAAGAACGCATTCAGGAGATAAACCGTTTCAGTGTGAAATTTGTGACTACAAATGTGCACAGAAGAATAATTTAGTAAGTCATTTAAGAACGCATTCAGGAGATAAACCGTTTCAGTGTGAAGTTTGTGACTATAAATGTACGGATAACGGAAATTTACTAAGGCATTTAAGAACGCATTCAGGCGATAAACCGTTTCAGTGTGAAATTTGTGACTATAAATGTGCACTGAAGCAAAATTTAATTAGTCATTTAAGAACGCATACAGGAGATAAACCGTATGAGTGTGAAATTTGTGACTATAAAAGTGCACATAGGAGTAGTTTAAAAATTCATTTAAGAACGCATTCAGGAGATAAACCGTTTCAGTGTGGAATTTGTGACTACAAATGTGCACAGAAGAATAATTTAGTAAGTTATTTAAGAACGCATACAGGAGATGAACCGTATGAGTGTGAAATTTGTGACTATAAAAGTGCACATAGGAGTAGTTTAAAAATTTATTTAAGAACGCATTCAGGAGATAAACCGTTTCAGTGTGAAATTTGTGACTTCAAATGTGCACAGAAGCAATCATTAAAAAATCACTTAAGAACGCATACAGGAGATAAAAAATAG
Protein Sequence
MDKLIKLEKLEEAIDGLRAASDDEEIRTDKMEAMDAKLEDLHHSIDIKEDDDANLEYQEDIDEGTPSHTSRHSKIKSDEIELNLDELHHHPVHSRKEISDHFQKTKTDCNPLTTPQISNYKFKCGICDYKSGRKQHFKMHLMTHSGEKPFQCEICDYKSAHRNSLKIHLRTHSGDKPYECEICDYKCAQKQNLLSHLRTHTGDKPFQCEICDYKCALKHHLERHLRTHSGDNPFQCEICDYKFTDRNSLKSHLRTHSGDKPFQCEICDYKCAQKNNLVSHLRTHSGDKPFQCEVCDYKCTDKGNLVRHLRTHSGDKPFQCEICDYKCALKQNLISHLRTHTGDKPYECEICDYKSAHRSSLKIHLRTHSGDKPFQCEICDYKCAQKNNLVSHLRTHSGDKPFQCEVCDYKCTDNGNLVRHLRTHSGDKPFQCEICDFKCALKQNLISHLRTHTGDKPYECEICDYKSAHRSSLKIHLRTHSGDKPFQCEICDYKCAQKNNLVSHLRTHSGDKPFQCEVCDYKCTDNGNLLRHLRTHSGDKPFQCEICDYKCALKQNLISHLRTHTGDKPYECEICDYKSAHRSSLKIHLRTHSGDKPFQCGICDYKCAQKNNLVSYLRTHTGDEPYECEICDYKSAHRSSLKIYLRTHSGDKPFQCEICDFKCAQKQSLKNHLRTHTGDKK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-