Basic Information

Insect: Rhagonycha fulva
Gene Symbol: -
Assembly: GCA_905340355.1
Location: HG996555.1:296670-302329[+]

Transcription Factor Domain

TF Family: HSF
Domain: HSF_DNA-bind domain
PFAM: PF00447
TF Group: Helix-turn-helix
Description: Heat shock factor (HSF) is a transcriptional activator of heat shock genes [1, 4]: it binds specifically to heat shock promoter elements, which are palindromic sequences rich with repetitive purine and pyrimidine motifs [1]. Under normal conditions, HSF is a homo-trimeric cytoplasmic protein, but heat shock activation results in relocalisation to the nucleus [2]. Each HSF monomer contains one C-terminal and three N-terminal leucine zipper repeats [3]. Point mutations in these regions result in disruption of cellular localisation, rendering the protein constitutively nuclear [2]. Two sequences flanking the N-terminal zippers fit the consensus of a bi- partite nuclear localisation signal (NLS). Interaction between the N- and C-terminal zippers may result in a structure that masks the NLS sequences: following activation of HSF, these may then be unmasked, resulting in relocalisation of the protein to the nucleus [3]. The DNA-binding component of HSF lies to the N terminus of the first NLS region, and is referred to as the HSF domain.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 26 0.43 7e+03 -1.6 0.0 50 64 126 144 124 172 0.72

2 26 0.0064 1.1e+02 4.3 0.0 50 64 204 224 198 255 0.73

3 26 0.0049 82 4.7 0.1 49 64 267 288 262 317 0.68

4 26 0.016 2.6e+02 3.0 0.0 37 64 319 348 310 381 0.69

5 26 0.32 5.3e+03 -1.1 0.0 45 64 391 416 372 450 0.69

6 26 0.0095 1.6e+02 3.7 0.0 47 64 457 476 436 512 0.72

7 26 0.39 6.5e+03 -1.4 0.0 45 64 519 542 503 571 0.69

8 26 0.011 1.8e+02 3.6 0.0 47 64 585 604 568 637 0.72

9 26 0.32 5.3e+03 -1.2 0.0 45 64 647 672 628 705 0.69

10 26 0.0074 1.2e+02 4.1 0.0 47 64 713 736 690 764 0.69

11 26 0.0027 45 5.5 0.0 41 64 771 797 756 831 0.69

12 26 0.0027 44 5.5 0.0 39 64 833 862 819 896 0.69

13 26 0.0031 51 5.3 0.0 44 64 902 924 887 956 0.69

14 26 0.0028 46 5.5 0.0 41 64 963 989 948 1022 0.69

15 26 0.0016 26 6.2 0.1 38 64 1024 1056 1014 1085 0.66

16 26 0.0025 42 5.6 0.0 35 64 1085 1117 1076 1150 0.69

17 26 0.003 50 5.3 0.0 34 65 1148 1179 1142 1210 0.75

18 26 0.0028 47 5.4 0.0 41 64 1219 1245 1204 1277 0.69

19 26 0.0032 53 5.3 0.0 41 64 1283 1308 1268 1339 0.71

20 26 0.0016 27 6.2 0.0 34 64 1340 1376 1329 1405 0.68

21 26 0.0031 51 5.3 0.0 44 64 1414 1437 1399 1470 0.69

22 26 0.0016 27 6.2 0.0 34 64 1468 1504 1457 1537 0.69

23 26 0.0034 55 5.2 0.0 39 64 1537 1564 1524 1598 0.73

24 26 0.0033 54 5.2 0.0 45 64 1607 1628 1592 1660 0.69

25 26 0.0022 36 5.8 0.0 43 64 1669 1696 1654 1725 0.66

26 26 0.0034 57 5.2 0.0 45 64 1735 1756 1719 1795 0.73

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	26	0.43	7e+03	-1.6	0.0	50	64	126	144	124	172	0.72
2	26	0.0064	1.1e+02	4.3	0.0	50	64	204	224	198	255	0.73
3	26	0.0049	82	4.7	0.1	49	64	267	288	262	317	0.68
4	26	0.016	2.6e+02	3.0	0.0	37	64	319	348	310	381	0.69
5	26	0.32	5.3e+03	-1.1	0.0	45	64	391	416	372	450	0.69
6	26	0.0095	1.6e+02	3.7	0.0	47	64	457	476	436	512	0.72
7	26	0.39	6.5e+03	-1.4	0.0	45	64	519	542	503	571	0.69
8	26	0.011	1.8e+02	3.6	0.0	47	64	585	604	568	637	0.72
9	26	0.32	5.3e+03	-1.2	0.0	45	64	647	672	628	705	0.69
10	26	0.0074	1.2e+02	4.1	0.0	47	64	713	736	690	764	0.69
11	26	0.0027	45	5.5	0.0	41	64	771	797	756	831	0.69
12	26	0.0027	44	5.5	0.0	39	64	833	862	819	896	0.69
13	26	0.0031	51	5.3	0.0	44	64	902	924	887	956	0.69
14	26	0.0028	46	5.5	0.0	41	64	963	989	948	1022	0.69
15	26	0.0016	26	6.2	0.1	38	64	1024	1056	1014	1085	0.66
16	26	0.0025	42	5.6	0.0	35	64	1085	1117	1076	1150	0.69
17	26	0.003	50	5.3	0.0	34	65	1148	1179	1142	1210	0.75
18	26	0.0028	47	5.4	0.0	41	64	1219	1245	1204	1277	0.69
19	26	0.0032	53	5.3	0.0	41	64	1283	1308	1268	1339	0.71
20	26	0.0016	27	6.2	0.0	34	64	1340	1376	1329	1405	0.68
21	26	0.0031	51	5.3	0.0	44	64	1414	1437	1399	1470	0.69
22	26	0.0016	27	6.2	0.0	34	64	1468	1504	1457	1537	0.69
23	26	0.0034	55	5.2	0.0	39	64	1537	1564	1524	1598	0.73
24	26	0.0033	54	5.2	0.0	45	64	1607	1628	1592	1660	0.69
25	26	0.0022	36	5.8	0.0	43	64	1669	1696	1654	1725	0.66
26	26	0.0034	57	5.2	0.0	45	64	1735	1756	1719	1795	0.73

Sequence Information

Coding Sequence: ATGAATATTATTAATATTATTTTTGCTGTAACACTACTGCTTGTACCATCAATTTTGACATCGGAGTTAAATAGAAGCAAAAAACAAATTAATTTTGGTTCCGATAATGAAAGAGAAGGCTATTTTTATGATAAACCGTCTATTTCGTTTGAACTACCAACACAAAAGCCAACATCAACTCCGTTTGTAGCGGCCACCACAATTGCACCAGTTCCAACAGGATACAATTATCCAAAACCAAGCATTAAATTTGAAGAAAATCCACAACCAGTAGGAATAAGGCATGAACAAATATCTTCTACATTGTTTGGAAGCGGTGGTGGATCCCCAATTTCTTCAAAAACTCCATCAATCAGTATAGGCGGAGGAGTACAAAGTTCGGTTACCACTAGCTTTAATAAATATGAATTTAATAAACCACAAGTTAATATCGAAGTACAAAAGCCATCATCATTTGGCATTTTTGGTAATGGAGGATCCACTATTACAACAAACGTAAATAGATACGATACTTTTAAACCGAGTATTACCACTATCGCGCAGAAAATCGCTCCACAAGCTCCAGTCACCTCCAAAATACCTACTGGTGGTATATCTGGTTATGGACAAACATCATTTGTGTCTACCGTCAACAAGTACGATTTTAACAAGCCCACACTAACATTTGATATACCTAAACCGACATCTAAACCAGCAAGCCAGACTTCTTTTGGTGTTTTTGGAAGTGGTGTGCAGAAAACGACTTCACAGTCTACAATCGGTTCTCAGTTTCCCTCTGCAGGAACAAGCGGAAATGGTCAAACTTCATTTGTATCAACCGTTAACAAGTACGAATTTAAGAAGCCCACCGTAACATTTGACGTACCTAAACCGACTCCTAAACCAGTTGACCAGTCTTCATTTGGTTTTTATGGTAGTGGTGTACAAAAGACAACTTCCCAATCAACTTTTGGCTCCAAGGTTCCATCTACAGGAATTAGCGGAAGTGGTCAAACTACATTTGTATCAACCGTCAACAAATACGATTTTAGCAAACCCACAGTAACATTTGATGTACCTAAACCGACTCCTAAACCAGTTGGTCAGTCTTCATTTGGTTTTTATGGTAGTGGTGTACAGAAGACGACTGCCCAATCAACCTTTGGCTCTAAGGTTCCATCTACCGGAAGTAGCGGAAGTGGCCAAACTTCATTTGTCTCTACCGTCAACAAAAACGATTTTAGCAAGCCCACAGTAACATTTGATGTATCTAAACCGACTCCTAAACCAGTCGGTCAGTCTTCATTTGGTTTTTATGGTAGTGGTGTACAAAATACGAATTCCCAATCAACTTTTGGCGCTAAGGTTCCATCTACAGGAACTAGTGGAAGTGGCCAAACTTCATTTGTGTCTACCGTCAACAAATACGATTTCATCAAGCCCACAGTAACATTTGATGTACCTAAACCGACTCCTAAACCAGTTGGTCAGTCTTCATTTGGTTTTTATGGTAGTGGTGTACAGAAGACGACTGCCCAATCAACCTTTGGCTCTAAGGTTCCATCTACCGGAAGTAGCGGAAGTGGCCAAACTTCATTTGTCTCTACCGTCAACAAAAACGATTTTAGCAAGCCCACAGTAACATTTGATGTATCTAAACCGACTCCTAAACCAGTCGGTCAGTCTTCATTTGGTTTTTATGGTAGTGGTGTACAAAATACGAATTCCCAATCAACTTTTGGCGCTAAGGTTCCATCTACAGGAACTAGTGGAAGTGGCCAAACTTCATTTGTGTCTACCGTCAACAAATACGATTTCATCAAGCCCACAGTAACATTTGATGTACCTAAACCGACTCCTAAACCAGTTGGTCAGTCTTCATTTGGTTTTTATGGTAGTGGTGTACAGAAGACGACTGCCCAATCAACCTTTGGCTCTAAGGTTCCATCTACCGGAAGTAGCGGAAGTGGCCAAACTTCATTTGTCTCTACCGTCAACAAAAACGATTTTAGCAAGCCCACAGTAACATTTGATGTATCTAAACCGACTCCTAAACCAGTCGGTCAGTCTTCATTTGGTTTTTATGGTAGTGGTGTACAAAATACGAATTCCCAATCAACTTTTGGCGCTAAGGTTCCATCTACAGGAACTAGTGGAAGTGGCCAAACTTCATTTGTGTCTACCGTCAACAAATACGATTTCATCAAGCCCACAGTAACATTTGATGTACCTAAACCGACTTCTAAACCAGTTGGTCAGTCTTCATTTGGTTTTTATGGTAGTGGTGTACAGAAGACGACTTCCCAATCAACCTTTGGCTCTAAGGTTCCATCTACCGGAAGTAGTGGAAGTGGCCAAACTTCATTTGTGTCTACCGTCAACAAATACGATTTTAGCAAACCCACAGTAACATTTGATGTACCAAAACCGACTCCTAAACCAGTTGGTCAGTCTTCATTTGGTTTTTATGGTAGTGGTGTACAGAAGACGACTTCCCAATCAACCTTTGGCTCTAAGGTTCCATCTACAGGAAGTAGTGGAAGTGGCCAAACTTCATTTGTGTCTACCGTCAACAAATACGATTTTAGCAAGCCCACAGTAACATTTGATGTACCTAAACCGACTCCTAAACCAGTTGGCCAATCTTCATTTGGTTTTTATGGTAGTGGTGTACAAAAGACGACTTCCCAATCAACCTTTGGCTCTAAGGTTCCATCTACAGGAAGTAGTGGAAGTGGCCAAACTTCATTTGTGTCTACCGTCAACAAATACGATTTTAGCAAACCTACAGTAACATTTGATGTACCTAAACCGACTCCTAAACCAGTTGGCCAATCTTCATTTGGTTTTTATGGTAGTGGTGTACAGAAGACGACTTCCCAATCAACCTTTGGCTCTAAGGTTCCATCTACAGGAAGTAGTGGAAGTGGCCAAACTTCATTTGTGTCTACCGTCAACAAATACGATTTTAGCAAACCTACAGTAACATTTGATGTACCTAAACCGACTCCTAAACCAGTTGGCCAATCTTCATTTGGTTTTTATGGTAGTGGTGTACAGAAGACGACTTCCCAATCAACCTTTGGCTCTAAGGTTCCATCTACCGGAAGTAGTGGAAATGGTCAAACTTCATTTGTATCAACCGTCAACAAATACGATTTTAGCAAGCCCACAGTAACATTTGATGTACCTAAATCGACTTCTAAACCAGTTGGTCAGTCTTCATTTGGTTTTTATGGTAGTGGTGTACAAAATACGAATTCCCAATCAACCTTTGGCTCTAAGGTTCCATCTACCGGACTTAGTGGAAGTGGCCAAACTTCATTTGTGTCTACCGTCAACAAATACGATTTTAGCAAGCCCACAGTAACATTTGATGTACCTAAACCGACTCCTAAACCAGTTGGTCAATCTTCATTTGGTTTTTATGGTAGTGGTGTACAAAAGACGACTTCCCAATCAACTTTTGACGCTAAGGTTCCATCTACCGGAATTAGTGGAAGTGGCCAAACTTCATTTGTGTCTACCGTCAACAAATACGATTTTAGCAAACCTACAGTAACATTTGATGTACCTAAACCGACTCCTAAACCAGTTGGTCAGTCTTCATTTGGTATTTATGGTAGTGGTGTACAAAAGACGACTTCCCAATCAACCTTTGGCTCTAAGGTTCCATCTACAGGAAGTAGTGGAAGTGGCCAAACTTCATTTGTGTCTACCGTCAACAAATACGATTTTAGCAAACCTACAGTAACATTTGATGTACCTAAACCGACTCCTAAACCAGTTGGCCAATCTTCATTTGGTTTTTATGGTAGTGGTGTACAGAAGACGACTTCCCAATCAACCTTTGGCTCTAAGGTTCCATCTACCGGAAGTAGTGGAAGTGGTCAAACTTCATTTGTATCAACCGTCAACAAATACGATTTTAGCAAGCCCACAGTAACATTTGATGTACCTAAACCAACTCCTAAACCAGTTGGTCAGTCTTCATTTGGTTTTTATGGTAGTGGTGTACAAAATACGAATTCTCAATCAACCTTTGGCTCTAAGGTTCCATCTACCGGAATTAGTGGAAGTGGCCAAACTTCATTTGTGTCTACCGTCAACAAATACGATTTTAGCAAGCCCACAGTAACATTTGATGTACCTAAACCGACTTCTAAACCAGTTGGCCAATCTTCATTTGGTTTTTATGGTAGTGGTGTACAGAAGACGACTTCCCAATCAACTTTTGGCTCTAAGGTTCCATCTACCGGAAGTAGTGGAAGTGGTCAAACTTCATTTGTATCAACCGTCAACAAATACGATTTTAGCAAGCCCACAGTAACATTTGATGTACCTAAACCGACTCCTAAACCAGTTGGTCAGTCTTCCTTTGGTTTTTATGGTAGTGGTGTACAAAATACGAATTCTCAATCAACCTTTGGCTCTAAGGTTCCATCTACCGGAATTAGTGGAAGTGGCCAAACTTCATTTGTGTCTACCGTCAACAAATACGATTTTAGCAAGCCCACAGTAACATTTGATGTACCTAAACCGACTTCTAAACCAGTTGGTCAGTCTTCATTTGGTTTTTATGGTAGTGGTGTACAAAATACGAATTCCCAATCAACCTTTGGCTCTAAGGTTCCATCTACCGGAAGTAGTGGAAGTGGTCAAACTTCATTTGTATCAACCGTCAACAAATACGATTTTAGCAAGCCCACAGTAACATTTGATGTACCTAAACCGACTCCTAAACCAGTTGGTCAGTCTTCATTTGGTATTTATGGTAGTGGTGTACAAAAGACGACTTCCCAATCAACCTTTGGCTCTAAGGTTCCATCTACAGGAAGTAGTGGAAGTGGCCAAACTTCATTTGTGTCTACCGTCAACAAATACGATTTTAGCAAACCTACAGTAACATTTGATGTACCTAAACCGACTCCTAAACCAGTTGGCCAATCTTCATTTGGTTTTTATGGTAGTGGTGTACAGAAGACGACTTCCCAATCAACTTTTGGCTCTAAGGTTCCATCTACCGGAAGTAGTGGAAGTGGTCAAACTTCATTTGTATCAACCGTCAACAAATACGATTTTAGCAAGCCCACAGTAACATTTGATGTACCTAAACCGACTTCTAAACCAGTTGGCCAATCTTCATTTGGTTTTTATGGTAGTGGTGTACAAAAGACGACTTCCCAATCAACTTTTGGCGCTAAGGTTCCATCTACAGGAATTAGTGGAAGTGGCCAAACTTCATTTGTGTCTACCGTCAACAAATACGATTTTAGCAAACCCACAGTAACATTTGATGTACCTAAACCGACTCCTAAACCAGTTGGTCAGTCTTCATTTGGTTTTTATGGAAGTGGTGGATCTTCATTGAATACACAGAAAACAACTTCAATATTTTCATCAAAGCTTCCATCTACAGGAAGTGGTCAAACTGTGGTGTTTTCAAATGTTAACAGATATGATGTAAATAAACCGAAAATTGAGTATTCCTCATCTAAACCAGCTAGTGGGTCATCATTTGGAGTTTTCTCTACGCAACGTCCTTCTACAAATGCGCCCGAATACCTACCTCCACTTGGTTCAACGTTCCAAAAAGTAAAATATAACGATGACATTAAATATTTTTAA
Protein Sequence: MNIINIIFAVTLLLVPSILTSELNRSKKQINFGSDNEREGYFYDKPSISFELPTQKPTSTPFVAATTIAPVPTGYNYPKPSIKFEENPQPVGIRHEQISSTLFGSGGGSPISSKTPSISIGGGVQSSVTTSFNKYEFNKPQVNIEVQKPSSFGIFGNGGSTITTNVNRYDTFKPSITTIAQKIAPQAPVTSKIPTGGISGYGQTSFVSTVNKYDFNKPTLTFDIPKPTSKPASQTSFGVFGSGVQKTTSQSTIGSQFPSAGTSGNGQTSFVSTVNKYEFKKPTVTFDVPKPTPKPVDQSSFGFYGSGVQKTTSQSTFGSKVPSTGISGSGQTTFVSTVNKYDFSKPTVTFDVPKPTPKPVGQSSFGFYGSGVQKTTAQSTFGSKVPSTGSSGSGQTSFVSTVNKNDFSKPTVTFDVSKPTPKPVGQSSFGFYGSGVQNTNSQSTFGAKVPSTGTSGSGQTSFVSTVNKYDFIKPTVTFDVPKPTPKPVGQSSFGFYGSGVQKTTAQSTFGSKVPSTGSSGSGQTSFVSTVNKNDFSKPTVTFDVSKPTPKPVGQSSFGFYGSGVQNTNSQSTFGAKVPSTGTSGSGQTSFVSTVNKYDFIKPTVTFDVPKPTPKPVGQSSFGFYGSGVQKTTAQSTFGSKVPSTGSSGSGQTSFVSTVNKNDFSKPTVTFDVSKPTPKPVGQSSFGFYGSGVQNTNSQSTFGAKVPSTGTSGSGQTSFVSTVNKYDFIKPTVTFDVPKPTSKPVGQSSFGFYGSGVQKTTSQSTFGSKVPSTGSSGSGQTSFVSTVNKYDFSKPTVTFDVPKPTPKPVGQSSFGFYGSGVQKTTSQSTFGSKVPSTGSSGSGQTSFVSTVNKYDFSKPTVTFDVPKPTPKPVGQSSFGFYGSGVQKTTSQSTFGSKVPSTGSSGSGQTSFVSTVNKYDFSKPTVTFDVPKPTPKPVGQSSFGFYGSGVQKTTSQSTFGSKVPSTGSSGSGQTSFVSTVNKYDFSKPTVTFDVPKPTPKPVGQSSFGFYGSGVQKTTSQSTFGSKVPSTGSSGNGQTSFVSTVNKYDFSKPTVTFDVPKSTSKPVGQSSFGFYGSGVQNTNSQSTFGSKVPSTGLSGSGQTSFVSTVNKYDFSKPTVTFDVPKPTPKPVGQSSFGFYGSGVQKTTSQSTFDAKVPSTGISGSGQTSFVSTVNKYDFSKPTVTFDVPKPTPKPVGQSSFGIYGSGVQKTTSQSTFGSKVPSTGSSGSGQTSFVSTVNKYDFSKPTVTFDVPKPTPKPVGQSSFGFYGSGVQKTTSQSTFGSKVPSTGSSGSGQTSFVSTVNKYDFSKPTVTFDVPKPTPKPVGQSSFGFYGSGVQNTNSQSTFGSKVPSTGISGSGQTSFVSTVNKYDFSKPTVTFDVPKPTSKPVGQSSFGFYGSGVQKTTSQSTFGSKVPSTGSSGSGQTSFVSTVNKYDFSKPTVTFDVPKPTPKPVGQSSFGFYGSGVQNTNSQSTFGSKVPSTGISGSGQTSFVSTVNKYDFSKPTVTFDVPKPTSKPVGQSSFGFYGSGVQNTNSQSTFGSKVPSTGSSGSGQTSFVSTVNKYDFSKPTVTFDVPKPTPKPVGQSSFGIYGSGVQKTTSQSTFGSKVPSTGSSGSGQTSFVSTVNKYDFSKPTVTFDVPKPTPKPVGQSSFGFYGSGVQKTTSQSTFGSKVPSTGSSGSGQTSFVSTVNKYDFSKPTVTFDVPKPTSKPVGQSSFGFYGSGVQKTTSQSTFGAKVPSTGISGSGQTSFVSTVNKYDFSKPTVTFDVPKPTPKPVGQSSFGFYGSGGSSLNTQKTTSIFSSKLPSTGSGQTVVFSNVNRYDVNKPKIEYSSSKPASGSSFGVFSTQRPSTNAPEYLPPLGSTFQKVKYNDDIKYF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -