Basic Information

Gene Symbol
-
Assembly
GCA_033557875.1
Location
JAWQRP010009989.1:1-5470[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 22 0.0018 0.15 13.4 1.5 2 23 44 66 43 66 0.94
2 22 0.71 59 5.3 1.0 1 21 203 223 203 224 0.94
3 22 0.1 8.3 8.0 4.2 1 23 253 276 253 276 0.95
4 22 0.17 14 7.3 0.1 5 20 286 301 283 303 0.92
5 22 0.0096 0.8 11.2 0.3 1 23 309 332 309 332 0.94
6 22 0.0011 0.094 14.1 4.1 2 23 409 430 409 430 0.98
7 22 9.8e-05 0.0081 17.4 0.7 2 23 438 460 437 460 0.93
8 22 1.2e-05 0.001 20.2 0.2 1 23 478 500 478 500 0.99
9 22 0.00014 0.012 16.9 0.9 2 23 504 525 503 525 0.97
10 22 0.00024 0.02 16.2 0.1 2 23 553 574 552 574 0.96
11 22 2.4 2e+02 3.6 0.7 1 23 597 620 597 620 0.94
12 22 0.014 1.1 10.7 0.8 2 23 632 653 631 653 0.97
13 22 0.00027 0.022 16.1 7.3 1 21 678 698 678 700 0.95
14 22 2.8 2.3e+02 3.4 2.3 3 23 722 742 720 742 0.96
15 22 2.3e-05 0.0019 19.4 0.3 1 23 800 822 800 822 0.96
16 22 0.00086 0.071 14.5 0.1 2 23 836 858 835 858 0.95
17 22 0.00055 0.045 15.1 1.7 1 23 876 898 876 898 0.94
18 22 0.0011 0.091 14.1 0.3 1 23 925 948 925 948 0.95
19 22 0.11 9.3 7.8 0.5 2 23 959 980 959 980 0.94
20 22 0.00071 0.059 14.7 1.5 1 23 995 1018 995 1018 0.95
21 22 1.8e-05 0.0015 19.7 0.6 1 23 1026 1048 1026 1048 0.97
22 22 0.00019 0.016 16.5 0.4 1 23 1068 1091 1068 1091 0.98

Sequence Information

Coding Sequence
AAcccagtaattaaaaatgaacctGCTGAGCCAGTGGAAACCGATGCCGACTCTGAACTTTTCATAGAAACACCAGAGTTCGGAAAACTAAATGATCTTGCTGTATACAAATCCTCAAACAATGGTAAAGAGTGCATGTACTGCTATAAGACTTTTAGCACACCAGGCAATCGTAGAAAGCATGAAAAGCTAATGCATGAAATGCGAGGATTCGAAAAGAAAGACACagCAAGCAGTGCAACCGAAGAAACGGCACAAAGCACAACAGAGGAAGAAGAATCAGCCAGTGTGGTCAGCTCACTTCAAGAAGAAAACCACGACAACGATGAAGCTTCTGCTGAAGAATCCCAGGAATCTTCAGTCACTGATccggaaattaaaaaaatcgagTTTGCCGGAGCGCTAAAATTGCAGGCGGCTAACGGACCGTCTCGATTCCCAGCACCCGACAATTCCTTGACGAAGATAGAAAATTGCTACCTAGATAAGTGCAAGAAGATGATAATCATGTTCAACACGTTATCTTGCATTTGCCACAGCATCCAGCACAAGACGATCAAGAGGCTTTTCGCCCACTTAAGGTCTTTGTGCCATTGGTTCCCTATCTACACTTGCTACAATTGCATGATTACATTCGTTGATCGGTCTTCCGCGATGAGACACCATTCGAAATGCCAGAGGAGACCTCTGGAGAATCTCATAAAGCTGTCGTCCTTGCAGCACAATACCGACAAGAAGATCCGTTTGTACCAGAATTACAAGTGTGTGCACTGCAcgtatgtttttaatttttacgaaGACTACTGCGATCACATCGATAACGAGCACATAGTCGATGAACCTCCGTATACGTGCATTTGCGGAATTGTTTTCGAAAACGCCGACGATTACCAACAGCATCTGCATAACACctgtttattgaatttttactgCGACATTTGTTTCAAAGTGATTCCATCATTGAGCGAGTTTAGAAAGCATGTTTTGGAAAACCATGATCAATCTGATGGGTTTGAATTCTTGCCGGTGGGAGGCagtattaaaattgataaaagtaTTGATACTACTTTGGATTCAACTTTGGAATCCGGGAATGACGACACGATGAATTCCACGGATCATGAAATGGTGGAGTGTGCCCCGGATTTCGAACTtgctaattataatgagtatAGTGATATCCCGGCCCCTCCGCCTCCGCCGAAGAATTGGAATACCAAGGCGACTTGCACAGTGTGCAACAgagtttattcaaattatcaTAATATGATGAGGCATTTTAAGACTCACAGTGAATCGGAAAAGACGATTCCGTGCGAACATTGCGACCAATTCTTCCGACTTAAGAGCCAGTTGAAGGAGCATATGGTGATCGACCACGGGGTTTTGGACATAAAACCTACGGTTAACAAATCGTTCAAACATGATAATTACCCTTGCCCGGAATGCAACATTATATTCTCCTCGCTAGATGAATGGACTAAGCATAAGCGGACTCATCCTTTGAAGACTTGCAATGATTGTGGGAAACAATTTTCTCTTCAGACTGAGCTTGACCAACACCGCAATGTGCATTTGACGTTAAAAGTGTACAGGGATTCGAAAACTCACTCGTATAAAAGTGCTCAAGTAAGTCCCAGCTCTTTAGTAGACCTTATGTGTAAAATTTGTAACTTAACGTTTGGAACTTCTGAGGAGTTAGAGGAACACATAGGTacacataatataaaactagAACCTGTGGAGAATGTAGTAGAAGGAGTAAAAGAAACGAAGAAGCCGAAAAAGTTTTCGTGCGAACCATGCAATAAGCATTATGCCGGCTATGGCGGATTATGGGAGCATAACAAACGTTACCATCCGGATAAGAAACCTTCGAGGGACTTCCCGAAGAAGTGTAAATATTGCGATAAGGTCCTAATGACTGCCGGGGCCTACTTTATGCATAAACAAATGCACGAGCGATTGTTGAAGCCTGTTAAACAAGAGGCCGAAGACGATAGCGAAAGTAAGGCTGACGACGAAGATTACTTTACTTGCAAACGTTGCTTTAAGGTATTCACCAGCAAATACAATTTGAAGAACCACATGAAGTGTCACGGAATTACTAAGAATTCTGGACGGAGTTCTGCGGGAAAAGGCGGTAAATTCAAAACTTACTGGTGCAACATCTGCCATCAAGCATGCCAAGGATACATGGAACTCCAATCCCACAAACAAGAGCACGAAGTGGAGAAACGGAACGAAATGAAGGAGATGAACCATGTGAACGATAAACCTCACCATCTGAAGGCAGCTAAAGTTGAAGAGGTAGAGATGATGGAGTACACCGACATGGATTTCCAACCGGAATACAGCGACGAACTAGAAATATTAGCGATTAAGGATAACGTCATATATCCTTGTGACATTTGCGACATGGAATTCACCAACAAAGCCGCACTGAAGAAACATAAGGAACAACATGACCTGGAACTCCCGCCCACGCAAAAACACACTTACGTGTATTGCAAGTATTGCAAAATTCCGTTCGTCAGCGTGAGCAAACTAAACGAACACATGGAAATTGAACACGATGAAATCCCTGGCAGAACGAAACCGAAACCTCCAACAAAAACGCAGAAGCATCCTTGCAATTTGTGCAAAAAGGTCTTCGATACATCGGGAGCTTTATGTTCCCATCAAGGGTGGCATAAGCGGATAAGGGCCGGCGAAAAAAGCAAAGTTCTACTTAAGCAAGTTTTGAGAGAATATCCAAACCCAGTCCCCAGTTTTCAATGCAAAAACTGCTCCCAACAATTCACCAACGATACAGCCCTGCAAATACACATCCTGGAAGTTCACCGAAACATCAACGCTTCCATTATATTGCCCCGATGCAACTTGTGCGACATGGAATTCGACACCCAAACAGCTTATGACAACCATAATCAGTTGCATCGAATCGTGGCTAAACAAAAAGAGCATCAGCAGAAGTATTACTTCAATTGCAAGCACTGCAACAGAAGTTTTAATGGGGCCGAAGCCTTACTTACTCATGTTAAGCAATCCCACAAAGATAGGCACCACCAAGGGCACTCTTGCCCAATTTGCAATCGGACGTTTGATCGACCTCAGGCCCTCTCCACTCACGTGAAAATACATGACAAGGAACGCGCGCAAGCCGGGCCCCCAAAACCTTCAAAGGCAAAAGGATTTCTGTATTCTTGCTCGATCTGCCACACCGGTTTCAACATTCCGAAGGAATTAAGAAACCACATCATTACTGCGCATCCTTTCtaa
Protein Sequence
NPVIKNEPAEPVETDADSELFIETPEFGKLNDLAVYKSSNNGKECMYCYKTFSTPGNRRKHEKLMHEMRGFEKKDTASSATEETAQSTTEEEESASVVSSLQEENHDNDEASAEESQESSVTDPEIKKIEFAGALKLQAANGPSRFPAPDNSLTKIENCYLDKCKKMIIMFNTLSCICHSIQHKTIKRLFAHLRSLCHWFPIYTCYNCMITFVDRSSAMRHHSKCQRRPLENLIKLSSLQHNTDKKIRLYQNYKCVHCTYVFNFYEDYCDHIDNEHIVDEPPYTCICGIVFENADDYQQHLHNTCLLNFYCDICFKVIPSLSEFRKHVLENHDQSDGFEFLPVGGSIKIDKSIDTTLDSTLESGNDDTMNSTDHEMVECAPDFELANYNEYSDIPAPPPPPKNWNTKATCTVCNRVYSNYHNMMRHFKTHSESEKTIPCEHCDQFFRLKSQLKEHMVIDHGVLDIKPTVNKSFKHDNYPCPECNIIFSSLDEWTKHKRTHPLKTCNDCGKQFSLQTELDQHRNVHLTLKVYRDSKTHSYKSAQVSPSSLVDLMCKICNLTFGTSEELEEHIGTHNIKLEPVENVVEGVKETKKPKKFSCEPCNKHYAGYGGLWEHNKRYHPDKKPSRDFPKKCKYCDKVLMTAGAYFMHKQMHERLLKPVKQEAEDDSESKADDEDYFTCKRCFKVFTSKYNLKNHMKCHGITKNSGRSSAGKGGKFKTYWCNICHQACQGYMELQSHKQEHEVEKRNEMKEMNHVNDKPHHLKAAKVEEVEMMEYTDMDFQPEYSDELEILAIKDNVIYPCDICDMEFTNKAALKKHKEQHDLELPPTQKHTYVYCKYCKIPFVSVSKLNEHMEIEHDEIPGRTKPKPPTKTQKHPCNLCKKVFDTSGALCSHQGWHKRIRAGEKSKVLLKQVLREYPNPVPSFQCKNCSQQFTNDTALQIHILEVHRNINASIILPRCNLCDMEFDTQTAYDNHNQLHRIVAKQKEHQQKYYFNCKHCNRSFNGAEALLTHVKQSHKDRHHQGHSCPICNRTFDRPQALSTHVKIHDKERAQAGPPKPSKAKGFLYSCSICHTGFNIPKELRNHIITAHPF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-