Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 2.7e-06 0.0023 21.3 0.8 1 23 125 149 125 149 0.98

2 6 1.6e-05 0.014 18.9 0.1 1 23 155 179 155 179 0.96

3 6 6.8e-05 0.057 16.9 0.2 1 23 185 209 185 209 0.97

4 6 1.2e-05 0.0098 19.3 1.1 1 23 214 238 214 238 0.95

5 6 6e-05 0.051 17.1 3.0 5 23 250 268 244 268 0.91

6 6 4.3e-05 0.036 17.5 0.4 1 23 274 299 274 299 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	2.7e-06	0.0023	21.3	0.8	1	23	125	149	125	149	0.98
2	6	1.6e-05	0.014	18.9	0.1	1	23	155	179	155	179	0.96
3	6	6.8e-05	0.057	16.9	0.2	1	23	185	209	185	209	0.97
4	6	1.2e-05	0.0098	19.3	1.1	1	23	214	238	214	238	0.95
5	6	6e-05	0.051	17.1	3.0	5	23	250	268	244	268	0.91
6	6	4.3e-05	0.036	17.5	0.4	1	23	274	299	274	299	0.96

Coding Sequence: ATGGCGACCTGGTCGTGTCACGAGAACTTCTTGAAGCTCGAGACTGAGCCAAACGGATCATTGGATGTTGTAACCCCTGATCTTCAAGATTACATTGATGACAGCCTTGATCCTTCAACTTTCGGGAGGGTGTTCGAGCAGATTCCTGTGTTTTCTGTGGTTCCCGAGCAGAGTAAGCCTTGCTCCGATGATTTCAGTGGAATTAGCGAAAGCCAGGACGAAAATGCCGGGTATATCCACCATACCATCACCTCGGATGAAATTTACTTCAGCATTCACCCTGGTAACTCTCAAATGCCGGAAAACCCATCTCATGCTACTTTAACAATAGAGACCCATGATCCAAAAACGAAtaccaaagaaataaaaaggtACAGATGTGAATATGACAACTGTGCTCGGAGTTACAGTACCGCTGGTAACCTTAGGACTCATATGAAAACGCATAAAGGAGAGTATCGTTTCAAATGTGCCGAACCAGGTTGCGGTAAAGCTTTTCTCACCTCCTACAGCTTGAAGATACATATTCGCGTTCACACTAAAGTTAAGCCTTTTGAATGTGGCTATATTGGATGTGAAAAGGCCTTTAACACCCTCTACAGgCTCAAAGCACATTTGAGGCTCCACAGTGGGAATACCTTTAACTGCGGTGAATATGGCTGTTTGAAGTTTTTCACAACTCTAAGTGATTTGAAAAAACATGTCAGAACTCACACCAAGGAGAAACCATTTAGGTGCATAGAGGCAGGTTGTGGAAAGGCATTTACTGCCAGCCATCACTTGAAGACTCACCGGCGCACCCATACAGGAGAGAAGCCATATCCTTGCCATGCCTCTGACTGCTCTGCTGCTTTCTCAACCCCATATTCCCTCAAGGCTCATACAGCCAGGAGGCATCCTCATGCAGACAGTGAAGAGCATAGTTCATCTAATGCTTGTGTGAGTGAAGAGGAGCTTCATGAGGAAACCCTTGACACTTCTTGTGAAGATGATGAGGAAGAGGATTCAAGGGTAAGTTTTCCAGTTAAAAATAGGTTTCCTATGTAA
Protein Sequence: MATWSCHENFLKLETEPNGSLDVVTPDLQDYIDDSLDPSTFGRVFEQIPVFSVVPEQSKPCSDDFSGISESQDENAGYIHHTITSDEIYFSIHPGNSQMPENPSHATLTIETHDPKTNTKEIKRYRCEYDNCARSYSTAGNLRTHMKTHKGEYRFKCAEPGCGKAFLTSYSLKIHIRVHTKVKPFECGYIGCEKAFNTLYRLKAHLRLHSGNTFNCGEYGCLKFFTTLSDLKKHVRTHTKEKPFRCIEAGCGKAFTASHHLKTHRRTHTGEKPYPCHASDCSAAFSTPYSLKAHTARRHPHADSEEHSSSNACVSEEELHEETLDTSCEDDEEEDSRVSFPVKNRFPM

Sequence clustering based on sequence similarity using MMseqs2