Basic Information

Insect: Pyrrhia umbra
Gene Symbol: lz
Assembly: GCA_963891755.1
Location: OY982934.1:8846284-8867060[-]

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 4.2e-18 2.3e-14 53.9 0.2 93 129 119 155 116 155 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	4.2e-18	2.3e-14	53.9	0.2	93	129	119	155	116	155	0.97

Sequence Information

Coding Sequence: ATGAAGAGGGAAAGATCAGATCTTAAAGGCTCTCAGAGTCTTAAGTTCACACCTGTCAACGTTGATGGATACCTGCATCTTCATGCTTCGGAGTATACCTCGGGAAGATTCTGCAATAGAAACAACTTGAAGAATCCAGATGGGCTTGGTTGGATTCAGACGCCTGCttttttcgcGTGTAGCCAGCGGCCAGCCGCTCCGGGGCCCATTAAAGCTTACATGTCACTCTCCCGCGGCCCCCCCGGGGGGAGGCGGCCGCGAGGGGGGGCGCTGGAAAAATCACAAAATCGGTATTGGCTGCATCCCGCAGCGCGAACGCCCGCCAAAGCGCTCTACAATACAGCTTTGACGGACGGTAAATCGTTCACACTAACGATAACAGTGTCGACGACGCCGCCCCAAGTGACCACATACAACAAAGCCATCAAAGTGACGGTGGACGGTCCGCGGGAACCCCGATCTAAGACCATGCTCTCTCTCCTAGGGCAGCAGCAGCAGTTCCACTTCGCGTTCGGACAGAGGCCGTTCCCGTTCCCGCCGGACCCCTTGGGGGGGTTCCGAATGCCACCCATCACTACCTGCCAAAACATGAGTCAATTCGGCCTAAGTTCGAGCAACTCGCACTGGGGctacggcggcgcgggcgcatacCCGGCGTACTTGCCGTCGTGTGCCGCACCAGCCGCCTCGCAGTTCAACCCTCCAGCGCTGGGCTTCGCCGGCACCGTGCCTGATCAGACGCCCACGCAGGACTTCACAGCTAATAATACAGTTCTTCCGGACACAACAGGCGTCGACCTAGACCAGCAGCTGTCCGGCCTAGTAGGGTCCTCTCCATCACACCACGGCAGTCTGCTACCACGCTATAACAACAATACCGACTACAGCCTCTCAACGGGCCCCCGATCACTTAGCGACAACAGTTCGCAGCCCGAGTCGCCCGTACAGGATGATTTGCTCACTTCAAACACGTCGACGAACATCGGCCACAATCACACAAACAGCTCAAACTTCCCTTCGTTAATGGGATCTCAGAACGCTTCGTACGGCGGCAGTAACTGCAACAACTCGCTGTACCCCGTCCTACCGGCGAGCTTGCTTTATAGCCAGTTATATACTGCTGCCAACCAAACGCACAACTTTCACCCGCTGCATTCGAACTCGATACACTCAACGCAAAATCATCACAATGAGCTACAAACGATGATGGATCAAATATCATCGACGACGAACAATCATAGACAACACGGGAATCATGGACAAGACTTGCTTCTAGGCGGAGGGAATTCTTGCGCGGCGGCCGCGGCTAGGGGCGAGGACGGACGGGTGAATAATCTCGGACAAAGAGGTAATCCGCAGCCAGACAGCAACACAGTGTGGCGACCCTACTAA
Protein Sequence: MKRERSDLKGSQSLKFTPVNVDGYLHLHASEYTSGRFCNRNNLKNPDGLGWIQTPAFFACSQRPAAPGPIKAYMSLSRGPPGGRRPRGGALEKSQNRYWLHPAARTPAKALYNTALTDGKSFTLTITVSTTPPQVTTYNKAIKVTVDGPREPRSKTMLSLLGQQQQFHFAFGQRPFPFPPDPLGGFRMPPITTCQNMSQFGLSSSNSHWGYGGAGAYPAYLPSCAAPAASQFNPPALGFAGTVPDQTPTQDFTANNTVLPDTTGVDLDQQLSGLVGSSPSHHGSLLPRYNNNTDYSLSTGPRSLSDNSSQPESPVQDDLLTSNTSTNIGHNHTNSSNFPSLMGSQNASYGGSNCNNSLYPVLPASLLYSQLYTAANQTHNFHPLHSNSIHSTQNHHNELQTMMDQISSTTNNHRQHGNHGQDLLLGGGNSCAAAAARGEDGRVNNLGQRGNPQPDSNTVWRPY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01532804; iTF_01538518; iTF_00185915; iTF_00000960; iTF_01142190; iTF_01033498; iTF_01034308; iTF_00461333;
90% Identity: iTF_01532804; iTF_01538518; iTF_00000960; iTF_00666285; iTF_01436793; iTF_00185915;
80% Identity: -