Basic Information

Gene Symbol
topi
Assembly
GCA_963921415.1
Location
OY992871.1:5856925-5861663[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 6 0.043 4.5 9.0 0.6 3 23 169 190 167 190 0.95
2 6 9.8e-05 0.01 17.3 4.2 2 23 200 221 199 221 0.96
3 6 0.0023 0.23 13.0 0.7 1 23 226 248 226 248 0.98
4 6 0.00035 0.036 15.5 0.4 1 23 254 277 254 277 0.98
5 6 0.0075 0.77 11.4 4.4 1 23 284 306 284 306 0.98
6 6 0.09 9.2 8.0 8.8 1 23 312 335 312 335 0.94

Sequence Information

Coding Sequence
ATGTCTGCAAAAACTTGTAAACTTGAAACGAGCAAAGTAGAAACTAATATGTTGGATACATGCAGAGTTTGCATGTATAAACAGCTAGAAATGACTTATATATTTGAAAACAACAGCGACATCATCGAAAAAATTCATTACTGTACAGGTTTGCAGatcACCAAAGAAGATGGTCTGCCGCCACAGATATGCAAATACTGCATGCTAGATTTGGCTACCGCTTATAAATTCAAATCGTCATGCATACTTGCATATGACACATATCAGAACCTGCTGAAGAACGAAATAAAGACTGAACCAGACTTGCACTACGATGACAGCGATGGATTTGTCGATGACAATGACTATTTTAAGGTCAAAGACGAACCTGTTAAGTTGGAAGTGGAGGCGGCAGAACACAATGATCACCCAATAATACCACGTAAAAGGCCAAGAGGACCATACAAGAAGAGGGTGAAACCCAAAGGTGTTAAGCATAAGCCAAAACCAAAGGCCACATATTGGTGTCAATCGTGTAAAATCAGTTTTAAGAATAAAGCACAGAAAATTGAGCACGAGAAGAGCATTCATAATATTACTCCGGATACAGAGACGTGGATTTGTGAGCACTGCGGCAAGCTCTTCACAAACAAATCGTCGATGTGTTCTCACTTGTACACGCATCTGCCGCCAAAGTACTCGTGCGAGCAGTGCGACTACAAGGCCACGTTTAAGAACGACCTGGCCAAACACAAGCTAGTACACGCAGGCATAAAACTATTCCAGTGCCAAATGTGCGCGGGCCGGTTCCGAACCGCGTCCGGACTCAGTCAGCACATACAAAGGAACCACGATATGATACCCAAGAAGTTCCAATGTGAGCTgtgcgaaaaaagtttttttgatagAACAAAACATACCAGGCATATGGACTCGCATAATAATATCAAACGtttcgaATGTGAAGTCTGCCACTCCTGTTTCTCGAGGCGATGCTACTGGAAGAAGCACCGCCTTGAGAAGCACAACATCGTCATGCCCCGCGAAAGGCCTGGCAGGCAACGGACTGGCCTAATGCCTGGCAACACGACAGGCAACACTGAGCAAGCTGTTGTGAcgtaa
Protein Sequence
MSAKTCKLETSKVETNMLDTCRVCMYKQLEMTYIFENNSDIIEKIHYCTGLQITKEDGLPPQICKYCMLDLATAYKFKSSCILAYDTYQNLLKNEIKTEPDLHYDDSDGFVDDNDYFKVKDEPVKLEVEAAEHNDHPIIPRKRPRGPYKKRVKPKGVKHKPKPKATYWCQSCKISFKNKAQKIEHEKSIHNITPDTETWICEHCGKLFTNKSSMCSHLYTHLPPKYSCEQCDYKATFKNDLAKHKLVHAGIKLFQCQMCAGRFRTASGLSQHIQRNHDMIPKKFQCELCEKSFFDRTKHTRHMDSHNNIKRFECEVCHSCFSRRCYWKKHRLEKHNIVMPRERPGRQRTGLMPGNTTGNTEQAVVT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-