Basic Information

Gene Symbol
-
Assembly
GCA_963584085.1
Location
OY757265.1:475853-482668[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 0.019 1.6 10.1 2.2 1 23 183 205 183 205 0.97
2 11 0.011 0.94 10.9 0.2 2 23 210 231 209 231 0.96
3 11 0.0072 0.62 11.5 1.8 3 23 239 260 238 260 0.95
4 11 2.1e-05 0.0018 19.4 0.9 2 23 269 291 268 291 0.95
5 11 0.005 0.43 11.9 1.6 1 23 296 318 296 318 0.97
6 11 0.0016 0.13 13.6 1.8 2 23 325 347 324 347 0.95
7 11 2.2 1.9e+02 3.6 2.4 3 20 354 371 352 373 0.90
8 11 0.23 20 6.7 0.2 3 23 379 398 378 398 0.94
9 11 0.00051 0.044 15.1 0.1 1 23 403 425 403 425 0.97
10 11 2.9e-05 0.0025 19.0 1.7 2 23 432 453 431 453 0.97
11 11 7.3e-08 6.3e-06 27.2 0.3 1 23 459 481 459 481 0.98

Sequence Information

Coding Sequence
ATGCCGCACTACCTGACGTTGCCCAGGGTGAACCGCGACAGGCGCTACTGCTTCCCTACTGACGTGTCAGAGTGGATTCAGCAACAGCCCAGTCGGCACGTGGAGGTATCTTTACAAGATTCAATGCCACAGTTTGTATGTCAAAACTGTGTGGAATTAGTGAAATCTTTCATAAAATTCAGAGAAAAATCAATTATATCGGAAACTACCTTGCAACAGGTGATACAGGATACAAAACTAAAGCAGGAGGAGTTAAATGAGGGTGAATTATGTGTAAAGCAAGAGGTTAAGAAAGAAAATGAGTCAACAttatttgatgatgattattttgATGATCCTTGTCACAAATACcaagaagaagaaataaaagctccagtgaaaattaaaaaagaaccagtttcaaagaaaaagaaacaaaaaagaacATCTAATaaagaaagtaagaaaaagaatataatcaaatcgaaacacctTAGAAGTTTTTCACCAATTTCTAGGCCACCAGAAAAGCCTGCTCAAGATAAAATAACAACAGAAGAAGAAAGTTTTCCATgtgGAATATgcaagaaacatttttttgatGACACTATTTTGAAAAAACATTTGCAGTCACATACAAAAACCACTGAATGTGAGATTTGTCATGAGAGATTTACCGCGTGGCCGGGTTTGCTGGGGCATAGAATAAAGCATTTATCAGGGAAACCAGGCCATTGTCATCTGTGCAATAAACGATTTGTAGCTCCTACGTACTTGGAATACCATTACATATCTGTACACAATGATGGGCAGcAAACCGCACTTGTATGCAGTATTTGTCAACGAACTTATAAAacaccaaaaaaattaaatgaacacATGAAGCTTACACATTCAGCACCAAAATTTTTTTGTGATCATTGTTCTAAAGGATTCACTGCCAAATCTATCCTTAGAGGTCATATAAAAATACACAACAAGATCAAATCTTTGGTTTGTGACTTATGTGGATTTCGGTGCAAATTAAAAGTGAACCTAAGGGCTCACCAATTGAGAAAACATACACCCGGTGCGATTAATTGTAAATCGTGTTCCACCATGTTCGTGAATCAAGAAAGATTCGACAAACATAAATGTAACCTCGGCGAGGGCCCGTGTTCTGAATGTGGGAAAATAGTGTTGAACAAATCGATGTCTCGGCACATGGAGCAGCACGGCGAGGCGCGACACCGCTGCGCGCTGTGCCCCGCCGCGTTCCGCACGGCCGGCGCGCTGCGCGTGCACAGGGACCGGCACGAGGGCGTGCGCCGGCTGCAGTGCGAGTACTGCCACGCGCGCTTCTACTCGCCCTCGGTGCTCATCAAGCACCGCCGCACACACACAGGTGAAAAGCCTTACGTTTGCACGATTTGCGGCAAAGCGTTCACAGGCCGCTACAATCTCAAAGTCCACCTGAAGGTCCACGGCATACACGCGATTGTGAAAAAAGACACTCGGACAGACAATGAAAGTTTTGGAGatcttataaaaaatacaaagaaattTTAA
Protein Sequence
MPHYLTLPRVNRDRRYCFPTDVSEWIQQQPSRHVEVSLQDSMPQFVCQNCVELVKSFIKFREKSIISETTLQQVIQDTKLKQEELNEGELCVKQEVKKENESTLFDDDYFDDPCHKYQEEEIKAPVKIKKEPVSKKKKQKRTSNKESKKKNIIKSKHLRSFSPISRPPEKPAQDKITTEEESFPCGICKKHFFDDTILKKHLQSHTKTTECEICHERFTAWPGLLGHRIKHLSGKPGHCHLCNKRFVAPTYLEYHYISVHNDGQQTALVCSICQRTYKTPKKLNEHMKLTHSAPKFFCDHCSKGFTAKSILRGHIKIHNKIKSLVCDLCGFRCKLKVNLRAHQLRKHTPGAINCKSCSTMFVNQERFDKHKCNLGEGPCSECGKIVLNKSMSRHMEQHGEARHRCALCPAAFRTAGALRVHRDRHEGVRRLQCEYCHARFYSPSVLIKHRRTHTGEKPYVCTICGKAFTGRYNLKVHLKVHGIHAIVKKDTRTDNESFGDLIKNTKKF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-