Pful008677.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Pycnomerus fuliginosus
Gene Symbol
topi
Assembly
GCA_963924575.1
Location
OZ004618.1:15075524-15083865[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 56 0.0072 0.42 12.0 0.5 2 23 27 49 26 49 0.95
2 56 0.0037 0.22 12.9 1.6 1 23 55 78 55 78 0.97
3 56 0.15 8.8 7.9 3.0 1 23 83 105 83 105 0.91
4 56 2.7e-05 0.0016 19.7 6.0 2 23 114 136 113 136 0.96
5 56 0.00026 0.015 16.6 0.1 1 23 143 165 143 165 0.98
6 56 0.00035 0.02 16.2 1.8 1 23 171 193 171 193 0.98
7 56 0.002 0.11 13.8 0.6 1 20 199 218 199 219 0.95
8 56 0.035 2.1 9.9 1.4 2 23 226 247 225 247 0.94
9 56 0.0091 0.53 11.7 1.0 2 23 253 275 252 275 0.93
10 56 0.0028 0.16 13.3 0.7 1 23 283 306 283 306 0.95
11 56 0.0011 0.063 14.6 0.6 1 23 312 335 312 335 0.97
12 56 0.0088 0.52 11.8 2.3 1 23 340 362 340 362 0.95
13 56 0.00076 0.044 15.1 2.8 1 23 368 390 368 390 0.97
14 56 5.4e-05 0.0032 18.7 0.2 1 23 397 419 397 419 0.99
15 56 1e-06 5.9e-05 24.2 0.8 1 23 425 447 425 447 0.98
16 56 1.1e-05 0.00063 20.9 1.3 1 23 453 475 453 475 0.98
17 56 0.0027 0.16 13.4 1.6 1 23 495 517 495 517 0.97
18 56 0.00086 0.051 14.9 0.1 2 23 523 545 522 545 0.96
19 56 0.00057 0.033 15.5 0.6 1 23 567 590 567 590 0.97
20 56 0.04 2.3 9.7 0.5 2 23 597 619 596 619 0.94
21 56 0.07 4.1 8.9 4.9 1 23 624 646 624 646 0.97
22 56 7.5e-05 0.0044 18.3 5.6 1 23 653 675 653 675 0.97
23 56 0.00011 0.0063 17.8 0.9 1 23 682 704 682 704 0.99
24 56 0.0012 0.073 14.4 0.4 1 21 710 729 710 730 0.85
25 56 0.025 1.5 10.3 2.9 2 21 770 789 769 791 0.92
26 56 0.011 0.67 11.4 0.9 2 23 797 819 796 819 0.96
27 56 0.07 4.1 8.9 0.5 1 23 826 849 826 849 0.96
28 56 0.0065 0.38 12.2 1.4 2 23 856 878 855 878 0.96
29 56 0.00091 0.053 14.9 3.8 2 23 884 905 883 905 0.97
30 56 0.00074 0.043 15.2 4.2 1 23 911 933 911 933 0.97
31 56 1.5e-05 0.00087 20.5 0.1 1 23 940 962 940 962 0.99
32 56 7.8e-05 0.0046 18.2 1.4 1 23 968 990 968 990 0.98
33 56 3.3e-06 0.0002 22.5 1.0 1 23 996 1018 996 1018 0.98
34 56 0.0016 0.096 14.1 3.5 2 23 1045 1066 1044 1066 0.96
35 56 0.0095 0.55 11.7 4.1 3 23 1073 1094 1071 1094 0.95
36 56 0.0075 0.44 12.0 0.4 1 23 1101 1124 1101 1124 0.95
37 56 0.00065 0.038 15.3 2.9 1 23 1130 1153 1130 1153 0.97
38 56 0.00028 0.016 16.5 3.5 1 23 1158 1180 1158 1180 0.98
39 56 0.00083 0.048 15.0 5.2 1 23 1187 1209 1187 1209 0.97
40 56 2.8e-05 0.0017 19.6 0.3 1 23 1216 1238 1216 1238 0.99
41 56 5.2e-05 0.0031 18.8 1.3 1 23 1244 1266 1244 1266 0.98
42 56 3.6e-06 0.00021 22.5 2.0 1 23 1272 1294 1272 1294 0.98
43 56 0.00092 0.054 14.8 1.4 1 19 1300 1318 1300 1321 0.94
44 56 0.0014 0.084 14.2 2.0 2 23 1329 1350 1328 1350 0.96
45 56 0.0016 0.096 14.1 0.3 1 23 1354 1377 1354 1377 0.95
46 56 0.0045 0.27 12.7 1.3 1 23 1384 1407 1384 1407 0.96
47 56 0.00025 0.014 16.7 5.0 1 23 1413 1435 1413 1436 0.95
48 56 0.0004 0.024 16.0 1.2 1 23 1441 1463 1441 1463 0.98
49 56 7.5e-06 0.00044 21.4 1.6 1 23 1468 1491 1468 1492 0.97
50 56 0.0036 0.21 13.0 4.0 1 23 1498 1520 1498 1520 0.97
51 56 4.9e-05 0.0029 18.9 0.3 1 23 1526 1548 1526 1548 0.97
52 56 0.00026 0.015 16.6 2.9 1 23 1554 1576 1554 1576 0.98
53 56 0.01 0.61 11.5 0.5 3 23 1616 1637 1615 1637 0.91
54 56 0.0035 0.2 13.0 0.2 1 23 1640 1662 1640 1662 0.95
55 56 0.024 1.4 10.4 0.4 2 23 1670 1692 1669 1692 0.93
56 56 0.00024 0.014 16.7 0.3 1 23 1701 1723 1701 1723 0.97

Sequence Information

Coding Sequence
ATGTTTGGCCCCTCCAGATTAAGGAAGCACTTCAGGCTTGTTCATGAAAACATTCGACGGATCCAGCTTCCAAAGATTAAGTGTGAAATGTGCGATAAATACTTCAACCTCAGGCGGGCGTTGAAAGACCACACCATCAGAGCTCATTCCAAGGATTTTCCTTTCAAATGCGAGACATGCAGCGCCGGATTCTGCTATCGGAGCGACATGGAGAGGCACGTCAAAGTAGAGCACCAGGGCTATTGTCACACCTGTCCCGTTTGCCAGAAGAAGTTCAAGAACGTAGAATACTTCAACTTCCACGTGGAGAGGCATGATGGCAAGAATCTGGAAAGATTGTCTTGCCCGCATTGCGATAAAACTTTTTCCGTCAAAAGCACCTTACATAGACACCAGAAAAAGTTTCATTCTggaaaattcaattattttacttGTGAAGTTTGCGGAAAAGGTCTAAGTACTAAATCGATTTTGCAAGAGCATATAAGGATACATACGGGTGAGAAGCCGTTCGTTTGTGACAAGTGTGGCAAAGCCTGCACCACGAAGAAGGCTCTTGATACCCACAACCGGATACACACTAAAGAGAAGCCTCATCAGTGTGACACTTGCGGTAAAAAGTTTGCACAGAGAACCGCTTTTGTGATTCATCAGAGCCCACCCGATTTGAAATTAACGTGCACCCCCTGCCAGAAAATCTTTCCAACCCGTAGAAAGTACACCAAGCATATGGGACGACACAAAGAGAAGACAATTCAGTGCGAATTCTGTCCCAAAAAGTTCCATGTTCGCTTCGAGTTAATGAAACATATCAGTGGCGTTCATGAAAAAATCAAGATTAAAAAGTACAAGTGTGAGTTGTGCGAAAAAGAGTTTCGGGGTAAGGACGGCTTGAACTATCACTTTATAAAAGAACACTCTAAAGAGTTTCCCTTCAAGTGTGACACTTGCAATGCAGGGTTCATAGAGAAGAGCTACTTGATAAAGCATAAAAAAGTGGAGCATGAGGGTTTGCGTCACGCCTGCCCAGTTTGCAAAAAACTCTTCAAGAGCGTTGACTACCTTAAAATTCACGTAAACCATCATAATGAAAACGAGAGACACTCCTGCACGATCTGCACCAAGTCCTTTGCTTTCAAGGCAACTTACGTCAAGCATTTGAGGGAGCATAAAAAAGCTCGCGAGGGATACACTTGCGAGATTTGCGGGAAGAACGTGATTACAAACAAGGGCTTAGAAGTTCACAAAAGAACGCACACGGGGGAAAAACCGTTCGTATGTGATATCTGCGGTAAAAGTTTCAACTCAAGCGGGTCTTTCACGGTGCACAAACGTACGCACACTAAGGAGAGACCGTATGAGTGCGATATTTGCCAAAAGAAATTCACACAAAGGTCCACGCTCGTTATTCATAAGAGGCTACACTCGGGGGAGAGGCCTTATCAGTGCGAGATTTGCCTGAAAAGGCAAAACTCTCAACATTTCTTCTGCGAAGTTTGCAGCAAAATTTTCCCCACCCTCAACAAACTGAGCCAACACAGAAGATACCACAGAGAGAAAACCATCGTGTGTGACCTTTGTCCCATGACATTCAGATTGGCCTTTCAATTAAACCGGCACGTGAGATCCGTGCACGAAAACTGTGTCCCCAACAACCCATCCAAAAACGGTGTCCCCAACAACCCATACAATAAGACGTTCAAATGCGAAATATGCGACAAAATTTACGCCTCAAAGGTGAAATTGTATTCTCATAGGATCAGGGAACATTCTAAGGATTACCCATTAAAATGCGAGACCTGCAACGCAGGATTTTGTTTCGAAAGGGACTTGGAGAAGCACGTCGCGGTGGAACACGAAGGTCTACGTTTTAACTGTCTCGTTTGCGagaagattttcaaaaacgagCGTCATTTCCACTTGCATTTGGAGAAGCACGACGAGCAAGCCAAGAGGCATTCGTGTACGCTTTGTGGCAAGTCGTTTTCGTTCAAGACGACCCTGTACAAGCATTTGAGGAAGCACCAGAAGGCGCCCGAGGGATACACTTGCGAGATTTGCGGGAAGAACGTGGTGAGTCACAGGACTTTAGTGGCTCACAGAAGAACTCACACGGGAGAAAAACCGTTCGTCTGTGACATATGCGGCAAAAGTTTTACCACTAACAAGCTCGCGCGGCATAAACGCTCGTGCGCAAGGGAGAGGCCTTTTCGGATAAGGATTTCACCAAACAAAAATACACAATATCAATGCGAGATTTGCTCGAAAGGGCAAAATCCGCAACAAGATTTCAAGTACGCCCTTTTGATATGCGATGTTTGCAACGAAACTTTCCCAACTCGCAATAAGCTGAACAAACACAAGAAATGTCACAGAGAGAAAACCCTACAGTGCAAGCTTTGCCCCATGAAATTCAACTTCGTCTCTCGCTTAAACCGGCACGTGAAATCCGTCCACGAAAACCGATCCAAGACATTCAAATGTGAAGCATGCGACAAACTTTACGCTTCAAAGCTGACACTGAATTCTCACACTATCAAAGAACATTCCAAGGATTTTCCCTTAAAATGCGAGACTTGCAGTGTAGGATTCTGTTTCGAGAAGGATTTGACGAGACACATCAAAGTGGAACACGAAGGACTACGACTTAGCTGTCCCTCTTGCGAGAAAACTTTCAAAAACGAGCGGCACTACCAGTCGCACTTGAAGAAACACGACGGGGAGTCGAAGCATTCATGTACGCTTTGTAGCAAGTCGTTTTCGTTCAAGACGGCCCTGTACAAGCATCTGAGGGAGCATAAAAAAGCGCGTGAGGGGTATACTTGCGAGATTTGTGGAAAGAACGTGATTACAAGCGTGGGCTTAAAAATTCACATAAGAACACACACAGGAGAAAGGCCATTCGTATGTGACAGTTGCGGCAAAAAATTTGCTACTAAAAAGACTCTCGTGATGCATAAACGTTCACATACCAATGAGAGGCCTTATCAGTGTAACATTTGCCAAAAAGAATTCACGCAAAGTTCCTCGCTGGTTGTTCATAAGAGGTTGCATTCGGGGGAAAGGCCTTATCAATGCGAGATTTGCTCGAAAGGGCAAAATCCACAACGCGATTTCAAGTACGAAATGTTGAAGTGCGAGGTTTGCAGCAAAACATTTTCAACCCTCCCCAAACTGAACCACCACAAGAAATACCACGGAGAAAAAAACGTACACTGTAAAACTTGTTCCAAGAAATTCGTCTTCTGCTATCAATTAACCCAGCACATGGCTATCGTTCACAAAATCACAACCGAGACGTTCAAATGTGAAATCTGCGACAAAATATGTGCCTCAAAGTTGGGTCTAAGCTCTCACACGATCATTGAACACTCCAGGAACTTTCCTTACACATGCAAAACCTGCAGTGCAGGATTCTGCAACAAAAAGGACCTTGAGAGACACACCAAAGTAGAGCACGAGGGTATGCGTTATATCTGTCCAGTTTgcaagaaaattttcaaaaacaaacaGCATTACCAATACCACTTGGAGAAACACAACGGGGAAGCAAACAGACATTCGTGTACTCTTTGCAGCAAGTCTTTTTCCTTCAAAACCAGTCTGTACAAGCATTTGAAGGTCCATCAGGGACAAGCGCGGTGTTATACGTGTGAGATTTGTGGGAAAACTTTGACTAGTAGCGTGAGCTTGGAGGGCCACAGGAGAAGACATACAGGAGAAAAGCCCTTCATTTGTGAGACTTGCGGCAAAGGTTTTGTTTCAAACAACGAGCTTCACATTCACAAGCGCACGCATACAAAGGAAAAACCGTATCAATGCGAcgtttgtcaaaaaagtttcaCTCAAAAATCTACTTTGGTCGTTCACAAGAGGTACCATTCAGGGGAGCGACCGTTCCAGTGCGAAATCTGCCCGAAGAATTTCGTGACGAGGACTCTGTTGAACAATCACAATTGCCGCCTAGCAGAGGGGGAGGTGCTTACCTGTGAGACTTGTGGCCGAACTTACAGTAGCAAAAAGAAGTACTCGAATCACTTAATGTATCACAAAACTCCGTTCGCGTGCAAATCCTGTCCTCAGGCCTACTCCACTACTAGTCTCCTAAGACGCCACGTGGAGAGAATACACTTAGGAGTAATAGAGCAGCATCCGTGCTCTGAATGCAACTTAGTACTACGTTCGAAAGCGAATCTTCGACTTCACAAAATGAGATATCACACGAAAGACTTCCTTCATAGCTGCGATCTTTGCAAGAAGGGTTTCACTCAAAAAAACGCCTACACGCGTCACATGAACATCCACCACAAAGGCCTTCGCTTTCCTTGCGAGACCTGCAAGAAAGAGTTCCGCACTATGGAGTATTACAAGCAGCACATCATGATTCACCAAGATACAAAGTTTAGCTGCCCAGAATGCGACAAAAGTTTTGCTTTCAAAACTTCGCTCCAGGGCCACATTAGGAAGGACCATCATCAGATAGCTGCTAAACATGTTTGCGAGTTTTGCGGCAAGAAGTACTTTCACTTGACGGCGTTAAAGATTCATCGTAGGATTCACACGAAAGAGCGGCCTTTCGCCTGCGAGAATTGCGAGAAGAGCTTTAGAAACTCGCAGGGATTGGTGGTTCACAGGCGGGTTCATACCAAGGAAAAGCCGTATCAGTGTAAAGTTTGTCTAAAAAGTTTCTCGCAGCGGATTTCTTTGACCGTTCATGAAAGGCATCACACGGGGGAAAGGCCGTTCAAGCCATTAACGCCGAACCTACCTATAATCATAGTGAAATGTGAGGAATGTGGACTTTCCTATTATGGCGCTCACGATTGTATGGTTGAAGGAAACTTCTGCTTGAAGTGCGAAGTGGAGTTTCCGACTCGAGACGAATTGCGTCGTCACATGTACTTTCTTCATGGAGAATTTCCCTGCAGGATTTGCGGCCTAATTTTCAGGACCCGTTACTTGGCACGCCGTCACGTCATAGAACACAAACCCGACGAAGAACTATTAACTTGTGATTCGTGCGGAAAAAAATTTATGCAAGAAAAGAGCCTTGATGAACACAGGCAGGCGGTGCATGATGTTCTTTTCAATCCTTTCAGATTCAGTTGCCCTATTTGCAACCTTACCTTCGTGTCTCAAGAACGTTTGAGTCGACATGGGAAAGTTCATCGTGATCAGGGTTACCATATTGTTTGA
Protein Sequence
MFGPSRLRKHFRLVHENIRRIQLPKIKCEMCDKYFNLRRALKDHTIRAHSKDFPFKCETCSAGFCYRSDMERHVKVEHQGYCHTCPVCQKKFKNVEYFNFHVERHDGKNLERLSCPHCDKTFSVKSTLHRHQKKFHSGKFNYFTCEVCGKGLSTKSILQEHIRIHTGEKPFVCDKCGKACTTKKALDTHNRIHTKEKPHQCDTCGKKFAQRTAFVIHQSPPDLKLTCTPCQKIFPTRRKYTKHMGRHKEKTIQCEFCPKKFHVRFELMKHISGVHEKIKIKKYKCELCEKEFRGKDGLNYHFIKEHSKEFPFKCDTCNAGFIEKSYLIKHKKVEHEGLRHACPVCKKLFKSVDYLKIHVNHHNENERHSCTICTKSFAFKATYVKHLREHKKAREGYTCEICGKNVITNKGLEVHKRTHTGEKPFVCDICGKSFNSSGSFTVHKRTHTKERPYECDICQKKFTQRSTLVIHKRLHSGERPYQCEICLKRQNSQHFFCEVCSKIFPTLNKLSQHRRYHREKTIVCDLCPMTFRLAFQLNRHVRSVHENCVPNNPSKNGVPNNPYNKTFKCEICDKIYASKVKLYSHRIREHSKDYPLKCETCNAGFCFERDLEKHVAVEHEGLRFNCLVCEKIFKNERHFHLHLEKHDEQAKRHSCTLCGKSFSFKTTLYKHLRKHQKAPEGYTCEICGKNVVSHRTLVAHRRTHTGEKPFVCDICGKSFTTNKLARHKRSCARERPFRIRISPNKNTQYQCEICSKGQNPQQDFKYALLICDVCNETFPTRNKLNKHKKCHREKTLQCKLCPMKFNFVSRLNRHVKSVHENRSKTFKCEACDKLYASKLTLNSHTIKEHSKDFPLKCETCSVGFCFEKDLTRHIKVEHEGLRLSCPSCEKTFKNERHYQSHLKKHDGESKHSCTLCSKSFSFKTALYKHLREHKKAREGYTCEICGKNVITSVGLKIHIRTHTGERPFVCDSCGKKFATKKTLVMHKRSHTNERPYQCNICQKEFTQSSSLVVHKRLHSGERPYQCEICSKGQNPQRDFKYEMLKCEVCSKTFSTLPKLNHHKKYHGEKNVHCKTCSKKFVFCYQLTQHMAIVHKITTETFKCEICDKICASKLGLSSHTIIEHSRNFPYTCKTCSAGFCNKKDLERHTKVEHEGMRYICPVCKKIFKNKQHYQYHLEKHNGEANRHSCTLCSKSFSFKTSLYKHLKVHQGQARCYTCEICGKTLTSSVSLEGHRRRHTGEKPFICETCGKGFVSNNELHIHKRTHTKEKPYQCDVCQKSFTQKSTLVVHKRYHSGERPFQCEICPKNFVTRTLLNNHNCRLAEGEVLTCETCGRTYSSKKKYSNHLMYHKTPFACKSCPQAYSTTSLLRRHVERIHLGVIEQHPCSECNLVLRSKANLRLHKMRYHTKDFLHSCDLCKKGFTQKNAYTRHMNIHHKGLRFPCETCKKEFRTMEYYKQHIMIHQDTKFSCPECDKSFAFKTSLQGHIRKDHHQIAAKHVCEFCGKKYFHLTALKIHRRIHTKERPFACENCEKSFRNSQGLVVHRRVHTKEKPYQCKVCLKSFSQRISLTVHERHHTGERPFKPLTPNLPIIIVKCEECGLSYYGAHDCMVEGNFCLKCEVEFPTRDELRRHMYFLHGEFPCRICGLIFRTRYLARRHVIEHKPDEELLTCDSCGKKFMQEKSLDEHRQAVHDVLFNPFRFSCPICNLTFVSQERLSRHGKVHRDQGYHIV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-