Basic Information

Gene Symbol
-
Assembly
GCA_947425015.1
Location
OX380339.1:34850062-34854114[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 1.1 1.6e+02 4.6 1.4 2 23 1088 1108 1087 1108 0.94
2 9 5.6 8e+02 2.4 0.4 2 9 1115 1122 1114 1135 0.75
3 9 0.0012 0.17 13.9 0.9 1 21 1141 1161 1141 1162 0.95
4 9 0.00081 0.11 14.4 4.6 2 23 1174 1195 1173 1195 0.97
5 9 0.00011 0.016 17.2 1.4 1 23 1204 1226 1204 1226 0.95
6 9 0.11 15 7.8 1.4 1 23 1232 1254 1232 1254 0.89
7 9 1.7e-05 0.0025 19.7 0.6 1 23 1264 1286 1264 1286 0.97
8 9 0.092 13 8.0 1.6 1 23 1292 1314 1292 1314 0.96
9 9 7.2e-05 0.01 17.8 2.7 1 23 1322 1344 1322 1344 0.99

Sequence Information

Coding Sequence
ATGAATATTGCAAAGAAACTACGCCAAGAAGAAATAaaccagcaacaacaagaacaacaatggcagcggcaattgaaacaacaatacctgccaccgcgacaacaagagcaaggacaacgagatcagcaacgacgacgacaacaagaagaacaacagctgttcttaaaacaacaacaataccagctacaattacaacaacaatatcagcaacagctgaaacaacaacaccttccacaacgacaagaacaaggattacaacagcagcagcaacaacaagtgctcaatgtccaagcgttgcaactccagccaccactacaacaagagggacaacaacagcaacaacaacataaacagctacaacaacaacatcaacagctacaacaacaacatcaaccgctacaacaacaacctcagcagcaacaacaacaacgacgacgccaacaagaagaacaacgtgagcgcttgaaacaacaataccagccagaactccaacaaaatcaaggacaagaacaacaacagatgaaacatgtgcaaaacgcccaagCGCTGCAATACATGCCACCAGGACAACTAGAACAACAACAACAACGACAGCAAGAAGAACAAAGACAACGGGCGAAACAACAAAACCAGCCAGAACTTGAACAAAAACAAGGTGAACATCAACAACAAGAACAACAACAGCTGAAACAACAAGACTTTCCACACCGACAAAAGCAAGGATTACAACATCGGCAGCAACAAGTGCTCAACGTCCAAGCGTTACAACTCCAGCCACCACGACAACAAGAGGGACAACAACAACGACAGGAAGAAGAACTACGTGAGCGCATGAAACAACAATACCAGCTAGAACTTCAACAAAAGCAAGAGGGAGAACAACAACATATGAAACAACAGGAGCACAACGTCCAAGCACTGCATTATcagccaccacgacaacaacagcaagaagaacaaatgcaacggttgaaacaactaaatcagccagaactccaacatcaacaacaacagcaaggactacaacagcagcagcagcaacaagttcaaaacatccaattgttgcaatttgctcaacaacAAAGACAAATAGAAACAACAAAACCAGTATTAAATTACGTAAATTTAAATAGTACAGACACAGTTTTACTTTCTCATAACGAAACACGTATACAGAAATATCCTGTTGCTGATATTATCAATTCTAACAAAGATGTGGCTCCGTGCGATTATAGTGCTACTGGAAATTATATAAAGTTACTAGAAAAACAAAACAATTCCGATAGAAGATCCGAACGAGTTATTAATAATAAACTCAACCATAGTAATCTACATACTCAAAATTCTTTCCAAATAAATTCCAATATAAATGGCAACGCTGTTCCAAAAAATTCAACTCCAATCTATACTCAACTGCATAATAGTAGTAATGAAAATCAAGGAACAAGTCAGTCAAAACATACCAATACAAAAGGAAACGAAGAAATTTTTAAAAATGTAGAACATTTGAAAAATAATTTATTCGAACATAGCAACTATGTCAAAGAAAATCATGTTCCATTTTATAATAATACTAACAGTAATGAAAATAATATTCAATTAACAGGAAACCTGAATGATGTTGAGACAAGAACAACATCAGAAGTTGTTGAAAACTTTATTCCATTTTGTGATAGTATCACTGATAGACAACTACCAAAAGAGGAAAATATTGTCGAGACAAAAATTACTGAAAAACATTTTAATGACAAATTAAAGTGTACAAATTTAGAAACACAAGATACAGCTTTAGTATCTGCAGAAAAACATGAACAAAAGAATTCCAATCTGGAAAATATTCAACAACAACTAACAACAAAACAAATAAAACATGAAGCAAATTTGGATCAATTTTGTGACCAACAACAACGAATAAACAAACAAATAAAAGAAGAAGAAATTTTTCATAATGAAATAAAGTTTGCTAAGACAGAAACTGAAGATTCATTTATATTATCTGCAGAAGAACATTTAAAAAAAGATTTAAATGGAAAAGAGAATTCTGTAAAAATAGAAGAACAGAAAAATATGGAACCTACAAATACAGGAACAGTATTCGATAACAATTTAATTTGTTTTAATCAAGAAACTAAAGAAGAAAATATTTCAAAAAATGATATAGAAATTAAAGAAAATTTTGATCCATTTTATGGCCAACATTTAACAAATCAACAGATAAATATAGAAAGAAGAAGATTAGAAGATATTTTCGAAAATGAAATAAAGGAGTCTAAACCTAATATTGAAGATTCCATTTTAATGTCTGAAGAACATTCACTGACAGATGATATCGATGTAAAAGAAAATATGCTTCTATTTCCTGGCCAACAATTAACAAATAAACAAAAGTATGTCGAAACTAGAAAATTAGAAGAAATTTTTCAAAATGAATTAAAGTGTTCCAAAACAGAAATTAAACAATCAGTTTTATTTTCTGCAGAAGAACAATCACAAAAGAATTTTGTGAAAGAAGTCAATAATGAGAAAGGAAACTTTTCTTCGTTTCATACTCAACAAGTAACAAATGAACAGAAGGATTTTGAAGCAAAAAAGGAAAGAAGAAATTATACAGTACCATGTATTAAACTAAGAAATGAATATTCCCATTCGTCGTCTTCTAATGAAGATAATAATGATATAAAACCAAACTTTGCTTCTTTGGATATTCAACAACTTGCAGACGGTCAGAAACAATTGAAAACAGAAAGTACAGAACCAAAAAAACAGTATTTATCATCTTTTAAACTAGAAATTGAAGAATCTGTAGAAGAAAACCTTTCTTTATTCCATACTGAAGATCTTTCACACAATAAAGATTTCGGATCAAATAACCACGAAACAATTTCACAAAATGATTTACCGTGCTCAAAAGTAGAATCTGAAGATTCTAATTCATCACCTGAAGAACAAAATACAGATACAAATTCCTCTACAGATGATTTTGAAGTTAAAGAAGAATTTATTCCACATTATAGTTCAGACAGTAAATTTTATCAAGAACTAGTCAACAGCATAAATTCTGAATCAACATCAAATAATTCATCAGCTTCAAGTGAAACAAATACAATAATAAATAATTTTTATAATAACTTTCATAAAAAATCTGCTAGTCTAAACAATTGTGATATAGTTACTTGTCCAGTTTGTTCGCAAAAAATAGTAGTAAGGTCTATGCATGCTCATCTTAAAATGCATGTTAATAAAAATGATTTTGAGAAATGTAAATGTACAATTTGTAATGAACAGATATTACAAGGAATGCTTGTCCGCCATATGAAATTACATCAAAATAAAGTTAAAGTTAAGTGTCCAATTTGTGATAAAGAAGTGTTAAAACATGGAATGCCTAGCCATCTTAAAATGCATGATGATATTAGCGATTATAAATGTAGAATCTGTAATACAGAATATAAGTCTTTAGCTTCTTTACAGAAACATAAAAAAATGTATGAGACCCGACCTAAAGCAATAAAAAACTTAAAATGTGACATATGTCACAAGAAATATGCAAGTGAAACACATTTTAAAGTGCATTTAAAGATGCATGCTGAAGGAAACGAAAAATGGAAGTTTCAATGTGAGGTTTGCAAGAAAAAGTTTTATTTTAAAGATGGTTTAAATGCACATATGGTGTTTCACAAAAATGATAAAAAATTTGAATGTTCGATTTGTAAAAGAGCATTTTTGTACGAAGCTCATATGAAACAACATGAAAAAGCTCACACCACCATCACCAAAGCCAAGAAGATTTTCGAATGTGCTTACTGTGATAAGACATTTGTACGGAAAGCTAATATGATACAACATAATAAAATTCACATTGGCATTAAGAAATATCAGTGTAAAGTTTGTGATATGAAATTTTTACTTGGCGCACATTTGAAACAACATGAACAAACCCACACAGGAAGAACGAAAAAGAAATTTAAATGTACAGTTTGTAAAAAAGCGTTTTTGTATAACGGTACTTTAAAAAAACATATGAAAACTCATGATGATGACGATAGTGAATAA
Protein Sequence
MNIAKKLRQEEINQQQQEQQWQRQLKQQYLPPRQQEQGQRDQQRRRQQEEQQLFLKQQQYQLQLQQQYQQQLKQQHLPQRQEQGLQQQQQQQVLNVQALQLQPPLQQEGQQQQQQHKQLQQQHQQLQQQHQPLQQQPQQQQQQRRRQQEEQRERLKQQYQPELQQNQGQEQQQMKHVQNAQALQYMPPGQLEQQQQRQQEEQRQRAKQQNQPELEQKQGEHQQQEQQQLKQQDFPHRQKQGLQHRQQQVLNVQALQLQPPRQQEGQQQRQEEELRERMKQQYQLELQQKQEGEQQHMKQQEHNVQALHYQPPRQQQQEEQMQRLKQLNQPELQHQQQQQGLQQQQQQQVQNIQLLQFAQQQRQIETTKPVLNYVNLNSTDTVLLSHNETRIQKYPVADIINSNKDVAPCDYSATGNYIKLLEKQNNSDRRSERVINNKLNHSNLHTQNSFQINSNINGNAVPKNSTPIYTQLHNSSNENQGTSQSKHTNTKGNEEIFKNVEHLKNNLFEHSNYVKENHVPFYNNTNSNENNIQLTGNLNDVETRTTSEVVENFIPFCDSITDRQLPKEENIVETKITEKHFNDKLKCTNLETQDTALVSAEKHEQKNSNLENIQQQLTTKQIKHEANLDQFCDQQQRINKQIKEEEIFHNEIKFAKTETEDSFILSAEEHLKKDLNGKENSVKIEEQKNMEPTNTGTVFDNNLICFNQETKEENISKNDIEIKENFDPFYGQHLTNQQINIERRRLEDIFENEIKESKPNIEDSILMSEEHSLTDDIDVKENMLLFPGQQLTNKQKYVETRKLEEIFQNELKCSKTEIKQSVLFSAEEQSQKNFVKEVNNEKGNFSSFHTQQVTNEQKDFEAKKERRNYTVPCIKLRNEYSHSSSSNEDNNDIKPNFASLDIQQLADGQKQLKTESTEPKKQYLSSFKLEIEESVEENLSLFHTEDLSHNKDFGSNNHETISQNDLPCSKVESEDSNSSPEEQNTDTNSSTDDFEVKEEFIPHYSSDSKFYQELVNSINSESTSNNSSASSETNTIINNFYNNFHKKSASLNNCDIVTCPVCSQKIVVRSMHAHLKMHVNKNDFEKCKCTICNEQILQGMLVRHMKLHQNKVKVKCPICDKEVLKHGMPSHLKMHDDISDYKCRICNTEYKSLASLQKHKKMYETRPKAIKNLKCDICHKKYASETHFKVHLKMHAEGNEKWKFQCEVCKKKFYFKDGLNAHMVFHKNDKKFECSICKRAFLYEAHMKQHEKAHTTITKAKKIFECAYCDKTFVRKANMIQHNKIHIGIKKYQCKVCDMKFLLGAHLKQHEQTHTGRTKKKFKCTVCKKAFLYNGTLKKHMKTHDDDDSE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-