Basic Information

Gene Symbol
ZEB1
Assembly
GCA_014825455.1
Location
QVNV01010302.1:14405-16233[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 7 9.5 9.2e+02 0.9 0.3 2 13 227 238 226 240 0.81
2 7 2.1e-06 0.00021 21.9 0.9 1 23 243 265 243 265 0.99
3 7 0.0055 0.53 11.1 0.7 1 23 266 288 266 288 0.98
4 7 0.0016 0.16 12.8 1.2 1 23 345 367 345 367 0.99
5 7 0.0031 0.3 11.9 0.7 1 23 403 425 403 425 0.98
6 7 0.0011 0.11 13.3 2.1 2 23 438 459 437 459 0.95
7 7 8e-07 7.8e-05 23.2 0.1 1 23 464 486 464 486 0.98

Sequence Information

Coding Sequence
ATGATGATAACCTGCGCGATCAAAGGCTGTCCCTCCACACAGTTCACAAAGATAAATGGCGAACAGATATCGTTCTTCGCATTTCCAGAAGATGATGGAGTAAGGAATCAGTGGCTTGAAAATTGTAATTTAGCATCAGGCATTGTTAATGATGCAAAAACTCCGTATCTTTGTGAACTGCACTTTGAGAAGGTTGATTTTACATCATCCAAAGATCTGAAAGCAGAAGCTGTTCCCACCTTGTTTGGTCACATAGAAGAACCTTTGAGAAAACGTTCAGCTGAAGATGTACTAGAAACTACAGTGAAAAAAATGTCCTTTAAAAATGAAAGCTTAAACGAACAAATTATAACACCATCAGAAAGCCCACCTTTGCAAGATGATGTCACAAAACAAGATGAGAAAAATAAAATGGATATATCAAGTGATAGTGGAAAAAATATGAATGGTTGTGACACAAGTCTTGAACATGAAACGTCCAAAGCAAAAAAGTCAAAGATATATCGTCTGACTATAAGAATAGATAAGATACGAAATAAATCAGGTTTAAAGAATAAGCCTGTAAGTTTTGCAGAAACAGAGAATATAGAATCCCAAGAGTTAGAAAATCGCAAAAATATCTGCAAAAACAATAGTTGCCAATTGAAAAAATGCTTATTTTATTCAAAACCGGCACTTCAGTGTGAAGTGTGTAAGGAATATTATTTTCAAAAAGAAGAAGACACTTACTCGTGTTCCGTGTGTTCCGAGACTTTTTCTACTCCACAGAAGTTGTTCATTCACATTAGGAAACATTTTACTTGTGAAATTTGTCATTTAGAAAGTGACTCTGAAACAGCATATGAGAAGCATATAAAATTACATGTTAGTAACGATCCGTCGAGTCCGTTTAAATGCAATCAGTGCTGCAAAACATTTGCCTACAAAGAAAAGGCTAAGCATCATTGCTTGAACGAGCACCTCAAAGTAAAATTACAGACGAATGTAGTTCAAATTAACTCACCGTCTGTAATTTTGTCACAACAAATGGACTACCAATGTGCAAACTGCAAGCTTAATTTTAAGACCGAACAATCTTACGATGATCACATAAAATCTCATAGAACAAACGAAGACATAAAATATAATATCGGCGATACCAACAACATAATCGCGGTTCCAAATCCTTTGACTGGGAATCAAATAGGTATTCTTCATGCGGTGAAGTTTAGCTGTCGGGTGTGCCAAAAACAATTTGACAACTTCGGCGAAGTTGACGCGCACACCAAAACTCATTTGAACGAGAAAAAAACCTCGTCTCAGGATGGACTCAAGTGTAATATTTGTAAGAAAACTTTCACAGACAATGTTGTATTTGGTGAGCACTTAAAACATCATTTGTCGCGCGCGTATCCTTGTCCAGTTTGCTCAAAAGCCTTCATAAATCGAACCACATTGAAAGCACACTTAGAAACACACTCTAAGTCATAG
Protein Sequence
MMITCAIKGCPSTQFTKINGEQISFFAFPEDDGVRNQWLENCNLASGIVNDAKTPYLCELHFEKVDFTSSKDLKAEAVPTLFGHIEEPLRKRSAEDVLETTVKKMSFKNESLNEQIITPSESPPLQDDVTKQDEKNKMDISSDSGKNMNGCDTSLEHETSKAKKSKIYRLTIRIDKIRNKSGLKNKPVSFAETENIESQELENRKNICKNNSCQLKKCLFYSKPALQCEVCKEYYFQKEEDTYSCSVCSETFSTPQKLFIHIRKHFTCEICHLESDSETAYEKHIKLHVSNDPSSPFKCNQCCKTFAYKEKAKHHCLNEHLKVKLQTNVVQINSPSVILSQQMDYQCANCKLNFKTEQSYDDHIKSHRTNEDIKYNIGDTNNIIAVPNPLTGNQIGILHAVKFSCRVCQKQFDNFGEVDAHTKTHLNEKKTSSQDGLKCNICKKTFTDNVVFGEHLKHHLSRAYPCPVCSKAFINRTTLKAHLETHSKS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01267809;
90% Identity
iTF_01267809;
80% Identity
iTF_01271264;