Basic Information

Gene Symbol
ZFX
Assembly
GCA_014825475.1
Location
QVNW01000379.1:41866-46459[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 1.7 1.8e+02 3.2 0.1 3 23 15 35 14 35 0.94
2 15 0.57 61 4.7 2.5 1 23 977 1000 977 1000 0.81
3 15 0.00076 0.081 13.8 3.9 2 23 1087 1109 1086 1109 0.96
4 15 0.011 1.2 10.1 0.1 2 23 1122 1143 1122 1143 0.98
5 15 1.9e-05 0.002 18.9 2.3 2 23 1146 1167 1145 1167 0.97
6 15 0.0023 0.25 12.3 0.3 1 23 1173 1195 1173 1195 0.96
7 15 3.7e-05 0.0039 17.9 4.4 2 23 1202 1223 1201 1224 0.95
8 15 0.11 12 6.9 3.7 5 23 1237 1255 1236 1255 0.97
9 15 9.6e-06 0.001 19.8 2.2 3 23 1262 1283 1261 1283 0.97
10 15 0.042 4.5 8.3 0.0 2 23 1299 1319 1298 1319 0.96
11 15 3.8e-05 0.004 17.9 1.2 1 20 1325 1344 1325 1347 0.92
12 15 8.7e-05 0.0092 16.8 2.7 1 23 1355 1377 1355 1377 0.99
13 15 0.0024 0.26 12.2 3.2 1 23 1383 1405 1383 1405 0.97
14 15 4.4e-06 0.00047 20.8 3.9 1 23 1411 1433 1411 1433 0.99
15 15 0.0015 0.16 12.8 6.3 1 23 1439 1461 1439 1462 0.96

Sequence Information

Coding Sequence
ATGGAGCTCAGCGGCGGGGGGGCACCCACCGGGGCCGTGGCCTGTCCCGTGTGTACTCTCTACCTGCGCGAAGGCATCAGTCTGCAAAAGCATCTGGACACACATCCCAAGGAACAAGTTATAGAAGCGCTCATCAAAGCCAGCGCTTCTTCGTTGCAGACACATCAACAGCAACAACAGCTGCAACCACAAAATGTACCAGTATCAGCGACAACGGGGCTATCGGCGTCGTTGCAATCGCAAACCGTGCCTCAGGCTTCTACCTCTCTTCAAACACCCCAAGTGTCGCCCCAGGTCACACAGAATGCGCACATCTCTACTCACTCACCGTATCCGATAGGACCTATCTTTGAATGTCCGCCCGTAGGCATGATGCCACCACAGTTTACCTCGTTTAACTATCAACAGTTTGTGAACAATGGGACCATGATGATACCACAGTATGCGATGGCGCCACAAGCTAATCAGATGATGCAGATGCTGTATAATCCGTATGGTTTGTATCAACAGCAGCAAATACCCACCGTCCAAATGATCTCACCAGTTGCAGCTGTTCCTGGCCAGACTAGGATTCGACCAGTGGTCACCATGGCGGCAGAAAGCAATGCCAGAACCACTCTAACTGTTCATGTAAATAGTCCTGAGCCTAAGCAGATCCTGCCTGAAATTTTGCCAGAGAATGAGCCCGAGTCTGGACCAATCATACCAGATGTGAGCCTACCAGCATCACCTGTGTTGCAGAATGAAGACACGTCTGTTAGACGAGAAGAGAATGATAACAATTCACTGGAAATTGATCGTAGAGGACAGCAGACACCAAGTTCTACACCACCAGGTGAAAATGCAGTACAGCGCGAATTTAATGCTATTTCTAGATCCATCACAATTACCCGCTCTATAGATAATGCCGATGAAGACAAAGTGGAAAGTGTATTGCCAGATATAGTAGATGAGGAGCAGAGTGAAATTTTGCCTGGGGATATGCAACATAATCAGAGCAACCAGAACAATCGTATTTTTGAACAATCGGAAACACAACAGGTTTTAGAGAAGGAGTATGCCGGTGTGTCAGAGAAGAAGGACGAAACAGCTGATGTCGATTCCATAATTTGTGAACATGAATCAGAAATGGTGAGTAATGACAGACCTGTAAGTCGCAGCAGCAGTATCAATAATAATATCGCGTTATCAAGAGATCCGGTAATAGAGGCACTGAAAGACTCTGCTCAACCGGAACTTAATCCTGTAGAAAGATTGGAGAGTTTGATAACTATAATGGAGACAGAGCTTAATAATGCCTCACTTCAGAAAGAAAGCGATGATGCGCAGAACAATCAGGAGGAGAGATTAACAAGTGCAAAGGAGAAACCTTTAGTAAATAGGGAAGAGAGCGTGATCCATGATACTGTTGTCACTATTCCAGGTTCTCACGAGAAAGATCACATATTGCCTGATATACAAGAAGACAACAATGCATGGTGCCCGAACGATTATGTGGATGACGAATTGAGAACGTTAGAAAAGACTTGTCGTTATTTATCATACAATGAAGAGTGTCCGAAAGATGATCGAGTGGATGATCAGCCAAAAACATTAGAAAAGAATGATTTGTATAAGTATAAACATAGTTTTTCAGCACCAGCTTCTCCTGTCGCGGGAAAGAAGAGTTGCAAGACCACACGCCGTTATAGCACCAGATCGGAATTGGGATCGTGTGAAAATCTTAGCGCATGGCATCATCCTACCGGTTTTGACGACGCAACGATTGTGCGCGAAGAAGATGAAGACGAGGACGAGGACGACGATATAACGGATGATGACGAGCGTGAAAAAATGGACGAAGACAACTTCGATGAAGCGGACATGGAGATCGAGGAGATACCCAGTCCTCATACGCCGTTTGTGAAATATGGTGAGAATGCTGAAAGTAGCGTCAGGTCGCATACGCCGTTGTCCACGATCAGCGGTATTTCTGTATTAAGAGTCAGGAAGGATCTCAGTAAACCCTGTTCACCTACGTCCATAAATTCGTTCCATCAAATGATGGAAGACAGTGATAGCGAAAGTCACGACGAGGACAGTAATACTGTAGATAATAATGTTGTAGATAAAGCTGTAGATAAGGCGGCGAAGGATCCGATTGACTGTTCTGTGGTCGAAGAGAAAATCAAGACTGATCATCAGCAGCAAGCATCAGCTCATACTACGGTATGTCAAAATGTTGAGAAAGTTCAAGAATCGAATAGTAATTACATGTACCATCATCAGTCAGTGATAACTGAACACATTAGTTCATTCCCCACGATTCATTCGCAGCAATCCGTCTTAATGCACGAGTCATTTTCCATGACAAATACGAAAACGCAAAGTCTCTTAAATCTACCGGAATCGATCAATCCCACAACTAGCACCGATCCCAAAAGCTTTCACTCCACCAAATCTCTGATGCAAAAACAATCAATGGAACTGCTCAACATAAATGAAGATGCTCATGCTGGACCGATGAACGTCTTTGAATTTGACGGACTACAAATATTAGTTCCTAGTACATTTATAAGTGACTCATCTCAGAAGGCAGTGAGTGCGACTAGCCAGCAATCTATGGCAAGTAGCGAGGGTGCAATAGGTATTGACGAAGAAGTTAAAAGTATTAATATGCGTGCCGATGAAACTATGCCACCCAGAGGCGAATTGTCAGAACAAGAGAGTAACGGATGCACAGAACAATCTACGTGGCAGTTATACATGGGACAAGAATCTTCACGTATGTCTACTTCTTACGACTTACTGGCGCGCGAAAGCTGGGAAGAATCGGAAGGATCCGACAACGAGATTAGCGGACCGTTGTTGGACAGCAGATCGCTAGCAACGCACTTCACTTCGAGTCTGTTTTTGGACCGGGATCGAAAGACACCGACCAAACGGACGTTCAAGTGTTCCTATTGTAACGAGGTGTTCGATTGCCCAAAAGAGCGTAGAGTCCACAGCACGACAGTGCACAAAGAAGCGATTCCCAGTAGCAGTAGAGACCAATTGGATCAACCGGAGATGAAAGATATCAAGTTGTTAGACAATCGTGTGAACATGTTCGACGATCTGTTCGTGCCAAGTCTTCATATGCAGCAGATGTATCATCAGCAGCCACTCTTGCATCAGCTGCAGCCGCCGCCGCAGCCTAATTCGGAAGTTGGCCTGACGAAGGCTGAGAGTGAGCAAAAGATCGGTGAAAATTTGGCGTTACCGTCGAATATCGAGACGACCTGTACAATATGCAATCAACGATTCAATAGCGAAAAATCTCTGCAGTTACATCACAGGCGCATGCACATCGCCGAAGTGAACAAACGTATACGCGAAAACGCAAAGTGTCAGATATGCAACGAGGAATTCCCGTCGGTGTTGCTGTTTAATGCCCATCTAAAGATACACCCGTTGGAGTGTGGGCAGTGCGGCAAGTATTTCTACCGCAAGCAAAATTTCAAACTTCACATGAAACGACATTTGGGTATTAAACCGTTTCCGTGCACCGTGTGCGACAAAGCGTTCCTTACCAAGCAGAAATTGGAAGAACACACCAATGGTCACACCGGTAACGCGCCAGTAAAGTGTAGTCTATGCAACGAGACTTTCCGCAGGTATTCGAATTTAACTCAGCACAAAAACCGTCATCATCTCAACATCAAGAAGAAGCTCAAGGACTATATATGTCACTGCGGCGAAGTGTTTCACACAAAGAAGAAACTCGCTTGGCACAAAGAGACGCACGACGAGAAGCCCAAAGCGTGCACGTACTGCAACGAACGTTTTATCCACATGTCCAGCCTGACGCGTCATATGCGTCGTGCTCACAATCGGCGATTCGTGCCCGACGCTCAGCGCGAAAGTGAGAACGTCGAGTGCCCCGTTTGTAATAGCATCTACTTGCGATCGTCACTAGCAGTGCACATGCGCGTTCACAACGGTGAACGGCCGTACGAATGTCAAGTCTGCTCGAAGTCGTTCAGCACCAAGTGGAATCTGCAGTTGCACAAGTGGACTCACGCCGCCCGCAGCACCAAGCCGTTCAAGTGTAATCAATGCAGCGCGGCGTTCTACCGTCACAGCGACTACACGGCGCACATGAACTCCCACCGAAATGTACGGCCGTATACATGCAACTACTGTGGCGCACAGTTCATCCGTAAGTACAACTGCCTGCGACACGTGAAGGAGCATGAAGAGAACAAGGCGTACACGTGCGACGTGTGCAACAAGACCTTCCATCGCTCGTACTATCTGAAGGAGCACTTGAGAGTGCACTCGGGCGCGCGACCGTACACATGCCACATCTGTGGCAAGTCCAGCGGCACCAAGTCTAATCATAACAAGCACGTGCGAATTCATCACGCGCGTGAGCCTGTAAATACAGAGAACTAA
Protein Sequence
MELSGGGAPTGAVACPVCTLYLREGISLQKHLDTHPKEQVIEALIKASASSLQTHQQQQQLQPQNVPVSATTGLSASLQSQTVPQASTSLQTPQVSPQVTQNAHISTHSPYPIGPIFECPPVGMMPPQFTSFNYQQFVNNGTMMIPQYAMAPQANQMMQMLYNPYGLYQQQQIPTVQMISPVAAVPGQTRIRPVVTMAAESNARTTLTVHVNSPEPKQILPEILPENEPESGPIIPDVSLPASPVLQNEDTSVRREENDNNSLEIDRRGQQTPSSTPPGENAVQREFNAISRSITITRSIDNADEDKVESVLPDIVDEEQSEILPGDMQHNQSNQNNRIFEQSETQQVLEKEYAGVSEKKDETADVDSIICEHESEMVSNDRPVSRSSSINNNIALSRDPVIEALKDSAQPELNPVERLESLITIMETELNNASLQKESDDAQNNQEERLTSAKEKPLVNREESVIHDTVVTIPGSHEKDHILPDIQEDNNAWCPNDYVDDELRTLEKTCRYLSYNEECPKDDRVDDQPKTLEKNDLYKYKHSFSAPASPVAGKKSCKTTRRYSTRSELGSCENLSAWHHPTGFDDATIVREEDEDEDEDDDITDDDEREKMDEDNFDEADMEIEEIPSPHTPFVKYGENAESSVRSHTPLSTISGISVLRVRKDLSKPCSPTSINSFHQMMEDSDSESHDEDSNTVDNNVVDKAVDKAAKDPIDCSVVEEKIKTDHQQQASAHTTVCQNVEKVQESNSNYMYHHQSVITEHISSFPTIHSQQSVLMHESFSMTNTKTQSLLNLPESINPTTSTDPKSFHSTKSLMQKQSMELLNINEDAHAGPMNVFEFDGLQILVPSTFISDSSQKAVSATSQQSMASSEGAIGIDEEVKSINMRADETMPPRGELSEQESNGCTEQSTWQLYMGQESSRMSTSYDLLARESWEESEGSDNEISGPLLDSRSLATHFTSSLFLDRDRKTPTKRTFKCSYCNEVFDCPKERRVHSTTVHKEAIPSSSRDQLDQPEMKDIKLLDNRVNMFDDLFVPSLHMQQMYHQQPLLHQLQPPPQPNSEVGLTKAESEQKIGENLALPSNIETTCTICNQRFNSEKSLQLHHRRMHIAEVNKRIRENAKCQICNEEFPSVLLFNAHLKIHPLECGQCGKYFYRKQNFKLHMKRHLGIKPFPCTVCDKAFLTKQKLEEHTNGHTGNAPVKCSLCNETFRRYSNLTQHKNRHHLNIKKKLKDYICHCGEVFHTKKKLAWHKETHDEKPKACTYCNERFIHMSSLTRHMRRAHNRRFVPDAQRESENVECPVCNSIYLRSSLAVHMRVHNGERPYECQVCSKSFSTKWNLQLHKWTHAARSTKPFKCNQCSAAFYRHSDYTAHMNSHRNVRPYTCNYCGAQFIRKYNCLRHVKEHEENKAYTCDVCNKTFHRSYYLKEHLRVHSGARPYTCHICGKSSGTKSNHNKHVRIHHAREPVNTEN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01268464;
80% Identity
-