Basic Information

Gene Symbol
-
Assembly
GCA_014825475.1
Location
QVNW01003090.1:1310-5870[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 5.8e-06 0.00062 20.5 1.5 1 23 143 165 143 165 0.98
2 15 0.00011 0.012 16.4 3.5 1 23 171 193 171 193 0.97
3 15 0.0006 0.064 14.1 0.1 1 23 325 347 325 347 0.98
4 15 0.0047 0.5 11.3 0.2 1 23 353 376 353 376 0.97
5 15 3.1e-05 0.0033 18.2 2.0 1 23 405 427 405 427 0.98
6 15 0.22 23 6.1 0.0 1 23 442 464 442 464 0.92
7 15 0.17 18 6.4 0.5 2 23 472 494 472 494 0.95
8 15 0.004 0.42 11.5 3.0 2 19 502 519 502 523 0.95
9 15 1.2e-05 0.0013 19.4 5.0 1 23 529 551 529 551 0.98
10 15 0.014 1.5 9.8 0.1 3 23 558 578 557 578 0.97
11 15 8.2e-06 0.00088 20.0 0.4 1 23 587 609 587 609 0.98
12 15 0.0036 0.38 11.7 0.2 3 23 617 637 615 637 0.97
13 15 0.0032 0.34 11.8 0.2 3 23 645 665 643 666 0.94
14 15 0.016 1.7 9.7 0.0 1 23 680 702 680 702 0.92
15 15 0.012 1.2 10.1 0.0 1 20 1132 1151 1132 1154 0.94

Sequence Information

Coding Sequence
ATGGATGTTGCCGGAGATCTAAATTTGCAATGGGTGGGGGATGTGGATCTTCACGAAGAGGTGATATGTGGCCTAGAGGCACAGCTAGTTACTTCTGGAGAAGAAGTGATAGGTGCTTGCGAGGAGGTAGCAGTAGAAGAAACTGTGGAAACTGTTCCTGATGTAGCACCTACAACAGAATCTGAGATATTGATGATACCTCAAACTAATGATATGGAATCTATTTACATAGTACCACAAGATCAAGGCCATGACTATCTAAACATACAAGTTACAGAAGAAGTAATAGCTGATAATTGGGACAGACCTCCAGATGATGGGGTTGAGATTCCAGAGGCTAAAATAACTCAAGACAATCCACTAGAGTATGATGACATAGAGATACCACTACCACCTGATCAGGATTCGTACCAGAACATTCGACCGTATCCATGTGACTTCTGCAATCGCAGGTTTCGAAAAAAAGTAAATCTGTCAAATCATATTTTGACGCACCAAACTGATCGACCGCACAGCTGTAATTTGTGCGGAGCACGTTTTGTGCGCAAGTGCGATCTGAACAACCATCTGAAAATTCATGCATACGCACCGTCGTCGCGAGATGGCTTAGAGGATGATCTGAACGACGAGGATTCATTGGTGGCTGAGGAAGAGGACACTACAACTGGCGGCACTAGGGGCAGGCGCAAGAAGGTGCAATCGAGCGCGCCACGCAAACGAAAGAGTAATACCACTGGGATGTCGAAGCGCAATAATACAGAGGATATCAAACTGGAGATGGGCAAGTATGTGTATAAATCGCACGACGATGAATACACGTACAGCGAGGATGCGCAACTGTTCGAGGACGATCTGATCGATGATAATTCTGCACGCAGCGACAATTATGCATCCAGTTCGAAGTGGCCAAAGATGTCTGTTACTGGCGAGGAACATCCAACGCAGTGGCCGGTCACCGATCCAACCAAGCCGTATGTTTGCCAGTTTTGCGGCGTCGGATTTGCTAGGGAAAAAGCGTTAGCTTCGCATTCTCGTATCCACGGTGGTGACAGCCCATTCGAGTGCACTACATGTGGTGAAATGTTTTGGGATGTCAATAGTCTGCGGGAGCATGTACGTGTCAAACATGGCGGCATTTCTCAGTCACCGTCTGATGCAGAAGAGTTTGACAACGACGGCACATATACAGGCGACAATGAGAGAATTGGTGAATTCTACTGTAACACTTGTGGCGTACCTTTTCATCGTCTGGATCTTCTCAAACGTCATCAGAAAATTCACATCAAGCAAGAAATAGAGACGATGGAAGGTTCCAGTCAGCATCATGTGTGCAATGTATGCGGAGAATTGTTTGAAGAAGCTTTAGCATTATTAGCACACGCTGAACTTCACGCTTCAAGATCTCCTAGTCGTCGTTGCCTACTATGCGGAACAAGATGTCGCGACGAAGCCGAGGTTGCCGAACACGTAAGGCAGAATCATGCCGAAGATGCACCACCGAATACATGTACATTGTGCGGAAAAACGTGCAAAGATAAGCGCAGTTTACTGAAACATTCGTGGGTTCATAATGTTGAAAAGACCTTTAGTTGTACAAAATGTGGCAAACGTTTCCACAGTAAAGCCAGATTGCGAAGACATATGATGTCGCACCGTAACAAAATGGTAGCTTGCGATGAGTGCGGCGAAGAATTCCCTGATGGACGGGCTCTCGTAAGCCATCGTCATTCGCATAATAAGGAGTTGGGCGGCCGTTCTTTCCCGTGCCGTGAGTGTGGGAAGACTTTTGGCAGTCGCAGTTCACAACAGATTCATATACGTATTCACACAGGCGAAAGACCGTATGGTTGTCGATTCTGTTGGAAAGCATTTGCTGATGGCGGCACTTTGAGAAAACACGAACGTATCCATACTGGCGAGAAACCGTATGGATGCGCTATTTGCCCTCGGGCTTTCAATCAAAGAGTGGTTCTCCGAGAGCACGTGCGCGCTCATCATTCTGGTCCAGATCCGAAGTGTGTAGGAAGCGCGACGCCATATCTGTGTAAAGTATGCAGTGAATCTTTCGCCACGCCTGAGGAAATAGTGCTGCATATAGTGCAGCATTGCGACCACAATACTGCATTAAGACGCCAGCCGCAGACTGGGCCACGCAAGTATAAGAGAAGACGTAAGCTAAAACCTCATGAAACAAATACTATGGTGCGTAGGAACGAATTTACATACGATATGACAGAAGCCGATAACGGAGCTATCGCCACCGCTNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGGTTCTGATTCTGAAGACAATACAAAAAGAAAACTTGGCAAGAAAAATAAACAGAGATCGAACGTTGAAGAAGGTTACCAGAATGTGTTGAAGAGCTTCGAGAGCTCGTTACAGAACATAAACTCGATCGTAAGCAATTCCAAGTTAAATGCGTCCAAGTCGAAAGTCTCGAAAAAGAAACTGCGTAAGGAAGATAAGAAGCAAGAGGCGCAAACATCAAATCAGTCGGGTCGACCCAAAATGATACACACACAAAAGACACGAGTGCCAGTTGAGTTGGGCAGCGACGGCGCGAAAAAGGGTCAGAAAACAAAAACAATGGTGACGCGAACACCGAAGGTAATGCCAAATGAGCACAAAACCGGTGCCTTTCCGGGCGGCGAACGTAATCGGCCGCGCACAAAAAACGTTAGTTATCATATCGAAGGTAAGATGCTACTCACGCCGGCAACATTCCCGGCGAAATCGGTGAAGGAAGAAGCGCTTTCAACACAATCGTCGCAGCAAATGGTAATTAATATCAAGCAAGAACCAGGCATACAGAAGACTGCTCACGACAGCTATAAAAACAATAATGGTAATATTGTCGGTAAAAATCAAGAATCAACTCCGAATGTTTCTAAAAGGAAGTCGTCGGTCGCACCGAAGAAGCCGAAAAGACAGAAACAGGTGACAGTGAAGCAAGAAGTAAACATGTCGGTTGAAGCAAATACAGAGCAGCAACAGTTACAGTTGCATAACAATAACAATAATATCATGGGAAACAGTGGCGATTCGGCGCAATTAATGGAACCTGTGGTAGATGGCAGTCACTTGGAGGTCGCTTTCGAAGCGAGCGTTGTTACCGCTCAAGAAGAAGAGGATAATGCTGACGAGGGAGATGAGGGACGCATATTACAGTCTAACACAACGACGGAAATAAGTAATGGCGACGTGAAACTTAGTGTAAAGGTAGAATCGGCGCCGCCGGCGAGAATGCTTGCTGTACACAGTGTTATCGCATCGGTAGACGATGTCCCGGAAACAATAATCCCAGATGCGGTGGAATACACGTGCGAAATGTGCGCTGCGGTGTTTTCCAGTCGAGCCGAGTTATTAGTGCATGTGCCGATACACATTTGA
Protein Sequence
MDVAGDLNLQWVGDVDLHEEVICGLEAQLVTSGEEVIGACEEVAVEETVETVPDVAPTTESEILMIPQTNDMESIYIVPQDQGHDYLNIQVTEEVIADNWDRPPDDGVEIPEAKITQDNPLEYDDIEIPLPPDQDSYQNIRPYPCDFCNRRFRKKVNLSNHILTHQTDRPHSCNLCGARFVRKCDLNNHLKIHAYAPSSRDGLEDDLNDEDSLVAEEEDTTTGGTRGRRKKVQSSAPRKRKSNTTGMSKRNNTEDIKLEMGKYVYKSHDDEYTYSEDAQLFEDDLIDDNSARSDNYASSSKWPKMSVTGEEHPTQWPVTDPTKPYVCQFCGVGFAREKALASHSRIHGGDSPFECTTCGEMFWDVNSLREHVRVKHGGISQSPSDAEEFDNDGTYTGDNERIGEFYCNTCGVPFHRLDLLKRHQKIHIKQEIETMEGSSQHHVCNVCGELFEEALALLAHAELHASRSPSRRCLLCGTRCRDEAEVAEHVRQNHAEDAPPNTCTLCGKTCKDKRSLLKHSWVHNVEKTFSCTKCGKRFHSKARLRRHMMSHRNKMVACDECGEEFPDGRALVSHRHSHNKELGGRSFPCRECGKTFGSRSSQQIHIRIHTGERPYGCRFCWKAFADGGTLRKHERIHTGEKPYGCAICPRAFNQRVVLREHVRAHHSGPDPKCVGSATPYLCKVCSESFATPEEIVLHIVQHCDHNTALRRQPQTGPRKYKRRRKLKPHETNTMVRRNEFTYDMTEADNGAIATAXXXXXXXXXXXXXXXXXXXXXXXXXXXGSDSEDNTKRKLGKKNKQRSNVEEGYQNVLKSFESSLQNINSIVSNSKLNASKSKVSKKKLRKEDKKQEAQTSNQSGRPKMIHTQKTRVPVELGSDGAKKGQKTKTMVTRTPKVMPNEHKTGAFPGGERNRPRTKNVSYHIEGKMLLTPATFPAKSVKEEALSTQSSQQMVINIKQEPGIQKTAHDSYKNNNGNIVGKNQESTPNVSKRKSSVAPKKPKRQKQVTVKQEVNMSVEANTEQQQLQLHNNNNNIMGNSGDSAQLMEPVVDGSHLEVAFEASVVTAQEEEDNADEGDEGRILQSNTTTEISNGDVKLSVKVESAPPARMLAVHSVIASVDDVPETIIPDAVEYTCEMCAAVFSSRAELLVHVPIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00730239;
90% Identity
iTF_01268446;
80% Identity
-