Basic Information

Gene Symbol
topi
Assembly
GCA_014825605.1
Location
QVNY01020207.1:31351-33638[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 0.016 3.2 9.8 0.7 1 23 246 268 246 268 0.95
2 16 0.053 11 8.1 1.2 2 23 275 297 274 297 0.95
3 16 0.0004 0.082 14.8 0.7 1 22 303 324 303 324 0.95
4 16 5.6e-05 0.012 17.5 0.4 1 23 331 353 331 353 0.96
5 16 2.5e-06 0.00051 21.8 3.0 1 23 359 381 359 381 0.97
6 16 0.046 9.5 8.3 0.2 2 23 393 415 392 415 0.86
7 16 0.0056 1.1 11.2 2.3 1 23 431 453 431 453 0.98
8 16 0.07 14 7.8 0.6 1 23 459 481 459 481 0.96
9 16 0.73 1.5e+02 4.6 1.5 1 23 491 514 491 514 0.93
10 16 0.04 8.1 8.5 0.0 1 21 528 548 528 549 0.93
11 16 0.0052 1.1 11.3 0.1 1 23 554 576 554 576 0.98
12 16 1.1e-06 0.00023 22.8 3.0 1 23 582 604 582 604 0.98
13 16 2e-05 0.0042 18.9 0.3 1 23 610 633 610 633 0.98
14 16 0.057 12 8.0 0.7 1 23 639 661 639 661 0.89
15 16 3.7e-07 7.6e-05 24.4 2.2 1 23 667 689 667 689 0.99
16 16 7.1e-06 0.0014 20.3 5.1 1 23 695 718 695 718 0.96

Sequence Information

Coding Sequence
ATGTTAAGAGCAGAATCAATTAGCACACTAAGGAACTACGAAGATGATGTTAACGATTTAGATGGCTCTATTATATGGTCTCAAGAGGAGCCATTGTCATCTAATGAAATATTGATGCTGCTAAGTGAAGATCAAAGAGAAAACAATTTGGCTGCGTTCTGCCGATTGTGTGCTAATCAAACTAATAATCCAATAAATATTTATTCTGAACTTGGAGAATCCATGAAATTAGAGCATAAAATAAACACATATCTAAGCATCAAGATTAGAAAAACAGATCTGTTGTCAAAACAACTTTGTCTGTCTTGTATTGAGAAGATAAACTGGTGCAACGAATTTGACACTCAGTGCGTCAAAGCAGAAGAAATTTTGTTGACAATGCTACGAGAAAAACAACAATCTTTCAATATCAGTCATGAAAATAAAATCTTATCTGATCAACAATCCTGTCTTTTATGTACAGAAGATTCTATGAACACATGTGAAGACACTTCCCAAGATACAAAAAGTATGGAAGTGTATGAAAACATTATTATTCTTGAGAAGAGTGATGAAGAGAACATTGGTAATATTGCAAAAGTTGAGAAGGAAAACAGAGATTATTCTATCGTGCTACAATATCTGGGAGATAAACAAAAATATTTGAAATGCGGAGCATGCATGAATCTCTATCACACTCAGGAGACTCTAGACAGTCACAAGTGTAAGCCACATGCCCAGAGCACGACACAGCTATACGAGTGTTCTATGTGCGGCTTGACGTTTGCCTTTGAGGAACGACTAAACTTTCACATGCAATTTCACAAGGATGGAAAAGCACTGTATTGTGAAGTCTGCAAACTGACGTTTGCCAAAGAATTAAAGCTGTTTTATCATTACAAAAGATATCATTCCAGTGATATTAGCTTCTCATGTTTGCAATGCGGAAAGCTATTCGAGAACCAGAATGCGCTTCGAGTGCACATCTGTACCGACGGCAAGACTCGGCCGCACATCTGCGAAGTGTGCAACAAGGGCTTTACGGATGGTTATGCTTTGAAGCGTCACGTAGTAACGCACTTGCCGGAGAAGCCGTTTAAATGTTCGCAGTGCTCGAAGAGCTTTACGCAGAAGTCGAGATTGAACAAACATATCGCAAATCATTGCATCGTCATCGAAGACAGCCAGACGGTCTGGAAATGCGTCCAGTGTGGCGAGGTGTTTGTCTCCTGCGACAACGCCGATGTACATTATTACGAAATACACGAGGAAAAAATCACGCTGATTGAGGAACTGTTGATATCGAGGATTTATCATTGTGAGTTCTGCAACAGTTACTTCGCCGATGTGGACAATCTAAGTTCTCATCAAAATAAACATGTTATCGAGAGACCGTACACGTGTAACACCTGCAAAACCATTTACAAATCTTTCGGGGAAGCTGTTACGCATTGGAAGGAACATCCTAGACTCTTCAGAGTTCTCATCTTCTTCTTATGCGACATTTGCTACAAAGACATGAAGGAACTGTCATTGTTGTACAAACACAAGCAGAAGAGACACGGTTACGCGTCGAGATTGTCCGAGTCCGGTGACTCCAAGTTCATTTGCCAGCTCTGCGGAAATGTGTTCGATAAAAGCGAGGATATACAGAATCACGGACGGGAACAATGCTCGAAATTTCCTTGCGATATCTGCGGCAGTCTACTGCCCACCGCAAACTCGCTGAACGCTCATAAGAGACGGCACAATGGATTAAGACCGTACGTTTGCAACATCTGCGGAAAAAGTTACACTCAGTCCAGCCACATGTGGACTCACAGGAGATTTCACATGGGCGTAAAACCTTACGTTTGTGATTACTGCGATCAGCGTTTCACGATAAAGCCGGATCTGGCGGATCACATCAGAAAGAAGCACACCAAGGAGAGACCGTTCAAATGCGACGTGTGCAACAAGGCCTTCCTGACTGGTTCTGTATTTTATCAGCATAGATTGATACATCGTGGTGATCGCAGATACAAATGTCATTATTGTGAGAAGGCTTTCACTAGAACAGAAGCTTTAAATAATCACATCAAAATACACACCGGAGAAAAGCCGCACGCTTGCGATGTGTGCGGCAGATGTTTCAGACAGAAGGGAGATATGAAAAAACACAGACGCACGCAGCATAGCTCTAGTCAAGAGATTTCTGAAAGTTGTCATGTTCCAGATGTAGCATAA
Protein Sequence
MLRAESISTLRNYEDDVNDLDGSIIWSQEEPLSSNEILMLLSEDQRENNLAAFCRLCANQTNNPINIYSELGESMKLEHKINTYLSIKIRKTDLLSKQLCLSCIEKINWCNEFDTQCVKAEEILLTMLREKQQSFNISHENKILSDQQSCLLCTEDSMNTCEDTSQDTKSMEVYENIIILEKSDEENIGNIAKVEKENRDYSIVLQYLGDKQKYLKCGACMNLYHTQETLDSHKCKPHAQSTTQLYECSMCGLTFAFEERLNFHMQFHKDGKALYCEVCKLTFAKELKLFYHYKRYHSSDISFSCLQCGKLFENQNALRVHICTDGKTRPHICEVCNKGFTDGYALKRHVVTHLPEKPFKCSQCSKSFTQKSRLNKHIANHCIVIEDSQTVWKCVQCGEVFVSCDNADVHYYEIHEEKITLIEELLISRIYHCEFCNSYFADVDNLSSHQNKHVIERPYTCNTCKTIYKSFGEAVTHWKEHPRLFRVLIFFLCDICYKDMKELSLLYKHKQKRHGYASRLSESGDSKFICQLCGNVFDKSEDIQNHGREQCSKFPCDICGSLLPTANSLNAHKRRHNGLRPYVCNICGKSYTQSSHMWTHRRFHMGVKPYVCDYCDQRFTIKPDLADHIRKKHTKERPFKCDVCNKAFLTGSVFYQHRLIHRGDRRYKCHYCEKAFTRTEALNNHIKIHTGEKPHACDVCGRCFRQKGDMKKHRRTQHSSSQEISESCHVPDVA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2