Basic Information

Gene Symbol
-
Assembly
GCA_029228625.1
Location
CM055404.1:111140764-111143120[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 20 2.1e-05 0.0025 19.7 0.4 2 23 86 107 85 107 0.96
2 20 6.4e-06 0.00078 21.3 0.8 1 23 113 135 113 135 0.98
3 20 0.00036 0.044 15.8 3.0 1 23 141 163 141 163 0.98
4 20 4.5e-07 5.5e-05 25.0 1.1 1 23 169 191 169 191 0.98
5 20 2.8e-07 3.5e-05 25.6 2.4 1 23 197 219 197 219 0.97
6 20 3.5e-05 0.0043 19.0 1.1 1 23 225 247 225 247 0.97
7 20 0.0014 0.17 14.0 0.4 1 23 253 275 253 275 0.95
8 20 3.1e-05 0.0038 19.2 0.5 1 23 281 303 281 303 0.98
9 20 6e-06 0.00073 21.4 0.5 1 23 309 331 309 331 0.98
10 20 0.00027 0.033 16.2 0.3 1 23 337 359 337 359 0.97
11 20 9.4e-06 0.0012 20.8 3.9 1 23 365 387 365 387 0.98
12 20 0.00025 0.031 16.3 0.9 1 23 496 518 496 518 0.93
13 20 3.1e-06 0.00038 22.3 3.4 1 23 524 546 524 546 0.95
14 20 9.1e-07 0.00011 24.0 1.4 1 23 552 574 552 574 0.98
15 20 2.1e-06 0.00026 22.9 0.9 1 23 580 602 580 602 0.96
16 20 0.0002 0.024 16.7 0.4 1 23 608 630 608 630 0.97
17 20 1.2e-05 0.0015 20.5 1.7 1 23 636 658 636 658 0.98
18 20 1.5e-05 0.0018 20.2 0.3 1 23 664 686 664 686 0.97
19 20 0.012 1.5 11.0 1.0 1 23 692 714 692 714 0.95
20 20 0.052 6.4 9.0 0.3 1 15 720 734 720 737 0.91

Sequence Information

Coding Sequence
ATGGAAGAAGTTTGGATAAAAACAGAACCAAGTGACAATGATGTGTCAGGTCATTTACTCATTGAACGTAAAGATGAAAGTGACACCCCAAGGAACCACTCATTGCCAAAAATACCAACCATATCAACTTACATCGCACAACCGATGGAAGTAAAATCAGAAATAACGCTCGCCGAGTATGAATGTACTCCTTACAGTACACCGCAAAAGATTACGAAAACTAATACGGAACTATCGCAATGCAACCCTGAATTAGTGTGCGACGTCTGCGGAAAGAAATTCAACCGGAAAGGCTTCTTCATCAAACACTTGTTGATACACACAGCGGACAATCCGTACGCCTGTGACGTATGTGGCAAAAATTTTACGAACAAAACTGTGTTGAAACAACATAAGCGCATACACACTGGCGAGAAACCGTTCCATTGCGATGTGTGCGGAATGAATTTCGCCCAAGGCAACCACTTACAAAAACACAAACGGATACACACGGGCGAGAAGCCATTTCCATGCGAAGAATGTGGTGTAAGTTTTGCACGCAAATCGTACCTTCAAGAACACCATCGGACACACTCTGGCGAGACCCCGTTTGTTTGTGAACAATGTGGAAAAGCTTTCAAATCCAAGACACATCTCAAGAGACACATTGATTCACATTCCGGCAAAAAGCGATACGCATGCCTTGAATGTGGAACGAGATTCACCGacaacttttcattaaaatCTCACAAATTGACACATACCGGGGAGAGGCCATTCGCTTGCGATGCGTGCGGCAAGACATTCTCTACCAAAGCCATTTTGAAGTCACACAAAGTGACGCACTCCATCGAGAAACCTTTCTCTTGCAATGTTTGCGACAAAAGATTTGTCAGTAAACCTCTAGTCAAGTCGCATATGGTAACACACACCGGCGAGAGACGTTTCCCATGCGACCAATGCGACATGAAATTCACCCGACCATGGCTACTAAACCAACACCAGAGGCAACACACCGGCAACAAACCCTTCGCTTGTGAGGAGTGTGAAATGAAGTTTACAGTCAAGTCTTCGCTAGTAGCCCATAAACTGAAGCATACCGGTGAGGCGCCGTTTCCATGCGATGAATGCGACAAGAAGTTTCGAACGAATCATTGGCTCaaacaacacaaaaaatcgCATGCCGGAAAGCCATCGAAAAAATCACACATCGCAGAGTCTGAAGTTGAAAAACAATCGGAAACACCGGGAAGTAATCCGCTAGACGATCTGGAAAACATTCCATGCTCTGAGACCATATTTTCAGCAAAGAAGGAACATCTTGATAATGGCGAAGATGGCCACAGTTGCAGTGATTTTGGCAATGAACCAGAGATTGATATACAAATTATTCCTGACACGCCATCTGCCACCAGAGACGATGCAACAGAAAAACTAGAGCATCCCATCTCGTGTAATGAAATTGAAACAGATGCTGACACTGACGCTAACGCTGATAACAAATTATTCGCTTGCGAAGAGTGTGAAAGGACTTTTCCAAACAAGCGTCAGCTTCGTGATCACAAATTTGAGCACACGGGTAAAAAGCCGTTCGCTTGTAATGACTGTGGAAAAACCTTTACCCACAAATATAAGCTCACCAAACACAGTGCCATGCACACAGACGACAAGCAATTTGTCTGCGACGAATGTGGAAAGTCATTCAAGTTAAAGTCAAGCCTCTTGAAACACAAACGTTTGCATACTGGGGAAAAAGACTTCGCTTGCGACCAGTGCGATAAAGCGTTCACTCAGAAAGCACATCTACAAGCGCACAAACTGGTACACACCGACGAAAGGCCGTTTGCCTGCGATGTCTGTGGAATGAGATTTAAATCCACATGGCAAGTTCGCATCCATCAACGCAACCACACAatcgaaaaacgtttttcttgcGATGTATGTGGAATGAAATTCACCCAAAGAAACAGCGTCAAAAAGCACCAAATGACCCACACCGGTGAGAGACCGTTCGATTGCGACGAATGTGGAAAGATGTTCGTAGCCAGAAGAGATCTTAAGGTACACCAAATGAGACACACTGGCGAAAAGCCTTTTGCTTGCGATATTTGTGGAATGAAATTCTGTCAAATAAATGAGGTAAATAATCACAAAGTCAGACACGGTAATGAGAAGCCGTTTTCGTGCGATGTTTGCGACATGAAATTCGCAAGGAAAAGTCAGCAAACCTGGTCTTTTAAAGCAACACAAACGACAGCACACTGGAGAAAAGCCATTCGCTTGCGATCATTGTGGAATGCGATTTAA
Protein Sequence
MEEVWIKTEPSDNDVSGHLLIERKDESDTPRNHSLPKIPTISTYIAQPMEVKSEITLAEYECTPYSTPQKITKTNTELSQCNPELVCDVCGKKFNRKGFFIKHLLIHTADNPYACDVCGKNFTNKTVLKQHKRIHTGEKPFHCDVCGMNFAQGNHLQKHKRIHTGEKPFPCEECGVSFARKSYLQEHHRTHSGETPFVCEQCGKAFKSKTHLKRHIDSHSGKKRYACLECGTRFTDNFSLKSHKLTHTGERPFACDACGKTFSTKAILKSHKVTHSIEKPFSCNVCDKRFVSKPLVKSHMVTHTGERRFPCDQCDMKFTRPWLLNQHQRQHTGNKPFACEECEMKFTVKSSLVAHKLKHTGEAPFPCDECDKKFRTNHWLKQHKKSHAGKPSKKSHIAESEVEKQSETPGSNPLDDLENIPCSETIFSAKKEHLDNGEDGHSCSDFGNEPEIDIQIIPDTPSATRDDATEKLEHPISCNEIETDADTDANADNKLFACEECERTFPNKRQLRDHKFEHTGKKPFACNDCGKTFTHKYKLTKHSAMHTDDKQFVCDECGKSFKLKSSLLKHKRLHTGEKDFACDQCDKAFTQKAHLQAHKLVHTDERPFACDVCGMRFKSTWQVRIHQRNHTIEKRFSCDVCGMKFTQRNSVKKHQMTHTGERPFDCDECGKMFVARRDLKVHQMRHTGEKPFACDICGMKFCQINEVNNHKVRHGNEKPFSCDVCDMKFARKSQQTWSFKATQTTAHWRKAIRLRSLWNAI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-