Pazu013493.4


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Protocalliphora azurea
Gene Symbol
Hsf
Assembly
GCA_932273785.1
Location
CAKNZW010000426.1:95527-109697[-]

Transcription Factor Domain

TF Family
HSF
Domain
HSF_DNA-bind domain
PFAM
PF00447
TF Group
Helix-turn-helix
Description
Heat shock factor (HSF) is a transcriptional activator of heat shock genes [1, 4]: it binds specifically to heat shock promoter elements, which are palindromic sequences rich with repetitive purine and pyrimidine motifs [1]. Under normal conditions, HSF is a homo-trimeric cytoplasmic protein, but heat shock activation results in relocalisation to the nucleus [2]. Each HSF monomer contains one C-terminal and three N-terminal leucine zipper repeats [3]. Point mutations in these regions result in disruption of cellular localisation, rendering the protein constitutively nuclear [2]. Two sequences flanking the N-terminal zippers fit the consensus of a bi- partite nuclear localisation signal (NLS). Interaction between the N- and C-terminal zippers may result in a structure that masks the NLS sequences: following activation of HSF, these may then be unmasked, resulting in relocalisation of the protein to the nucleus [3]. The DNA-binding component of HSF lies to the N terminus of the first NLS region, and is referred to as the HSF domain.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2.4e-37 1.3e-33 115.8 0.2 1 100 14 113 14 113 0.97
2 2 1.6 8.6e+03 -2.4 0.0 27 48 690 709 675 737 0.70

Sequence Information

Coding Sequence
ATGCACACATTCAGTGAGACGGGTGCCGGAGTGCCGGCTTTTTTGGCAAAGCTTTGGCGGTTGGTTGAAGATCCGGAAACTAATAATCTCATTTGTTGGAGCAAGGATGGGCGTAGCTTCATTATTCAAAATCAAGCCCAATTTGCTCGGGAATTGCTACCACTCAACTATAAGCACAATAATATGGCCTCCTTTATAAGACAGCTGAATATGTACGGTTTTCATAAGATAACATCCATTGACAATGGTGGCTTAAAATTTGATCGCGATGAAATGGAATTTACCCATCCCTGTTTCAAACGCAATTGTCCCTATCTTTTGGAACATATTAAACGTAAAATTGCCTCTACTAAATCAGTTGATGAAAAGTCAGCTCTAAAGCCCGAAGCTGTAACAAAAGTTTTGCAAGATGTCAAGGCCATGCGTGGAAGACAAGATTCTTTGGATTCTCGTTTCTCTGTAATGAAACAGGAAAATGAGGCATTATGGCGTGAAATTGCTTCGCTAAGGCAAAAACATGCTAAACAGCAGCAGATAGTTAATAAGCTAATACAATTTTTGATAACTATCGTACAGCCTCAACGTAATATGGCCAGTAGTGTAAAAAGACATATGCAGTTGATGATTAACGACATACCGGACAAGTCAGCCAAAGTACGCAAGTCTAGTGAATCAGAATCGGAATGTGGTCCAGTTATACATGAGTTGGGAGAAGAATTACTGGATGAGGTAGCGGAGGTAGAACCAGAATTAATGGTGCCCAACAGCCCTTTTGTACGTGTGGCTACACCAGCAACGCCAGCAACAGATCCGGATGTGGCACATTCACCTCACAATATGGAAAGGCCCCAGTCTAGTGTTAGTATGATGTCGTCTCAAAATTATGATTTCTCTAATCAAAGTGCTGAAGATGCTGGTGGCTACTTAAGTCCAGCAGCTACTACTGCTGCTGCTGGCAATGATGGCATTGTACAGACCGTTAATAATGATGGTTCAAAAATATTCTATCACATAACCGAGGTGCCCGATGCGCAACCCCAGGAAACAGCCGCTATTAGTCCTGTAAGCTTTAATGAAGAAAATGTATTAACCACACCAATGGTACGTGAGGAAATGGCTCGCAATAAATTATTAAAACAAAAAAATCGTCAGAGACGTACTAAAACAGAAAGCGCCATAGAAAATCTAAATAAAACAACTGGTCCCACCGCTACTAAAGTACAGCGTGTTGCAGTCAACCAACCACAATCATCACCAAAGTCTCAGCAACAACAGCAGCAAAAACAAGTATCACCACTGCATATTCCCCAACCCATACGAATAAAATCCGAACAAGATCCCGCTTTAGATCCGATTCTTTTTTTAAATGTCTATCCAGATAATCGTGGTATGACACCAGATCCAAATTTGATTTCTCCCAATTTTAGTGAAGATTCTCGTCAGTCTAATTCGAATACTACTGGTAGTTTTTTGATTAACAATTCTTCGGCAAACACAGCATCATCGGCAGAAAATGATTTATTGGGGGGCAATAATTCTGATTTGTACAACCCAAATAGTTTTATTACTAACGATATACCGGCTGATATATTTGAGGATAATTCCTTATTATCAGCCGGAGAGAATAGCAGCATCGAAACCAATCACAGTTATAAACAAGCCCAACAAAAGCAGTATGGGCGCTCCACTGTTAACAGTGGAAAATTTTCAACATTTTTGTCTGGATGTACATCGGGAAATGGTAGCCTGCAACCATCTACTTCTGCTGCTGCTGCAGCTGTACAATCAACAAATAATTGCAACAATGATGAAACTCAAAAGTCTGCAGCCACATCCGCATTGAAAAATGAAAATGGCAGTAACTTGGCTGTCACTAAATACAAGAATAATAATCCAGACATTATGCGGTTGAGTACTGCAGATGAAGTCCATGGACACTTGGAAATAGTACAGGATGAACTGGAAGGATTAAAAGATTTACTACGTAGCGATGTCTATTCTTTGGATCATAATACTTTGCTAGGTAATTCCAAACAGAATTTATGTATGAACACAAATAATCAACAAATATTTTTGCCGCCGGCTATGGAAGAGGATATTCTAAATAAGCTCTTTAATGAATCGGACATTTTGGGTCCATATGGTTTACATTTATCCAATGATGGAAGTAACAGCAATGATAAAAAAAGATCTGAATTGATGTCTTACCAACCTATGTATGATTTATCCGATATTATTAATGAACAAAATGATTTAGATGCTGATGTCAACATGCCCACTTCATCGACCTCAATGCAATTACAACAGCAGCAGCAAACTAAACCGGAATATAGCAATTCTGTATTAAATACACCGTATCATGAATAA
Protein Sequence
MHTFSETGAGVPAFLAKLWRLVEDPETNNLICWSKDGRSFIIQNQAQFARELLPLNYKHNNMASFIRQLNMYGFHKITSIDNGGLKFDRDEMEFTHPCFKRNCPYLLEHIKRKIASTKSVDEKSALKPEAVTKVLQDVKAMRGRQDSLDSRFSVMKQENEALWREIASLRQKHAKQQQIVNKLIQFLITIVQPQRNMASSVKRHMQLMINDIPDKSAKVRKSSESESECGPVIHELGEELLDEVAEVEPELMVPNSPFVRVATPATPATDPDVAHSPHNMERPQSSVSMMSSQNYDFSNQSAEDAGGYLSPAATTAAAGNDGIVQTVNNDGSKIFYHITEVPDAQPQETAAISPVSFNEENVLTTPMVREEMARNKLLKQKNRQRRTKTESAIENLNKTTGPTATKVQRVAVNQPQSSPKSQQQQQQKQVSPLHIPQPIRIKSEQDPALDPILFLNVYPDNRGMTPDPNLISPNFSEDSRQSNSNTTGSFLINNSSANTASSAENDLLGGNNSDLYNPNSFITNDIPADIFEDNSLLSAGENSSIETNHSYKQAQQKQYGRSTVNSGKFSTFLSGCTSGNGSLQPSTSAAAAAVQSTNNCNNDETQKSAATSALKNENGSNLAVTKYKNNNPDIMRLSTADEVHGHLEIVQDELEGLKDLLRSDVYSLDHNTLLGNSKQNLCMNTNNQQIFLPPAMEEDILNKLFNESDILGPYGLHLSNDGSNSNDKKRSELMSYQPMYDLSDIINEQNDLDADVNMPTSSTSMQLQQQQQTKPEYSNSVLNTPYHE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00045282; iTF_01194308; iTF_00199785; iTF_01260911; iTF_00921360; iTF_00331441; iTF_00350098; iTF_01235637; iTF_01237568; iTF_01236572; iTF_00258782;
90% Identity
iTF_01260911;
80% Identity
-