Basic Information

Gene Symbol
Zfa
Assembly
GCA_018397935.1
Location
CM031468.1:21376387-21378925[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 0.017 0.82 10.0 6.3 1 23 148 171 148 171 0.96
2 17 8e-05 0.0039 17.3 3.1 1 23 178 200 178 200 0.97
3 17 0.0026 0.13 12.5 0.2 1 23 235 258 235 258 0.98
4 17 0.034 1.7 9.0 6.5 2 23 274 296 273 296 0.94
5 17 1.1e-05 0.00055 20.0 0.8 1 23 310 333 310 333 0.97
6 17 0.0049 0.24 11.7 0.5 3 23 342 364 340 364 0.93
7 17 0.0012 0.06 13.5 2.9 1 23 379 402 379 402 0.97
8 17 5.1 2.5e+02 2.2 1.6 5 23 412 431 410 431 0.92
9 17 0.00027 0.013 15.6 0.1 2 23 455 477 454 477 0.95
10 17 0.00011 0.0056 16.8 1.3 1 23 483 505 483 505 0.99
11 17 0.00024 0.012 15.8 2.3 1 23 516 539 516 539 0.96
12 17 0.00094 0.046 13.9 4.1 1 23 544 566 544 566 0.98
13 17 0.0063 0.31 11.3 0.0 1 23 572 594 572 594 0.97
14 17 3.9e-06 0.00019 21.4 0.8 1 23 600 624 600 624 0.98
15 17 0.00034 0.016 15.3 2.6 2 23 633 656 632 656 0.92
16 17 1.6e-05 0.00077 19.5 0.9 1 23 662 685 662 685 0.97
17 17 0.27 13 6.2 1.7 1 23 691 715 691 715 0.92

Sequence Information

Coding Sequence
ATGAGCTCAGATGTGGCCAAAAATATATGTAGACTATGTTCCAGGGAATCGCACATGCTAGAATCAGTGTTTGGATTTGAGGGGGGCCGCTTGATATCTGATTTGATTACAATAATTTGTCCAATTAAGATTGCTGTTGAAGATTGGCTACCGAAGAAAGTTTGTAATGAATGCCTGGAAGTTGTAATAAGCGCCAATAAGCTCCGAGAGACAAGTGTTAGAAGCGACATCAGCTTCCGGACTAAGACCGTCCCGCTGACCGAGATGATAATCAAAGAGGAAGTCGCATTGAAGCTGGAAGATGATATACTACAATTTAACGATTATGATGACGATGAGGAAGAATCAGCTGAAGTCTACTGTGAGCCACAGATCAGTTTAGATGGATGGAATGATGACCACCCTTCAAGAAGCCGCTACAAACCCGAAGCTGATAGGCGTTACTATTGCAACGTTTGTACCCAGTCTTTTGCACACCACAACAACATAAAAAGGCATTTCCTGAGATTCCACGATGAAGCAACACTGCCATTCGCATGCGATCAATGTACCTTTCGTTTCCGGACTAAGAAAGAACTGAAAAATCACCAACTTCGACACGAAACTGGGTTCATATCAGTAAGACCGCCTCGCTATACTTCTGACGCGGGAAAGACTTCTCAGAAAAAACCCAAAATTGCGAAATTGAACCCTGGACTGGCTTATCAGTGTGATATTTGTGCTGCAGAGTTTACAAAACCAAATAATGTCGGACGTCATAAGCGTAAGATCCACAATGAAGACATTCAATCAAAACTGAGGAAACTTGATAATGTTATGCAATGCGATTTGTGTAAAAAACGATTTTTGCATAAGAAAAACTTGAAACTTCATATGACGCATTATCATCTTTTGGGAGACGCTGATAACTCTTTTAAACAGGAGCAGTACCATTGTCCCATTTGTGAATTCGTCTTCAGTGCTAAATTTAATCTCGAGAGACACATTTCCACAATTCATGACCCTCAGCTACGTCCTTTGGCTTGCAAATTTGCAGGCTGTAATGAAAGATTTAAAAATGAAGTGAAGCTTAAATCTCACCAAATCTTTCATGATTCTAATGACCTTAAGGTTCTAGCAGATCACACACCCGGTTATGAATGCGATGTGTGCCAAATGAAATTTACCATTAAGGGAAACATGATGCGTCACCAGCATAAATTTCATTCCCTGAATCTTCCTTTTGGTTGCATTTATTGCTCGAGTCGTTTTCGTACTGAGAGAATGATGAAAACTCATGTGGAACGAAAACATAGTAAAATATCAAGCCCACAACCGATTCAGAATTTGAAACAAATTGTGCAGCCTTCGTCATCAGAGTTGCCTTGTGAGCTGTGTGGCATAGCGTTTCCTTCTAAAAGACGTCTTGAGCGCCATTTGTTGAAAGATCATGAGCTGGACGAAACATACAAGTGCGATCTTTGTTCAAAAAAATTCGCATTTCGCCAAACGTTGGATATTCATATTCAAACTCATCGGAAAAAGATACGAACACAATCATTTCCTTATCAGTGTTCGACGTGTAAAAGACGATATACCAATGAGCAAACTCTGATCAGACATGTCAACAACAAACATAAAGAATCAAAGTATGTTTGCCATATTTGTGGTCGCACTCTTTGCAACTCAACGACACTTGATTACCACGTGAAGCGACATCAATCAACGCGTGATTTTCCTTGCCCTCAATGTCCAGCACAGTTCGTTGGAATCAATGAGCTTGAAAGACATGTGCTGATACATAAAGATGACCGTCCGTACGTGTGCTCTGTTGAAACGTGTGGAAAAACTTTTAAGCTTTCTGAAACTCTTCAAAAACATATCAAGCGTCATCAAGGGCTGTTGAAGAAAAAACATTTTTGTGAATTTGAATTTTGTGATAAAGCTTTTTACAGTCGATATGCTCTATTAAGGCATCGTCGTATACATACTGGCGAAAAACCATTTCAATGTTCCTATTGTGAGATGGCGTATACACAAAAAGGCGATCTCTTAAAACACTTACAGCGAACTCATGTTGGTGATGCACTTTATTGCTGTGAGTTTGAAAGTTGTCTTGCTTCATATCGTCTCAAATCTGAATTGACTGATCATTATAAGGTTCATTATCAGAATTAA
Protein Sequence
MSSDVAKNICRLCSRESHMLESVFGFEGGRLISDLITIICPIKIAVEDWLPKKVCNECLEVVISANKLRETSVRSDISFRTKTVPLTEMIIKEEVALKLEDDILQFNDYDDDEEESAEVYCEPQISLDGWNDDHPSRSRYKPEADRRYYCNVCTQSFAHHNNIKRHFLRFHDEATLPFACDQCTFRFRTKKELKNHQLRHETGFISVRPPRYTSDAGKTSQKKPKIAKLNPGLAYQCDICAAEFTKPNNVGRHKRKIHNEDIQSKLRKLDNVMQCDLCKKRFLHKKNLKLHMTHYHLLGDADNSFKQEQYHCPICEFVFSAKFNLERHISTIHDPQLRPLACKFAGCNERFKNEVKLKSHQIFHDSNDLKVLADHTPGYECDVCQMKFTIKGNMMRHQHKFHSLNLPFGCIYCSSRFRTERMMKTHVERKHSKISSPQPIQNLKQIVQPSSSELPCELCGIAFPSKRRLERHLLKDHELDETYKCDLCSKKFAFRQTLDIHIQTHRKKIRTQSFPYQCSTCKRRYTNEQTLIRHVNNKHKESKYVCHICGRTLCNSTTLDYHVKRHQSTRDFPCPQCPAQFVGINELERHVLIHKDDRPYVCSVETCGKTFKLSETLQKHIKRHQGLLKKKHFCEFEFCDKAFYSRYALLRHRRIHTGEKPFQCSYCEMAYTQKGDLLKHLQRTHVGDALYCCEFESCLASYRLKSELTDHYKVHYQN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-