Basic Information

Gene Symbol
lola
Assembly
GCA_963942575.1
Location
OZ012646.1:1508781-1517788[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 0.0015 0.15 13.0 0.7 1 21 48 68 48 69 0.95
2 11 0.00064 0.064 14.2 0.3 2 20 78 96 78 97 0.95
3 11 0.00092 0.091 13.7 0.1 1 21 188 208 188 209 0.95
4 11 2.5 2.5e+02 2.9 1.8 1 12 217 228 217 230 0.90
5 11 0.00047 0.046 14.6 0.2 2 17 276 291 276 292 0.92
6 11 6.1e-06 0.00061 20.5 0.3 1 21 392 412 392 413 0.95
7 11 8.2e-07 8.2e-05 23.3 1.3 1 21 436 456 436 457 0.96
8 11 1.4e-05 0.0014 19.4 0.4 1 22 527 548 527 548 0.96
9 11 0.00019 0.018 15.9 5.8 1 23 557 579 557 580 0.94
10 11 4e-05 0.004 18.0 0.7 1 21 668 688 668 689 0.96
11 11 9.3e-06 0.00093 20.0 7.6 1 23 697 719 697 719 0.99

Sequence Information

Coding Sequence
ATGCTACTGTCCCCTCAAGAGGCGCAACAGGTGCAGGACAACGGTGATTTGGCCTGGGCACCTGGTTATCTGGCGGCGTCTTCCTATAAACTAGTCAGAAGTCAAAGGAGGCGGGAATCGAAGGATACGAATGAAGCAAAGTACGCGTGCAACAGGTGTGGGAAGACGTACAAAGCTACCACGTCGCTGAGTCGTCATAAACGACTCGAGTGTGGCGTCGTGCCGTGCGAGGTTTGCCCAATTTGCGACCGAAGATTCAAGCACAGATTCGTCCTCAACTCGCATATCGTCGGCTGTCAGCGGAAGCTGCATCGGATCATGCAGAAGAGGAGGCCCGTTGTTAACGACGTTTGGAACATGTCAAATGAATATaaacaactgtcgatggtagaagATGAGGAGCAAAAGTCGAAGGAAGAGGCAATTGCAGTTGCAGAGGGAGTGTTGGACATGGACGCCCTGACAGGATTAGAATTGTCTGCTGCGGAAATGGACTTGGTCTCGAACGTACCTACGCAATCTGGTTCGCGAGGATGTACGAGTGCGTCGCAGGATCAACGATTTATCTGTGGCGAGTGTGGCAAGGGTTACAAGTGGATGGACAATCTGCGTAGGCATCAACGGCTGGAATGTGGAAAATTGCCGAAGTACCACTGCAGGACATGCAAGAAAATGTTTTATCGAGACCAGGAGGACGCAATCCATTGGTTCATAAAGCAGGAGGAATATGGGATACCGGAAACGTTCTTGCAGCTAGTGACAGCCGATTACAAGGATCCAACGACGAATACAGAGGAGCCCAAACGGAAGAACGCGAAGAACGCCGTGTGCGAAGAGTGCGGGAAAAGTTTCTCTAGGCTGGACAGCCTGAGACACGAGAATGTCCAGAGCAATGTGGAAAAGtgtcagcagcaacagcagcaacagcagcagcagcagcagcagcaacagcagcagctgcagcagcaacaacaagatCAGCAAGTTCAACAGCAGCCACAGCAGCAGCTGCAACAGCAGTTGCAGCAGCAGCCTCAGCAGGAGGAAGAACCCGAAGTTTGCGAGGTGCCCTTCCATGGCCAGTTAACGATGAACTATCTGCTATGTGACTCGTCCATCCTGAACCCCGTGGAGCCCAGTGTCGTCCAGAAGAATACTAAATCCTGCCAGCAGTTTCGGTGTGACGGTTGCGGAAGAGCTTACACGCGAGTGGATAGTTTGAAGCGACATCAGCAAAAGTGCGACGACCTTCTGGCTTCGCTGCAGGACCGCCAGGAGAAGTTTGAGAGGCTTCAACAGCAGGAGTACTACTGTAATCAATGCGGCAAAAGTTACAGGAGACTCGATACGCTGCGAAGGCATCAGAGACTCGTTTACGCGGAGGACCCGAGAGAGTACAACGCTCTGTGGATGCTGGAAAGAAAGGCACGCAGCATTGGGGAGAGTCAGGAGTCCTCGACCTCGTCCTTTCCCAGCAAATCGTATTCCCCGAAGCGGCGTGACATGGCGTGCGGCACAGGATATCCGGTGGCTCAACTGTACGGCGGCGATTCGTACGTGACCGTCCTTCAGGCCCAGTACGTCTGCACCGATTGCGGCAAGAAATACAAATGGCAAGACAGCCTCAAGAGGCACCAGAGGGTCGACTGCGGTAACAAGGAGAAGAAGTTCTCCTGTCACATGTGCGATCGCAAATTCAAGTACCGATACGAATTCCGCAACCACATTGCCGCGCATCATAACCGGGAATACTCGCCAGGTGCGGCGATCGAGTGGTACTACCAGTATCAAACGCTCTACCTCCGCTTGATGGCCGAGAATCAGTTGGCCGCCGAGACCGCTGTGCCAGGAGGCGATACCTTAAACGACGACCAACTTTCAAGGCCCGCAGGCTTAACGAACGAATACGTCGGTATCGAGAAGATTCAAGACTCGAGCTATGCGGACACTGGCCCCGGAACCAATTACAGTTCGACtaatatcgttcgcgatcaTTCGAGCTACTTTTGTCCCCGCTGCGGAAACGCTTATACGAGGCCGCATTCCCTCAACAGGCACATTCGCTTCGAATGCGGCGTTGAACCGCAATTCGAGTGTCCAATCTGTCACAAGAAGTCCAAGCACAAGCACAATCTGATGCTCCATATGCGAACACATCAGAAACCTTAA
Protein Sequence
MLLSPQEAQQVQDNGDLAWAPGYLAASSYKLVRSQRRRESKDTNEAKYACNRCGKTYKATTSLSRHKRLECGVVPCEVCPICDRRFKHRFVLNSHIVGCQRKLHRIMQKRRPVVNDVWNMSNEYKQLSMVEDEEQKSKEEAIAVAEGVLDMDALTGLELSAAEMDLVSNVPTQSGSRGCTSASQDQRFICGECGKGYKWMDNLRRHQRLECGKLPKYHCRTCKKMFYRDQEDAIHWFIKQEEYGIPETFLQLVTADYKDPTTNTEEPKRKNAKNAVCEECGKSFSRLDSLRHENVQSNVEKCQQQQQQQQQQQQQQQQQLQQQQQDQQVQQQPQQQLQQQLQQQPQQEEEPEVCEVPFHGQLTMNYLLCDSSILNPVEPSVVQKNTKSCQQFRCDGCGRAYTRVDSLKRHQQKCDDLLASLQDRQEKFERLQQQEYYCNQCGKSYRRLDTLRRHQRLVYAEDPREYNALWMLERKARSIGESQESSTSSFPSKSYSPKRRDMACGTGYPVAQLYGGDSYVTVLQAQYVCTDCGKKYKWQDSLKRHQRVDCGNKEKKFSCHMCDRKFKYRYEFRNHIAAHHNREYSPGAAIEWYYQYQTLYLRLMAENQLAAETAVPGGDTLNDDQLSRPAGLTNEYVGIEKIQDSSYADTGPGTNYSSTNIVRDHSSYFCPRCGNAYTRPHSLNRHIRFECGVEPQFECPICHKKSKHKHNLMLHMRTHQKP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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