Basic Information

Gene Symbol
-
Assembly
GCA_949715645.1
Location
OX454528.1:103413004-103437947[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 28 0.0059 2.5 11.2 1.8 1 23 680 702 680 702 0.97
2 28 9.2e-06 0.0039 20.1 1.3 1 23 709 731 709 731 0.97
3 28 0.0007 0.29 14.1 1.9 1 23 852 875 852 875 0.93
4 28 0.0013 0.56 13.3 1.4 1 23 882 904 882 904 0.98
5 28 2.1 8.6e+02 3.2 1.7 2 20 913 931 912 933 0.92
6 28 0.00027 0.11 15.4 0.4 2 23 944 965 943 965 0.97
7 28 0.41 1.7e+02 5.4 4.6 1 23 972 994 972 994 0.97
8 28 1.8 7.7e+02 3.4 0.3 3 23 1009 1029 1008 1029 0.96
9 28 0.03 12 9.0 0.3 1 23 1101 1124 1101 1124 0.96
10 28 1.3 5.3e+02 3.9 3.3 1 20 1163 1182 1163 1183 0.93
11 28 0.0045 1.9 11.6 2.8 2 23 1194 1215 1193 1215 0.97
12 28 3.2e-07 0.00013 24.7 3.4 1 23 1222 1244 1222 1244 0.99
13 28 8.6 3.6e+03 1.3 1.3 2 23 1276 1297 1275 1297 0.87
14 28 0.0011 0.46 13.5 3.0 1 23 1381 1404 1381 1404 0.96
15 28 0.014 5.9 10.0 1.9 1 23 1441 1464 1441 1464 0.95
16 28 0.56 2.3e+02 5.0 1.8 1 23 1474 1496 1474 1496 0.90
17 28 3.1e-06 0.0013 21.6 1.1 1 23 1503 1525 1503 1525 0.98
18 28 0.043 18 8.5 0.8 2 23 1549 1571 1549 1571 0.95
19 28 9.5e-05 0.04 16.9 1.8 1 23 1611 1634 1611 1634 0.97
20 28 1.4 5.9e+02 3.8 1.6 1 21 1641 1661 1641 1662 0.97
21 28 0.43 1.8e+02 5.4 0.6 1 23 1671 1694 1671 1694 0.91
22 28 0.014 5.7 10.1 1.8 1 19 1700 1718 1700 1719 0.95
23 28 0.00017 0.072 16.1 1.0 1 23 1730 1753 1730 1753 0.97
24 28 9e-06 0.0037 20.1 0.5 1 23 1771 1793 1771 1793 0.95
25 28 0.0038 1.6 11.8 3.6 1 23 1799 1821 1799 1821 0.99
26 28 1e-06 0.00043 23.1 3.4 1 23 1827 1849 1827 1849 0.98
27 28 1.6e-07 6.8e-05 25.6 1.7 1 23 1855 1877 1855 1877 0.99
28 28 0.00089 0.37 13.8 0.5 1 23 1883 1907 1883 1907 0.93

Sequence Information

Coding Sequence
ATGAAGAATGCAGTTGCCCTAGTAAGAAACGGAATGAGTCTTCGAAAGGCCAGCCAACAGTGCCATGTAGCTTTTCAGACTTTGGCTCGgtatgttcaaaaatcttccAGCAATGAAGACATTAAAATGAAACCCAACTACGAAGTTAATCGGATATTTACCGATGACCAAGAAAAAGCCCTCGTCGAATATGTTATAAATTGCGCACGCATGTTTTATGGCTTAACAAAATTGGATTGCCGCAAGTTGGCGTACGAAATGGCAGTAGCAGAAAACGTCAAGAGACCGAAGAACTGGGATGTTGAACAAATGGCAGGTCATCATTGGTTCATTAATTTTACTAAACGCCATTCTAATCTATCTATAAGAACTCCAGAAGGATGCAGACTTTCACGTGCAACATCATTCAACAGCCATAACGTGGAAATATTCTTTACAAATCTGAAATATGTTCTCTTGGGATCACAAACTTGCTTTGAAAGTGGAAACCGCATATACAACTTGGGCGAAACAAGCACAattacagcacaaaaatcaagaGAAATAATTGCAGAAAGGGGAAAACAGGGCTTTAAAGTAAAAAGcgcagaagatggaacactCGTCACTACTTGTTGCACGATAAGTGCCACAGGTCATTTTATTCCACCTGTTATGATTTTTCCACGCACTCATTTCAAAGGCCTTATGATGTGCGGTGCCCCATCTAACACTCTGGGACTAGCAAACCCGTCAGGACGGATGAACTCGGAGTGCTTTGTTGCtgttattgaacattttataaaGTTCActaaaagttctaaaaaaaatcctacGCTTCTCATAATGGACAATCATGAAAGTCATATAAACTTAGCAGCATTAAACTTGGCGAAAGAATATGGCATAACAGTTTTGACTGTGCCATCTCATTCTACCAATAAACTCCAACCGTTAGATGTTGCTGTTTATGGACCATTCGAAACCGCCTACAATGCTGCAGTTGACACATTCCTGATGCAGAATTCGGGGAAAACTTTTAACATTTACAATGTTGCTGCAGCAATTGGATATGCATTTGAGAAATCAATGACTCCCTCAAACATCACGTCGTCTTTCAAAAAGACTGGCATTTATCCGTTTGATGAAAAAGTTTTCACTGAAGCTGATATCTTATCCAGCTCTATAACCGACAGACCTGAACCAGTATTAGAACCACAAGTGAGCATTAATCCGGAGATAGAAAGAATGCATGAAGGTtcgttccacttcgcacaagcatatGGTGAAGCCTACGCACAAAGTGAAGTGGATCCCAAATCAGTTTTTGGAACGCTGAATCCCACTGTTTCCTGGGATCATAATTCACGTCGCACGGTAACTAGAACCAACGCTCATCGTAATCTCACCTCTCGACTGGCCATTGAGCACTGCGTGAAGGTGACCATGTGTTTGCGCCAGATTACCAATGAGATATCGACAGTAAAAAAGCTTATTTGCAATGGCGGCCTTTGTGTAAATATGAACAAAGTCTTTGGCAACTGGATTGTTGTGAACTATAATTACGAAGGAAACCGTGGAAAGAAGTCTTTAAAGGATCTGGCTATAGTTAATGAAATTCTGTTCCGCTCCCTCGAAAGAAAACTTCTGCTTCGATTATTTGGTACTCTATACGAAGATGCCAATAGAAGAGAAGATGTAACAGCAAACTTTATAAGCTATATGAAGACGTGGATGTACTCCAAAAAGCCAAGACTCTTCGACTACATTGACTCAACTACCTCGAGCTACTGGACTAAGTGGATCTTTGATTCGCAGACCCCAGGTTCAAGACTGTTAATACCGGCGTTACCAAATGGTACCGGAATTGCAGACGATGTAAGGCTGGAGTGTACCAGTCAGACATTGCTCAGGGGCGGTAGCCTGTTCAGTAAAGACAGTATAGTCTTGTTTGACTCCTTATCtgataaattcaaaaagaaactcaAAACTCGCTGCCAAAGATCAAAAGTGAAAACTCGcaggcaaatgaaaaaaactaaATCCTCTTCCGGTCGTTTTGAATGCGATTCCTGTAACAAAACGTTCGCCTGGAAAAAGGACTTATTCCGTCATGAAAAATACCACGACCCAAATAACAGGAAGTATGCCTGTCCGCACTGTGAACGTAGATTCGTTCGCAAGGACAAATTAACATCACATTTACTCGTTCATTTGACGGGTATTCCTAAACGCACAATGAAGAGCGCTCAATACTTTGCCCATCATTTATTTTCTGagagaaaattcaaagaaatcaaaTGTATGATTTGCAACTTTGACACCGCGGCTACCGTTACTGAACTGCGTCATCACATTGTCTTGCACAATAACTTGCAACCGATCGAAGGTTTAGAGAACAGTGAACTCGTTAAAACGTTCTATCCGGACAAGGGGCTGCAGGAAATTCTTCAACTGATGACCAGTGAAATCGCTGACAATCAGTTGGGCAAATTCTACTCCATAGTCAATTCATATAGTTACGAGATGGGGATCAGTGACTCGGATCAAAGTGATCCAGACTTAGAGCTGAAATACGAGTGTGAAGTGTGCAAGGAGGAATTCAATCGAAAGCATAAGCTCATGACGCATCAAGCCTTTGAGCACACTTTTGATGAGTGTCCGTACAAATGTGATAcctgccagctgaaattcaccAGCAAACCTGTGCTGGAAAGCCACCTGAAGTATCACtgtaaaaatctggaaaaaatgCTGCAGTGCACAAAGTGCCCGGGCCGATTTACTTGGCGGAAGAACTTTGAGAATCACAGATGTGGCAAGAAAATCATTGTCGCTAAAGAGTGCACCACGTGCGAGGTTTGTGGTAAAGTTTTCTCTTGGCCGCGGGATCTTAGACTTCATAAAAAGACACACATACCCGATGGCAAAGCACACAGTTGTTCCGTGTGTGATGAGAAATTCTTGCGGCTTGAGAATCTGCGTTGTCATTTGAAGACCCACTCGAAAAAGGTGATTGCTGTCTTGCGACCAAAAAAAATTCTCTGTATGCTTTGCAATGGTAAATTCGAGAGTATTCCCAGCTTAAAATACCATCTATATACGCATGCTGATGGCCAGACGGATGTAAACTTTGAAGATTCCGGTTTTATTAGCACTTTCTATCCCGAATTGGATAGGTCCACAATTTCGCAGTACATTCGGAGTTGTTTCCTCGAGCAGAAACTCTCGCAACTTTACATGGCGGTGAATAAATACGGCCACGAAATGGCCTTGAGTGACTCGGACTCGGATGATGAAGACAAGTCAAAGGAGGGCTCTTATGTCTGCGAGGTGTGCCATGTAAAGTTCCCTCGCATGCAGGACATTCTCCAACATCAACTCGTCGAGCATAACACAAAGAAGATAAATTGCACGCATAAATGCCAAGCGTGTGAGGATCAGTTTATTTGTGCGGCGCTCTTAGATCGCCATACGAAGAGCGAGTGCTTGAACTTGGACAGAATACACACATGTAAGAAGTGCGGCGTCAAATTTATGTGGAAACAGAATTTGTTCGCTCATACTTGTCCGTGCGTTGAAAACAACGAAAACGACAAAACATGCGAAATATGCGGCAAGAAGTTCATTTGGCTGAAAGACCTGCACCGGCATAAGCGGAGCCATATTCCAGATGAGTTGAAATTCCAATGTCATATTTGCGACCGGAAATTCAATCGCAAAGACAACATGCGAGCGCACATGAAAGTCCACGCCGATAACTACAAGCAACAGAAATTGAAACCGATGGTGAAGTGGGAAAAGCAAGACGAGAACCTGTGCAGGCCTCATGGTGTAAAGCAAATTCAATGCAAGATCTGCCTATCGAAGCACAACTCGATTCGTGATTTGACAGCTCACCTGATGACGCACAAGGACAAAGAGACTCTCAAGCATCGAGAGGCAGAGATCAGTGACATCTCCATGCTATTATACAACAAACAACTGGACATGCAAGCGCTTTCAGATGAAATAAATAGAGATCTCGCAATTGGCAAGAACTTTCGATTCTATTCGATCACCAACGAATTAGGCTATGAGTTGAGTCTAAATGATTCGGAGACCTGCTCTGATTTAGATGCACAAGGCTACGATGATGATGAGGACGGTATGCCCAATGGATACATCTGTAAACTGTGCAACAAATCATTTAATAGGAAGTTTAAGATTTTCAATCATCAAATGAACGATCATGTATGGGATGCACTGCCGTTCGAGTGTATTACGTGTCGTTCGAGGTTTGTCTGTGAGAAACTTTTCAGTTATCATCAGGAAAATGAGTGTGGCAACTCTGAAAAGCAATTTAAATGCAAGCAATGTCCAATAAGGTTCGTGTGGAAAGAGAATTTAAAGAGCCACGAAAAGCACGCACACGACAAAAACGCACCACAGGCAAAGAAGCATCCTTGTACATTCTGCGATAAAAGTTTTCTTTGGAATCGCGACCTGCTGCGACATAGTAAAATTCATCAGATCAGTGATTCGAAGTTCGAGTGCACGTGGTGCTTCAGGGTATTCATGCGAAAGGATAATCTTAAGGTCCACATGAAAGTCCATCAGAACGCAACACATCTCTTGCTGCCAGACATTTACTATCTAGCCCGACCGAATGGCGCGAAAACTGCCGAATGTATGCTTTGCAAAGAGAAGTACTCCACCATCCATGAATTGTTCGATCACATTCAGAGCGTGCATTTCCTACAGCTGAGCGCAACCATTCCCAATCCAAACACTTACTCGATTACAAATGCATTGGGCTATGAAATGGACATCGAAGATTCGGAAACCGAGAAGGAGGATCAGCAGGAAAAGTACTCGTGTGAGATTTGCGACACGCGTTTCAATCGTCGGTTCAAACTGTTGCAGCACCAGCAATCGCTTCACTACTCCGACAACATACCGTACAAATGTGACGCATGCCACTTCAAATGCGTCTCGAATGTGGTACTAAGCTATCACATGCGAGCACAGTgcttaaatgttttaaaaaaattccgaTGCAGCAGGTGTACCATGCGATTTATGTGGAAGGAGAACTTAGAAAATCATGAAAGCCTGATCCATGACAGTGCTCGAACGCACAACTGTAACGTCTGCAAAAGGGAATTTGCCACCCTGCACGATCTAAGGAATCATAGCGATTGCAAGCCACCCCTAGATGTAAAATACTTCGAATGTGACTTATGCAACCGTAAGTACAACCGCAAAGATCGACTTCTGAAGCATGTCCGGATTATACACAGCGAAACAGATGTTAAACCTGTTAAAAGTGCTCCATCTACAAATAAGAAGTTTCTGTGTTCGTTCTGTGGCAAAGAAGTGTCAAGTTCCTCAAATCTGGTCATACACATGCGTCGGCATACAGGAGAGAAACCGTTCAAGTGTGAGTTTTGCAATATGGGCTTCCCGCGGTCTTCGGATTTGAGTTGTCACAGGCGGACGCATACGGGAGAACGGCCACACAAGTGTACAGTATGTGAGAAGGCGTTTTCGCGTTCATACAAATTGCAAACTCACATGCGGATCCATTCCGGCGAGAGGCCGTACAAGTGTACATACTGCCCGAAGAGTTTTACTCAGTCTAATGACTTGACGGTGCATGTGCGACGGCATACCGGAGAACGACCGTATACATGTGAGACTTGTGGCGAGCGGTTTATGCAGGGAACCGCACTTCGGAATCACCGAAGAATGCGGGGACACTATGAGTTGTAA
Protein Sequence
MKNAVALVRNGMSLRKASQQCHVAFQTLARYVQKSSSNEDIKMKPNYEVNRIFTDDQEKALVEYVINCARMFYGLTKLDCRKLAYEMAVAENVKRPKNWDVEQMAGHHWFINFTKRHSNLSIRTPEGCRLSRATSFNSHNVEIFFTNLKYVLLGSQTCFESGNRIYNLGETSTITAQKSREIIAERGKQGFKVKSAEDGTLVTTCCTISATGHFIPPVMIFPRTHFKGLMMCGAPSNTLGLANPSGRMNSECFVAVIEHFIKFTKSSKKNPTLLIMDNHESHINLAALNLAKEYGITVLTVPSHSTNKLQPLDVAVYGPFETAYNAAVDTFLMQNSGKTFNIYNVAAAIGYAFEKSMTPSNITSSFKKTGIYPFDEKVFTEADILSSSITDRPEPVLEPQVSINPEIERMHEGSFHFAQAYGEAYAQSEVDPKSVFGTLNPTVSWDHNSRRTVTRTNAHRNLTSRLAIEHCVKVTMCLRQITNEISTVKKLICNGGLCVNMNKVFGNWIVVNYNYEGNRGKKSLKDLAIVNEILFRSLERKLLLRLFGTLYEDANRREDVTANFISYMKTWMYSKKPRLFDYIDSTTSSYWTKWIFDSQTPGSRLLIPALPNGTGIADDVRLECTSQTLLRGGSLFSKDSIVLFDSLSDKFKKKLKTRCQRSKVKTRRQMKKTKSSSGRFECDSCNKTFAWKKDLFRHEKYHDPNNRKYACPHCERRFVRKDKLTSHLLVHLTGIPKRTMKSAQYFAHHLFSERKFKEIKCMICNFDTAATVTELRHHIVLHNNLQPIEGLENSELVKTFYPDKGLQEILQLMTSEIADNQLGKFYSIVNSYSYEMGISDSDQSDPDLELKYECEVCKEEFNRKHKLMTHQAFEHTFDECPYKCDTCQLKFTSKPVLESHLKYHCKNLEKMLQCTKCPGRFTWRKNFENHRCGKKIIVAKECTTCEVCGKVFSWPRDLRLHKKTHIPDGKAHSCSVCDEKFLRLENLRCHLKTHSKKVIAVLRPKKILCMLCNGKFESIPSLKYHLYTHADGQTDVNFEDSGFISTFYPELDRSTISQYIRSCFLEQKLSQLYMAVNKYGHEMALSDSDSDDEDKSKEGSYVCEVCHVKFPRMQDILQHQLVEHNTKKINCTHKCQACEDQFICAALLDRHTKSECLNLDRIHTCKKCGVKFMWKQNLFAHTCPCVENNENDKTCEICGKKFIWLKDLHRHKRSHIPDELKFQCHICDRKFNRKDNMRAHMKVHADNYKQQKLKPMVKWEKQDENLCRPHGVKQIQCKICLSKHNSIRDLTAHLMTHKDKETLKHREAEISDISMLLYNKQLDMQALSDEINRDLAIGKNFRFYSITNELGYELSLNDSETCSDLDAQGYDDDEDGMPNGYICKLCNKSFNRKFKIFNHQMNDHVWDALPFECITCRSRFVCEKLFSYHQENECGNSEKQFKCKQCPIRFVWKENLKSHEKHAHDKNAPQAKKHPCTFCDKSFLWNRDLLRHSKIHQISDSKFECTWCFRVFMRKDNLKVHMKVHQNATHLLLPDIYYLARPNGAKTAECMLCKEKYSTIHELFDHIQSVHFLQLSATIPNPNTYSITNALGYEMDIEDSETEKEDQQEKYSCEICDTRFNRRFKLLQHQQSLHYSDNIPYKCDACHFKCVSNVVLSYHMRAQCLNVLKKFRCSRCTMRFMWKENLENHESLIHDSARTHNCNVCKREFATLHDLRNHSDCKPPLDVKYFECDLCNRKYNRKDRLLKHVRIIHSETDVKPVKSAPSTNKKFLCSFCGKEVSSSSNLVIHMRRHTGEKPFKCEFCNMGFPRSSDLSCHRRTHTGERPHKCTVCEKAFSRSYKLQTHMRIHSGERPYKCTYCPKSFTQSNDLTVHVRRHTGERPYTCETCGERFMQGTALRNHRRMRGHYEL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-