Basic Information

Gene Symbol
-
Assembly
GCA_949715645.1
Location
OX454525.1:82324516-82340656[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 18 6.7e-05 0.028 17.4 2.1 1 23 885 907 885 907 0.96
2 18 1.7e-05 0.0073 19.2 0.4 1 23 913 935 913 935 0.97
3 18 3.3e-05 0.014 18.3 0.5 1 23 941 963 941 963 0.98
4 18 2.8e-05 0.012 18.5 3.1 1 23 969 991 969 991 0.97
5 18 6.5e-05 0.027 17.4 4.7 1 23 997 1019 997 1019 0.99
6 18 0.00012 0.049 16.6 5.7 1 23 1025 1047 1025 1047 0.97
7 18 3.3e-07 0.00014 24.6 4.3 1 23 1053 1075 1053 1075 0.98
8 18 2.1e-07 8.7e-05 25.2 2.4 1 23 1081 1103 1081 1103 0.97
9 18 0.00028 0.12 15.4 5.7 1 23 1109 1131 1109 1131 0.97
10 18 3.5e-05 0.015 18.3 6.5 1 23 1137 1159 1137 1159 0.98
11 18 5.9e-06 0.0025 20.7 4.5 1 23 1165 1187 1165 1187 0.98
12 18 1.4e-05 0.0057 19.5 8.1 1 23 1193 1215 1193 1215 0.98
13 18 3.3e-06 0.0014 21.5 7.9 1 23 1221 1243 1221 1243 0.98
14 18 1.2e-06 0.00052 22.8 7.7 1 23 1249 1271 1249 1271 0.98
15 18 0.00039 0.16 15.0 9.5 1 23 1277 1300 1277 1300 0.95
16 18 0.00033 0.14 15.2 0.5 1 23 1306 1328 1306 1328 0.97
17 18 0.0015 0.61 13.1 4.4 1 23 1338 1360 1338 1360 0.98
18 18 1.2e-05 0.0051 19.7 1.7 1 23 1366 1389 1366 1389 0.96

Sequence Information

Coding Sequence
ATGAATTGTTCAGTCCCTGTACGGCGGTATAAGGGTGACCAACCCAACTCTTTGACCAACTCTAACTCTTCACAAGCTAACATACATGTATCGACCCCTAGTAGACGGGGTCGCTACCCACCCAACCCATCTTACCCAAACCACAAAGCTAAGAAATTCCAAATCCTCCAATGGAACATAAAAGGATTCATCAATAACTATGACGAATTGTGCAtcttaataaaagaaaagataccTGATATTATCGCTCTTCAGGAGACACATTGCGCCTATCTATTCAAGCCTTACATTCCTAAGTCTTATAAGGGCTACTTTGACAATTTTTCCTATAACACAAAAGCCAAGCAAGGAATCGGTatgttaataaaacaaaacatccCACATAAACAAATACCCATTATCAGTAGAATCCTAACCATAGCCATCGAAGTTCAGCTCGAGCTCAAGTTTACTGTTGTCTCCATCTATATCCCTCCTGACCAAACATTCTCCAGCTCCGATTTGGATACTATTTTCAGCCAGATCCAAACCCCCGTACTACTTGTCGGGGATTTCAATGCCTGGAGCGATTTGTGGGGCTCTTCCACCACAAATCGTAGAGGCACAATACTGGAAAAATTTCTAAACAACTCCTCTCCTCTCATGATATTAAATGACGGTTCCCCAACCCACTTCTCCACTCATAACACCTTAACACACATAGACCTGTCCTGCTGCTCGCCCGAATTGTTCACAAGGACTTCTTGGAAAGTTCTGGATGATCTGTACAACAGCGATCACTTCCCTATAATTTCCACTATTACTATTGGCCcaacatatttcaatacattaGTTACCCGTAAATTTAAAACTGACTTTGCTAACTGGGCTTGTTTTAACAAGCACATCTTAGAATATCTGTCAGATAAAATACCCTCCCCGAACATCAATAAAGAAGCCGCGGTACTTCAAAAAGCAATTAGAGTAGCAGCGAACAAATCCATCCCTCAAACCAACCCTAATACTCATCAGAGGACTGTGCCCTGGTGGAGCACAGAGTTGATTAATCTGAGGCATGAAAAAACAAAAGCCTGGAGAACATTTAAAAAGCATCCAAATACCAACAACCTAATCCTGTATAAAAAATCGAACGCCAAATTTCGCAGAGCGGTAAAAGCCAGTAAAGCCAAAAGCCTAAATGACTTTACCTCAACAATTAAACCTACTTCATCCATCAGCAAAATCTGGCAAAATATTCACTGCTTAACTGGGAACTACACCACGCAATTGATAAGGTGCATTGAAACACCCGAAGGCCCAATATCTACTGCTTCTGAAATTAGCAACTACTTTGCCCGCACTTGGTCGAATGTGGCCAATGACATAAACTTTCCAAATAGTTTCATAGCAAGCAAGATTAATTCCCATGCGCTTGCCCCAGACCTTGAGCTAATTTCCGAGTCAGCTAGACGCATCGAAGGCCCAATTACCTTACTAGAACTTGAAACATGCTTGACCAGACTCAAAGGCAAAACTCAGGACAGGGACAGAATATCGTACCCTATGTTAAAAAATCTCCCATCATCAACAAAACTTCGACTTATACAGCTGTATAATAGTATCCTCGATACAGGTCTTGGAAAATATTGGGTCGTTACGAATCTTTTTCAGGGTCCCGGTCAGCCGCCATACAACATTGGTGTAACACCAACAGCATCAGCAGTTCCTACACTACCGCCTCCAATATCATCTCATTCAAGCGCCTCAGCAATAAAATCAGGAAACTCCAAGCAACAGCAGCAAGACCAGCAACTAGTTGCAAACTCGCACACACAATCACCAGCACACATTGTCTCGTCGGTGGGTGCAACATCTCTTCAAATACCCAATCCAATGATCACAAATGCTTCACTGAATCAACAGCAGCTTCCAAATGGCACTATTATTGCCGGACCACGCCATCCGGATTCCCTTCACGTTCATGGAACGATGACCGCCGACGATAATCGACACGTCTCACACGGTATGCAAGACATAAAGGAGGAGAAACCTTTCGCCAATGGCAAGCAAAACAATCACATGGTGGCTCACGTCAATCCAGCATCTTCTGTTTCATCAAAAATGAACTCTGGCAGTGGTGGCAACAATCCGCTATCGTCCGAGACGGGTGGTGTTGGCGGCGGACAAATGGTAAATAAACTACAAGCGGGCGGACCCGGTGGCGATCAGCAAGAGCTGGGTAATAGCAAACCGCCGCATGGCGTTGAAATGTACAAAGTCAATATTGAAGATTTGAGTCAATTTTTATCATATCACGAGGTCTTTGGCAAGATTCATGGCGAAGTAATAAATCAACAGCAAATATCATCGCACACGGTAACGCATCCTACTACAAATGTATCAACCTCAAATGCTGGTGGCAATACCTCTGTGAGTGGTACTGTTACCGGCTCACTACCTCCACCTCCGCCACCGTCGACAAATGGCAATTCGATAGTGACAACAAACAGTCTTACCAGTACAGGCATTGTTGCACAAGCGGCTCCGCCGCCAGGTGTTTTACCCACTGCCCCCGGTGGCCTTTTAATGCCTAAAATGGAAAATCAAGGAATGGGAGTAGATCAGAATACCCCACTGTTGGCACCAGATGGTACACCCATAATGGGCGGTACGCATATCTGTGACATTTGCGGCAAAATGTTTCAATTTCGCTATCAATTAATTGTTCATCGTCGCTATCACAGCGAGCGCAAGCCATTCAATTGCCAAGTATGCGGACAGGGATTCACAACGTCGCAAGATCTTACCCGCCACGGTAAGATCCATATTGGCGGGCCAATGTTCACGTGTGTCATTTGCTTCAATGTATTTGCCAACAATGCCAGCCTGGAGCGGCATATGAAACGTCACTCGACCGACAAGCCATTCGCGTGCACCATATGCCAGAAGACATTTGCCCGCAAAGAGCACTTGGACAACCACTTTCGCAGTCATACGGGCGAGACGCCATTCCGGTGTCAGTATTGTGCGAAAACGTTTACACGAAAGGAGCACATGGTGAACCATGTACGTAAGCATACCGGAGAGACGCCGCATCGTTGCGATATTTGTAAAAAATCATTTACGCGGAAAGAGCACTATGTAAACCATTACATGTGGCATACAGGTCAGACTCCGCATCAATGTGACATTTGTGGGAAGAAGTATACTCGGAAGGAACATCTGGCCAATCATATGCGGTCTCATACGAACGATACACCATTCCGGTGTGAGATATGTGGCAAGAGTTTCAGCAGAAAGGAACACTTTACCAACCACATTTTATGGCATACAGgaGAAACCCCTCATCGCTGTGATTTTTGTGCGAAGACGTTTACCAGGAAGGAGCATCTGTTAAATCATGTCCGCCAACATACGGGTGAGTCACCACATCGCTGCACCTATTGCTTGAAGACCTTCACTCGTAAGGAACACCTAGTGAATCACATTCGTCAACACACAGGCGAAACCCCCTTCAAGTGCACCTACTGTACTAAGGCGTTTACTCGAAAGGATCACATGGTGAATCACATCCGTCAACACACTGGGGAGTCTCCGCATAAATGCACCTACTGCACGAAAACTTTCACGAGGAAAGAACATCTGACCAATCATGTGCGCCAACATACGGGTGAGTCGCCTCATCGTTGCACCTACTGCAAAAAAACCTTTACACGCAAGGAACACCTAACGAATCACATCCGGTTGCATACAGGCGACTCGCCACACAAATGCGAATACTGCCAAAAGACGTTTACACGCAAGGAGCACTTGAACAACCACATGCGACAACATTCAAGTGACAATCCTCACTGCTGCAATGTGTGCAATAAGCCGTTCACACGCAAGGAACATTTGATCAATCATATGTCACGTTGTCATACCGGTGATCGGCCCTTTGCCTGTGAGACGTGCGGCAAGAGCTTCCCACTGAAAGGCAACCTGCTCTTCCATCAGCGCAGTCACACCAAGGGACAAGAGTGTGAGCGTCCGTTTTCGTGTGAGAAATGCCCGAAAAACTTCATTTGCAAAGGTCATttggtgtcgcatatgcgttcGCATTCAGGTGAGAAGCCGCATGCATGCACTATGTGCAGTAAGGCTTTCGTAGAACGAGGGAACCTTAAACGTCACATGAAGATGAATCATCCCGATGCAGTTATGCCACCACCACCGACACCGATCCCCGGGATTTTGACACAAATCAAACAGGAAATCAACCCGATAATAATTCCTCATCAGCCTCCAACCATGCACACGATACAGCAAATCACTTCAACTGCAGGTAGTACAAGTGCAAATAATCCGGTTAATCCGACCCTCCTGGCCCCAGGCCTCGTTCCAATGGTAACGTCTACAATAACTTCAAATATTAGTCAAAAGCAACAATCTcatcaacagcaacagcagcagcaacaccaacatcaacagcaattgcaacagcaacaacagctcCTACAACTCTCCATTCAACAGGCAGCTCAACATCAGCAAGCTGAACATCggcagcaacatcaacaacagcagcagcaacagcagcaacaacagcaacatcaacagcaacatcaacagcagcaacagcaaaatcatcaacaacaccaacaacagcaacaacaacagcaacaacaacaacaacaacaacaacagcaacaacaacaacaacagcaagcTCAACAGCAATCACAGCATCAACAGCCCCAACCGCCACCAGTGCCGATAGCTCTCATTGGAACCGATCCCTCAGCGATAGCACGCGCTGCCATGCAATTACAACATTTACCAACCAACGTTGAACAACATCCTGTTGTGTACTAG
Protein Sequence
MNCSVPVRRYKGDQPNSLTNSNSSQANIHVSTPSRRGRYPPNPSYPNHKAKKFQILQWNIKGFINNYDELCILIKEKIPDIIALQETHCAYLFKPYIPKSYKGYFDNFSYNTKAKQGIGMLIKQNIPHKQIPIISRILTIAIEVQLELKFTVVSIYIPPDQTFSSSDLDTIFSQIQTPVLLVGDFNAWSDLWGSSTTNRRGTILEKFLNNSSPLMILNDGSPTHFSTHNTLTHIDLSCCSPELFTRTSWKVLDDLYNSDHFPIISTITIGPTYFNTLVTRKFKTDFANWACFNKHILEYLSDKIPSPNINKEAAVLQKAIRVAANKSIPQTNPNTHQRTVPWWSTELINLRHEKTKAWRTFKKHPNTNNLILYKKSNAKFRRAVKASKAKSLNDFTSTIKPTSSISKIWQNIHCLTGNYTTQLIRCIETPEGPISTASEISNYFARTWSNVANDINFPNSFIASKINSHALAPDLELISESARRIEGPITLLELETCLTRLKGKTQDRDRISYPMLKNLPSSTKLRLIQLYNSILDTGLGKYWVVTNLFQGPGQPPYNIGVTPTASAVPTLPPPISSHSSASAIKSGNSKQQQQDQQLVANSHTQSPAHIVSSVGATSLQIPNPMITNASLNQQQLPNGTIIAGPRHPDSLHVHGTMTADDNRHVSHGMQDIKEEKPFANGKQNNHMVAHVNPASSVSSKMNSGSGGNNPLSSETGGVGGGQMVNKLQAGGPGGDQQELGNSKPPHGVEMYKVNIEDLSQFLSYHEVFGKIHGEVINQQQISSHTVTHPTTNVSTSNAGGNTSVSGTVTGSLPPPPPPSTNGNSIVTTNSLTSTGIVAQAAPPPGVLPTAPGGLLMPKMENQGMGVDQNTPLLAPDGTPIMGGTHICDICGKMFQFRYQLIVHRRYHSERKPFNCQVCGQGFTTSQDLTRHGKIHIGGPMFTCVICFNVFANNASLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDICGKKYTRKEHLANHMRSHTNDTPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCAKTFTRKEHLLNHVRQHTGESPHRCTYCLKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHIRQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGESPHRCTYCKKTFTRKEHLTNHIRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFACETCGKSFPLKGNLLFHQRSHTKGQECERPFSCEKCPKNFICKGHLVSHMRSHSGEKPHACTMCSKAFVERGNLKRHMKMNHPDAVMPPPPTPIPGILTQIKQEINPIIIPHQPPTMHTIQQITSTAGSTSANNPVNPTLLAPGLVPMVTSTITSNISQKQQSHQQQQQQQHQHQQQLQQQQQLLQLSIQQAAQHQQAEHRQQHQQQQQQQQQQQQHQQQHQQQQQQNHQQHQQQQQQQQQQQQQQQQQQQQQQQAQQQSQHQQPQPPPVPIALIGTDPSAIARAAMQLQHLPTNVEQHPVVY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-