Basic Information

Gene Symbol
ZEB2
Assembly
GCA_951394255.1
Location
OX596272.1:8311949-8329240[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.31 24 6.5 0.6 1 23 455 477 455 477 0.96
2 9 1.4 1.1e+02 4.4 8.6 2 23 485 506 484 506 0.96
3 9 0.034 2.7 9.5 4.1 1 23 510 532 510 532 0.98
4 9 0.0074 0.57 11.6 4.3 1 23 537 560 537 560 0.96
5 9 9.5 7.4e+02 1.8 0.1 2 11 568 577 567 585 0.80
6 9 4.4 3.4e+02 2.8 2.4 3 20 600 617 598 619 0.92
7 9 0.055 4.3 8.8 0.1 2 19 629 646 628 648 0.93
8 9 2.9e-05 0.0022 19.2 2.9 1 23 673 695 673 695 0.96
9 9 2.7e-05 0.0021 19.2 2.7 1 23 701 724 701 724 0.98

Sequence Information

Coding Sequence
ATGGCTCTAGAAAACAATGAAAACTCGATGCGCGTGTGTCGAGGATGTCTCGCCACAGACGCACGGCTGTACGACATGCGCCAGGACCGACTGATGGAGGCCTATAACACACTACTGAGTACCGCTGTACAAGTAACAGATGACCTCCCACATTACTTATGCAGCTACTGCGCTGTACTGCTGGTCAAGTGTGACGCATTCAGAACAAAGTGCATAGATTCACTAATAGTGCTTAGAAATTATCAACACCAACATATAGATTTAACTATGGAACAATTAAATAATATGGAAAAATCTACATACTTCAAACAATCTGCGTTAAAAAATATGGATATTGTTGATAAAACTCTTAAACAAAACTATTCTAATATATCTACAGATACATCATCAGAATCTGATATATCTTTTGATTCTGATATGTCTTTAGATTCTGATGATTCTATAGAtagtgattttacagacatatCTGATTGTTCAGATAGTGATAACGAAATAAATCTTGATTTAAAACCCAAATCAAATATTAgaaaacgcaaaataataaaaacggaACAAGATCATCCTGCAAAGAAAGcaaataatgaaattaaaagTCTACTAaggacatattttgataatgaAAGAAGTGGTTTATTAAAAgactttaaaattaatattgattGTGAAGCCAGTAAAGCTATAAGTAACATTAGAGATCATGAAATGCATCAGTTGTCAGATATTATCAATCATATTCAGTATTCTAGTGAGAAAAGTAGTGAATTACTGAAGATATTAGATGAAGGTATATTAAAATGTGAAAATAATGCCTcgaaatatgtaaataaaactgtTAAAAGTAAAGTTATAAAACAAGAATCCAATTCTAATACAAATGCCAAAACTATAAATAAACAGAATTTTAATCAAACTGGTATGGAGAAAGTAAAACAGGATGCAAGTAAATCAGTAATAGAAATTGATATCAATATTAAATCAGATTTGAGTCAAATAGTTGATAAAAAGTCAGAAGAAATAAAGGTAGAAGTACCTGAAGATTTATCAATCGTCTTTGAAACAGAATCCGAAGAAATAAACGAAACCCGAGACTCAGACAACGACATTGCTATAGCAGACTTAGAACTTGATTCTAAGCCaacgaaatgtaaaaatattaataccaACGTCAAAAATTGTCCACCTAATTATAGAAGCTGTAAAAATTTAATCAGTGGTATATTAAAAGGAcatcaaaaaaacaaaaagaagaTACCAGAAGAGACCTTTGCAATGTATAACACAGAGGTAAGACGCCTAAGTAAAGAGgaacaaataaatgaatttaataaTAGAAAGCAGTCTAAGAACTACAGAAATGGACAGTTCAAATGCGACTTTTGCTACAAAGGATTCCTTGCTGAAGAAGCTTATAAGAATCACATGCTGCTACATGATGATATCAGCGGGAAGATTGTGTGTGACATCTGTCAGTGTCACTTCATGACTAAGAGATGCCTCTACAAGCATAAAAAAAATCACACTAAAATATATACGTGCAAAGAATGCGGACATACAACTAGCCATGGTTCCTTAGCAACCGAGCATTATAAACGGCACACTGGAAATAAATTCTCGTGCAAAGATTGTGGCAAAGAATTCCAAAAAAAATCCAGTAAATACGGACATATTAAGATGTGCCACCCCACCAGTGAACAGCTGGTGCGTTGTGAGATCTGTGGAGACTCGTTCAATGGACTCGTTGGactcaaatttcatgataaaagGTCACATAAAGAGATGTACTCACCGGAGTGTCTATGTTCTGGTTGCGACACTCAGTTCTACTGCTCGGACGCGTTTAAGGCGCATCAAGGAACCGACGGACTGTGCGACACGCTACACAAGTATTGTGTGCGCTGCGGCATGTCGTTTGAGACTGAAGAACTGCTGAAGGAACATGAGATAGAGCAACGGAAACCACAGAGTCAATTTAAATGTGATGTGGAACATATGCGCGTACACACGGGAGAGCGGCCGTTCAAATGCCAGCATTGCCCAAAAACGTTCTCGTACCTAGGAAACATGAAACGGCATAGCATAGTACACACTGGGGCGCGTCCATACTCATGTGACATCTGTGAAAAGAGCTACCAAAGCAAGTGTAATTTGAAGTTACACATTAAAACAGTGCACATGAAGATTCCCATGCCGCCGCGGATCCGACGGAGAAACAAAAAAACTGAGTGa
Protein Sequence
MALENNENSMRVCRGCLATDARLYDMRQDRLMEAYNTLLSTAVQVTDDLPHYLCSYCAVLLVKCDAFRTKCIDSLIVLRNYQHQHIDLTMEQLNNMEKSTYFKQSALKNMDIVDKTLKQNYSNISTDTSSESDISFDSDMSLDSDDSIDSDFTDISDCSDSDNEINLDLKPKSNIRKRKIIKTEQDHPAKKANNEIKSLLRTYFDNERSGLLKDFKINIDCEASKAISNIRDHEMHQLSDIINHIQYSSEKSSELLKILDEGILKCENNASKYVNKTVKSKVIKQESNSNTNAKTINKQNFNQTGMEKVKQDASKSVIEIDINIKSDLSQIVDKKSEEIKVEVPEDLSIVFETESEEINETRDSDNDIAIADLELDSKPTKCKNINTNVKNCPPNYRSCKNLISGILKGHQKNKKKIPEETFAMYNTEVRRLSKEEQINEFNNRKQSKNYRNGQFKCDFCYKGFLAEEAYKNHMLLHDDISGKIVCDICQCHFMTKRCLYKHKKNHTKIYTCKECGHTTSHGSLATEHYKRHTGNKFSCKDCGKEFQKKSSKYGHIKMCHPTSEQLVRCEICGDSFNGLVGLKFHDKRSHKEMYSPECLCSGCDTQFYCSDAFKAHQGTDGLCDTLHKYCVRCGMSFETEELLKEHEIEQRKPQSQFKCDVEHMRVHTGERPFKCQHCPKTFSYLGNMKRHSIVHTGARPYSCDICEKSYQSKCNLKLHIKTVHMKIPMPPRIRRRNKKTE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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