Basic Information

Gene Symbol
ken
Assembly
GCA_018290095.1
Location
CM031379.1:4724076-4728627[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 7.9e-05 0.0036 17.6 0.4 1 23 175 198 175 198 0.96
2 17 4.1e-05 0.0019 18.5 0.2 1 23 204 227 204 227 0.97
3 17 0.00053 0.024 15.0 1.1 1 23 268 291 268 291 0.95
4 17 0.0002 0.009 16.4 1.3 1 23 309 331 309 331 0.98
5 17 0.0058 0.27 11.8 3.1 1 23 340 363 340 363 0.98
6 17 0.15 6.7 7.4 0.4 1 23 369 393 369 393 0.88
7 17 3.4e-05 0.0016 18.8 1.0 1 23 399 421 399 421 0.98
8 17 0.0015 0.068 13.6 2.8 1 23 427 449 427 449 0.98
9 17 2.9e-06 0.00013 22.2 2.9 1 23 601 624 601 624 0.98
10 17 0.0084 0.38 11.3 3.7 3 23 634 655 634 655 0.98
11 17 0.0012 0.054 14.0 3.5 1 23 660 683 660 683 0.96
12 17 0.0023 0.1 13.1 1.0 1 23 704 726 704 726 0.97
13 17 0.0008 0.037 14.5 0.6 1 23 735 758 735 758 0.97
14 17 0.077 3.5 8.2 1.0 1 23 764 788 764 788 0.96
15 17 0.00052 0.024 15.1 1.1 1 23 794 816 794 816 0.98
16 17 0.0025 0.11 12.9 5.1 1 20 822 841 822 844 0.94
17 17 0.0029 0.13 12.7 0.2 1 20 850 869 850 871 0.95

Sequence Information

Coding Sequence
ATGGCAGACGTGCGAAGAGTCTGCAGAGTGTGTACACAGCAAGAGTTTAACTCTGAATTCCTTCCGATTTTTGGTGGCACTcaaacaacagcagcagacatttacaaaatttgtcaagttcaaATAATTGAAATCCCAAATTTACCAGCATTGATTTGTATGAAATGCTTTGGTGATCTCTCACAAGCTGTAATATTTAGAGATAAATGTCGAGAATCTGATGAGCTCTTTCGTATCcaatattcaaatattgataaattaagTTGGGACAATGATGTTAAACAAGAGCAACAGCAAGCaataatagaagaagaaaatttcataaatgcaGTAAAATCTGAACCAGAAGCAGAtgattcagaaaatttttattttgatgagaTCCCAATAAGACCAGAAGTAATGATAGTACAAGAAAATTcaagtgaaaatgaattaaataatgaacaatttgaagaaaaagaaaaaaggagaaaaagaagagagaaatatgAGCCTGAAGAAAACGttgaacaaagtttttttccaTGTCCACAATGTGATCAGGTATTAAGTACAAAAAAGACTTTAAAGTATCATATGGCAGTTAAACATTGTTCAAGTCATGAATATCCGTGTAAAATTTGTGGAAAAATTCTTCCattaaaaaatgcattaacAAGGCACATGAATCGATCTCATCTCAAATctatttcaagaaaattaaacaatgAAGGATGTCAGTATTGTATGAAACTCTTTCCCACTGTTGCAGCACAAAGAGATCatgtgaaaagaaaacatGAATTTGATGGTCGGGAATTCTTTTGTAATatatgTGACAAATCATTCTTTGCTAAATTAAAACTTGCCAAGCATATTCGAGATTCTCATGTAAGAAAACGAAAGCCTAAAAAGAAACAAGATTCAACAAATTTAGAGTCGTATCCATGTGCAGTTTGTGGTAAGGTCTGTGTTAGTAAAGGCAGTTTACATTCACATGAAAAAAGTCATAGAGTGATGAAACCATCAGACTATTATTATTGTGATTTATGTGGAAATAAGTTTAgaGAAAAATGTCCATTAAAAGTTCATATAAAGAAGCGACATGTGCAAAAAATTCGTTATGTTTGTGATGCTTGTCCTGGAAAGTCTTGGGCTACAAATCATCAGTTGAAACGACATATAAAGATCTACCATTATAATATAAGAGAATTTAAATGTGAATgGTGCGGAAAAGAATTTGCTGATAAAAGTAAATTAGTTTGTCATATTAGAATTCATACaggAGAACAACCTTTTCAGTGTAAATGGTGTGATGCAAAATATACTCATGAGACCGATTATCGTCGTCACTTATATGTACATACAGTCCCAATTAATCaagaaaataatcaaacaGACTcagacatttttttgattacaggagtgaaagtGCATGATTTACCAAATTGTCCAGCTCTAATATGTTTGAAATGTATTGAGGATCTTTCAAGAGCAATAATCTTTAGAAACCGTTGTAAAAGTGCTGATCAATTCCTTAAAAAATCTCTAAACTATTTTGACAAATCAGACTGGACAActgaattaaatcaattacAAGAAACAATTCCATACAATGATTATGatgtaaaaaatgaacaagacgttttaaaaacaatcaaaagtGAACCAATTGAAgttgaatctttttttgaatatccAACAATCAGTGCAGAGgcaatattaaatgaaaattcagaagaaaatgaatggataaatgaaaataatcaagaaaatgattatgaaatttttaaaaaaaagattaaaagaagagaaaaatttacatgtgAAATTTGTGGTAAATCATTTGAGCTCAAATCAAAATACAATCGACATTATCGAACAAAACATTTGaatgataaagaaagaatCAGTGGATGTCATTATTGtatgaaactttttgattcaaaatcaCAATTGAAAGATCACATAAGATACAagcatgaaatttatgatttttactgtgatttttgtaacaaaaatttttctgtgaaaaacaaattaatgaaACATTTTAGGGAATctcatttgaatattaaatcAACGAAAAAGCAACGAGTTAAAAAAGAACCAAAAGAAAGTCAATGCTTTCCATGTTCTGTTTGTGGTAAAATTTGTGCAAGCACTACATTTCTTCGAGTTCATGAAAAGAGTCATATTAAAATTCGACCTgaagattattattattgtgatCTCTGCGGCAACAAGTTTCGAACTAAGAATCCACTTGCACTACATATCACTACTAGACATGTACTGAAATTGAGATTTACATGTGATAAGTGCCCTGgAAAATCATGGGCAAGAAAAGACCATATGAAAAGACATGTTAAGGTTGTGCATGAAAATATTCGAGACTTTAAATGTGAATGgTGTGGAAAAGGATTTcctgaaaaaagaaaacttgaatGTCACATTAGGATCCATACAGgaGAGCAGCCGTTTTCGTGCCATTTTTGTGGTAAAAAATATACTCATGaaACTGACTATCGTCGTCATATTTGGTCACATACAGgaGAGAGAAAGTACAAATGCACATCATGTCGCATTGCATTCAATAAACGAAGTGAATTAATTGCCCACCGAAGTGAATgtgtttattataattataatcacaataatattaatatttaa
Protein Sequence
MADVRRVCRVCTQQEFNSEFLPIFGGTQTTAADIYKICQVQIIEIPNLPALICMKCFGDLSQAVIFRDKCRESDELFRIQYSNIDKLSWDNDVKQEQQQAIIEEENFINAVKSEPEADDSENFYFDEIPIRPEVMIVQENSSENELNNEQFEEKEKRRKRREKYEPEENVEQSFFPCPQCDQVLSTKKTLKYHMAVKHCSSHEYPCKICGKILPLKNALTRHMNRSHLKSISRKLNNEGCQYCMKLFPTVAAQRDHVKRKHEFDGREFFCNICDKSFFAKLKLAKHIRDSHVRKRKPKKKQDSTNLESYPCAVCGKVCVSKGSLHSHEKSHRVMKPSDYYYCDLCGNKFREKCPLKVHIKKRHVQKIRYVCDACPGKSWATNHQLKRHIKIYHYNIREFKCEWCGKEFADKSKLVCHIRIHTGEQPFQCKWCDAKYTHETDYRRHLYVHTVPINQENNQTDSDIFLITGVKVHDLPNCPALICLKCIEDLSRAIIFRNRCKSADQFLKKSLNYFDKSDWTTELNQLQETIPYNDYDVKNEQDVLKTIKSEPIEVESFFEYPTISAEAILNENSEENEWINENNQENDYEIFKKKIKRREKFTCEICGKSFELKSKYNRHYRTKHLNDKERISGCHYCMKLFDSKSQLKDHIRYKHEIYDFYCDFCNKNFSVKNKLMKHFRESHLNIKSTKKQRVKKEPKESQCFPCSVCGKICASTTFLRVHEKSHIKIRPEDYYYCDLCGNKFRTKNPLALHITTRHVLKLRFTCDKCPGKSWARKDHMKRHVKVVHENIRDFKCEWCGKGFPEKRKLECHIRIHTGEQPFSCHFCGKKYTHETDYRRHIWSHTGERKYKCTSCRIAFNKRSELIAHRSECVYYNYNHNNINI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
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90% Identity
-
80% Identity
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