Basic Information

Gene Symbol
-
Assembly
GCA_018290095.1
Location
CM031382.1:4896126-4899292[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 20 0.0003 0.014 15.8 0.9 1 23 160 182 160 182 0.98
2 20 0.023 1.1 9.9 4.7 1 20 187 206 187 208 0.94
3 20 0.00024 0.011 16.1 2.8 3 23 210 231 209 231 0.96
4 20 0.00015 0.007 16.8 2.1 2 23 242 264 241 264 0.96
5 20 0.027 1.3 9.7 1.2 3 23 274 295 273 295 0.97
6 20 7.1 3.3e+02 2.1 0.1 2 10 300 308 299 311 0.86
7 20 1.5e-06 6.7e-05 23.1 2.3 1 23 327 349 327 349 0.96
8 20 3.7e-05 0.0017 18.7 1.0 1 23 353 375 353 375 0.94
9 20 0.00019 0.0088 16.4 4.7 1 23 381 403 381 403 0.98
10 20 1.5 67 4.2 0.2 2 23 409 430 408 430 0.90
11 20 0.06 2.7 8.6 1.2 1 23 435 458 435 458 0.98
12 20 4.7e-05 0.0021 18.4 0.5 2 23 676 697 675 697 0.97
13 20 0.00029 0.013 15.9 3.5 1 23 704 726 704 726 0.98
14 20 8.8 4e+02 1.8 1.2 2 21 732 750 731 753 0.69
15 20 1.8e-06 8.1e-05 22.8 4.3 2 23 760 781 759 781 0.96
16 20 2e-06 9.4e-05 22.6 0.2 1 23 785 807 785 807 0.98
17 20 0.00087 0.04 14.4 0.8 1 23 813 836 813 836 0.94
18 20 5.2e-05 0.0024 18.2 3.5 1 23 851 873 851 873 0.99
19 20 0.54 25 5.6 0.1 2 23 888 910 887 910 0.95
20 20 0.00041 0.019 15.4 0.9 1 23 915 938 915 938 0.97

Sequence Information

Coding Sequence
ATGACTACAATAATTGACCAGAACTCattgttcattaaaattgaaccAGAAGATGATTGTGACGCATCAATTAGTGAATTCTCCAATTATAATGTcaaagaaaaggaagaaacagaaaaagaaattgaaaataaaaaaagtaaaaattctaaaaataattcaaatgataaaagtacaaaaaaatcatcaaaagacataaaagtgaaacaacaaaagcaaaattcaaaaagttcttcaataaataaaaggaaaagtcaaaataaaacaacagaagaacaaaatgaaatttcaatcaaaagtgaacctgaagatgaaaaaattgacgATGATGGatcaagtaaaattcaaaattcttcaaatgaatctaaaaatattttggaaatttcaaatacaatcatttcaaaagaattcaacaaaaatctCAAGAAATCctcaaataaaacaaaacaatcCAGAGAAAAATCACAACAACAAACTTTCATCTGCTCAATTtgcaatataatttttgacacaaaacaaaaattttcttctcatatgAAAATCCATAAAGAAGCAACTCATCAATGTTCAAAATGTGatcgaaaattcaaatcagAAAAACATGTAGCAAAACATGAATGtgcaatttgtaaaatttgtggGCATAAAAGTAAAACTCGAAGTGATTTGAAAGTTCACATGAAGCAAAATCATAGTGAAgctgcaaataaaatttatacagTTCAATGTGATTATTGTGGCAAGCATATAAAGACCAAAACTTATTTAATCCATCACATCAGAGCTGAACATATTAAGGATGAAAAAACGCATCTTTTATGTACTCTTTGTGGTACCAAAGTtcctcataaatttttacttgacaaACACATGCTGATAAAACATTCAGAAATGGTCACCTGTAAATTATGTGGCAAAATGGTAAAACCACTTTGTATGCCGTATCACATGAAACAAGTTCATGCAACAgatcgaaattttttatgtacaaTTTGTTCCGCTTCATTCAagacaaaatcaaattttcgtGATCATATGAGAACTCATAATAAACCTCATGCTTGCGATCTCTGTGACAAAATATTTGCTCGTCCAGATCATCTAAGGGAGCATAGAATTCTTCATTATGATCCTCATGCTTATTCATGTCAAATTTgtaatcatcatttttctacAATaggatatttaaaaaaacacatGAAGGCTCATGAAGAAAGCaatgtaaaatgtaaaatatgtGGCATTGATGTGAATGTTTTAAGTCTTAAttatcatatgaaaaattcacatcCATTTGATCGATTTCAATGCAGTAAATGTGGTGCAACTGGATTTGGAAATCATAGAGAATTTAGTGAACATTTAAGAATtcatgagaaagaaagagttgaaaatgagaaagctgaaataaaaaatagctCCATACAAAAGCGTGGaagtaatttaaagaaaactaAAGTTAtcagaaaagaagaagaagaaatccAAGCAGTAGCGATTATTGAAGCTCAAAATAGAGAAAgtactaaaaataattcaaataatttagatgaagacaaagaagaaattcatgaaaacttaaaaagtaatcaaaatagttctaaaaactttgataaaaatttgaaaaaccttcatcaaataaaaacaaataataaaactacAAAACCATCAttagaaaatacaaaagaagctaaagaatttacaaaaataataactgaaattgaagaaaaacttgaagaaaatcaaagtgaaaattcttttgatggATTTGAATATGAAGCTGATAATATGGATTGTAATTATCATTCACCAAATGAAACTTTACAACCAGAAATTCAACCTGAAATTCTTCCCaaagatgaaattaaagaagaacaaaaagaagcagtcaaaattgagcaatttcAAAATCCTTTCGATGTTTTAATTTGTGATGTAATTTCAAAACCAAGAAAAAGacaaagaaaagttaaaagtCTTGAACCACAACctcgatttattttaattccaaaaaattcaattgttacTTGTGATTTATGTGGTgaaagttttgataaaaagacaaaattaaTAACTCATATAAGACAGCATgtaagagaaaatgaaaatcatcaatgtcaaatttgttacaaatttttcatcactaaTTCAATTTTGCAAACTCATATGAGATCTCACATTGATATTTTGGTACCATGTGAGATTTGTGGCAAACAAGTCAAGCCTCATTGCATGCCAAATCATATCAGACAAGTTCATACAACTTTTAGAAATCTTGAATGTCATATTTgtggaaaagttttcaaaacaaaGCAAAATTTGCGTGAACATTTAAAACATCATAATAAAGCATTCCAATGTGCAGTTTGTGGTCGTAAATTTCCACGAAGTACTGATTTAAATGAACACATGATAAGTCATGAAAATCCTGAAGCTTTTGACTGTCCTCATTGCAATTTAAGACTTGCTGATCGTCGATCATTAAAGAaacatattgaaaatattcacatTGCAAAAAATGATGGATCAAGAGtaaaacaagagaaaatcTTCAAATGTGAGCTTTGCGATTATTCTTGTGTTCAAAagggaaatttaaaaattcattacaaaaaacatgaaaaatatcaagcaAAACTTCGAGCAAATCCTGATGcattaaaatgtgaaatttgtgAAGCTCTTTTTAGGTcagaattaattttgaaaattcacatGCAAAAAGTTCATTCAGATGAAAGATTTCCATGTGGACATTGTGAAAATGTTCTGAAAACTAAAAGCAGTTTGTGGTCACATTTAAGAAAAGTTCATCAAATTGAgcctgaaaaaagaaagaaaaaagaaaaatcagaaaaGGTTCAaggtgaaaaaaagaaaagacgaaaaagaagaaaaagaaatgaaaatggtgAACTTgtagaaagagaagaaattgaaaataatgtaaaagttattgaaattcaTAGTGTTGCTGATATGGAATATtattga
Protein Sequence
MTTIIDQNSLFIKIEPEDDCDASISEFSNYNVKEKEETEKEIENKKSKNSKNNSNDKSTKKSSKDIKVKQQKQNSKSSSINKRKSQNKTTEEQNEISIKSEPEDEKIDDDGSSKIQNSSNESKNILEISNTIISKEFNKNLKKSSNKTKQSREKSQQQTFICSICNIIFDTKQKFSSHMKIHKEATHQCSKCDRKFKSEKHVAKHECAICKICGHKSKTRSDLKVHMKQNHSEAANKIYTVQCDYCGKHIKTKTYLIHHIRAEHIKDEKTHLLCTLCGTKVPHKFLLDKHMLIKHSEMVTCKLCGKMVKPLCMPYHMKQVHATDRNFLCTICSASFKTKSNFRDHMRTHNKPHACDLCDKIFARPDHLREHRILHYDPHAYSCQICNHHFSTIGYLKKHMKAHEESNVKCKICGIDVNVLSLNYHMKNSHPFDRFQCSKCGATGFGNHREFSEHLRIHEKERVENEKAEIKNSSIQKRGSNLKKTKVIRKEEEEIQAVAIIEAQNRESTKNNSNNLDEDKEEIHENLKSNQNSSKNFDKNLKNLHQIKTNNKTTKPSLENTKEAKEFTKIITEIEEKLEENQSENSFDGFEYEADNMDCNYHSPNETLQPEIQPEILPKDEIKEEQKEAVKIEQFQNPFDVLICDVISKPRKRQRKVKSLEPQPRFILIPKNSIVTCDLCGESFDKKTKLITHIRQHVRENENHQCQICYKFFITNSILQTHMRSHIDILVPCEICGKQVKPHCMPNHIRQVHTTFRNLECHICGKVFKTKQNLREHLKHHNKAFQCAVCGRKFPRSTDLNEHMISHENPEAFDCPHCNLRLADRRSLKKHIENIHIAKNDGSRVKQEKIFKCELCDYSCVQKGNLKIHYKKHEKYQAKLRANPDALKCEICEALFRSELILKIHMQKVHSDERFPCGHCENVLKTKSSLWSHLRKVHQIEPEKRKKKEKSEKVQGEKKKRRKRRKRNENGELVEREEIENNVKVIEIHSVADMEYY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-