Pmex030646.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Polyergus mexicanus
Gene Symbol
ZFHX3
Assembly
GCA_030449975.1
Location
JAUDSZ010000019.1:2591138-2603606[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 0.42 73 5.4 0.1 2 23 283 305 282 305 0.91
2 17 0.00033 0.057 15.2 1.8 2 23 528 550 527 550 0.95
3 17 8.1e-05 0.014 17.1 0.7 1 23 582 606 582 606 0.92
4 17 0.012 2.1 10.3 0.4 1 22 663 684 663 687 0.91
5 17 0.7 1.2e+02 4.7 0.3 2 23 1070 1092 1069 1092 0.95
6 17 1.4 2.4e+02 3.8 0.0 3 23 1113 1134 1112 1134 0.95
7 17 4.6e-05 0.008 17.9 0.9 2 23 1203 1225 1202 1225 0.95
8 17 0.069 12 7.9 1.1 1 23 1242 1264 1242 1264 0.96
9 17 0.0001 0.018 16.8 0.8 2 23 1271 1293 1270 1293 0.95
10 17 0.0034 0.59 12.0 3.3 1 23 1381 1405 1381 1405 0.91
11 17 0.0095 1.7 10.6 0.6 1 22 1425 1446 1425 1449 0.89
12 17 0.0013 0.23 13.3 0.2 1 23 1491 1515 1491 1515 0.93
13 17 0.65 1.1e+02 4.8 0.5 2 21 1561 1580 1560 1581 0.93
14 17 0.28 49 6.0 2.0 2 19 1724 1741 1723 1746 0.91
15 17 0.0002 0.035 15.8 2.5 1 23 2334 2356 2334 2356 0.99
16 17 0.0028 0.49 12.3 0.3 1 23 2459 2481 2459 2481 0.98
17 17 0.018 3.2 9.7 0.3 2 23 2622 2644 2621 2644 0.95

Sequence Information

Coding Sequence
ATGCCCTCCAGTGAGCCTCATCCCCCGTACCACCTTCAGCACCACAATATTCCTCCGTCGCATATACAGCAGCACACGCCGAGCGCGATCGAGCATCAGTTCTTTCAGCAGCTGGTGGCGGTCCATcatcagcagcagcagcaacagcgaCAGCAGCAACACGGCGGGCCCTTTCAAAATTCCACGTACGCGCAGCAGAAGCAGGAGATGAGCCCGGAGGAGGAGGGGGGCCGAGGGGGTGGGTCCCCCCCGGCGGCTGGGGCTGCGTTACATCAGCCCCATCACCCCCGCACGGCCAGTCCACCTTCGGGCACGGAACCCTGCACCCGCGACGCGATACCGACACCTACACCTATCGCGGACACGACCACCGCCACTACGACTACTACTATGACGATGCAATCGCAGGGTCAGCAGCAACAGCAAGGCCCTAGTCCGAGTCCGAGTCCGACGGGCGGCGATGTGGAAAAATTCGACGGTAAGATCATCTACAATCCGGATGGGTCGGCCTACATCTTCGAGGGCGAGAGCGAGCTCAGTGAAGACGACTCTCTACCTGATGGATGTATCGTGGATGGGCGCGGTGTATCGGTTCCTCACTCTTTAGTTTTCCCGCAAATCGCGAACGCGTACTACGTATCGCGGTTGTACGCGCATCAGGCCTatcaacagcagcagcaacagcagcaacaacGCTCGACGGCTCAACAGCACAATCCCGATCTTCCCGTAATGCACAGTTACCGGGTGATCAGTTATAGGAGCGCAGAGGGTAGTAAACAACAGCCCGCTCCGAAGTTTACGGCGCCACCATCACCCGCATCAGTACCCATCAAACCTATCTTAATGTGTTTCATATGTAAGCTCAGTTTTGGATACGCGAAAAGTTTTGTCGCGCACGCTCAGGGTGAGCATCAACTTACTTTAATGGAGGACGAACGGCAGATACTTTCACAATCGACAGCGTCGGCCATTATTCAGGCTGTGGGTAGAGGAAAGCAGCCACTTGTTAGTTTCCTGGAGCCTGTCACGAATTTGGCTTGCACTCAGGCGTTACCCGCGCAAATACAAGGTCAACAGCCACAACAGCAGCAACGTAATGAGTCTAACGAACACGAGACAACGACAACGAACACACCGGCGAGTACACCTGGCGTACCTAGTAGTCCTCAACAACAGCAATCGCAACAGACGCAACAGCGACCATCGCCGAGTACTCCCACAACGCCGACGTCACATTCGAATCATCCTCTAACGTATAATCATCAACAACATCAGTGGACCGGCGCGCAGGTCAGTGCCGTATCCTGGGCCAAGGCACCCGATGTCATGCATTACAGTTCACCACCACCGTCGGCTTCGTCGGTTAAAGGATCTCCATCTTCATACGCGCTTACTCATCCACAAAATCCACCGAGTTACAGCGGCGGTACCACGATAGGTGTGTGTTCGGATCATATGCAAGGCAGACCGAGCGGAGTAGAGTGCGGCAGGTGTGAATTGATATTAGCTACCAGTCGACTCGCCGGTGCCGGTGGACCGCTCGCTGGCATCCATAGCCGAAACTCTTGCAAAACTCTGAAATGTCCTAAATGTAACTGGCACTACAAGTATCAAGAGACTCTCGAGATACATATGAAGGAAAAACATCCGGAAAACGAGACATCTTGCATCTATTGCATCGCTGGTCAGCCGCATCCTAGGTTAGCGCGTGGCGAAACTTACACTTGCGGCTACAAACCATACAGATGCGAAGTGTGCAATTATTCTACCACGACGAAAGGCAATCTCAGTATACATATGCAGAGTGACAAACATCTAAACAACATGCAAGAATTGCAGCAAGGTAGCGGGGGTGGTTCCGGTACCAGCAACCCCTCCTCGTCTCAGGACGCGCCAATGCCGACGCGGAGTCCTCACCATCAGCAAAATCACAATCCACATCTAACCGCTCAGAGTAGTAATCAGAGTAAACCGAAGCATTCGTTTCGCTGCGACGTATGCAACTATGAAACGAATGTCGCGCGGAATCTGAGAATACATATGACGAGCGAGAAACATACACACAATTCGCTCGTTTTGCATCAGAATATCAAGCACATGCAAACATTGTCCGTGTTGTCTCACCATCATCAAGCGCAGCAGCATCATCAGCAAGCGCAACAACAACAGCTCGAACAATTGCTCCACTTAGGCGGTCTGGATAAACCTCCGCAACATGCGGAGGCGGCATTGGCCGATATGGCTTACAATCAAGCGCTTCTGATACAAATGATGACCGGCGGTCCACTGCCGCAACAGCTCCCGCCTGACATCATGGCGAACATGGCTGCCATGACTAATCTTGGCGGCGATGTTGGGCTTTCGCCAGACAGCATGGAGCCTCCGCCAGAACCTGCGGACCAGGATCCCGCCCATCTTTATCACTGCTGTGTCTGCAACAACTTCGCGACGGATTCGCTCGAGGCTCTGGGCCATCATTTGGCCGTCGACAGAACGAGGACCCGCGAAGGCGAGATACTTACGGTGCTAAACGCACATTTCATTTGCAAGCTTTGTTCCTATAAAACCAATCTGAAAGCAAATTTCCAGCTGCATTGCAAGACTGATAAGCATCTGCAGCGGCTGCAGCACGTGAACCATGTGAAGGAGGGTGGTCCACGTAACGAATGGAAACTCAAGTACTTGGCGTCACCCACGAGCGCTGCACAATTGCGCTGTCATGCGTGTGATTACTACACTAACAGCGCCCATAAATTGGCTCTGCACGCCGCCTCGCCCAGGCACGAAGCCGCGGCGCTTCTGCTCCGTCATCTTATTGAGGCGAGCAGCAATATCCAAACTCCTGGGAAATTGTATCACTGCGCTCTGTGCGTATTCAGTGCCAAGCACCGATTGCCACTCTTACAACACGTGAAATCTATGCGACATTTTCAAATGGAGCAGTTACATCAGCTTCACAGGAGAAGCAGCCTCCAAGGAAATGAGACTCCGCACACGGATATCAGCGACGTGTTTCAAGTAGTCAGCGATCCCGATGTGCCGCCTACGCAACAATCGAGTCCGACCACGCCAACGACACCCAATGCTACAAGCACCAACAATGAACGACGGGAGGAAGGTAGTGAGTGCGGTAGTGAAGTGAAACAAGAACCGGATAATGATCCAGAACCGGAAATGGAGCCGGAGAATGATCAAGACGAAATTACGTGCCTATACTGTACGTATCAGCCGACGTCGCGGGAAGAATTACGACAGCATTTGCAAATGGCTCACGTTCATGATTCGGAAGAGAAAACTGAAGCAGTGAAGGAAGAGCCGACGCCGGACTTATTATGCCCCTTGTGCCAAGATGGTTTTAAGGAACGTCCTGCTCTCGAGAAACACGTGATGCAGATTCATTCCGTTAACACCGATGGCCTGCAGAGGTTATTGCTACTGGTGGATCAAAGTCATTGGCTGAATAATAATCCGAGGAATACTTCAACGTCAGCTGTAACGGCTGCAACGATGCCAACATCGCCGACGACAACGATGAAACCCCATCAGGAAGAAGACATGAGCGAACGGAGTGGCAACGATGACATCGAAGAACTCAACAGGACTGTGTGTACTGTGTGTGGTCGAACTTACCGTTCTCCCGAAGATCTTCAGCAACATCACAGAGAAAATCATCCAGCTACTATGCTCACTTTAGCAGTTAGCGAGAAACATGTTTACAAATATCGTTGTGGACAGTGCAGTCTCGCTTTCAAGACTTTGGAGAAGGTTCAACAACACTCCCAGTACCACGCGATCAGAGATGCAACCAAATGCACCCTCTGCGGACGATCTTTTCGTTCAGTTCAAGCACTTCAGAGACACTTAGAATCTACTCATGATCTCCATGAAGATGAGTTAGCTCAGTACAAACAGAGCTTAATCGCACATCCGTTGCTTCAAGCGCTCACGGAAGAAACGTTAAAGAGGCAAAGCGGCTTGATTGGCGAGCAGAATGTGGAAGATGATGCCGGTAGAGGTGACGAAGAAGAAAGTGATGCTAGTGATTCGTCTCCGTTGCAGAAAGAGCAACGCCTACTAGAGGATTATTTAAATAGCCAAACAATTGCCGAAGATTCTTATCATGATCCTAGTCGAAAATTCAAGTGTCACCGGTGCAAAGTGGCCTTTACGCGTCAGAGCTACCTCACCGGTCACAACAAGACTTTGTTGCATCGCAAAGGTGAAAAGATGTCTTATCCAATGGAAAAGTATCTGGATCCTAATAGACCGTACAAGTGCGATGTTTGCAAGGAGAGCTTCACACAGAAGAACATACTTCTCGTGCATTACAATAGCGTGAGCCACTTACACAAACTAAAGCGAGCGATGGCGCAGGAACAAGGTAACAACAATACATTGATCTCGGTAGTACCTCCGGCCAGTCCGACCGAATCGCCCGATTCCCAGCAAGATCAAGACAAGAAACCTTACAAATGCAATATCTGTAAAGTCGCGTATACCCAGGGAAGCACGCTGGATATTCACATGAGGAGTGTTCTTCATCAAACGCGTACCAGTAAACTGCAGGATCTTGCAGCTAGTGGTCAGGTAGATCTCGCTCGGCCATTAATTGAGCAACCATCGCCGACAAGCCCAACCAGTTCACCCGTTAACACTAGTAATGCAAGCGGGATGCTTTGTTGTTCACGCTGCAGTGCTCTGTTCGTCAATCAGGAACAATTGGCAACACATCAGCAACTATACTGCATTTTTAGTAATCCACTGGCATTGTTTCAACAATTGGCTGCTTCGCAGCAATTAACCTCATCCACTGCGGCTAAGACACCACCTCCTACATCCACGACGCCAGGACCGCAGCAACATATGCAACAAGCAACGCAACATTCGTCGCAGGACATTCTATCCCAACCTCGACATAAGACCTCGCAAATGTACAAACATCTTTTGGAAAGCTTTGGTTTTGATCTCGTCATGCAGTTCAATGAGAATCATCAAAGACGGCAGCGTAAGGAGGAGGAAGCGGCCGCCGCTCTTCAAGCGCAGCAGGAACAACAAAAGCAGGAACAGCAGAAGCAAGCTCTCGCTGCTCAAGCCGCgcaagagaaagaggaagaagctGAGGAGACTCACATTGATGATGACGTGATACCCGAGCTTACACGCAGCACTTGCCAGCACTGTAACAAAGAGTTTAGCAGTGTTTGGGTTCTGAAGGCTCACTGTGAAGAGGTCCATCGCGATCTTGTACCGCGCGAATTCCTCGAAAAGTACGCGCAGCAGTTCAAGTGCGAGTACGAGAAGAAAAGCGTGGTGGTGACCGTCGCGACGTCCTCATCAACTACCACGGCGCCGAGGAGCTCCACGCCTGCTGCTGGACAACCACAAGATCTTAGCTCTGATAAAGAATCAcgcgaaaaagaaaaggaagaaaacaCTGAATGCAAGGAACGTATCAGCCGAACACCAGAAGCCACATCAACTACTCCAGCTACTACTCCGGCATTGAGCAACACGCCCGTTTCAAGTACAGACTCTACGACGCCGACTGTACTCCCTACCAATTCGCATCATATTTCACAACAGCAGCAGtcgcagcagcagcagcaacaacaacaacaacagcaaCATTCACAACTTACATTTGCTCAGCAAATGTCGGAAATGCAAGCTGCTTTGAACGCAATGGCGGCATCGCAACTACAGCAACATCTGCAACAATATCCGGGATTGATGATGGGAATGATGGGATTACCATTCTCATTGAACGCTGTACCCGCTTTGGCAGCTATGAACTTACAGCCGCCTTTAGTGCCAATGATGTTACCACCACCACCGTATGATGGTGCTACCGCCGGATATCCACCAATTAATCAAGCGGATCTTCTTGCTAAACAGCATCTTGCTCTTCAGCAACAACAGGCGGCAGCAGCGGCGAACGCAGCTGCATCACAGAAACGAGCGCGTACGCGTATCACAGATGAACAGCTAAAGATACTACGCGGCCactttgatattaataattctccTGGTGAGGAACAAATTTTGGAAATGGCCGCCCAAAGCGGTTTGCCGCCTAAAGTTATAAAACATTGGTTCCGAAATACGTTATTTAAAGAGCGGCAACGTAACAAGGATAGTCCTTACAATTTCAATAATCCGCCAAGTACCACTTTGAATCTCGAGGAATACGAAAAGACAGGTGAAGCAAAAGTGACCCCATTAAATTCCAGCGTATCTGGCAGTTCCTGCGACGATAAAAGTCCAAATAAGCAAGTCACGCCTCCACCATCTATACAAAATGCAAGCACATCGCAACTTACCGAGATTAAACAGGAGGCGCCGGAGCAATCACAGTgtcaacaacaacaacaaagTCAACAACATCAAGAAGAGCAGCAACATCATTCACCCGGTAGCTCGGGTGGCCAACAATCACGACCGCATTCACCTGCGCTCAGTATGAGTTCTGTATTCTCGGGCATCCATCATGACATTTCGTCCCATCCCCCATTGACTACAAACGCCCCGAGTGCTCCGATGTTACCGCCGAAACTGGCGCCCCAAAACTTTGCCAATCCTACTCCGGGAACAGGTAACGTAGTATCGAACGCGATCGCTGCCATAGCACTTACACCGCAGAGATCTCTTAGCCCGGGCCGCGGACCGACAGATTATTCTTTCGGCGGCAATAGTAATGGCAGCAACGCTTCCGGCGGCAGTTCCGGAAAACGCGCCAATCGAACGAGATTCACCgattatcaaataaaagttcttcaagaattttttgagaaCAACGCGTATCCGAAGGACGATGATTTAGAGTACCTTAGCAAGCTTCTTGGCTTGAGTCCGCGGGTGATTGTGGTGTGGTTTCAAAATGCTAGGCAAAAGGCACGTAAAGTGTATGAGAACCAACCTGCCGCCGAGCCCGTGACAGCGGGTGGACGCGAGAACGATGATGGTTCCGGTAGATTTCAGAGAACACCAGGATTAAATTATCAGTGCAAAAAATGCCTGCTAGTATTTCAACGATATTACGAACTTATACGCCATCAAAAGACACACTGCTTCAAAGAGGAAGACGCCAAGAGGAGCGCGCAAGCCCAAGCTGCGGCGGCTCAGGTTGCCGCGGTTCTAAGTTCCGAAGACAGTAACAGCAGCTCTACTACAACAACAAATAACACGGTAGCTAACAATCCATCGGCCACCCCTGCGCTCGCCGAACAATTACAACAACCATTGAACACCGCCACGCCTCCTCATCAACATCAGCAGCAGACACTATCTCAAACGCATCAACAGTCTCAGCAGCAGTCGCAACAACAGCAATCGCAACAACAGCAATCACAAACGGAATCAAAGGAAAGTAGCTATCAGTGCGAGAAATGCAATTTGGTGTTCGGACGATTCGAGCTTTGGCGCGAGCATCAGCTAGTACATATCATGAACCCGTCCCTATTTCCGCCAACCTACCCACCTGATACACCTTTCGGAATTCTGCAGCAGCAAGCACTTAACGCTACATCCGGAGTTACAACAGACACTCCGCATCCGCTCATCGCCATGATGCAGAAAAGAAAATACGAAGACTCCGAGGAGGGAACGGGCAGCGACAACCGTTTAAATTCGGAACACAACGAGCAACCGAAGGACAAACGTTTGCGAACTACGATACTCCCGGAACAACTGGACTATCTCTATCAGAAGTACCAGATCGAGTCTAATCCATCGAGGAAGATGCTGGAGACGATCGCTCGCGAGGTCGGTTTGAAAAAACGCGTAGTGCAAGTGTGGTTCCAAAATACACGCGCTCGCGAACGTAAGGGTCAATTCCGCGCCCACAGCCAAGTGATCAACAAGCGCTGTCCGTTCTGTCCGGCGCTGTTTAAAGTAAAGTCCGCCCTGGAATCTCATCTCAGCAGTAAGCACGCGGATCAGGTAGCGCGCGGTGAAGTAAACATCGACAATATCCCAGATGAGGAGCTCTCGATGGAATCCGCTCCTTCAAATTCTAGCACTCCTCATATGATGCCACCGCTGTTTCCGCCGATCAATAGTGACATGGAGGCATCTTTGAAGTCTTTGAAAACCTCTTATTACGAGGAAATGAAGCGATACTTTAGCGAGCTGGCGCACGCCAGTAATGGAAAGCAAGAAATAGCGAATCATCAAATCCATAATACCGAGTCACCGTTGGATCTGAGCAAACCGGTCGATCTCAGCCGACCCATGAAACTTACTCTGGGCGGTTTAAGTAGTCTTCTCGAAGAACAACATGGCGCTCACTTCCGCGGTGGCAGCGATTGCGGACCTCTGACTGATTTATCCGAGCGCAGCATCTGCGACGATGACAGCATGAGCGAAACCACGGAATTCCTAGATGATGAAAGCGGCCCGGCAAGTCCGGCTTCGAGTACTCAGAGCTCGAGGCAAGGACCCGCTAGCGGAGGCACCGGGAATACCTCTGGGCCGCCGGTGACCAATGCACAGTCCAGCGGCGGGAACACCACTAGTCAATCCGGCGGCAAGCGGTACCGTACGCAGATGTCAGGCACCCAGGTGAAAGTGATGAAGTCGCTATTCTCGGATTACAAGACACCGACGATGGCCGAATGTGAAATGCTCGGCCGCGAGATCGGCTTGCCGAAGCGGGTGGTCCAGGTGTGGTTCCAGAATGCCCGTGCCAAGGAGAAAAAAGCCAGGCTAGCGGCGGGTCTGCCGGCCGAGAGTTCAGCCGTTCAACCGCATCGCGGACCGACCGGACCAGACGAATGTAGACTGTGTTCTGTGCGCTACTCGGCCAAGACCCCATTGCAGGAGCATGTCTTCTCGCGGCGGCACATCGAATCGGTACGCGTCGCTGTCGAAGAGGGCAGTCTGGTGCCGCCAACTCCCGGGGCACCGATCGTGCCtggtggcggtggcggcggcggcccTAGTATCAGCAATTCGCCGGTAGTCGCCACTACCAGTCAGCAAATCAACCAGCAGCAGCAGTCGGACGAAAATATGATGTACGGATCCGTGTTCCTCCACCCTACGGCAATGTTCCAGtcgcagcagcagcagcagcagcagcatccCGCCGGTGCTACGGCCAGCGCCGCAGCTAGCACCACTACCGGTGAGTGTGTAGCTGACCTCTTAGACGACTAA
Protein Sequence
MPSSEPHPPYHLQHHNIPPSHIQQHTPSAIEHQFFQQLVAVHHQQQQQQRQQQHGGPFQNSTYAQQKQEMSPEEEGGRGGGSPPAAGAALHQPHHPRTASPPSGTEPCTRDAIPTPTPIADTTTATTTTTMTMQSQGQQQQQGPSPSPSPTGGDVEKFDGKIIYNPDGSAYIFEGESELSEDDSLPDGCIVDGRGVSVPHSLVFPQIANAYYVSRLYAHQAYQQQQQQQQQRSTAQQHNPDLPVMHSYRVISYRSAEGSKQQPAPKFTAPPSPASVPIKPILMCFICKLSFGYAKSFVAHAQGEHQLTLMEDERQILSQSTASAIIQAVGRGKQPLVSFLEPVTNLACTQALPAQIQGQQPQQQQRNESNEHETTTTNTPASTPGVPSSPQQQQSQQTQQRPSPSTPTTPTSHSNHPLTYNHQQHQWTGAQVSAVSWAKAPDVMHYSSPPPSASSVKGSPSSYALTHPQNPPSYSGGTTIGVCSDHMQGRPSGVECGRCELILATSRLAGAGGPLAGIHSRNSCKTLKCPKCNWHYKYQETLEIHMKEKHPENETSCIYCIAGQPHPRLARGETYTCGYKPYRCEVCNYSTTTKGNLSIHMQSDKHLNNMQELQQGSGGGSGTSNPSSSQDAPMPTRSPHHQQNHNPHLTAQSSNQSKPKHSFRCDVCNYETNVARNLRIHMTSEKHTHNSLVLHQNIKHMQTLSVLSHHHQAQQHHQQAQQQQLEQLLHLGGLDKPPQHAEAALADMAYNQALLIQMMTGGPLPQQLPPDIMANMAAMTNLGGDVGLSPDSMEPPPEPADQDPAHLYHCCVCNNFATDSLEALGHHLAVDRTRTREGEILTVLNAHFICKLCSYKTNLKANFQLHCKTDKHLQRLQHVNHVKEGGPRNEWKLKYLASPTSAAQLRCHACDYYTNSAHKLALHAASPRHEAAALLLRHLIEASSNIQTPGKLYHCALCVFSAKHRLPLLQHVKSMRHFQMEQLHQLHRRSSLQGNETPHTDISDVFQVVSDPDVPPTQQSSPTTPTTPNATSTNNERREEGSECGSEVKQEPDNDPEPEMEPENDQDEITCLYCTYQPTSREELRQHLQMAHVHDSEEKTEAVKEEPTPDLLCPLCQDGFKERPALEKHVMQIHSVNTDGLQRLLLLVDQSHWLNNNPRNTSTSAVTAATMPTSPTTTMKPHQEEDMSERSGNDDIEELNRTVCTVCGRTYRSPEDLQQHHRENHPATMLTLAVSEKHVYKYRCGQCSLAFKTLEKVQQHSQYHAIRDATKCTLCGRSFRSVQALQRHLESTHDLHEDELAQYKQSLIAHPLLQALTEETLKRQSGLIGEQNVEDDAGRGDEEESDASDSSPLQKEQRLLEDYLNSQTIAEDSYHDPSRKFKCHRCKVAFTRQSYLTGHNKTLLHRKGEKMSYPMEKYLDPNRPYKCDVCKESFTQKNILLVHYNSVSHLHKLKRAMAQEQGNNNTLISVVPPASPTESPDSQQDQDKKPYKCNICKVAYTQGSTLDIHMRSVLHQTRTSKLQDLAASGQVDLARPLIEQPSPTSPTSSPVNTSNASGMLCCSRCSALFVNQEQLATHQQLYCIFSNPLALFQQLAASQQLTSSTAAKTPPPTSTTPGPQQHMQQATQHSSQDILSQPRHKTSQMYKHLLESFGFDLVMQFNENHQRRQRKEEEAAAALQAQQEQQKQEQQKQALAAQAAQEKEEEAEETHIDDDVIPELTRSTCQHCNKEFSSVWVLKAHCEEVHRDLVPREFLEKYAQQFKCEYEKKSVVVTVATSSSTTTAPRSSTPAAGQPQDLSSDKESREKEKEENTECKERISRTPEATSTTPATTPALSNTPVSSTDSTTPTVLPTNSHHISQQQQSQQQQQQQQQQQHSQLTFAQQMSEMQAALNAMAASQLQQHLQQYPGLMMGMMGLPFSLNAVPALAAMNLQPPLVPMMLPPPPYDGATAGYPPINQADLLAKQHLALQQQQAAAAANAAASQKRARTRITDEQLKILRGHFDINNSPGEEQILEMAAQSGLPPKVIKHWFRNTLFKERQRNKDSPYNFNNPPSTTLNLEEYEKTGEAKVTPLNSSVSGSSCDDKSPNKQVTPPPSIQNASTSQLTEIKQEAPEQSQCQQQQQSQQHQEEQQHHSPGSSGGQQSRPHSPALSMSSVFSGIHHDISSHPPLTTNAPSAPMLPPKLAPQNFANPTPGTGNVVSNAIAAIALTPQRSLSPGRGPTDYSFGGNSNGSNASGGSSGKRANRTRFTDYQIKVLQEFFENNAYPKDDDLEYLSKLLGLSPRVIVVWFQNARQKARKVYENQPAAEPVTAGGRENDDGSGRFQRTPGLNYQCKKCLLVFQRYYELIRHQKTHCFKEEDAKRSAQAQAAAAQVAAVLSSEDSNSSSTTTTNNTVANNPSATPALAEQLQQPLNTATPPHQHQQQTLSQTHQQSQQQSQQQQSQQQQSQTESKESSYQCEKCNLVFGRFELWREHQLVHIMNPSLFPPTYPPDTPFGILQQQALNATSGVTTDTPHPLIAMMQKRKYEDSEEGTGSDNRLNSEHNEQPKDKRLRTTILPEQLDYLYQKYQIESNPSRKMLETIAREVGLKKRVVQVWFQNTRARERKGQFRAHSQVINKRCPFCPALFKVKSALESHLSSKHADQVARGEVNIDNIPDEELSMESAPSNSSTPHMMPPLFPPINSDMEASLKSLKTSYYEEMKRYFSELAHASNGKQEIANHQIHNTESPLDLSKPVDLSRPMKLTLGGLSSLLEEQHGAHFRGGSDCGPLTDLSERSICDDDSMSETTEFLDDESGPASPASSTQSSRQGPASGGTGNTSGPPVTNAQSSGGNTTSQSGGKRYRTQMSGTQVKVMKSLFSDYKTPTMAECEMLGREIGLPKRVVQVWFQNARAKEKKARLAAGLPAESSAVQPHRGPTGPDECRLCSVRYSAKTPLQEHVFSRRHIESVRVAVEEGSLVPPTPGAPIVPGGGGGGGPSISNSPVVATTSQQINQQQQSDENMMYGSVFLHPTAMFQSQQQQQQQHPAGATASAAASTTTGECVADLLDD