Basic Information

Gene Symbol
Gzf1
Assembly
GCA_963920685.1
Location
OY987330.1:12960110-12964406[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 20 0.0019 0.62 13.6 3.8 3 23 53 73 51 73 0.96
2 20 1.6e-05 0.0051 20.2 0.1 1 23 84 107 84 107 0.95
3 20 0.043 14 9.3 0.8 2 23 116 137 115 137 0.96
4 20 3.7 1.2e+03 3.2 0.8 2 23 145 165 145 165 0.86
5 20 0.00066 0.22 15.1 0.1 2 23 172 194 171 194 0.95
6 20 0.13 43 7.8 0.2 5 23 208 227 202 227 0.88
7 20 0.0001 0.034 17.6 4.1 1 23 232 254 232 254 0.98
8 20 8.4e-06 0.0027 21.0 2.2 1 23 261 283 261 283 0.98
9 20 5.5e-05 0.018 18.4 0.4 1 23 289 311 289 311 0.94
10 20 0.0014 0.47 14.0 1.5 1 23 317 340 317 340 0.91
11 20 0.0014 0.46 14.0 3.7 3 23 417 437 415 437 0.96
12 20 6.7e-05 0.022 18.2 0.1 2 23 452 474 451 474 0.94
13 20 0.3 97 6.7 2.2 3 23 484 504 483 504 0.96
14 20 3.7 1.2e+03 3.2 0.8 2 23 512 532 512 532 0.86
15 20 0.00048 0.16 15.5 0.1 2 23 539 561 538 561 0.95
16 20 0.0091 3 11.5 0.4 5 23 575 594 569 594 0.88
17 20 0.00035 0.11 15.9 4.2 1 23 599 621 599 621 0.98
18 20 1.1e-05 0.0034 20.7 1.3 1 23 628 650 628 650 0.98
19 20 5.5e-05 0.018 18.4 0.4 1 23 656 678 656 678 0.94
20 20 0.012 4 11.1 1.0 1 23 684 707 684 707 0.90

Sequence Information

Coding Sequence
ATGTTCCGcaAAGAAGTAAAAGAAGAAGACGGTGCCTTTGATTTTAAGTTTAATAGCCTACTATGCACAGTTGCCTCCGATTCACAACAGTCGTCGACACATCATCGTGACACTGTTTCAGTGAAACAAGAAATTACAGTGGACCAAGGTCTATTTTGTGCTCAGTGTTCCAGATGTTTTACTGAAAATACCTCGTTCGTTAGACATATGCGCTATcataaacataaattaaaaagtattttagtaGCATTTCCATGTCCTCAATGTGGAAAAACTCTTGCTACCAAGTCCAGTCTCGTCGAGCACATTAAATTCGTTCACGAACAGATAGGGGATATAAAGGTAACATGTCAGGAATGCAATAAAGTGCTCAAAAAGTCCACTATAAGAATTCACATGCAGAGAATGCATAGAGGTAAAGTTAAGATAGAGCAATGCGACATTTGTGGCGCTATTTGCAGGGATACCTTGGAAGTTCACAAAAAGAGAGTACACTTCAAGCAGTATTCTGTGTATTGCGAGAGGTGTGGAAAAGGCTTTTTTGCTGCATCAACACTCAAAATACACATGGCGCGAGTACATGACGAAGGGGAAACCGTTCATTTTCCTTGTATTGAAGAGGGCTGTTCCAGGGTTTTTAAAGAGAGAATTTCGCTGAAGCATCACTTAGATGCAGTACATCGAGACACAAAATATGACTGCCAACATTGTGAAAAAACTTTTGCTCATCCCATTACTTACAAGAGGCACCTCAAAGTGCACCAGAATGGTCCTGTTATGCACACGTGCCCAGTGTGTAAGAAACGGGTAAACTCCAAAAGTAGTTTACGTGACCATATGCTGACTCATAGTGGCGAAAAACCGTTCACCTGTGTCGTTTGCGGTCGAGGTTTTATTACGAAAAAGAATCTTAAGACTCATTCTGTGGTACACACGAAGGAGAAACCTTTTGCATGCAATAGTTGTGATAAGAAATATACTCAACGAGGCCCGCTTAACAGACATATTGGTCTCTGTCATCCAGAGTTGGTTAAGGAAGCTGGCATTAAGAAATTACGTAGCAATAATATAGAAAATGGAACAAAAGGCGATGATGTCTCTGACTCATAcAAAGAAGAAGACGGTGCCTTTGATTTTAAGTTTAATAGCCTGCTATGCACAGTTGCCTCCGATTCACAACAGTCGTCGACACATCATCGTGACACTGTTTCAGTGAAACAAGAAATTACAGTGGACCAAGGTCTATTTTGTGCTCAGTGTTCCAGATGTTTTACTGAAAATACCTCGTTCGCTAGACATATGCGCTATCATAAACAGAAATTAAGAGGTATAAAAAGTGTTTCGGTGGCGTCTCCATGTCCTCAATGTGGAAAAACTCTTGCTACCAAATCCAGTCTCGTCGAGCACATTAAATTCGTTCACGAACAGATAGGGGATATAAAGGTAGCATGTCAGGAATGCAATAAGGTGCTTAAAAAGTCCACTATAAGGCATCACATTCAGAGAATGCATAGAGGTAAAGTTAAGATAGAGCAATGCGACATTTGTGGCGCTATTTGCAGGGATACCTTGGAAGTTCACAAAAAGAGAGTACACTTCAAGCAGTATTCTGTGTATTGCGAGAGGTGTGGAAAAGGCTTTTTTGCTTCATCAGCACTCAAAATACACATGGCGCGAGTACATGACGAAGGGGAAACCGTTCATTTTCCTTGTATTAAAGAGGGCTGTTCCAGGGTTTTTAAAGATAGAGCTTCGCTGCGGCATCACTTAGATGCAGTACATCGAGACACAAAATATGACTGCCAACATTGTGAAAAAACTTTTGGTCATCCCATCACTTACAAGAGGCACCTCAAAGTGCACCAGAATGGTCCTGTTATGCACACGTGCCCAGTGTGTAAGAAAGGGGTAAACTCGAAGAGTAGTTTACGTGACCATATGCTGACTCATAGTGGCGAAAAACCGTTCACCTGTGTCGTTTGCGGTCGAGGTTTTATTACGAAAAAGAATCTTAAGACTCATTCTGTGGTACACACGAAGGAGAAACCTTTTGCATGCAATAGTTGTGATAAGAAATATACTCAACGAGGCCCGCTTGGCAGACATATTGGTCTGTGTCATCCAGAGTTGGTTAGGGAAGCTGGCACTAAGAAATTACGTAGTAATAATATAGAAAATGGAACAAAAGGCGATGATGTCTCTGACTCATAG
Protein Sequence
MFRKEVKEEDGAFDFKFNSLLCTVASDSQQSSTHHRDTVSVKQEITVDQGLFCAQCSRCFTENTSFVRHMRYHKHKLKSILVAFPCPQCGKTLATKSSLVEHIKFVHEQIGDIKVTCQECNKVLKKSTIRIHMQRMHRGKVKIEQCDICGAICRDTLEVHKKRVHFKQYSVYCERCGKGFFAASTLKIHMARVHDEGETVHFPCIEEGCSRVFKERISLKHHLDAVHRDTKYDCQHCEKTFAHPITYKRHLKVHQNGPVMHTCPVCKKRVNSKSSLRDHMLTHSGEKPFTCVVCGRGFITKKNLKTHSVVHTKEKPFACNSCDKKYTQRGPLNRHIGLCHPELVKEAGIKKLRSNNIENGTKGDDVSDSYKEEDGAFDFKFNSLLCTVASDSQQSSTHHRDTVSVKQEITVDQGLFCAQCSRCFTENTSFARHMRYHKQKLRGIKSVSVASPCPQCGKTLATKSSLVEHIKFVHEQIGDIKVACQECNKVLKKSTIRHHIQRMHRGKVKIEQCDICGAICRDTLEVHKKRVHFKQYSVYCERCGKGFFASSALKIHMARVHDEGETVHFPCIKEGCSRVFKDRASLRHHLDAVHRDTKYDCQHCEKTFGHPITYKRHLKVHQNGPVMHTCPVCKKGVNSKSSLRDHMLTHSGEKPFTCVVCGRGFITKKNLKTHSVVHTKEKPFACNSCDKKYTQRGPLGRHIGLCHPELVREAGTKKLRSNNIENGTKGDDVSDS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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