Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.078 15 8.4 0.3 5 23 84 103 79 103 0.87

2 5 3.1 5.8e+02 3.4 0.5 2 23 113 139 112 139 0.80

3 5 1.7e-06 0.00032 23.1 3.7 1 23 145 167 145 167 0.98

4 5 2.1e-05 0.0038 19.7 0.4 1 23 173 197 173 197 0.97

5 5 3.3e-06 0.00061 22.2 0.6 1 23 203 229 203 229 0.94

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.078	15	8.4	0.3	5	23	84	103	79	103	0.87
2	5	3.1	5.8e+02	3.4	0.5	2	23	113	139	112	139	0.80
3	5	1.7e-06	0.00032	23.1	3.7	1	23	145	167	145	167	0.98
4	5	2.1e-05	0.0038	19.7	0.4	1	23	173	197	173	197	0.97
5	5	3.3e-06	0.00061	22.2	0.6	1	23	203	229	203	229	0.94

Coding Sequence: ATGGTGGTGGGACAGCCCCTTCGGTATTACTACGGATCGTCTCCACCACTGGATGAAAAtcgtttttcatattttcaacaatttgaccAAGTTATTGGTACAATGGACGCCCATGAAGAGTACCCAATGACTACGTCTCCAAGCAACAGCACCCAGAGTGATAGCGACAATTCCGTCTCAAGCATAGAAGTCCCATCTCACTCCATAGAAATTCCGAAAAAAGAAGAAAAGAAACAGTGTCTTTGGAAAAGTTGTGGCGTCATCTTTCCATCTTTAAGTGAACTAGCCAGTCACGTGTCCAAATGTCATTCGGCCAGCGGAGCTGAAGGACTTTTCTATTGTAGATGGGAGGGATGTAACAGGAACAACAAAGGATTTAATGCGAGATACAAAATGCTGGTCCACGTTCGCACCCATACCAACGAGAAGCCTCACAAATGTTTCCAATGCGATAAGTCATTTTCAAGGGCAGAGAACCTGAAAATTCACTCCAGATCGCATAGTGGAGAAAAACCCTATATCTGCCCAGTACCGGGCTGCAACAAAGCCTACTCCAACTCAAGCGACAGGTTCAAACACACCAGAACGCACTCTGTGGAGAAACCGTACCAGTGCAAGGTACCTGGTTGTCCTAAAAGATACACCGACCCCAGTAGCTTAAGGAAACACGTAAAAACCTACAAACACTTTGTCAATGACGTCAGCTTTACTGAAATTCCGAAAATCCCCGAAAATACCGACCGACTCTCACCTGAATCTACCGGTCCATTCACACCAGAATCCACTACTCGATTTGACGCAGGAACAAATGAAAATCGTATGCAAACAATGGAAAATCATGTACCAGTTATAACTGTCAATAAGATCAGATCTGACAGTTATATCAGACATTCTCCAACTCATACAGAAGACATTTTTAGGTTAGGAGCTTTAATTGACATTAAAAATGACAGGTATGGTTTTGTAGAATCGTACGAAAGTAAAAAGTTGTATAGACCTTATGAGATTGGAAATGAAAGCATTTCTATGGATTTAGATATGCCTTTAGATTTAAGTATAAGGagaaatatgtaa
Protein Sequence: MVVGQPLRYYYGSSPPLDENRFSYFQQFDQVIGTMDAHEEYPMTTSPSNSTQSDSDNSVSSIEVPSHSIEIPKKEEKKQCLWKSCGVIFPSLSELASHVSKCHSASGAEGLFYCRWEGCNRNNKGFNARYKMLVHVRTHTNEKPHKCFQCDKSFSRAENLKIHSRSHSGEKPYICPVPGCNKAYSNSSDRFKHTRTHSVEKPYQCKVPGCPKRYTDPSSLRKHVKTYKHFVNDVSFTEIPKIPENTDRLSPESTGPFTPESTTRFDAGTNENRMQTMENHVPVITVNKIRSDSYIRHSPTHTEDIFRLGALIDIKNDRYGFVESYESKKLYRPYEIGNESISMDLDMPLDLSIRRNM

Sequence clustering based on sequence similarity using MMseqs2