Basic Information

Gene Symbol
AKR1A1
Assembly
GCA_943735935.1
Location
CALSEV010000499.1:1278035-1312414[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 14 0.026 2.9 9.7 2.7 2 19 582 599 581 601 0.94
2 14 5.1 5.8e+02 2.5 0.5 3 23 644 665 643 665 0.93
3 14 0.003 0.34 12.7 0.2 3 23 673 693 671 693 0.95
4 14 0.11 12 7.8 0.4 1 23 700 723 700 723 0.94
5 14 0.00076 0.086 14.6 1.4 2 23 731 752 730 752 0.97
6 14 0.0027 0.31 12.8 7.4 1 23 829 851 829 851 0.97
7 14 0.83 95 5.0 1.7 1 23 867 892 867 892 0.96
8 14 0.11 13 7.7 1.1 1 23 904 927 904 927 0.96
9 14 0.4 46 6.0 3.6 2 23 933 955 932 955 0.96
10 14 0.00012 0.014 17.0 1.3 2 23 959 981 958 981 0.95
11 14 6.4 7.3e+02 2.2 5.2 1 23 987 1010 987 1010 0.89
12 14 0.0008 0.091 14.5 0.2 2 23 1016 1037 1015 1037 0.97
13 14 0.00016 0.019 16.7 0.8 1 23 1043 1065 1043 1065 0.98
14 14 0.48 54 5.8 0.4 5 23 1081 1100 1071 1100 0.86

Sequence Information

Coding Sequence
ATGGCGGTACAAGTTCCGATAACCATCAGGTCTTGTTTAAATTGCAAAATAAACTCTGATGCTAATGCTGAAAAGGATTTTCATGAAATCTTTGATGAAGTGGGTCTAGAATTACAATTACCCTTCTTAGTTAAAACATTTTTTCGCATTGATTTAAACCAAAGGGACAAACAACATCTTTGTGAAACCTGTGTCAATCGTTTAATAGAATTATATGATTTGGATGAGCACACCAAACAGGAAAGTTGTAATACAAATAATTTAAAAATAATACAACATAATACTCAAGTTAATATTCCCAAAAGCAATTCTATTGAATACACAAACTTTAAAACTTTTGTTTCAACACAAGGAGAAAATACTATTGAAATAAATAAACAAGATAAATCTGAAAATAAAAATCGAACGGAATATGAAAATATTAAAGATGAAGAATATTTTTTTAACAAAAGCAGATCTGCAGCTTTAACCCAACAGCAGAACCAAAGTAACAATGATATTGCTGAGTATTTTCCAAAAGAAGATTTTGACCAAAACGGTGAAAGAGAAGTTTCACAAGATTTCAATACTTCATTATCGTCTGGTGCAATAAATCATAAAAAATCAGATGAACTAGAATTGAACGAACATATTGAATTTATCATCGATAATGGCATCCAAAATCTCAAAATAAACAAACAGTCTAATACAGACATCATGGATAATGAATTCGAAGAAGTAGATGAAACTGTAAAATCATACATACCAAACAGAATTCAAAACAAAAATAAATGTCAAGATGATTTACATGCTGAAGTAGTCGATGATCGTTCAAATCAAGTTGCAAACAGTGATGATTCAAACTCATTACTAGAAGAACTTAAAATAACCGAAGATAATAAGGCTTCATTATTAAATGTAAGTAGTAGTGCAAAAGAATTTAATAATATAGAACACATTGATGCAGATGATTTTTTTGAACAGGAAGAAATTTCTAAAGAAACATATTCATTGGAAGAAGAGTATTTAATAGAAGAAACTATTTTGTCTGAGGAATATGATCAAGTTGATTTGAATGAGTATTTGGATAAGGTACTTATAACAAAATTTCAGGATTTGATGTGTAATTGGGAAATGGAATGTAAATTGTGGTGTCACTTTCATGAACCCGAACGTGTTAAATACGCCTGTCACAAAAGTTTAGCCAACTTTGGCCTCGATTTTGTTGACTTTAATTTAATGCACTGGCAATACTTTGATGTTGATTATATGGACACTTGGAAAGCCATGAAAGCTTTGGTGGAGAAGGGTTTGGTTAAAAGTATTGGTATTTCTAATTTAAATTCCGAAAAATTAACACGTTTGGTGGCCAATTACCGGAACCAGCTAAGAAAAGTTAAAGCAATTGGCAGTAAATGTAAAAATACAACAGCACAATTTGTATTAAGATATTTGATTGAAAACGGAGCTGTTCCCATTCCTAAACCTTTTAATAAAACTCGGATTGAAAATTTTTCAGTTTTTGATTTTAAACTTTTCCCGAGGACCATAAAATATTGGAAATATAAAACACTGTGGTGCCTTGAAAAATATTACACCTTTGGGGAATTATTAAATCATGCGTGTATGACAGAATTCGAAAAGAAGAAAAAAGTGTCTTGTATTGTTAAAGATTGCGAAGAACATGCGAAAGATTTACCAACTTTAGCAAGACATTTAGTACTAAAACATTATGATAAATTAGAAAGTATCGCCATTTATGGTAAATGTACAGATTGTCAAAAAACATTTTCAAATGTTTTAGATTTTAATAAGCACTCTTGTTGCCGAAATATAAAGCGAAAAATTGGTGCACCAAAGTATTGTAAATATTGCGATTTGGATTTTCAGTCTTTAAAAAGATATGTGTTTCATATGCAATTCCATTTAAAAAACCATAGGCCGAAAATTTGCTTATTATGTGGTGATTTATTCAATAATTCTAATGATTTCTTTGAACATACTCAATATAAACATAATCCTGAAACTAATTTGGCGTGTGTAAGATGTGACCGCTTTTTTGAGGATATACAAAATTTAAATAATCATATGGTAATGCATGAATATTCTAAATATCAATATGAATGTGCACTTTGCCTCAAAAAATATTATACTAAATTGGGTTTAAATCAACACGTGGATATTTATCACAACAAAAAATCTAATGCCTTACAATGTGAATATTGTGCCAAAGAATTTGTTAATAAAATGTCATATCGAAATCATACTAAATCTCATGCCAAAGAAGTACAAACATTTATATGCTCAACATGCGGTTTAATAACTAATAAAATGGAAATAATAAAGAAACATATTGAGTCAGATTATGAATCTCCGTGTTTTTCATCGCCGATTGAAGAGAAAGTTTTAGGTTTGGGTTATTCATGTGAAAATTGTTGCTTAGATTTTTATACAATGAAACATCTTAAAGATCATCGTTTAAGTGATAGTCACAGATCTGATTTATTTCATTGTGTAATGTGTAAAAAAAGCTTCAATACTTTGAATCATTTGCGTAATCATTCCAAAACACACAAGGATTTAAAAGAATGGCAGGAATTATTTCCTATAACTAGACGTTTTGTATGCAATGTAGGGGATTGCCAAGAGTTTTATTCCATTTGCACCGCTTTATATAACCACAAAAAACGTTCTCATATAACTGAAGAAATCACAAATTCACCCACTGAGTTTAAATGTCAATTTTGTCAGCAGATGTACCTTTCACAAGCGTCTTTGTCTAGGCATGTAGCTAAAAGTCATAAAAATGCAAATATAAAATGTTCATATTGCAAGGGAAAGTTTCATTCCCAAAATATTTTACAAAAACATATTAATAAATTTCATACAGCCGTTGAATGTGAGATATGTTTAAAGAAATTTAAGCATCAGCGCAATTTAGAATCACACACTAATATCGTACATAATAATATAAAGCGGTTTTTTTGTAAACATTGCCAAAAGGGATATTATTATAAAAAAGAAAAATATTTACATGAAAAGCAAGTTCATTCTAAAAATACTTTAAAATGTAAATTATGCGATTTTGTAACCACTTATCCGGAATCTTTGGAAATTCATATGGACAGGCATAATAATCAGCTTAAGTTTCAATGTTTACTTTGTAGCAAATCATTTGGACGAAAACCACAATTGGAGGGTCACTTGAAAAGGCATCAAAACAGAAAAAACTACAGCTGTGCCCGTTATTTAAAAGAAAGTGGCTGTGATGCTTCTTTTTTGAATTATAATTTACTGAGAAAACATGCACGAACTAAACATGAAAACTCAAGTTTTAGTATTAATTTAAAAAGAGAAGAACAACGAAAAAATGATCATGACCTTGTGCAATTTGAGTATGTTTCCTATAAAAAATTGACTTGTGACGATAGCAGTAAATATGAAAAACGGCCAAAAACATCACATGAAATTCATTTTAATGCTGAAGATTTCGATCAAGATGCTTCTATTTCAACCTTGGAAAATGACATGGAATTCGAAGAACAGAAACCTGATATTGAGAGTTTAATAATATGA
Protein Sequence
MAVQVPITIRSCLNCKINSDANAEKDFHEIFDEVGLELQLPFLVKTFFRIDLNQRDKQHLCETCVNRLIELYDLDEHTKQESCNTNNLKIIQHNTQVNIPKSNSIEYTNFKTFVSTQGENTIEINKQDKSENKNRTEYENIKDEEYFFNKSRSAALTQQQNQSNNDIAEYFPKEDFDQNGEREVSQDFNTSLSSGAINHKKSDELELNEHIEFIIDNGIQNLKINKQSNTDIMDNEFEEVDETVKSYIPNRIQNKNKCQDDLHAEVVDDRSNQVANSDDSNSLLEELKITEDNKASLLNVSSSAKEFNNIEHIDADDFFEQEEISKETYSLEEEYLIEETILSEEYDQVDLNEYLDKVLITKFQDLMCNWEMECKLWCHFHEPERVKYACHKSLANFGLDFVDFNLMHWQYFDVDYMDTWKAMKALVEKGLVKSIGISNLNSEKLTRLVANYRNQLRKVKAIGSKCKNTTAQFVLRYLIENGAVPIPKPFNKTRIENFSVFDFKLFPRTIKYWKYKTLWCLEKYYTFGELLNHACMTEFEKKKKVSCIVKDCEEHAKDLPTLARHLVLKHYDKLESIAIYGKCTDCQKTFSNVLDFNKHSCCRNIKRKIGAPKYCKYCDLDFQSLKRYVFHMQFHLKNHRPKICLLCGDLFNNSNDFFEHTQYKHNPETNLACVRCDRFFEDIQNLNNHMVMHEYSKYQYECALCLKKYYTKLGLNQHVDIYHNKKSNALQCEYCAKEFVNKMSYRNHTKSHAKEVQTFICSTCGLITNKMEIIKKHIESDYESPCFSSPIEEKVLGLGYSCENCCLDFYTMKHLKDHRLSDSHRSDLFHCVMCKKSFNTLNHLRNHSKTHKDLKEWQELFPITRRFVCNVGDCQEFYSICTALYNHKKRSHITEEITNSPTEFKCQFCQQMYLSQASLSRHVAKSHKNANIKCSYCKGKFHSQNILQKHINKFHTAVECEICLKKFKHQRNLESHTNIVHNNIKRFFCKHCQKGYYYKKEKYLHEKQVHSKNTLKCKLCDFVTTYPESLEIHMDRHNNQLKFQCLLCSKSFGRKPQLEGHLKRHQNRKNYSCARYLKESGCDASFLNYNLLRKHARTKHENSSFSINLKREEQRKNDHDLVQFEYVSYKKLTCDDSSKYEKRPKTSHEIHFNAEDFDQDASISTLENDMEFEEQKPDIESLII

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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