Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.0008 0.056 13.6 1.4 1 23 55 77 55 77 0.94

2 7 0.0004 0.028 14.6 1.2 1 22 87 108 87 108 0.97

3 7 8.4 5.9e+02 1.0 0.5 2 16 117 131 117 133 0.84

4 7 0.0056 0.39 11.0 5.1 1 23 141 164 141 164 0.97

5 7 0.0014 0.097 12.9 5.7 1 23 185 208 185 208 0.96

6 7 5.5e-06 0.00039 20.4 3.8 1 23 255 277 255 277 0.97

7 7 0.065 4.6 7.6 1.0 1 17 281 297 281 298 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.0008	0.056	13.6	1.4	1	23	55	77	55	77	0.94
2	7	0.0004	0.028	14.6	1.2	1	22	87	108	87	108	0.97
3	7	8.4	5.9e+02	1.0	0.5	2	16	117	131	117	133	0.84
4	7	0.0056	0.39	11.0	5.1	1	23	141	164	141	164	0.97
5	7	0.0014	0.097	12.9	5.7	1	23	185	208	185	208	0.96
6	7	5.5e-06	0.00039	20.4	3.8	1	23	255	277	255	277	0.97
7	7	0.065	4.6	7.6	1.0	1	17	281	297	281	298	0.89

Coding Sequence: ATGAACAACTCGTTATTGATAGATGAACAAATAATGAACTCAGAAAAAGCcgtaatcgaaataaaagtagaacCTGCAGATGAGTGCATTATTCCAGATATGCCAAATCCATTAATAACTACCAAGCATCTTGAACAATCGAAAACGAATGTGacctatgtatttatatgttacgTATGTAAGAAGTTTTTTGATACAAATTCGGACCTGCAGTTTCACCTGATGGATCACAATGACACATACGATTACAAGAATTTTTACAAGTGTTCGATGTGTAATATTCTGTTGAAGAACAAAAAGTCTTTGAAACTTCATATGAAAACAAATGGCTCCAAATCTGAGATGCgttattgtaaaaattgtgAATTCAAATctataaggaaagaaaacgtGACGAGTACTTATTTCAGAATTTCTCGATTCTGTTGTCCGCAGTGTCCCAATCTTTATAatcacaaaaaagatttactaAGACATGTAAGGAAGAAGCATTACCAAAATGATTGCATTTCACCAGAGAATACACTTGTTAGAGATGAAGTAGTAGTTCGATTTTGTTGCTCATATTGTCcgaagaagtataatttcaaaGGAGATGTAAAgagacatatacatataaaacatGTCTTAAAAAAGTATATGGAAGATATTTATCCTATGGACAATATTGATAAGAATAGTAAGCTCATTACAAATCCATTACCTATTGGTTGGAAACATAAAATCTTAAGAGCAAACGAGAGagataaatctaaaaataatcatcaGTGTCCTCATTGTAAATGGTCTTTCAAAAATGCTTCCGTTCTCGAAAAACATAAGCTACGACATTCGCTTAATTTTTCATGCGACATCTGTAAAgcgaaatttaaatatcaaggTTCTTTTTTGAAGCTCAAAGCATTACatgagatttaa
Protein Sequence: MNNSLLIDEQIMNSEKAVIEIKVEPADECIIPDMPNPLITTKHLEQSKTNVTYVFICYVCKKFFDTNSDLQFHLMDHNDTYDYKNFYKCSMCNILLKNKKSLKLHMKTNGSKSEMRYCKNCEFKSIRKENVTSTYFRISRFCCPQCPNLYNHKKDLLRHVRKKHYQNDCISPENTLVRDEVVVRFCCSYCPKKYNFKGDVKRHIHIKHVLKKYMEDIYPMDNIDKNSKLITNPLPIGWKHKILRANERDKSKNNHQCPHCKWSFKNASVLEKHKLRHSLNFSCDICKAKFKYQGSFLKLKALHEI

Sequence clustering based on sequence similarity using MMseqs2