Basic Information

Gene Symbol
-
Assembly
GCA_947397865.1
Location
OX377622.1:25959202-25970591[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 2.3 4.3e+02 3.4 0.2 5 23 356 375 351 375 0.89
2 16 0.0067 1.2 11.4 1.3 2 19 387 404 387 406 0.95
3 16 4.1 7.5e+02 2.7 0.3 5 23 450 469 447 469 0.88
4 16 2.8e-05 0.0052 18.9 4.2 1 23 503 526 503 526 0.96
5 16 3.1e-05 0.0057 18.8 1.8 2 23 534 555 533 555 0.97
6 16 3.6 6.7e+02 2.8 0.0 1 20 564 583 564 585 0.80
7 16 0.49 90 5.6 3.4 1 22 602 623 602 626 0.91
8 16 0.0014 0.25 13.6 3.4 1 23 631 653 631 653 0.97
9 16 4.5 8.3e+02 2.5 0.2 1 23 669 693 669 693 0.95
10 16 0.0076 1.4 11.2 0.9 2 23 704 726 703 726 0.94
11 16 0.022 4 9.8 5.1 2 23 732 754 731 754 0.92
12 16 1.8e-05 0.0033 19.5 0.6 2 23 758 780 757 780 0.93
13 16 0.0013 0.25 13.6 1.8 1 23 786 809 786 809 0.95
14 16 0.24 45 6.5 1.3 1 21 814 834 814 837 0.90
15 16 1.7e-05 0.0032 19.6 0.5 1 23 843 865 843 865 0.98
16 16 0.17 30 7.0 3.2 3 23 877 899 871 899 0.90

Sequence Information

Coding Sequence
ATGTCGTCGGTTGATTCTGCATCAAGCAGTATCTGCTTATATTGTAAATCATCGTCGTCTGATTTTCATGATGTTTTCGATGAAATTGGTTTGGAATTGCAATTGCCAAGTCTAATACAGCAGTTTTTCGGAATCAATGTGAAGAAGAAGAGCAATGGAACTAAACAACAGTTGTGCGATGATTGTGTCAATCGTTTAATAGAATTATTTGATTTGGAAGAACATTACAAAGAGGTTGAGGCAACAAGTGTCGCACAAGCAGCCGAGGAAGAGTTACAACCCAATAGTCAGAGTGTGTATGTCGATTTGCTGTCTGAAGATGGTTCCCAAGATAACAGCAATGATGACCATGTGCAAAGTGGTACAGAAACCCATGTTAGTGTGCATGACGAACACGACGAAGAATTGGAGGAGTGTTTGGCTCATGACCAAACCATTAACCATAAGTCTGAAATACTTTGTGCGGCATTGGAGTTGGCTGACGATAGTCAGATGGAGGATGAAACAAACATCCTAGGAAATGAACAAGACGCCACGGGATCTGTGGCTAATAATCTTTTTGAAATTGAGGTGGACCAACAAATTGAGGATGATGACTACTTGGAGTGTGCTAGCGAAACAACAACAGTAAATGAAGAATGCGAAGAAGTAATGACTATGGAAGATATGCAAGAAGACTTGGGTAATGAATATTTCCGCATGGAAGAAGTGAAATCGCAAGATGCAGCTGATGAAGTTCTCAACGAGGCTATCCAGGAAACAATAAATGCCGCTATAGTCGAGGAATATGAGGAAAACTCAATTGATGTCGTAGGTGGTGAAATCAGTTCAGACATCGAGGAGGAATATTTAATCGAAGAAACTATTTGCTTCGAGCAATATGACAAGGTCGATCTGAATGAATATCTGGATAAAGCTATAATCACAAACTTTGTGGACTTCCAACTAGAATGGACAGTCGAATGCAAATTATGCCTCTATAAACACTATACCTTCCAAGAGCTAATAAACCATCCGTGTGTCAACGAACTAATAGGCGAACAGCAATGGTGTTGTATTATTAATGAATGCGATGATGTTGTCTCAAATTTGAAATCACTAGCCAGACATTTGATAATAAAACATTATGCCAATGTTGAAAGTGTCACCGTTTACGGGCGTTGTCCAGAATGTCAAAAGCCCTTTTCAAACATTGTGGATTTCAACAAACATTCCTGTTGCAACATCAAACGTAAGGCGGGAACCAGAAATTTTTGTCAATCGTGTTCTATGGATTTTCAGTCTCTGAAAAGATATGTTTTCCACATGCAATTTCATTTGACCAATCATCGTCCAAAAGTTTGCATTTTATGCGGCGCCTTGTTTAATAATGCCGATGATTTCTTTGATCACGTTCACTACTCCCATGAACCAGTTACGGCTATGGCTTGTATAAAATGCGATCGTTTTTTCCACGAGCAAAGTGTCTTCGACCGGCATATGGCTTGCCATGAAACTCAATATTCGTTTGAGTGTACCCATTGCCCCAAAAAATATACCAATAGAAGCGGTTTGACCAGTCATATGGATATTTGCCATAACCATGAGATGAAGCCCTTACAATGTGAATATTGTTATAAGGAATTTGTTAACCAAACCAGTTATCGTAGCCACATGAAGTCTCACATGCCCGAAGCTAAAGTACCTGCCTATATATGCTCAGAATGTGGACTCATTTCAAATAATGTAGATGTAATTCAGAGCCACATAGAAACAGATGAAAGTTTTACCGGTGATATTATTGAAAAAATCATCTCCGTTTCATATACCTGTGAAAGCTGTTCCATGGATTTCTTTTCTGCGCGTTACTTGCACCAGCATCGTCAGTCGTCGAAACACAGTGAGAAACTATTCTACTGTCCCATATGCCGCAACGTTTTTAAAACTCTGAAGCACATGCGCAATCATTTGACAAGTCATAAGGACTACGACGAATGGCTTAACATATTTCCTATTGCCCGATTTTACATGTGTAATATCGATGATTGTTGGGATGCCTATCCACTATGGACGTCTTTGTATTATCACAAAAAGCGACACAAAAACACCGAAATATCTGCAGATCAACTAAAGTGTCAATTTTGTGAGAAAGCCTGCACATCGAAAATGTCATTAGCAATACATGTAGCTCGGGTCCACAATAATAACAACCTCAAGTGTGAGCATTGCCAGAAATCGTATAAAAACGAGGAGGAGCGAAAAAGGCACACAGAACACATGCATGTATCGGTTCAATGTACAGAATGCCAAAAAGTTTTCAAAAATCGTCGAAATCTGATTACACACGAACAATTAGTTCATAAAAATGAAAAACGTTACTTTTGCAGTCATTGTGGAAAGGGCTATTATTATAAAGGCGAAATGAAAGCGCATGAGAAAAATGTTCATCCCGATACTACTTATAAATGTCAACTGTGTAACTTCGTTACCAACTATCCCAAATCGCTAGACATTCATCATGTGGCCAAACATACTGACAATTTACCGTTCGAATGTCCATCATGTTCAAAGGGGTTTGCGCGCAAACAACTTCTAGCCATGCATATGAAACGTCATAAAGAAGATAAAGATTTCATTTGCTACGAATATTGTCGTGGTGGCTGTAATGCCTCCTTTATAACTCATTTTCGGCTGAAAAAACACATCCAACAAAAGCATCCAAACGCCACCGCAAAAGAACAACAAGCCAAACCGCCAGTGAAAAGCAACCCGAAAGAGAGCAATGCCAGTCGACGCCAAATACTTATAGTCGAAGATGAGGGTGGCGATGTTGAATTAGTATTGGCCAATAGTGAAAGTGAGGCCGAATACGAAGAAATACGTTATGATATTGACGGTGATGAAGGTGAGGCGGATGAAATCGTGGATGAATTGGACGAAGATGATGACGGTTTCGATTACGATTTTCATAAATAA
Protein Sequence
MSSVDSASSSICLYCKSSSSDFHDVFDEIGLELQLPSLIQQFFGINVKKKSNGTKQQLCDDCVNRLIELFDLEEHYKEVEATSVAQAAEEELQPNSQSVYVDLLSEDGSQDNSNDDHVQSGTETHVSVHDEHDEELEECLAHDQTINHKSEILCAALELADDSQMEDETNILGNEQDATGSVANNLFEIEVDQQIEDDDYLECASETTTVNEECEEVMTMEDMQEDLGNEYFRMEEVKSQDAADEVLNEAIQETINAAIVEEYEENSIDVVGGEISSDIEEEYLIEETICFEQYDKVDLNEYLDKAIITNFVDFQLEWTVECKLCLYKHYTFQELINHPCVNELIGEQQWCCIINECDDVVSNLKSLARHLIIKHYANVESVTVYGRCPECQKPFSNIVDFNKHSCCNIKRKAGTRNFCQSCSMDFQSLKRYVFHMQFHLTNHRPKVCILCGALFNNADDFFDHVHYSHEPVTAMACIKCDRFFHEQSVFDRHMACHETQYSFECTHCPKKYTNRSGLTSHMDICHNHEMKPLQCEYCYKEFVNQTSYRSHMKSHMPEAKVPAYICSECGLISNNVDVIQSHIETDESFTGDIIEKIISVSYTCESCSMDFFSARYLHQHRQSSKHSEKLFYCPICRNVFKTLKHMRNHLTSHKDYDEWLNIFPIARFYMCNIDDCWDAYPLWTSLYYHKKRHKNTEISADQLKCQFCEKACTSKMSLAIHVARVHNNNNLKCEHCQKSYKNEEERKRHTEHMHVSVQCTECQKVFKNRRNLITHEQLVHKNEKRYFCSHCGKGYYYKGEMKAHEKNVHPDTTYKCQLCNFVTNYPKSLDIHHVAKHTDNLPFECPSCSKGFARKQLLAMHMKRHKEDKDFICYEYCRGGCNASFITHFRLKKHIQQKHPNATAKEQQAKPPVKSNPKESNASRRQILIVEDEGGDVELVLANSESEAEYEEIRYDIDGDEGEADEIVDELDEDDDGFDYDFHK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-