Basic Information

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 3.1 2.2e+04 -3.3 0.1 11 31 77 97 72 104 0.69

2 3 9 6.3e+04 -5.5 4.7 55 79 186 211 169 215 0.67

3 3 1.4e-47 9.5e-44 149.9 0.0 4 98 220 314 217 321 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	3.1	2.2e+04	-3.3	0.1	11	31	77	97	72	104	0.69
2	3	9	6.3e+04	-5.5	4.7	55	79	186	211	169	215	0.67
3	3	1.4e-47	9.5e-44	149.9	0.0	4	98	220	314	217	321	0.95

Coding Sequence: ATGCATTTAACTTCCCTCTCCAACAGCAGCCAGGCCAACAACTACTCGACGACCTCCTCCTCCTTATCATCTGCAGCCGTTAATCATCATTTAGGTTCATATACCGCTCTTGCGGCCACCGTAGCCACCACACCACTTTTGGGTGGTAGCATCATTGAAGCATCAGGTGCTACCACCAACCACCACCAACACCACCACCTATCATCGCCCTCGTCCAGCATCGCCAATATGGTGATTTCCTCAGTATCGCCGGCCTCAGCGACAACAGCATTGCACCAGCAACATCATCATCACCACCACCATCATCACACGCATCCGCACTCCCACCCGCCGCCGACACCAACGTCGTCGACGCATTCCTTGGGACATTCACAGCCGCCGCCTCCGCCATCGCATACCCACTGGAATTCTGAAGTGACGGTGGCCTCAATGGCTTCGGAGACGATAGTGGCCAGTAGTTCTGCCAGTGTGGGCAGTAATTCGCCGAATGGAGCGGCCAGTAATGGCACAGCCAATAGCAATAATAGCAGTTCGAATAACAATAACAACAATACCACACAAAATTCCAATAATAACAATAGTAGTAATAATAATAGCAACAACAACAACAATGTCATGCATCAGGATTTGGCGTGGCTGGAGAGGTCAATAATGCATGCCCATCAACAGTTTCCAAATGAATTGGTGCGCACAAGTAACCCGTATTTTCTATGCTCAGCTCTGCCCACCCATTGGCGCTCCAATAAAACCCTGCCAATTGCCTTCAAAGTTGTGGCTCTCGTGGATGTGGGCGACGGCACCAATGTCTACATAAGAGCGGGCAACGATGAGAACTACTGTGCCGAATTGCGCAACGAGAGGGCGACCATGAAAGATCAAGTGGCCAAATTCAATGATCTGCGTTTTGTGGGACGTAGCGGTCGAGATATTCCCATGTCTTTGGGCTGGCTGGCTGGCAATGATGCGCATTCATTGATTGATTGA
Protein Sequence: MHLTSLSNSSQANNYSTTSSSLSSAAVNHHLGSYTALAATVATTPLLGGSIIEASGATTNHHQHHHLSSPSSSIANMVISSVSPASATTALHQQHHHHHHHHHTHPHSHPPPTPTSSTHSLGHSQPPPPPSHTHWNSEVTVASMASETIVASSSASVGSNSPNGAASNGTANSNNSSSNNNNNNTTQNSNNNNSSNNNSNNNNNVMHQDLAWLERSIMHAHQQFPNELVRTSNPYFLCSALPTHWRSNKTLPIAFKVVALVDVGDGTNVYIRAGNDENYCAELRNERATMKDQVAKFNDLRFVGRSGRDIPMSLGWLAGNDAHSLID

Sequence clustering based on sequence similarity using MMseqs2