Basic Information

Gene Symbol
pol
Assembly
GCA_951329385.1
Location
OX589608.1:9893562-9907945[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 6 4.8e-05 0.0082 18.4 1.0 2 23 721 742 720 742 0.97
2 6 4.9e-07 8.4e-05 24.6 2.7 1 23 748 770 748 770 0.99
3 6 3.4e-05 0.0058 18.8 0.6 2 23 776 797 775 797 0.97
4 6 0.0013 0.22 13.9 0.9 2 23 804 826 803 826 0.95
5 6 0.071 12 8.4 0.2 1 20 833 852 833 853 0.95
6 6 0.0001 0.018 17.3 1.1 3 23 865 886 864 886 0.96

Sequence Information

Coding Sequence
ATGAGGCGCACACCACCGCCTAAGAGCCTGTCTGCGTCGGATCCTAGCATTAACAAAACAGATGAAGCATCACTGCTGCCTAATGTCACAGTAAGAAGTGGCAAAAGAGTACGACTGGAAGAGGATGTAGTTACGGACTTTGAAACATTTAAGGTTGAGGTTATGGAAATGCTCACAGCGATGATATCCCCTTTGAGCTTAAGACTACAGGGTGTTGAAAAAACCTTATCAGACATCCTCTTGCAAAATTCTGAGATAAAGTCGTCTAATATTGAGATAGAAAAGTCGACcgactttataaaaaatcagATCTTTGAGTTTGAAAGGAAAATTAATGGGCTGGAAAGGGAACAAAGTGCTACCAACCTTTTGCTGGCAGAACTAGACGAAAAGTCGGAAAACCTTGATCGCATTCTGAGGAAAACTTCGGTAGAAATTAGAGGAGTTCCTAAAAACTTAAAAATCGCTCACGAAAAAGCCCTACTGGAAAGCTCGAAAGGCAACAGTAAAAATACATGGGCTGCAGTAAAATCTATCTGTAACCTGAACAATAAGACATCGTCTAATATGGCCCTCCTAAATGTCAATCCTGATCCAGTGGTTGCGCTGGACATGGCGAATAATTTCTTTGCCAATATAGGAGAACAATTAGCTAAAAACACTTTACTGCGTCTAAAAAAATCGGAAACCGACCTAGCTAAATTGATCAAAACAACTGAGAATACGGATATTTCACCAATTAACTCCTTTTTCATGAACCCTACCAATGAGATGGAAGTGAAATCAGTTCTGTCAAGCCTAAAAAATGACTCAGCTCCTGGATGGGATGGCATACCAAATCGGGTCCTCAAACTCACTCAGCACTGTCTTGCAGCTCCCATCGCGCACATTTGTAACTTAAGCATGTTTAATGGAAAAGTCCCACCCCAAATGAAGATAGCAAATGTGTGTCCGATTCATAAGGGAGGTGATGCAACTATGGTGTCAAACTACAGACCAATATCACTGCTCAcgtcattgtcaaaaatactGGAGAAACTAGTGAATAAGAGGCTGTTGACATATCTGGAAGACAAGAAGTTGCTTTCCACAAAACAGTACGGCTTTCGCAATGGCAGGTCCACGGAGGACGCTGTCACTAATTTAGTAGACTTTGTTGTTGGCCAACTTGACAGAGGGTTAAGATGTGGAGGTGTCTTCCTGGACCTTGCGAAGGCTTTTGATACTGTGTCGAAACCGATCCTTTTCCAGAAAATGGAATACAATGGCATTAGGGGCACTGCACTGGATTGGTTTATTTCGTATTTGACAGAACGCAAACAAAGGATCTGCTTGGGTGATATCCAGAGTTCCCTCGCCAATGTTGGATACGGAGTGCCTCAGGGCAGTGTCCTGGGCCCTACTTTGTTCCTACTATATGTCAACGGTCTCTGTTCATTGAACCTCAACAATGCACAGATCTTTGCGTATGCCGATGATACGGCTGTCATCTTTTACGGAAAGTCCTGGGAAGAAGTCTACAGAGCCGCAGAGTGTGGGATGATGACTATCTCTAATTGGCTACAGTACAACTTGTTGACACTTAacgtttcaaaaacaaaaatagttaaTTTCTCAATCAACAAAAAATCATCTGCTCCAGAACCCTCACTCAAATTCCATAGCTGTATCTACTTCCCGGGATGTACCTGCAACTGTCCCACATTTGAACAGATCGAATGCATTAAGTATCTTGGCATTAACATTGATCAAAACTTGACTTGGAGTAGGCATATTGACTCCCTGAACACACGTGTGAGAAAGCTGCTATACATATTCAGAAAACTGAGATCGATAGTAGACCACAACACTATGAAAACAACCTACTATGCACTGTGTCAGGCAATCCTAGGGTATTGTATAGTAGCTTGGGGCTCTGCAGGCAAAAGCATCTTAATtactgctgaacgagcgcaaaGAGCCATCCTAAAAACATCATATAGCAAAAGGTTACGTTACGCTACAGATGCACTGTATCGAGACACTGCCCTCCTCTACGCGCAGCCCAAAGAATGCATCCACTGCCATCGTTGTTTCAAGCGCGTGAACGAATGTAAACGTCACATCATAGAGCACTTACTAGTCGACGCGTACAACCAGAAGCATTTATACAAGGAACTGAAGTGCCAGATCTGCGACACCGGGTTCTCGGTCTCAGACAAATATAAGCAACACATGCGCAATCACGCGTCGTTACCCGTCTACAAGTGTGAATTGTGTGACAGAACATTTAGTGACTCCAGCAACTTCACCAAACATAAGAAAGTTCACAATTTGGAAGTGATCGTATGCGATCTGTGTGGCAAGAAATTCCAGTCTAAACTGTCTTTGGAAAAGCATATTCAGAAACATCAGACCACCACACCAATAGTTTGCAACGTTTGcaacaaaatattttactttgaGACTACCTACCGTCGACACGTCAGATATTATCACGAGAAAACCACGACCGAGTTCCGATGCGTCATCTGTAATAAACGCTACCCGAGTTTAAAACAGAAATGGGATCATATGTGGGAGGTACATAAAGAGAGAAAACAAAAAGCCGACTGCCCGATATGCCACAAATCTTTCAGGAAATACTCCGATGTACGAGCCCATGCGAAGTCTGAACACCTGAAGACAATTACCATTATGAGCGTCAAGAACGCCAGACCTCAAACGGCTAGTAAACGCGACGTTGTTCCGAATAAGTATTCCAGTAGTTCTGTGCCAACGGAGATCACTGTTCGCCAGGAACCGGAGACTTTGATTATTTATGATTCTGATTAA
Protein Sequence
MRRTPPPKSLSASDPSINKTDEASLLPNVTVRSGKRVRLEEDVVTDFETFKVEVMEMLTAMISPLSLRLQGVEKTLSDILLQNSEIKSSNIEIEKSTDFIKNQIFEFERKINGLEREQSATNLLLAELDEKSENLDRILRKTSVEIRGVPKNLKIAHEKALLESSKGNSKNTWAAVKSICNLNNKTSSNMALLNVNPDPVVALDMANNFFANIGEQLAKNTLLRLKKSETDLAKLIKTTENTDISPINSFFMNPTNEMEVKSVLSSLKNDSAPGWDGIPNRVLKLTQHCLAAPIAHICNLSMFNGKVPPQMKIANVCPIHKGGDATMVSNYRPISLLTSLSKILEKLVNKRLLTYLEDKKLLSTKQYGFRNGRSTEDAVTNLVDFVVGQLDRGLRCGGVFLDLAKAFDTVSKPILFQKMEYNGIRGTALDWFISYLTERKQRICLGDIQSSLANVGYGVPQGSVLGPTLFLLYVNGLCSLNLNNAQIFAYADDTAVIFYGKSWEEVYRAAECGMMTISNWLQYNLLTLNVSKTKIVNFSINKKSSAPEPSLKFHSCIYFPGCTCNCPTFEQIECIKYLGINIDQNLTWSRHIDSLNTRVRKLLYIFRKLRSIVDHNTMKTTYYALCQAILGYCIVAWGSAGKSILITAERAQRAILKTSYSKRLRYATDALYRDTALLYAQPKECIHCHRCFKRVNECKRHIIEHLLVDAYNQKHLYKELKCQICDTGFSVSDKYKQHMRNHASLPVYKCELCDRTFSDSSNFTKHKKVHNLEVIVCDLCGKKFQSKLSLEKHIQKHQTTTPIVCNVCNKIFYFETTYRRHVRYYHEKTTTEFRCVICNKRYPSLKQKWDHMWEVHKERKQKADCPICHKSFRKYSDVRAHAKSEHLKTITIMSVKNARPQTASKRDVVPNKYSSSSVPTEITVRQEPETLIIYDSD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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