Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 1.8e-05 0.0016 19.0 1.2 1 21 13 33 13 34 0.95

2 6 1.1e-06 9.9e-05 22.8 1.8 1 23 42 65 42 65 0.97

3 6 2e-05 0.0018 18.9 2.1 1 21 119 139 119 140 0.95

4 6 0.00012 0.01 16.5 3.4 1 23 148 171 148 171 0.95

5 6 1.9e-05 0.0017 19.0 0.1 3 21 200 218 199 219 0.95

6 6 0.00024 0.022 15.5 3.8 1 23 227 250 227 250 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	1.8e-05	0.0016	19.0	1.2	1	21	13	33	13	34	0.95
2	6	1.1e-06	9.9e-05	22.8	1.8	1	23	42	65	42	65	0.97
3	6	2e-05	0.0018	18.9	2.1	1	21	119	139	119	140	0.95
4	6	0.00012	0.01	16.5	3.4	1	23	148	171	148	171	0.95
5	6	1.9e-05	0.0017	19.0	0.1	3	21	200	218	199	219	0.95
6	6	0.00024	0.022	15.5	3.8	1	23	227	250	227	250	0.95

Coding Sequence: ATGGTCAAAGAAGTCAGCTAtcgaaatatgttattatatcaaTGTTCAATGTGCGGCCGCATGTATAAACATAGAAATACATTAGTAAGACATGTACAATATGAATGCGGAAAAATGCCTGGATTTTTTTGCCCATATTGTCCCCATAGGACTAAACAAAAGACCAATTTGGAAGCGCATATTCGTACTGTTCATTCAAACgtaaaatttttcgaaatgtctttaaatgatattcgtcctatcaattttttattttatttagtgtaCACCAAACCAAATCACACGAAAGCAGgAAGTTACCTCTCATGGCAATATTCAAACGTCGAAGGATTTACTTTAAGAGCTGATAAAGCATTTCCATGTAATAATTGTAATCATGGCTATTCacgaaagaaaaatttaataagacatCAAAAGTATGAGTGTGGAAAACAGCCGACATTTCAATGTCCCCATTGTCCGCATAAATCTAAGCAAAAATCTAATTTGGGGgctcatatttataataaacatatttcctcatatttgaaaattgcaTGGGATTTACGAATCGATCCAATGGATatcctaaaattaaaaaaattgcctGAAAATATATGTCCGCAATGTGGAAATGCGTATAAAAGAGCAAGTTCGTTAAAAAGACATCTAAAATATGAGTGCCAAAAGGAACCCCAACATATTTGTCCAATATGTAGCAAAAAAACACatcttaaaagtaatttattacagCATATGCGCTTAAGACATAATGTTACATCTTACGTTTag
Protein Sequence: MVKEVSYRNMLLYQCSMCGRMYKHRNTLVRHVQYECGKMPGFFCPYCPHRTKQKTNLEAHIRTVHSNVKFFEMSLNDIRPINFLFYLVYTKPNHTKAGSYLSWQYSNVEGFTLRADKAFPCNNCNHGYSRKKNLIRHQKYECGKQPTFQCPHCPHKSKQKSNLGAHIYNKHISSYLKIAWDLRIDPMDILKLKKLPENICPQCGNAYKRASSLKRHLKYECQKEPQHICPICSKKTHLKSNLLQHMRLRHNVTSYV

Sequence clustering based on sequence similarity using MMseqs2