Basic Information

Gene Symbol
-
Assembly
GCA_002278615.1
Location
NEEE01002629.1:22747-25777[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 6.7e-05 0.0059 17.2 1.7 2 23 30 51 29 51 0.96
2 16 0.016 1.4 9.8 1.7 1 23 57 80 57 80 0.93
3 16 0.005 0.44 11.4 2.4 2 23 84 106 83 106 0.94
4 16 5.2e-06 0.00046 20.8 1.4 2 21 115 134 114 135 0.93
5 16 0.02 1.7 9.5 5.0 1 23 143 165 143 165 0.99
6 16 0.0046 0.4 11.5 0.4 1 23 171 193 171 193 0.98
7 16 0.0004 0.035 14.8 3.4 1 23 199 221 199 221 0.95
8 16 0.00054 0.047 14.4 2.0 1 23 227 249 227 249 0.99
9 16 0.0078 0.69 10.7 1.6 2 23 515 536 514 536 0.95
10 16 3.2 2.9e+02 2.5 5.9 1 23 548 571 548 571 0.95
11 16 1.4e-05 0.0012 19.4 0.2 2 23 576 598 575 598 0.96
12 16 7.5e-05 0.0066 17.1 0.1 1 21 608 628 608 629 0.94
13 16 1.6e-05 0.0014 19.2 1.1 1 23 637 659 637 659 0.98
14 16 0.0042 0.37 11.6 2.6 3 23 667 687 666 687 0.98
15 16 1.7e-05 0.0015 19.1 0.9 1 23 693 715 693 715 0.96
16 16 0.016 1.4 9.8 4.6 1 23 721 743 721 743 0.97

Sequence Information

Coding Sequence
ATGAGATCAAACAATGACtctgaaataatatcttctaAAGAAactAAAATTGAAACCGATGATACAAatgacaacaataaaaaatcagaATGTTCGAAATGTGGtaaaaaatttcgatttttaaaagctttacAAAAACATGAAGAGCGTCATGAAGGTGCAGGTGGATTTATTTGTAGAACTTGTGGAATGACATTTACCTCACAATTTGAGAAAGATAAACATTACGATAAAGaacataaaatattacgGTGTCATATTTGTAACATACGTTTTGATTCAGAAACTGAATATTTACACCATATATATAGTTTGCATGAAGGCCGTGGTAGAGAAGTATCTATGTGTAGTACTTGcggaaaacaatttaaaacaaaaagcgAACTAACACatcatataaattcaaaatgtggcacattaaaaaaatataaatgtaaagtttGTTTTCAACATTTAATGACTTCTGGATCTTTACATAATCATATGTTAAGACACACTGGTTTACGTAAATATATGTGCAGATTTTGtgctaaaacttttttaacagCCGGACAATTAACCGTACATGAAAGAATACATACGCAAGAAAAAGCATTTGTTTGTGagataTGTAATAAAGGTTTTTGTCACCGTCAAAGTTTAATTACGCACAGCACTATTCACACAGGTATAAAACCATTTCAATGCGAAGGATGTGGAAATTCATTTTCATGTGTTGGtaatcttttaaaacataGAAAAACTCATGCAGAAACATGCGGAAAAAATCCATTAACTACCCATCGAGTTAAAAATcctataacaaaattaaaagtgcTTATAAATACGCCCGcaacagttaaattaaaagctttagaaaaacgcaaaaaaataGAACAAGTATCTATTGAACAAATACAATGTTCTAAATCATCGCAAGATACAAGTAATAGCTTGCCAGATAACAcagaagataataaaatgaaacatgaatcgaaagataattttaacatagaTATCGATGAAAGTTTTTTACATCCTTTTGAAAATGTACCCATTAAAGAAGaacaTTTAAATGATACTAAATGcagtaatattacaaatattcctTTGGAAGAAGAtccattatttatagataataatattgaaaaaacagAATTACCTCCACTTATTCCTTTTAACGATGAATCTCAAAcaacaaaagatattaatatatctataaatttaaataatacatatacaaacGAATCAGAAAATGAATCAAATTCAGAAGATTCAACGGACTTACATACaagacaattaaaattatatcaaataaatatagataataatattaatactcAAACTTTAAACAACGCAAATACAAATAcggataaatttaatttacaaataaacgttaaaaatgaaaatcccAGTACTACAAATAGTGATTTATCTATTGATTccgataaaaatttgaatagaaataGCGATCCAGATAATTCGAAAGATACTGATTTAAGTCCGAGGAAaactaaaaaagataaaaataagaagGATTCAAGAGAGCGAGGgcagaatttaaattgtaaatattgtggaactaaatatacatttacattATGGCTTAAGAAACATGAAGAAAAGCATGAAAAAGATATTAGAGaaggaaaaacaaatttatttaaatgtagctGTTGTAGTAAAACATTTGATTCCAAACAAGAATGTGTTAATCATCAACAAATTGAACATAGAAAtgaattaacatGTACAGATTGTGATAAATTATTCGCAAACACTGATAGTTTAAAAGCGCATATCAATGTATTTCATAAAGGAATTCAGCGTAAACAATATGTTTATGTATGCAAAAAATGTGGCCGAATTTATAAACAGAAAGCATTATTAATAGcacatgaaaaaaataattgtcgcAATGAATCAATATACCCATGTCGGATTTGCGGAAGATATTATGCCAGTAAACATACATTAAATGGTCACATGCGTATACATTTACCAGAAAAGGCATTACTTTGTAAATTTTGCGGAAAAAGTTTTCATTGGAAAGgacaattgaaaatacatgAACGATCTCATACGGGCGAGAAACCTTTTAAATGTcaggaaTGCCCGAAAACTTTCGCATATCGAGAGAGTCTAATAACTCATACAACTTTACATACGGGAATTAAACCGCATATGTGCAAAGGTTGTGGTTCAAGATTTTCCTGTataggaaatttattaaaacatcgaCGAACGCATGCTAGTACTTGTGGTATAGAACatattaaacaagaaaaactAGATGTTTTTGTTAcaacataa
Protein Sequence
MRSNNDSEIISSKETKIETDDTNDNNKKSECSKCGKKFRFLKALQKHEERHEGAGGFICRTCGMTFTSQFEKDKHYDKEHKILRCHICNIRFDSETEYLHHIYSLHEGRGREVSMCSTCGKQFKTKSELTHHINSKCGTLKKYKCKVCFQHLMTSGSLHNHMLRHTGLRKYMCRFCAKTFLTAGQLTVHERIHTQEKAFVCEICNKGFCHRQSLITHSTIHTGIKPFQCEGCGNSFSCVGNLLKHRKTHAETCGKNPLTTHRVKNPITKLKVLINTPATVKLKALEKRKKIEQVSIEQIQCSKSSQDTSNSLPDNTEDNKMKHESKDNFNIDIDESFLHPFENVPIKEEHLNDTKCSNITNIPLEEDPLFIDNNIEKTELPPLIPFNDESQTTKDINISINLNNTYTNESENESNSEDSTDLHTRQLKLYQINIDNNINTQTLNNANTNTDKFNLQINVKNENPSTTNSDLSIDSDKNLNRNSDPDNSKDTDLSPRKTKKDKNKKDSRERGQNLNCKYCGTKYTFTLWLKKHEEKHEKDIREGKTNLFKCSCCSKTFDSKQECVNHQQIEHRNELTCTDCDKLFANTDSLKAHINVFHKGIQRKQYVYVCKKCGRIYKQKALLIAHEKNNCRNESIYPCRICGRYYASKHTLNGHMRIHLPEKALLCKFCGKSFHWKGQLKIHERSHTGEKPFKCQECPKTFAYRESLITHTTLHTGIKPHMCKGCGSRFSCIGNLLKHRRTHASTCGIEHIKQEKLDVFVTT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-