Basic Information

Gene Symbol
-
Assembly
GCA_002278615.1
Location
NEEE01004245.1:110832-113249[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 0.0038 0.34 11.7 0.0 1 20 190 209 190 213 0.90
2 16 1e-05 0.00089 19.8 2.5 1 23 218 240 218 240 0.99
3 16 3.3e-05 0.0029 18.2 0.9 1 23 264 286 264 286 0.98
4 16 0.00011 0.0099 16.5 0.5 1 23 299 322 299 322 0.96
5 16 0.00013 0.011 16.4 0.6 1 23 332 354 332 354 0.98
6 16 0.35 31 5.6 0.3 1 23 371 394 371 394 0.92
7 16 0.01 0.9 10.4 1.6 1 21 407 427 407 428 0.94
8 16 3.8e-06 0.00034 21.2 0.3 1 23 446 470 446 470 0.97
9 16 8.6 7.6e+02 1.2 2.7 2 23 477 499 476 499 0.89
10 16 3.4e-05 0.003 18.2 2.2 1 23 505 527 505 527 0.93
11 16 0.00014 0.012 16.3 1.7 1 23 533 555 533 555 0.98
12 16 1.6e-05 0.0014 19.2 1.1 1 23 561 583 561 583 0.98
13 16 0.00024 0.021 15.5 3.1 1 23 589 611 589 611 0.99
14 16 0.00051 0.045 14.5 1.0 1 23 617 639 617 639 0.98
15 16 5.1e-07 4.5e-05 23.9 1.5 1 23 645 667 645 667 0.97
16 16 1.8e-05 0.0016 19.0 2.4 1 23 673 695 673 695 0.97

Sequence Information

Coding Sequence
atggcAGATCAAATAGATGATCAGTGTCGTACTTGTTTAACACAAGTATGTGATATGGTTTCTTTAACAGCAGATCATGTTGTTTGCAGTAAGGTTATGTCTATtctagatttattaaaaacatgtacATCTGTTGAGATTAAAGTCGACGATGATTACCCacaatttgtttgtttggAATGTATTCGTAAAGTTGAAAAATCTTACGAATTTAGAATACAATGCGAGGAAGCTGATAAAGCATTACGCTCGCGCGATTCAATCATTTCTGATTCGAAATCGgaccatttaataattaaaaaagaggaattaaatattaccgATAAAAAAACACCCGGTGATTCAGCTTCAGAATTGAATAAAGATGATGAAGATTCATTAAGTGAATACGAGGATTATGAAGTTTTAGAAGAAAGTACTGaagaaaattttgatgaaaatgatGAAGTTACAGCTGATGAAACGCTTGAAGTTGTTAATGAAACTAATTTCGAAGAAATAAGTATTGATGTGTTACAAAGTAATACAAATGGTATTAAATGTcaagaaattgaaattattgaagCATATTCATGcacaatttgtaatttaatttatcctaCACCAGCGGCGTTAGCTAAACACAGTGCTTTCGCACATCCCCCCGTATTTTTTCAATGCACGCATTGTCCTGTTAGATTTATAACCGAGGAATTATTAAAACGACATCTTAAAAAACatactacaaataaaaaagacgAACAAAAACCTACgcgtaaatacataaaacaaaaaaataaaccaattgattatatttgtaCAACATGCGGTAAAAAATTCTCGTCAATGCCAGCATTACGGTTACACAGTCGCAAACATTCTCAACCAGAAATTGACCCAGAtccaattaaaacatttaattgcgATTCGTGCAACGAACAATTCACCTCTGAAGATGATTTAAAAACGCATATATCTAGAAtccatataaaaaaagaaaaaccacCGCGTAAATATAATTGCGTACAATGTTCGAAAGATTTTCCGAACATGGATACTTTGAAAAAACATCTAGCAACCCATCAATCCGATTCCGAACAACAATCGGTACcggctttatataaaatggtttataaatgtaaagtttGTAACTtcgaagttaaaattttaactgatattAAAGATCATTTAATGAATGAGCATGATATACCGACggagaatatttttaagaatttattatatatgtgtaATGAATGCCAGAAAGATTTTGATAGTATTTATGATTACTTTCATCATACAAATAATCGTAAGGCAGATGATCAAGTTACTTGTTCATTAACTACGAAAAAAAGGCCGTATGTTTGTAGTATAAGCACTTGCGGGAAAACTTTTCCAACTCCGAGCGCGTTAAAAAATCATAGTAAAAGTCATCAATCGCATTGGccgaaaaaatgtaaatattgcgATGCGTTGGTTCATAAATTGCATGAATATATTCAACATTTAAACGATAACCATGAACATTTAAAAGGATATCAGTGTAAAACTTGCgggaaaaagttttttaacgaaagaaatttaaaaacgcaTTCAGGAATACATACAGGCGAACGAAATTACATATGTGATTATTGCGGTTTTAGTTTTCACGCGCGTAACAATTTGGTTTCTCATCGAAGAATTCATGAAGGTGTTAAGCCATATAAATGTACGTATTGTCCTATGGCGTTTTCACAACACGCGGGTTTAAGATCACATTTATTAAACCATACGCAAGAGAAAAAATACGAATGTCCAACTTGTAACCGTAAATTTTTACGTCATAGTGCAATGAAAAATCACATAAAAACGCATACCGGGCAAAAAGATTACGTTTGTCATGTATGCGGAGCAAAATTTGGTGCATCATCTTCTcggaaaaaacatttattaacacATACAGGTGAGAGAAATCATGTTTGTGACTTTTGCGGGAAGGCATTTGGccgtaaatcaaatttaaccgTACATAGAAAAATACATACCGGCGAAACTCCCCATGTGTGCGAGCAATGTGGGAAAGGATTTATTCAAAAGCATGTTTTACGTTCACATATGGATACACATAAGAAACAAGCGGAAATAATTTCTGGGAAAAGAGCTGCTAGGAGAAAAAGAGCCGCGGAAATTATTgaagaattaaaaagtaacaacGACTCCGAGGAATTAACTGTGTTTGTTGAATTTCAAGAATAA
Protein Sequence
MADQIDDQCRTCLTQVCDMVSLTADHVVCSKVMSILDLLKTCTSVEIKVDDDYPQFVCLECIRKVEKSYEFRIQCEEADKALRSRDSIISDSKSDHLIIKKEELNITDKKTPGDSASELNKDDEDSLSEYEDYEVLEESTEENFDENDEVTADETLEVVNETNFEEISIDVLQSNTNGIKCQEIEIIEAYSCTICNLIYPTPAALAKHSAFAHPPVFFQCTHCPVRFITEELLKRHLKKHTTNKKDEQKPTRKYIKQKNKPIDYICTTCGKKFSSMPALRLHSRKHSQPEIDPDPIKTFNCDSCNEQFTSEDDLKTHISRIHIKKEKPPRKYNCVQCSKDFPNMDTLKKHLATHQSDSEQQSVPALYKMVYKCKVCNFEVKILTDIKDHLMNEHDIPTENIFKNLLYMCNECQKDFDSIYDYFHHTNNRKADDQVTCSLTTKKRPYVCSISTCGKTFPTPSALKNHSKSHQSHWPKKCKYCDALVHKLHEYIQHLNDNHEHLKGYQCKTCGKKFFNERNLKTHSGIHTGERNYICDYCGFSFHARNNLVSHRRIHEGVKPYKCTYCPMAFSQHAGLRSHLLNHTQEKKYECPTCNRKFLRHSAMKNHIKTHTGQKDYVCHVCGAKFGASSSRKKHLLTHTGERNHVCDFCGKAFGRKSNLTVHRKIHTGETPHVCEQCGKGFIQKHVLRSHMDTHKKQAEIISGKRAARRKRAAEIIEELKSNNDSEELTVFVEFQE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-