Basic Information

Gene Symbol
-
Assembly
GCA_950381575.1
Location
OX494460.1:1698008-1708629[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 7.6 6.4e+02 1.8 1.6 1 12 279 290 279 294 0.85
2 13 5.2 4.4e+02 2.4 0.1 2 14 351 363 350 364 0.83
3 13 0.022 1.9 9.8 0.2 2 20 374 392 373 394 0.93
4 13 0.72 61 5.1 1.2 1 23 399 421 399 421 0.80
5 13 4.4 3.7e+02 2.6 0.4 1 9 651 659 651 670 0.75
6 13 6.5 5.5e+02 2.0 0.5 1 23 683 709 683 709 0.86
7 13 0.61 52 5.3 0.1 2 13 715 726 714 736 0.79
8 13 1.6e-05 0.0013 19.7 0.5 2 23 849 870 848 870 0.96
9 13 1.8e-07 1.5e-05 25.8 2.8 1 23 876 898 876 898 0.98
10 13 0.0012 0.1 13.8 1.2 1 23 903 925 903 925 0.98
11 13 0.51 43 5.5 3.1 3 23 933 954 931 954 0.94
12 13 3.4 2.8e+02 3.0 0.2 1 20 961 980 961 981 0.93
13 13 0.00062 0.052 14.7 0.4 3 23 993 1014 992 1014 0.95

Sequence Information

Coding Sequence
ATGGCAGATACTACAAGAAAAAGGTCGAGAAAATCAAAAATAGTACCTCGAAAGTGTaactttataaatttaaattctgaCAGCGATGACAATAGTTTGGAGGAGTCACCGCTGAATAAATTCTTAAGACAAGCCTGCAACGCCTTTGATATAAAAGATGAACCGACCACCTCCGCATGTCCTATCACAGAAATGTATGCTACAGAAACATTTACCAATCAAATGCCAATGATTCACATAACAGAACCACCGATGAAGATTAACGTACAAGTTAAAGTAGAACAATGTGATGATAGAATTGAAACTTATAAGCAgaaacaaccaaaaaaaaaagtttttaatcaaGCAGccttttggaaaaaatacaAGTTAAGAAAGTTTAATTTAAGCAACAGTGTAATATGTTTTGCTGCTGATAAAATAAAGGAACATTCCACAAGTGTTGCAGATAAAATTCTTGATATCGCAGTAAGAAATACATCTGGCCATATTGTCAAAGGATTGCAACACAATACTTTTCATAATATTGCTATACAGAATGCTTTAGATCAATGGAAGGTCTGGCAGACCAAGCATTTCTTGAGAGACGGACCGTTATTCTACAAATGTTATATTTGTACGGAAGCATGGTGGTATTTAGAACATTTTAAGCAGCATTTAGTAATACATGCAGAGGTCAATATCTCAATTGAAGGCCAGTCACTCCATGAGATTAATATCATAGCCTACATCGATTCTTTTCCAACGAAAGAGGATATATTTGTACATGGAAGATGTGGCCGTTGCGGTGAAGATTATAACAAGCACAGCGGTGTTCTTAAACCAAGTAAATTATACACCTGTAACGGTTGCTTGAAGCAGTTTCATACTTGTTTGAGTTTAGGTTTCCATGTCTCAAATTGCCAGACAGGTGGTGTCCCAGAAACAAGGATACCTTGCCATATATGTAAATTACTGGCAATACCGTCTGAAAACAACTTTGAACATTTGATAACGGTGCACTCAGTGAGATCAGATGTTCCAATTATAACGAGACGGTGTCAGTTTATTACTTGTGAGAAGTGTAATGAAAGTTATATTATGAATAGTGAACATGTCTGTGATATGACTCCTTATATACGTTGTGAACACTGCTTCAGAGGGTTTCCAACAAAAACCTTGTTGGATTCACATTTAGAAGGCTATTCTGGATCATACCAGTGCCCAATATGTGATGAGACATTGGAATGGCAGTGTAAGAAATATGAACATATGTTAACGCACAGTGACAAGTATGCTATTGTtatgaaatgtatattatgcATTAAATTAAGTGTGTATCTTAGTCATACAGGATTTGTGAGACACTTGAAATCGGTCCATCCATATGCGGATTATACTAAACCAGGGTTTTTTACTCAAATAATGATTCCAGTAAGTTGTTTACATCCTTTCTTCGATACATACGCTGAGGATAATAACCGGATactaaaagataaagatattacAGAAGTAACTGAAGTAACAGAAGAAAACATTATAAACGTAAAACAGGAAGTAATCGAAGTAGATTCAGATGATAATGAAGACacagtaaaaattaaaactgaaatagAGAGCGAAGCAgaagaaattaaagaaattgAAGACGAAACTcctgaaattcaaataaaaaCTGAACCTCTTGAAACAGAGCCATTCTCTGAACTAACAATCAAAGAAGAACCACTTGAAGGGGCCAACGAAATTGATGCAGCTGAATATTACTCCACACTCGATGTTATTGTTAAAGATGAATTGAACCAAGATGATATAGATGTTTATGAAgaagatataataaaactagACATGGACTTCAATTATGAAACTAAAAATGAAAACGATGAGAGCCAAGACGCTGTATCAAATGAATTTGATAATCAATCCGATTTTGAAGATGAATTATTAGAACTGAGGAAAACTAAGAAAATTTACAGATGCACTGAATGTGGATTCAAGGCCTTACACAGAAGTTATAAAAATCATATCGCAAATAATTGTAGTAGAAAATTCATTTCGACGAACCAATTTGTTTGCACCCAATGCGAGGTTTATCAAAATAGCTCCTTCAAAAGTCTTGGGAAATATCTTGCACATTTAACTTCCCATGGCTATGAAGCTACGACTTGCCCTGTATGCTCCCGAGAGTTTAGTTCCAATTTGAGACTTGGACCTCATGTCCTAAGTCATGTGaaacaattatatataaaagtgAAATCGTTTACCGGAGAGGGACCACATAATAAAGATGAATTTCAGTGTAGTAAGTGCTCTAGTATAGTTGAAATGGACAACTTTTTCGCTCACTGGGAATCGCACTTAAGTTTGAGGGCTACTCAGCCTGAATTGACTGAGAAAACAGTTACGTCGCCCGAAGTCGTCGAGTTATTGGctcGAATCCACAAGCGAACGAAGGAATGCTGTTTCTGCCAGCGAACCTTCACCAGATTCAATGAGTGCAAAAGACATCACATAGAACATCTCCTGACTGATGCATATGAACACAAGGACCAGTACCAAGAACTACGGTGCCAGATCTGTGGAGAAGGCTTCAAAACAGCAGAGAAATATAGACAGCATATGCGGGACCATGCGTCCCTACCCGTCTATAGATGTGACATGTGTGATAAATCGTTCAGTGACTcaagtaattttacaaaacacaaaaaagtgcATAATTTTAAAGTGTTTGTGTGTGATCTGTGCAGAAGGAAGTTTCAATCGAAGACGGGACTTGTTAAACATCTCACGATGCACATGAATACGGAACcaatattttgtgaattatgtaaaaaatcttttcattttGATTCCGTTTACCGGAAACACGTAAAGTATTACcataataaagaaaatgtgGGCTATCCTTGTATCATATGTAATATTAGATTCAATTCTATTAAACATAAGTGGAATCATATGTGGGAGGTGCATAGGGAAAGGAAAATTATAGCTGATTGTCCCATATGCCATAAATCCTTCAGAATTCTCTCTGAAGTTCGAGCGCATGTGAAGAATGTACATAGGCAGAAAATTAAGCTCGGTTga
Protein Sequence
MADTTRKRSRKSKIVPRKCNFINLNSDSDDNSLEESPLNKFLRQACNAFDIKDEPTTSACPITEMYATETFTNQMPMIHITEPPMKINVQVKVEQCDDRIETYKQKQPKKKVFNQAAFWKKYKLRKFNLSNSVICFAADKIKEHSTSVADKILDIAVRNTSGHIVKGLQHNTFHNIAIQNALDQWKVWQTKHFLRDGPLFYKCYICTEAWWYLEHFKQHLVIHAEVNISIEGQSLHEINIIAYIDSFPTKEDIFVHGRCGRCGEDYNKHSGVLKPSKLYTCNGCLKQFHTCLSLGFHVSNCQTGGVPETRIPCHICKLLAIPSENNFEHLITVHSVRSDVPIITRRCQFITCEKCNESYIMNSEHVCDMTPYIRCEHCFRGFPTKTLLDSHLEGYSGSYQCPICDETLEWQCKKYEHMLTHSDKYAIVMKCILCIKLSVYLSHTGFVRHLKSVHPYADYTKPGFFTQIMIPVSCLHPFFDTYAEDNNRILKDKDITEVTEVTEENIINVKQEVIEVDSDDNEDTVKIKTEIESEAEEIKEIEDETPEIQIKTEPLETEPFSELTIKEEPLEGANEIDAAEYYSTLDVIVKDELNQDDIDVYEEDIIKLDMDFNYETKNENDESQDAVSNEFDNQSDFEDELLELRKTKKIYRCTECGFKALHRSYKNHIANNCSRKFISTNQFVCTQCEVYQNSSFKSLGKYLAHLTSHGYEATTCPVCSREFSSNLRLGPHVLSHVKQLYIKVKSFTGEGPHNKDEFQCSKCSSIVEMDNFFAHWESHLSLRATQPELTEKTVTSPEVVELLARIHKRTKECCFCQRTFTRFNECKRHHIEHLLTDAYEHKDQYQELRCQICGEGFKTAEKYRQHMRDHASLPVYRCDMCDKSFSDSSNFTKHKKVHNFKVFVCDLCRRKFQSKTGLVKHLTMHMNTEPIFCELCKKSFHFDSVYRKHVKYYHNKENVGYPCIICNIRFNSIKHKWNHMWEVHRERKIIADCPICHKSFRILSEVRAHVKNVHRQKIKLG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-