Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.0017 0.94 13.4 1.0 2 23 79 100 78 100 0.94

2 7 0.0077 4.2 11.3 1.7 1 23 106 128 106 128 0.96

3 7 0.74 4e+02 5.1 1.2 1 20 133 152 133 155 0.94

4 7 0.022 12 9.9 4.6 1 23 161 183 161 183 0.95

5 7 0.001 0.54 14.1 0.5 1 23 189 211 189 211 0.98

6 7 0.00017 0.095 16.5 0.6 1 23 240 263 240 263 0.96

7 7 0.0047 2.6 12.0 2.9 2 23 267 288 266 288 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.0017	0.94	13.4	1.0	2	23	79	100	78	100	0.94
2	7	0.0077	4.2	11.3	1.7	1	23	106	128	106	128	0.96
3	7	0.74	4e+02	5.1	1.2	1	20	133	152	133	155	0.94
4	7	0.022	12	9.9	4.6	1	23	161	183	161	183	0.95
5	7	0.001	0.54	14.1	0.5	1	23	189	211	189	211	0.98
6	7	0.00017	0.095	16.5	0.6	1	23	240	263	240	263	0.96
7	7	0.0047	2.6	12.0	2.9	2	23	267	288	266	288	0.97

Coding Sequence: ATGTTCGACGCTGAAACTTCTACGAATCTAAACGAAGATGAAAAACCCCTTTCTGCTGATGTGGTTGAACCTAGCTCGTCTACGTTACAATTTGTTAAAAAAGAGCCCGAACCTATTGAAGACCACCCTAAAGAAGACGCAAGTTTAACCCAAGACGAAGTCGAATTGTATGCAACCACAGGCCAAAGCGATCACGAACAACAATGCACAACTGTTGCTAGTAACGAATCGCTGACGTGTAACTTGTGCTCGTACAAAACATTTCAGAGCGACGACCTTGAGCAACACATGACAAACCATGTTATCAAGAAGTTGTATATCTGTCATTTGTGCGATTACAAATCGCTTAAAAACGCCGAGCTGCTATCCCACATGAAAACGCATGCTCCTAAGACGTATTCATGCAGATTCTGTGATTATCAAGCGTTTACTGGAAGTCATCTTAAGCTTCACATATGGGGCCATAAAGGTGAAACTCCGTTTCCGTGTCATTTATGCGAGTTTCAAGCGTTTAATAAGAGTCATCTTAAGCTTCATCTAACCACACACGCCGCCGAGAAACCCTTCGTATGTTACGTATGTAAATTCAGAGCAAGCAACAAGACAGGTTTGAATTTACATATACGTATTCATGCTAAAACTGGGTATGCATTGAGTGTTGCCTACCCGTGCAAGGTACGTCATCATATCAGAAAATCAATCAATAACAATAACATCTTTGCTTGCAACTACTGCGATTATATAACACCGTATCAAGGAATGCTCAATCGTCATACTAGACAAAACCACCAGATCATAACATGCAGCGTGTGTAAGTACAGAACAACTAAgaaatttttcttgaaattacaTATGAAATTGCATATGAAATTTCACGCTGCAAAGAAAGCGCTTGCAAAGCGTAACCGCAAAAACTCTGGAAAAGCTCgtaagtataaataa
Protein Sequence: MFDAETSTNLNEDEKPLSADVVEPSSSTLQFVKKEPEPIEDHPKEDASLTQDEVELYATTGQSDHEQQCTTVASNESLTCNLCSYKTFQSDDLEQHMTNHVIKKLYICHLCDYKSLKNAELLSHMKTHAPKTYSCRFCDYQAFTGSHLKLHIWGHKGETPFPCHLCEFQAFNKSHLKLHLTTHAAEKPFVCYVCKFRASNKTGLNLHIRIHAKTGYALSVAYPCKVRHHIRKSINNNNIFACNYCDYITPYQGMLNRHTRQNHQIITCSVCKYRTTKKFFLKLHMKLHMKFHAAKKALAKRNRKNSGKARKYK

Sequence clustering based on sequence similarity using MMseqs2