Basic Information

Gene Symbol
-
Assembly
GCA_941918875.1
Location
CALNXE010002424.1:155093-156823[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 7 0.0011 0.09 13.9 5.9 3 23 115 136 113 136 0.94
2 7 5.2e-05 0.0042 18.1 0.7 1 23 143 166 143 166 0.97
3 7 6e-05 0.0049 17.9 0.1 1 23 171 193 171 193 0.98
4 7 0.00031 0.026 15.6 0.7 1 23 199 222 199 222 0.94
5 7 0.0009 0.074 14.2 3.8 1 23 228 250 228 250 0.99
6 7 2.3e-05 0.0019 19.2 3.7 3 23 258 278 257 278 0.97
7 7 0.0042 0.34 12.1 1.6 1 23 284 307 284 307 0.97

Sequence Information

Coding Sequence
ATGAAACCACTCACCTTTGACCAATGGGACGATGCTACATGTAAATTCATCGAGATATATGCGAAATTTCCACTACTTTATAATGGAGAACATCCGTTATATGGCAGATATGAAGAGATGCAAAAGGCCATAACGGAAATTCACAACATTTTGCAAAGCGAGCACAAAATAGATTTTAGTGAAGAAACACTATCCGATGCTATAGATCAACTGCAAACGTGGTATTATTCAACCAAACGTCGAAATCATAAGGCTGACAATGCTAAATTCGGCAAATATCGCGAGGACTATTTGAAAAAGTGCAAATTTTTACCGGTGAAGCGATTAAAAGTAAAGATTATTTGTAGTATCTGTGACAAAAACTTTCATACAGAACATAATTTTAAACACCATTTAACGAAAGTTCATCAAATCGGAGACTTTACATTTCAATGTGATCAATGCGGAAAGAAACTTATTTCGAAATCGGTTCTACAGAGTCACACTCAAAGAGTTCATTTGAAAAAAAAATATCCATGCGAGTTTTGTGGAAAGTTATTTGCTATTCCTTCAGAATTGAGAACCCACACTCTGGTACACACGGCCGAGAAGCCACATATTTGTGAATTGTGTGGCAAAGGATTTAGATTACGAAATAATTTGGTTCTACATGTAACACGCATGCACACCAAAATACGTGCCTTTAAATGTACGATGTGTCCCAAAGACTTTCTAAAAAATTGCGATCTAAAGGACCATATGAAATCTCATTTAAATATACGCGACAAAATATGCGAAACTTGTGGCAAAGGTTTTACAAATTGTCACTCCTTAATACGTCATCGTCAAATACACTCAGAAATAAAGAAATTTGCTTGCAAACTATGCGATGCAAAATTCCATCAATTCGTTGGACTCAATGGTCATATGAAACGTACTCATAATATAGTAAAAAAAGACGCTAGCAATTAA
Protein Sequence
MKPLTFDQWDDATCKFIEIYAKFPLLYNGEHPLYGRYEEMQKAITEIHNILQSEHKIDFSEETLSDAIDQLQTWYYSTKRRNHKADNAKFGKYREDYLKKCKFLPVKRLKVKIICSICDKNFHTEHNFKHHLTKVHQIGDFTFQCDQCGKKLISKSVLQSHTQRVHLKKKYPCEFCGKLFAIPSELRTHTLVHTAEKPHICELCGKGFRLRNNLVLHVTRMHTKIRAFKCTMCPKDFLKNCDLKDHMKSHLNIRDKICETCGKGFTNCHSLIRHRQIHSEIKKFACKLCDAKFHQFVGLNGHMKRTHNIVKKDASN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

90% Identity
iTF_01201920;
80% Identity
-