Pcog065415.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Philonthus cognatus
Gene Symbol
Runx1
Assembly
GCA_932526485.1
Location
CAKOBG010000396.1:1193474-1193881[+]

Transcription Factor Domain

TF Family
Runt
Domain
Runt domain
PFAM
PF00853
TF Group
Beta-Scaffold Factors
Description
The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 1e-53 1.6e-49 169.1 0.0 4 94 34 124 31 132 0.95

Sequence Information

Coding Sequence
ATGCATCTGGCCAGCGAGGTCAGCTCCACGACGGGTCACTACGACCGCAACTACGGAAACTTGACGGCGGAGATGCTCGCCGAAAGGACGCTGGACGGACTCCTCGCCGAGCACCCGGGGGAGCTCGTGAGGACGGGAAGTCCGCACGTCGTGTGCACGGTGTTGCCGCCGCACTGGAGGTCCAACAAGACGCTACCTGTGGCTTTCAAGGTCGTCGCCCTGGGGGATGTGGGCGACGGCACCGTCGTCACCGTGCGCGCTGGTAACGATGAGAACTACTGCGCCGAACTGAGGAACTGTACCGCCGTCATGAAGAACCAAGTAGCTAAATTTAATGATCTTAGATTCGTCGGAAGAAGTGGAAGAGGTGAGTTATCTATAACACAACAAAAAATCCTTTTACTTTGA
Protein Sequence
MHLASEVSSTTGHYDRNYGNLTAEMLAERTLDGLLAEHPGELVRTGSPHVVCTVLPPHWRSNKTLPVAFKVVALGDVGDGTVVTVRAGNDENYCAELRNCTAVMKNQVAKFNDLRFVGRSGRGELSITQQKILLL