Basic Information

Transcription Factor Domain

TF Family: TEA
Domain: TEA domain
PFAM: PF01285
TF Group: Helix-turn-helix
Description: The TEA domain is a DNA-binding region of about 66 to 68 amino acids that has been named after the two proteins that originally defined the domain: TEF-1 and AbaA. The TEA domain is located toward the N terminus of eukaryotic transcription factors of the TEA/ATTS family. It shows a three-helix bundle with a homeodomain fold [3, 1]. Two α-helices are nearly anti-parallel and pack on either side of the third one, which is the DNA-recognition helix of the TEA domain. Phosphorylation of one or both of the two conserved serines found on the DNA-binding surface could interfere with DNA-binding activity, by introducing electrostatic repulsion and/or steric hindrance, and help regulate the transcription factor activity of the proteins [2, 1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 4 4.3e+04 -4.1 0.9 30 37 33 40 22 47 0.53

2 3 4.4e-10 4.7e-06 28.0 0.0 2 38 102 140 101 143 0.89

3 3 1.8 1.9e+04 -2.8 0.4 33 35 285 287 266 320 0.49

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	4	4.3e+04	-4.1	0.9	30	37	33	40	22	47	0.53
2	3	4.4e-10	4.7e-06	28.0	0.0	2	38	102	140	101	143	0.89
3	3	1.8	1.9e+04	-2.8	0.4	33	35	285	287	266	320	0.49

Coding Sequence: ATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAGGATAAAGATAAGAATAAGAAAAAGGATAAGAACAAGGAGAAGGAAAAGGCATGGGTTAATCATTAACGGTATTGTCGGACCCGGCACCATAACGTCGCCGTGGACACCAGTAAGTGCCGGTCCCCCAGGTCCATTGGGACCGGCAGACACAAATGGCAGCATGGCGGATAGCAAAAACTTGGATGTCGGCGATATGAGTGACGACGAAAAAGATCTCTCATCCGCCGATGCCGAAGGCGTCTGGAGTCCTGATATTGAACAAAGTTTTCAAGAGGCTCTCTCAATATATCCACCATGTGGAAGACGGAAAATTATACTCTCCGATGAGGGCAAAATGTATGATAACAACAATAACAACAACAATAACAACAACAACCACAACAACAACCACAACAACAAAAACAATAACAACAACAACAACAACAACAACAAGAACAACCACAACCTTAACAATTGCGGAAGTAATGTTGAACGCCAACAACAAATTGCGAAAAATTCAAATCAGAAAATCGCCCAAAATGATCTATGTGTCTACTTGATACTGAACGCAACATCAAAGTGCATCTTCGTCACCACACACAGAAACGACGACGACAACGACGTCAACACTGAAAACAATATAGTACATAAAATATGGTTGAAAACTTTCGAAACTTCATGTGTAACAGTTAAAGTAACAGCAACGGAAATGACAACAACAACACCATCAACAACAACAACAACAACAACAACAACAGCAACAACAACAACAACAACAAAAAGGATAAAACAAGAACACCAAAGACAAATATGTCAAGCGAAGTATTTACAACTAAGCATATTTTTAGGCATGTTTGGGTTGGGCAACACTTCAACACAGCAGCAACAGCAACAACAGCAGCAGCAGCAGCATAAGTTGAGCAACTATTTTGCAAAGTTCAAAAAGTTCAATATTATCTAA
Protein Sequence: IRIRIRIRIRIRIRIRIRIRIRIRIKIRIRKRIRTRRRKRHGLIINGIVGPGTITSPWTPVSAGPPGPLGPADTNGSMADSKNLDVGDMSDDEKDLSSADAEGVWSPDIEQSFQEALSIYPPCGRRKIILSDEGKMYDNNNNNNNNNNNHNNNHNNKNNNNNNNNNNKNNHNLNNCGSNVERQQQIAKNSNQKIAQNDLCVYLILNATSKCIFVTTHRNDDDNDVNTENNIVHKIWLKTFETSCVTVKVTATEMTTTTPSTTTTTTTTTATTTTTTKRIKQEHQRQICQAKYLQLSIFLGMFGLGNTSTQQQQQQQQQQQHKLSNYFAKFKKFNII

Sequence clustering based on sequence similarity using MMseqs2