Basic Information

Gene Symbol
-
Assembly
GCA_905333125.1
Location
HG995427.1:2053389-2065074[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 2.9 1.7e+02 3.1 0.1 1 20 263 282 263 286 0.88
2 10 1.6 97 3.9 0.7 1 23 318 340 318 340 0.88
3 10 0.0091 0.54 10.9 1.9 1 23 393 416 393 416 0.96
4 10 2.7e-05 0.0016 18.9 3.1 2 23 421 442 420 442 0.97
5 10 1.3 75 4.2 0.8 2 23 450 470 450 470 0.92
6 10 2.9e-05 0.0017 18.8 1.9 1 21 476 496 476 501 0.95
7 10 0.0009 0.054 14.1 0.3 1 23 509 532 509 532 0.94
8 10 0.00013 0.0078 16.7 0.1 1 23 538 561 538 561 0.97
9 10 1.8e-05 0.001 19.5 0.6 1 23 571 593 571 593 0.94
10 10 6.5e-05 0.0039 17.7 2.9 2 23 600 622 599 622 0.96

Sequence Information

Coding Sequence
ATGGAGCAGGATGTGGAAAGTGGATTCGGTACTATGTGCTGTACGTGCCTGAGTAGCTCACGCGATTTATTTTCAATAAATAACGTATCTCAAGTGTATCAAATATTTAGATTGCTCATGTACGATTTCGCGGGAGACAGATTTGGTGACTCCCTGTCAGACATGGAGCAGCTCGTCTGCTGGGAGTGCCTGGCGCTGATGAGGAGATTCATCAAGTTCAAATGGCAGGTGCATAATGCTCAAGAGCACTTAAGGGTTATAGCACTCAGTCGCAGTCAAGAGAGCATGGACCACACATACATGTCCCAGTCGCTCTCCTCGCTCCAAATTGAGACTAAAACGGAGTATGATAAGATCTATTTCGAGTTCTCCAACGAGCCCGAGGAGCAGCAGTACATAGCTATTAGCAGTGTCCACACGCATGTCAAGAATGAGAGCTTCGATGTTGCCCAAGCGGTCCGGGATAACATCAATTTGGGTTTGGAGGATCATATCTTGGATGTGCCCATATTGGAGAATCCTGTGCTCGGTGTAATGTCACACATAGTGGTGGGCACCGATGCACTAGTCTCCTCCGCCGACTTGCCCCATACCGATGGGGCAATACCTCACCTAACTATTGCGCCGCTATTAAACACTCCGAAGCTGGAGATGATGCCCAAGGGCAAGCAGAAGCCGGACCAGGCAGTCAGCAAGTGTGGCTTCGTCACCGAGTACATGACGGAACCGGAGATGTTGGGATGCAGAGAGGCGGCCAAGCAAAAAGTACAATATGCCAGCTCTGTATACAAATGTGAGCTGTGCATAATAGGGTTCTACACGCAACAACAGGTCGAGGACCATTTTGTTGGTGCCCACAGAGCTAAACCCGGGCAGGAGCCGTGCAAAGTGTGCTACGTGTACGTGGACGAGGCGAAGCTCGCTGCCCACGTGGACCAGCACTACTGCCGGTACTCGTGCAAGCTGTGCGGCCACGTGGAGTACAGCGCCAGGCTGGCGCAGCAGCACCAGCAGGGGCACAGCGTCAAGCCGCTGCCCGGCGCCGTCATCAAGATCGGCGACGTCGGACCCACTGCCGCGGGCAAGAGTAAAAAGAAAAAAAGCAAGGAGCCCCAGAAGACCCCGCCGAAGCCCGGCGACCTGAGGAAGCTGCTGTCCAAAACCACGATAGAGGGATACCAGTGCCTGGAGTGCGAGATGTTCTTCAAGAATTCTCGCTCTCGTAAAAATCATGTAGCGAGATACCACAGGGAGGGGCTGCAATGCGACCATTGCAAGAAGCGATTCGTGAACCGAACCACGCTGGCAACACACCTCAGGCTCCACGAAGGCCCCCTGCCCCGCGAGGAGTGCCCGGTCTGCCACAAGCTGGTGCGCGTCATCCAGCTCAAGTACCACGTGCAGCGCCACCAGAGCAAGAGCCGCTACCAGTGCCGCGACTGCGACAAGACTTTCTCGCACCTCGCCACCTACCAGGCGCACCTCAAGTACAGCCGCGCGCACGCCAGCGACAACGTCTTCAAATTCCCATGTCCTATGTGCAACAAGGGCTACCCGACCAAGGAGGCGATGCAGGACCACTTTAACTACCAACACCTGGGCAAGACCTCGCACAAGTGTCCAGTTTGCGAAAAGCCGATAGCGTCTCGGGCCAACGTGGAGAGGCACATGATGCGGGTCCACGGCGAGAAGAAGGAGAAGCCCCGGAGCCACGTCTGCCAGATGTGCGGGAAAGGGTTCACTGATAAGAAAGCTTTAACCCAACACGAAGTGATCCACTCCGGGGAGCGGCCTCTGTCGTGCGAGATATGCCACCAGACGTTCAAGCAAAAAGCGTCTTTATATACACACAGAAAGAGAGTTCATAAAGTCTTCCCCACGAAGCGAGTTGTTGAGTATATGGATACTAAAGTCGAAGGGAATTAA
Protein Sequence
MEQDVESGFGTMCCTCLSSSRDLFSINNVSQVYQIFRLLMYDFAGDRFGDSLSDMEQLVCWECLALMRRFIKFKWQVHNAQEHLRVIALSRSQESMDHTYMSQSLSSLQIETKTEYDKIYFEFSNEPEEQQYIAISSVHTHVKNESFDVAQAVRDNINLGLEDHILDVPILENPVLGVMSHIVVGTDALVSSADLPHTDGAIPHLTIAPLLNTPKLEMMPKGKQKPDQAVSKCGFVTEYMTEPEMLGCREAAKQKVQYASSVYKCELCIIGFYTQQQVEDHFVGAHRAKPGQEPCKVCYVYVDEAKLAAHVDQHYCRYSCKLCGHVEYSARLAQQHQQGHSVKPLPGAVIKIGDVGPTAAGKSKKKKSKEPQKTPPKPGDLRKLLSKTTIEGYQCLECEMFFKNSRSRKNHVARYHREGLQCDHCKKRFVNRTTLATHLRLHEGPLPREECPVCHKLVRVIQLKYHVQRHQSKSRYQCRDCDKTFSHLATYQAHLKYSRAHASDNVFKFPCPMCNKGYPTKEAMQDHFNYQHLGKTSHKCPVCEKPIASRANVERHMMRVHGEKKEKPRSHVCQMCGKGFTDKKALTQHEVIHSGERPLSCEICHQTFKQKASLYTHRKRVHKVFPTKRVVEYMDTKVEGN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00622289;
90% Identity
iTF_01179799;
80% Identity
-