Basic Information

Gene Symbol
-
Assembly
GCA_905333125.1
Location
HG995427.1:1143639-1148206[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 4.7e-06 0.00028 21.3 2.4 1 23 195 217 195 217 0.98
2 12 0.00025 0.015 15.9 1.8 1 23 223 245 223 245 0.97
3 12 1.3e-05 0.00079 19.9 3.1 1 23 251 273 251 273 0.96
4 12 2.2e-05 0.0013 19.2 0.5 1 23 279 301 279 301 0.92
5 12 4e-06 0.00024 21.5 2.5 1 23 307 329 307 329 0.95
6 12 8.1e-06 0.00048 20.5 0.4 1 23 335 357 335 357 0.99
7 12 4.3e-05 0.0026 18.3 0.2 1 23 363 386 363 386 0.97
8 12 2.3e-05 0.0014 19.1 0.4 1 23 392 414 392 414 0.99
9 12 3.1e-07 1.9e-05 25.0 0.2 1 23 420 442 420 442 0.99
10 12 0.00053 0.031 14.8 5.8 1 23 448 470 448 470 0.97
11 12 2.8e-05 0.0016 18.9 0.8 1 23 476 498 476 498 0.98
12 12 2e-07 1.2e-05 25.6 1.6 1 23 504 527 504 527 0.97

Sequence Information

Coding Sequence
ATGGAGAGGCTGACTATTTGTCGTATCTGCCTCGATGGGAATCCTCAGCATGAAACTGTGAACACACAGCTGCAAGAAGTATATCAAAAACTAACGACGCAACCGTTTCAAACAAGTGACATGCGGCCCATGGCATTATGCTACATATGTCACGCACAATTAGAAACCTCTCGCAGACTCATGCTCAAGTGTCTGAAGGCCGAGGAACTGCTTGCGGATATGGTGAAGCACATATTGCCCGACGAGACAGAGGTACCAAAACCTACTCACCTAGTTCAATCAATCAATACTCGGTTACCAACTTCTTCGATGGAAGAAATCGGTGATGATGATGATGTTCAACACCAACATAGTAACGTCAAAGTGGAAATACCAATCATTAAAACGGAGGAACCAAGTTTGCAAGAGACAGCATCCGACGACGAACTGAGAGTGGATCTTGAGGAGGAAGCACCCTCCAGTGTAATGAAGCCCAAACTGGAAATCGAACTGCAAACACCAACAAATAGTATTAATTACGTGATCTTGAACCCTGATAAACTAAATAATAATGTTACCACAAGTCATCCTGTTAAAGACAAATTCGTTTGTGGTATATGCAAGAAAACGTTCCGCAAGAGTTTCAATTATAAATTGCATTTGCGGGTTCACACCGGCGAGAAGCCGTACGTGTGCAAAGTTTGCAACAAATCCTACAACCAAATGTGTGATTTGAGGACACACGAGATTATACACACGGGCGAGCAGCCGTTCGTGTGCAAAGTGTGCAACAAAAGCTTCAATAGGAAGACGTCGTTGCAATTGCACGAGCACATACACTCCAGCGAGAAGCATCACGTGTGCAAAGTTTGCGATAAAGGTTTCACGTCGAAGGGCCAATTGATACAACATGAGGTGCTACACACTGGCAAAAAGCCCTTTTTATGTAACATTTGTAATAAATGTTTCAGCCGGAAGGGTGTTCTGTCGAAACACATGCTCATACACACAGGCGAGAAGCCATACACATGTAATGTTTGCAACAAAAGTTTTAACGCGCTCGGTGGGCTTAAAACTCACGCACGCACCCACACGGGCGAGAGACCGTTCGTGTGCAATGTTTGCGACAAAGGTTTCATTGCGCAGTCTGGCTTGTTAATTCACACACGAAGACGACACACCGGCGAAAAGCCGTACGTCTGCGATGTGTGCGGTAATAAATTCATCGATGGTGAGTCTTTGAAAAGGCACACGCGAAAGCACACAGGCGAGAAACCTTACACGTGCAACGTGTGCGATAAAGGATTCAGTGCGCAGAGCAGTTTGACAGCGCACGCGCGCACTCACACGGGTGAGAAGCCGCATGTGTGCAAATTTTGCGATAAACGATTCGCACAGAGCAATCGGCTGAAACTCCACCACCGTATTCACACCGGTGAAAAGCCTTTTAGTTGTGGCGTGTGTGAGAAAACATTCACGGCGAGATACACTCTGCAGATACACAAACGTATACACACCGGCGAGAAGCCGTACATTTGTGATGTTTGCAAGAAATCCTTCGTACAAAGGACCGAATTGAAAAGGCATATGCGCAATTATCACACCGACGCCGAGGCCGATGTGAAGACGTAA
Protein Sequence
MERLTICRICLDGNPQHETVNTQLQEVYQKLTTQPFQTSDMRPMALCYICHAQLETSRRLMLKCLKAEELLADMVKHILPDETEVPKPTHLVQSINTRLPTSSMEEIGDDDDVQHQHSNVKVEIPIIKTEEPSLQETASDDELRVDLEEEAPSSVMKPKLEIELQTPTNSINYVILNPDKLNNNVTTSHPVKDKFVCGICKKTFRKSFNYKLHLRVHTGEKPYVCKVCNKSYNQMCDLRTHEIIHTGEQPFVCKVCNKSFNRKTSLQLHEHIHSSEKHHVCKVCDKGFTSKGQLIQHEVLHTGKKPFLCNICNKCFSRKGVLSKHMLIHTGEKPYTCNVCNKSFNALGGLKTHARTHTGERPFVCNVCDKGFIAQSGLLIHTRRRHTGEKPYVCDVCGNKFIDGESLKRHTRKHTGEKPYTCNVCDKGFSAQSSLTAHARTHTGEKPHVCKFCDKRFAQSNRLKLHHRIHTGEKPFSCGVCEKTFTARYTLQIHKRIHTGEKPYICDVCKKSFVQRTELKRHMRNYHTDAEADVKT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-