Basic Information

Gene Symbol
-
Assembly
GCA_905333125.1
Location
HG995427.1:1071857-1086136[+]

Transcription Factor Domain

TF Family
THAP
Domain
THAP domain
PFAM
PF05485
TF Group
Zinc-Coordinating Group
Description
The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion. It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 5 3.2e-14 3.5e-11 43.8 0.0 19 86 22 81 10 82 0.87
2 5 6.3 6.9e+03 -2.0 0.8 39 76 274 314 245 321 0.60
3 5 7.1 7.7e+03 -2.1 0.1 36 58 339 362 307 379 0.68
4 5 4.4 4.8e+03 -1.5 0.1 51 62 587 600 569 617 0.66
5 5 0.78 8.5e+02 0.9 0.9 51 59 672 680 632 699 0.70

Sequence Information

Coding Sequence
ATGATCACTCTGACATCTTTCTCACCGACAAGCGATAAACTAACTAAATTCAGTATTCAAGACAGCTACTTTCTATTTCCAAAGGAACCGAACCTCCGTACAGCGTGGGTGGATGCTCTGGAGCTGACGGACTGGGAGCCAAAAGACCGGAGCACAATATGTTCCGAACATTTTAGAAATGAGGATTTCTATGTAACAAAACGGGGTCTTCGGAGGATTAAGAGTGGAGCAGTACCTGTTGTGGCTCAGGACTCCACGGACGACCTAGACGCGCCGGCCGCGTTGAGGGTCTGCAGGGTGTGCCTCGTTATGGACGTCAAGATGTATCACATGACAGAGTTCAAACTTGACCAGATGTACGAGCAGATCACTGGCATCACGACTTGTGGTGAGAGTCTGTTGCCGCAGCGGGTGTGCTGGGAGTGTGGGTCCCGGCTCGCGGCCGCCGCCAAGTTTAGGAGCAAAGCGTTGCGCGCGCACACCATCCTACAGGACTTGGTGCAGCCGCACACTTATATTAGAATCCGCGATATAAAATCAATAAACCGCACCCACGCCGACCTAAAAACATCGCTAATTCAAAAAATCTACGAGAACAACGACCACGACTTGCACATCAACGATGACACAATAAAAACGGAAACCGAACTCGCCATAGACGTGCCGGATGTAGACATAGACAAGAGCATAGACAACGATTTTAAAACACCACAATTGACGGAAATCGAAGTTAAAAACGAAAGCAACGAGATATATTTTGATGAGTTCAACGATGATTTCGGTGACTCCGACGAGAGGGCGTTGAGTGAGGTGTGCGAGGTTAAGAAGAGGATCAAGAAGAAGAGAAGCAAAGAGAAGAGAGTGAAGAGTAAGAAGATAGAAGAGGACGATACTCCGGAGACTACCACGGATAGATACAAGAAGAACGACGTCAAACGTCGTCGAACCAACGAGGCCCTCGACGAGAATCTGTTTACCATAACAACACTGACATACGATGAACAAATACAGGAGGTGTTGAAACGGCAAGAGAGCGCGAGCTATACCAACGCACCCTATAAGTGTACAGTGTGTTACAGAGGGTTCATGATAAAGGACAGATATACTGCGCACGTGGTGCGGCATAGCGAGCAAAGCGGTGCCTTCGAATGTTTCATATGCAAGACCAGACTAAAAGCCAGTCGAGCGCTTCGCAAGCACCTCACAGCGCAGCACACCGAGCAGTACAGCTGCAAGGGATGTCCGTTCGTCACGAGAAACCGGGGCGTCGCGAGGGAGCACGAGAAGTGGCACGCGGGTACTAAATACCAGTGTCCGCACTGCGCCAGCGAGTTCGATAAACTGACAACATACATGGGGCACATACGAATCAAGCACGTGTCGGACTTTGTGTGCGAGCTGTGCGGGTACACGTTCGTCAGCCAGAAGGGTATCGATGTTCACAAGAAGAAGAAACATCGACTTATCGATAAAACTGTGGACTTGGAGGGGCCGTACTGTGAAGTGTGCGATGTCAGGTTCGTGTCGGAGGAGGCGCACGACAGACATCTCAAATTATCTTCCAGACACAGCAGCGATCAGGATCCTAATCGGATACGAAACGATTCACAAAGCATGAACGCGGAAAAGAACGGCCGTGTCGTGAGACGGATAGAACGGAGACCCGTCATCCATTCCCGAGACCCGGCCGACAAGATGAACCAACAAGAGCCCCACACCCCGGTCGCGTGCGAGCAGTGCGGCGTACAGCTCCGCGACCTGCGGATGTACGCGCAACACTTCCGGCGCGCGCACCCCGACAAGAACCGCACCAAGTACCCCGCGATGAAGACCCCCTGCATGTGCGAGCAGTGCGGCAAGCTCTTCCAGAGCATGGCGCTGCTGAAGGACCACATGTGGGTGCACACGGGCGAGAAGCGCTTCAAGTGTGAGCGGTGCAGCAAGAGCTTCACGCAGAAGACCAACCTGGTGTTCCACATGCGCGTGCACAGCGCGCAGCGGCCCAGCTACCCGTGCCCGCTGTGCGGCAAGCACTTCGCCTTCTACAACAACCGCCGCCGGCACATGTTCATCCACACGGGGCTGAAGCCGTTCAAGTGCGACACGTGCGGCAAGTGCTTCACGACGGCGGGCGAGCAGCGCGCGCACGTGTCGCACGTGCACCAGAAGAAGCCCTGGCCGCGCCGCGCGCGCGCGCCCGCCTCGCGCTGGGACAAGGCGCACGACCAGCCCCTCGAGGACTAG
Protein Sequence
MITLTSFSPTSDKLTKFSIQDSYFLFPKEPNLRTAWVDALELTDWEPKDRSTICSEHFRNEDFYVTKRGLRRIKSGAVPVVAQDSTDDLDAPAALRVCRVCLVMDVKMYHMTEFKLDQMYEQITGITTCGESLLPQRVCWECGSRLAAAAKFRSKALRAHTILQDLVQPHTYIRIRDIKSINRTHADLKTSLIQKIYENNDHDLHINDDTIKTETELAIDVPDVDIDKSIDNDFKTPQLTEIEVKNESNEIYFDEFNDDFGDSDERALSEVCEVKKRIKKKRSKEKRVKSKKIEEDDTPETTTDRYKKNDVKRRRTNEALDENLFTITTLTYDEQIQEVLKRQESASYTNAPYKCTVCYRGFMIKDRYTAHVVRHSEQSGAFECFICKTRLKASRALRKHLTAQHTEQYSCKGCPFVTRNRGVAREHEKWHAGTKYQCPHCASEFDKLTTYMGHIRIKHVSDFVCELCGYTFVSQKGIDVHKKKKHRLIDKTVDLEGPYCEVCDVRFVSEEAHDRHLKLSSRHSSDQDPNRIRNDSQSMNAEKNGRVVRRIERRPVIHSRDPADKMNQQEPHTPVACEQCGVQLRDLRMYAQHFRRAHPDKNRTKYPAMKTPCMCEQCGKLFQSMALLKDHMWVHTGEKRFKCERCSKSFTQKTNLVFHMRVHSAQRPSYPCPLCGKHFAFYNNRRRHMFIHTGLKPFKCDTCGKCFTTAGEQRAHVSHVHQKKPWPRRARAPASRWDKAHDQPLED

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01173657;
80% Identity
iTF_01180700;