Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 9.7 1.5e+03 1.6 0.1 10 23 28 41 26 41 0.89

2 6 8.3e-06 0.0013 20.7 0.9 3 23 49 70 47 70 0.95

3 6 0.064 9.8 8.5 1.2 2 23 82 104 82 104 0.96

4 6 5.4e-05 0.0082 18.1 1.2 1 23 111 134 111 134 0.94

5 6 4.1e-06 0.00062 21.7 1.2 1 23 140 162 140 162 0.98

6 6 3.5e-06 0.00053 21.9 5.3 1 23 168 191 168 191 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	9.7	1.5e+03	1.6	0.1	10	23	28	41	26	41	0.89
2	6	8.3e-06	0.0013	20.7	0.9	3	23	49	70	47	70	0.95
3	6	0.064	9.8	8.5	1.2	2	23	82	104	82	104	0.96
4	6	5.4e-05	0.0082	18.1	1.2	1	23	111	134	111	134	0.94
5	6	4.1e-06	0.00062	21.7	1.2	1	23	140	162	140	162	0.98
6	6	3.5e-06	0.00053	21.9	5.3	1	23	168	191	168	191	0.98

Coding Sequence: ATGGATGGTGCGACATCTCTAAATAAACTCGGTTCATACAACATTTTTACATTATGTTGGGTCCATTCCATGAGAATGATatTCCCAACCGAGAAACGTTTGAGTGTCCACAAAAATACACATAATCCGCAGAGTATAGTAATTTGCGATAAATGCggtaaaacatttaaaagtaaaGTTCGTTTAAAAATCCATAATCGAAGTGATCATTCCAATGAACCGAAACCAGAAAAAATACCAGAACAATGTCCATTCTGTAATAAATGGTATTCGTCAAGATGGAGCGTGCATGAACATGTACGCAATATGCATACGAACAATGACATAGAACATCGTTGTCCCACCTGTGGTTTTGTGTCGACCACTGCAAAAGCTTTAAAGAAACACATACTCTTTAATCATGATGTCGTGCGTAGACACAAATGTAATTTATGTGAAAAAGCCTTCAAGAGACCCCAGGATATAAAGGAACATATGGCCACTCATACGGGCGAACCGTTGTACACTTGTGTCAATTGTGGTAAAACATTTAAGTCTAAAGCGAATATGTTTCATCATCGTAGACGTTTTCATCGAGCCGAGTGGATAGCTGATCGTACTAAACCGCCTAAAGAGAAATATTCCAGAAACTGA
Protein Sequence: MDGATSLNKLGSYNIFTLCWVHSMRMIFPTEKRLSVHKNTHNPQSIVICDKCGKTFKSKVRLKIHNRSDHSNEPKPEKIPEQCPFCNKWYSSRWSVHEHVRNMHTNNDIEHRCPTCGFVSTTAKALKKHILFNHDVVRRHKCNLCEKAFKRPQDIKEHMATHTGEPLYTCVNCGKTFKSKANMFHHRRRFHRAEWIADRTKPPKEKYSRN

Sequence clustering based on sequence similarity using MMseqs2