Basic Information

Gene Symbol
-
Assembly
GCA_951640565.1
Location
OX621195.1:14945307-14954779[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 6.3 5.7e+02 2.1 0.2 3 23 205 222 204 222 0.75
2 15 0.012 1.1 10.7 1.7 1 23 231 254 231 254 0.97
3 15 6.2 5.6e+02 2.1 0.2 2 9 260 267 259 279 0.80
4 15 0.0091 0.82 11.1 1.1 1 23 286 308 286 308 0.97
5 15 0.00079 0.072 14.4 1.4 1 23 314 337 314 337 0.93
6 15 0.0015 0.14 13.5 7.3 3 23 345 365 343 365 0.96
7 15 4.9e-08 4.4e-06 27.6 2.1 1 23 371 393 371 393 0.98
8 15 3.1e-05 0.0028 18.9 1.4 1 23 399 421 399 421 0.97
9 15 0.013 1.2 10.5 4.7 1 23 427 450 427 450 0.96
10 15 5.5e-06 0.00049 21.2 0.8 1 23 555 577 555 577 0.98
11 15 0.0041 0.37 12.1 0.8 1 23 581 604 581 604 0.95
12 15 1.2e-05 0.0011 20.2 3.1 1 23 614 636 614 636 0.98
13 15 0.021 1.9 9.9 0.5 1 23 642 664 642 664 0.96
14 15 2.2e-06 0.0002 22.5 1.9 1 23 670 692 670 692 0.99
15 15 0.0031 0.28 12.6 2.6 1 23 698 721 698 723 0.90

Sequence Information

Coding Sequence
ATGAGTGTGTGTAGAGTTTGTCTTTGCAGTAAGCCTAGAAAAGATATAGCTCAACTTAACCTTATTGAAAACACGGAAAAACAAAGTTACGAAGATGTCATGTTGTTTTGTTTAGGAATTCAGATCGTTAAAGATTCAATTATAAGTACTAAACTATGTACGaagtgctataaaaaaataggtgaattttatattttcaaaactttGGCTCTTAAAAATGATGCGCATTTGCGGGCCCTTGAATTGTCAGGGCCGAAAAACGAGATATATCTGAATAATGCCGATATTAAAAGAGAAAACTTAACAGAAGACAGTGACAATGAGAATTATGAAGATGCGGTGGTACATGTAAAACAAGATGTGAACTATGAAGAACCCTTAATCTATATAAAAGAAAATGGAAACGGTGAAGCTGAGTTGGTTGTTGTTAAAGAAGAGTGCAAACAGGAAGGCCAGTCAGATGATGAGTTACTAAGTGACATTCAAAAGATCAAACATGATTCTGCtgaagaaacaaaagaaaatgCACCGGTCAAAAAGAAACGAGGTAGGCCAAAAAAACTGCCCACATTGCTGACAAAACGTGTCAAAACAGTAAATGAAACTAAGATATGCACAGAATGCGGCTTGGCAGTCAAAAACCTGAGGACCCATGCACTCAGGCATTTGCCTATTGAAAAGCGGAAACAATTCAAATGCGAAATCTGTGACAAATACTTCTTAAGCAATCCTGCAAAACGAAAACACATAAAACGGAAACATCTGGCTATCAAAATGCAATGTCATTTATGCGACAAagCGGTTCTTAACATAAAGCAGCACATTCTGAGGATTCACGACACGGATTCCTTAAAGTTTGAATGCGTCTCATGCAGCCGTCGCTTTCAATCGCAGGCGCATCTCGACTTGCACATCACTATCCATACTAAGGACAAGCCCCACGAGTGCAGCATTTGTGGGAAACGGTTTCGGCTCAAACTCAGCTTGGTGCAACATAAACTCCAGGTACATGACAAAGAAAAGTCTCATCTATGCCAGTTCTGTTCGAAGAGTTTCTTCAAAAAATACCATTTGCAAGTACATTTGAGATCACATACAAACGAAAAGCCATACCCTTGTCCTGATTGCGGTAAACACTTCACTTCGAGTTCGACGCTCAAGAACCACCGCCTCACGCACGGAAAAGAGAAAAACTTCATCTGCGACCACTGCAACATGAGCTTTGTATCGCGCAACTACCTCCGCGCGCATCTTATCAGCCATGTAAAAGACAAACGCTATCCGTGCACATTCTGCGGCGTGAGATTCCACCGCTCCGACCATCGTAAGAGACATGAATACACGGCGCACTTGCAGGAAAACCCTACGGGGAAGACGAGGAAAGTTCGCACTGCGTTACCGGCACCACCATCTGATAATCCAGACGAAGAGCGATCAGAAGGAGACAACATGCTACAAACTCCATCCCCAAGCCACAGTGAGAACGACCACATGGATAAGCTACAAGATGAACAATTACAGGAAAATATATCTGATAAATCTGAAGATGAACCGCAAAGTGAACAGGAAACAATGGAAACTCAAGAAATTGTTCAAGGGCTTGCAACAGACTTGGATAAGAACATGAAAAGCACTCCACAACAGGATTCCATTCCGCTCCCATTCCCATGTACAAAATGCGATCTTCGGTTTCCGAAGAAGGCTCAGCTTAACAGGCATATATTGAAACACAATAGGATATACAAGTGCACTAAGTGTGATAACAAATATGATGAACAGGCTAGCCTTAAAGAGCACAAaaAAGCGGCACATCCTAGAATACAAAATACTAAAGCTCATTTCATGTGCTCCCAATGTTCCAAGAGCTTCTACAAACAACAACTATTGGACCGACATATGAGGACACACGCAAAGAAGAGGCCATACAAATGTCCCGACTGCAGCCAGACATATCTCTCGGCCAAGCTCATGAGGGTGCACCGCACCATCCACACCACTGAAAGGAACTTCAAGTGCACTCTCTGTCCGAAGACCTTTACGACCGACTATTACCTCCGAGCTCACGTGAAGACTCACACAAAGGACAGTTCATTCCCGTGTCAGTTTTGCGGCACAGTGTTCTACCGACCGGATCACCGCACGCGACACGAGTTCAACAAACACATGCGACAGTCTGTCGCAAGACTCGCGAGCGCAGCCGCGACACGGAAAAAGCAGGCAGAGGAGAAAGAAAAGGCATCTGAGGGAAGGGAAAGTGtatcaaataataatgttatctaa
Protein Sequence
MSVCRVCLCSKPRKDIAQLNLIENTEKQSYEDVMLFCLGIQIVKDSIISTKLCTKCYKKIGEFYIFKTLALKNDAHLRALELSGPKNEIYLNNADIKRENLTEDSDNENYEDAVVHVKQDVNYEEPLIYIKENGNGEAELVVVKEECKQEGQSDDELLSDIQKIKHDSAEETKENAPVKKKRGRPKKLPTLLTKRVKTVNETKICTECGLAVKNLRTHALRHLPIEKRKQFKCEICDKYFLSNPAKRKHIKRKHLAIKMQCHLCDKAVLNIKQHILRIHDTDSLKFECVSCSRRFQSQAHLDLHITIHTKDKPHECSICGKRFRLKLSLVQHKLQVHDKEKSHLCQFCSKSFFKKYHLQVHLRSHTNEKPYPCPDCGKHFTSSSTLKNHRLTHGKEKNFICDHCNMSFVSRNYLRAHLISHVKDKRYPCTFCGVRFHRSDHRKRHEYTAHLQENPTGKTRKVRTALPAPPSDNPDEERSEGDNMLQTPSPSHSENDHMDKLQDEQLQENISDKSEDEPQSEQETMETQEIVQGLATDLDKNMKSTPQQDSIPLPFPCTKCDLRFPKKAQLNRHILKHNRIYKCTKCDNKYDEQASLKEHKKAAHPRIQNTKAHFMCSQCSKSFYKQQLLDRHMRTHAKKRPYKCPDCSQTYLSAKLMRVHRTIHTTERNFKCTLCPKTFTTDYYLRAHVKTHTKDSSFPCQFCGTVFYRPDHRTRHEFNKHMRQSVARLASAAATRKKQAEEKEKASEGRESVSNNNVI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-