Basic Information

Insect: Petrophora chlorosata
Gene Symbol: -
Assembly: GCA_951640565.1
Location: OX621190.1:18599626-18601524[-]

Transcription Factor Domain

TF Family: P53
Domain: P53 domain
PFAM: PF00870
TF Group: Beta-Scaffold Factors
Description: P53 is a tumor suppressor gene product; mutations in p53 or lack of expression are found associated with a large fraction of all human cancers. P53 is activated by DNA damage and acts as a regulator of gene expression that ultimatively blocks progression through the cell cycle. P53 binds to DNA as a tetrameric transcription factor. In its inactive form, p53 is bound to the ring finger protein Mdm2, which promotes its ubiquitinylation and subsequent proteosomal degradation. Phosphorylation of p53 disrupts the Mdm2-p53 complex, while the stable and active p53 binds to regulatory regions of its target genes, such as the cyclin-kinase inhibitor p21, which complexes and inactivates cdk2 and other cyclin complexes [PMID: 20066118, PMID: 12629332, PMID: 1397838, PMID: 6544917, PMID: 19826090, PMID: 19776744, PMID: 6278740, PMID: 221923, PMID: 6318442, PMID: 20030809].This domain is found in p53 transcription factors, where it is responsible for DNA-binding. The DNA-binding domain acts to clamp, or in the case of TonEBP, encircle the DNA target in order to stabilise the protein-DNA complex [PMID: 11780147]. Protein interactions may also serve to stabilise the protein-DNA complex, for example in the STAT-1 dimer the SH2 (Src homology 2) domain in each monomer is coupled to the DNA-binding domain to increase stability [PMID: 9630226]. The DNA-binding domain consists of a beta-sandwich formed of 9 strands in 2 sheets with a Greek-key topology. This structure is found in many transcription factors, often within the DNA-binding domain.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.01 1.6e+02 2.8 0.0 91 127 70 106 59 115 0.82

2 7 0.01 1.6e+02 2.8 0.0 91 127 153 189 142 198 0.82

3 7 0.01 1.6e+02 2.8 0.0 91 127 236 272 225 281 0.82

4 7 0.01 1.6e+02 2.8 0.0 91 127 319 355 308 364 0.82

5 7 0.01 1.6e+02 2.8 0.0 91 127 402 438 391 447 0.82

6 7 0.01 1.6e+02 2.8 0.0 91 127 485 521 474 530 0.82

7 7 0.028 4.5e+02 1.4 0.1 91 124 568 601 557 614 0.80

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.01	1.6e+02	2.8	0.0	91	127	70	106	59	115	0.82
2	7	0.01	1.6e+02	2.8	0.0	91	127	153	189	142	198	0.82
3	7	0.01	1.6e+02	2.8	0.0	91	127	236	272	225	281	0.82
4	7	0.01	1.6e+02	2.8	0.0	91	127	319	355	308	364	0.82
5	7	0.01	1.6e+02	2.8	0.0	91	127	402	438	391	447	0.82
6	7	0.01	1.6e+02	2.8	0.0	91	127	485	521	474	530	0.82
7	7	0.028	4.5e+02	1.4	0.1	91	124	568	601	557	614	0.80

Sequence Information

Coding Sequence: ATGTATCGGAACAGGCGCGGCGGCTCTGCGTCGACGCGCAGACACTGTATACTCACTCGGTGGAGTGCAGCCAGCGGTCGGCGATGTATCGGAACAGGCGCGGCGGCTCTGCGTCGACGCGCAGACACTGTATACTCACTCGGTGGAGTGCAGCCAGCGGTCGGCGATGTATCGGAACAGGCGCGGCGGCTCTGCGTCGACGCGCAGACACTGTATACTCACTCGGTGGAGTGCAGCCAGCGGTCGGCGATGTATCGGAACAGGCGCGGCGGCTCTGCGTCGACGCGCAGACACTGTATACTCACTCGGTGGAGTGCAGCCAGCGGTCGGCGATGTATCGGAACAGGCGCGGCGGCTCTGCGTCGACGCGCAGACACTGTATACTCACTCGGTGGAGTGCAGCCAGCGGTCGGCGATGTATCGGAACAGGCGCGGCGGCTCTGCGTCGACGCGCAGACACTGTATACTCACTCGGTGGAGTGCAGCCAGCGGTCGGCGATGTATCGGAACAGGCGCGGCGGCTCTGCGTCGACGCGCAGACACTGTATACTCACTCGGTGGAGTGCAGCCAGCGGTCGGCGATGTATCGGAACAGGCGCGGCGGCTCTGCGTCGACGCGCAGACACTGTATACTCACTCGGTGGAGTGCAGCCAGCGGTCGGCGATGTATCGGAACAGGCGCGGCGGCTCTGCGTCGACGCGCAGACACTGTATACTCACTCGGTGGAGTGCAGCCAGCGGTCGGCGATGTATCGGAACAGGCGCGGCGGCTCTGCGTCGACGCGCAGACACTGTATACTCACTCGGTGGAGTGCAGCCAGCGGTCGGCGATGTATCGGAACAGGCGCGGCGGCTCTGCGTCGACGCGCAGACACTGTATACTCACTCGGTGGAGTGCAGCCAGCGGTCGGCGATGTATCGGAACAGGCGCGGCGGCTCTGCGTCGACGCGCAGACACTGTATACTCACTCGGTTGAGTGCAGCCAGCGGTCGGCGATGTATCGGAACAGGCGCGGCGGCTCTGCGTCGACGCGCAGACACTGTATACTCACTCGGTGGAGTGCAGCCAGCGGTCGGCGATGTATCGGAACAGGCGCGGCGGCTCTGCGTCGACGCGCAGACACTGTATACTCACTCGGTGGAGTGCAGCCAGCGGTCGGCGATGTATCGGAACAGGCGCGGCGGCTCTGCGTCGACGCGCAGACACTGTATACTCACTCGGTGGAGTGCAGCCAGCGGTCGGCGATGTATCGGAACAGGCGCGGCGGCTCTGCGTCGACGCGCAGACACTGTATACTCACTCGGTGGAGTGCAGCCAGCGGTCGGCGATGTATCGGAACAGGCGCGGCGGCTCTGCGTCGACGCGCAGACACTGTATACTCACTCGGTGGAGTGCAGCCAGCGGTCGGCGATGTATCGGAACAGGCGCGGCGGCTCTGCGTCGACGCGCAGACACTGTATACTCACTCGGTGGAGTGCAGCCAGCGGTCGGCGATGTATCGGAACAGGCGCGGCGGCTCTGCGTCGACGCGCAGACACTGTATACTCACTCGGTGGAGTGCAGCCAGCGGTCGGCGATGTATCGGAACAGGCGCGGCGGCTCTGCGTCGACGCGCAGACACTGTATACTCACTCGGTGGAGTGCAGCCAGCGGTCGGCGATGTATCGGAACAGGCGCGGCGGCTCTGCGTCGACGCGCAGACACTGTATACTCACTCGGTGGAGTGCAGCCAGCGGTCGGCGATGTATCGGAACAGGCGCGGCGGCTCTGCGTCGACGCGCAGACACTGCAGCAGCGTGCACAGCGCCGCGTACCGCATGTCGTGTCGCATCActagcgccgccgccgcgggtAGTATGCGAGACACCTCGCCGTGGCTCTTCTCTATCTCCCTGTAA
Protein Sequence: MYRNRRGGSASTRRHCILTRWSAASGRRCIGTGAAALRRRADTVYSLGGVQPAVGDVSEQARRLCVDAQTLYTHSVECSQRSAMYRNRRGGSASTRRHCILTRWSAASGRRCIGTGAAALRRRADTVYSLGGVQPAVGDVSEQARRLCVDAQTLYTHSVECSQRSAMYRNRRGGSASTRRHCILTRWSAASGRRCIGTGAAALRRRADTVYSLGGVQPAVGDVSEQARRLCVDAQTLYTHSVECSQRSAMYRNRRGGSASTRRHCILTRWSAASGRRCIGTGAAALRRRADTVYSLGGVQPAVGDVSEQARRLCVDAQTLYTHSVECSQRSAMYRNRRGGSASTRRHCILTRWSAASGRRCIGTGAAALRRRADTVYSLGGVQPAVGDVSEQARRLCVDAQTLYTHSVECSQRSAMYRNRRGGSASTRRHCILTRWSAASGRRCIGTGAAALRRRADTVYSLGGVQPAVGDVSEQARRLCVDAQTLYTHSVECSQRSAMYRNRRGGSASTRRHCILTRWSAASGRRCIGTGAAALRRRADTVYSLGGVQPAVGDVSEQARRLCVDAQTLYTHSVECSQRSAMYRNRRGGSASTRRHCSSVHSAAYRMSCRITSAAAAGSMRDTSPWLFSISL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -