Basic Information

Gene Symbol
topi
Assembly
GCA_963921195.1
Location
OY992536.1:292716544-292722549[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 2.6e-05 0.0022 19.7 2.6 1 23 316 338 316 338 0.97
2 9 0.13 11 8.0 0.0 2 23 372 393 371 393 0.94
3 9 1.4 1.2e+02 4.8 0.1 2 19 461 478 460 480 0.94
4 9 0.13 11 8.0 2.2 1 22 529 550 529 553 0.90
5 9 1.1e-06 9.2e-05 24.0 1.9 1 23 610 632 610 632 0.95
6 9 0.0066 0.57 12.1 1.1 1 23 638 663 638 663 0.95
7 9 0.98 84 5.3 1.7 1 23 669 691 669 691 0.88
8 9 8.4e-08 7.2e-06 27.5 0.4 1 23 697 719 697 719 0.99
9 9 0.095 8.1 8.4 1.4 3 23 727 748 725 748 0.95

Sequence Information

Coding Sequence
atgaaTGTAAACGACGAAGACTTTAACAATTCTGATGCTTGGTTATCAGAACAATTGTTTGCACAATTAAAAGATTTTAATGGAGATTACATAGATAGAAATGCAACTGGATTAATGATGAATGAAACATACCAAAATTGTTCCCAAAATATGCCACTACTAGAGGAAGACAACGACGTTCAACCCCAAGatttatcaacaaaaatttgtttagatTCCTGTGATGATGCTTTTAAGAAACATAATTTCAATTATAATCTAAATTCCGAAGTTTTGGATTTAAGTAATACAACAATTAAAACTGTTGAAATTATGGAGCCAACCCCCACAACTTTACTAAACATGGTCTCAGCAAAAATACCGGTGGTAACAGCACCTGTGGTTGCAGAGGCAGCAGCAGTTGTAAGTGAAGTTGTTAAACAAAATGCATTGCCTACATTTAATCCTTGTGAAGAAGAAttaaaaatattgacatttttagaGGGTCATCAACCAAAAAGTGATTTTATAGATTCAAATATTTTTGTATCACCCGAATTACCTTGTTCGTCCTATCGCATTGTAAAGTGTGCAAATTGTAACTGTATATTTGATATAATTTCCTTCCAATCTCATGTTTGTGATTATGATGAACAACATAATTTAATAGTGTCCCCCACAAACTCAACTACTTTAAGTAAATCTATAAAAGAAGAACCCCTATTGCCACCAGAACCAGCATGTATACGTTTATTAAAGGAAAATCAAATTCGAATAAGACGTTTTCTTAAAGATGAATTAAAATATGATGTTAATGCGGTTGGTAATAATATTAGTACTACTAGCAGCAATAACACGAATTCCAGTACATTAAACAGTTCTTCCACATCTAATGAGGGCTTAAATTCTTCGTCAACTTCTATTATGTCCTCAAATTCATCTAGTACCAAAAAAACGGATGGTCCTCATGAATGTACCTTGTGTGATAGAAAATTTGTTCATGCTTCTGGATTATTACGACATATGGAAAAACATGCAATGGATTTAATACCCACATCTAATACAACTGGTAATAAATCGACAGCACCTCAAGGAAACTCTTTACATGGTGTTAATGGTTTACGAGTTGTTATTAAATGCACTTTATGTGGTCGCATATTTTTTGAACCGAATGCTGCTTTAGCACACTTAGGTACACATTTTCCCAACACTTTAAAAGATGAAAAAGAATTGGATAATTTTGGTGAAATTCCATATGATGTTTATGTTGATGATGCTTTGAACTATTTAAGAACGGAGGCCCAATTATCATCACCTAATCAAAACAATTCTACCAACATTAATTATCAAGAAGACAAACCTCCTGTTTATCTTAAAATGGTTATATTAAGTTGTTTACTGCAATGTGAATTTTGTGATTTGCTATTTTCCGAAGTCTCTTATTTATTTGTTCATTCTGCTTGTCATCTTCCTGAAAGAAGATTTGAATGCTTTGCttgtgaaatttttgtaaaaacatctAAAGAAATCTGTACACATTGGCAGGCAGAATGTGTATTTATGCGGGAAAATTTAAAAGTACACCAGGCAACAACTCAGCGTTATTTTGTTTGTAATGTATGCGAAAATAAATTTCAATCTTTGGATCAACTGCATGAACATCGTTATACATCCTATCATTTCTTTCCACGACTAaacaaaaatttgggaattttacaATTGCCCTGTGAATATTGTGAGAGTATTTTCGATAATGTTCAAGAATGCGTTGCTCACTATGAGGAGAAACATTACAAGAAGTATAAAAGAGATAAAGATGGTACTGGTAGTTCCAGCAAGACACGACAATATTTGTGTGAAATTTGTGGTAAATCATATACGCAGTCCAGTCATTTATGGCAACATTTACGTTTTCATCAGGgtgttaaaccgTTTGCCTGTAAAGAACCGGGTTGTACGCGTAAATTTACAATACGTCCTGATTTGAATGATCATATACGCAAATGTCATACTGGAGAAAGACCTTACCACTGTTTGGTATGCGGCAAACGTTTTCTTACCGGTTCGGTATTCTATCAACATCGTCTTATACATCGTGGTGAACGACGTTATGAATGCGAAGAATGTGGTAAACGTTTTTATCGTGCTGATGCACTCAAGAATCATCAACGCATACACACTGGCGAAAAACCATTTGGCTGTTtattttgtactaaaaattttagACAGCGAGGCGATCGTGATAAACATATTCGCGCAAGACATTCACATTTAGATGCTAATGCTCGTTTAATGATGCAAAtgcaaaaattacaattagaagcTGCTGCAGCTGAGTCAACTGCCCAATTGCCCCAACAACAGAAAATAACTACAAATAATACAATATCATCATCATTAAATACAATTGCcaataataatgaaaatattccaCCTTCTATTAATTACCAGTACAATACAAATGATAACGAGTTACTACAAGATGTTATGATTGGTAATGTTGCATTTCCAAGATGTATGTTTGATTCTATAATTCCAAATATTAACCAGGATAAAGATTTTTATTCTATACATTAA
Protein Sequence
MNVNDEDFNNSDAWLSEQLFAQLKDFNGDYIDRNATGLMMNETYQNCSQNMPLLEEDNDVQPQDLSTKICLDSCDDAFKKHNFNYNLNSEVLDLSNTTIKTVEIMEPTPTTLLNMVSAKIPVVTAPVVAEAAAVVSEVVKQNALPTFNPCEEELKILTFLEGHQPKSDFIDSNIFVSPELPCSSYRIVKCANCNCIFDIISFQSHVCDYDEQHNLIVSPTNSTTLSKSIKEEPLLPPEPACIRLLKENQIRIRRFLKDELKYDVNAVGNNISTTSSNNTNSSTLNSSSTSNEGLNSSSTSIMSSNSSSTKKTDGPHECTLCDRKFVHASGLLRHMEKHAMDLIPTSNTTGNKSTAPQGNSLHGVNGLRVVIKCTLCGRIFFEPNAALAHLGTHFPNTLKDEKELDNFGEIPYDVYVDDALNYLRTEAQLSSPNQNNSTNINYQEDKPPVYLKMVILSCLLQCEFCDLLFSEVSYLFVHSACHLPERRFECFACEIFVKTSKEICTHWQAECVFMRENLKVHQATTQRYFVCNVCENKFQSLDQLHEHRYTSYHFFPRLNKNLGILQLPCEYCESIFDNVQECVAHYEEKHYKKYKRDKDGTGSSSKTRQYLCEICGKSYTQSSHLWQHLRFHQGVKPFACKEPGCTRKFTIRPDLNDHIRKCHTGERPYHCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPFGCLFCTKNFRQRGDRDKHIRARHSHLDANARLMMQMQKLQLEAAAAESTAQLPQQQKITTNNTISSSLNTIANNNENIPPSINYQYNTNDNELLQDVMIGNVAFPRCMFDSIIPNINQDKDFYSIH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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